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1 supporting a role in protein sorting to the zymogen granule.
2 ypoplastic and individual acini produced few zymogen granules.
3 2 may mediate the sequestration of zinc into zymogen granules.
4 creatic cancer cell line, MIA PaCa-2 without zymogen granules.
5 hat are predominantly associated with mature zymogen granules.
6 ding proteins and is localized on pancreatic zymogen granules.
7 ed that GP2 is important in the formation of zymogen granules.
8 nstrated the presence of Rab3D on pancreatic zymogen granules.
9 protein showed wild type Rab3D localized to zymogen granules.
10 us fluorescence imaging of quinacrine-loaded zymogen granules.
11 ity of the Gq/11 protein immunopurified from zymogen granules.
12 try, myosin I was also localized on isolated zymogen granules.
13 ting GTPase activity of the Gq/11 protein on zymogen granules.
14 -like protein to the cytoplasmic face of the zymogen granules.
15 beta subunits were not found on membranes of zymogen granules.
16 ed with disorganized and dilated ER, loss of zymogen granules, accumulation of autophagic vacuoles, a
17 on the total GTPase activity of the purified zymogen granules and a larger inhibitory effect on the G
21 Ca signals ultimately induce exocytosis of zymogen granules and identification of the proteins invo
22 in Gq/11 was identified on pancreatic acinar zymogen granules and its function in calcium-regulated e
23 ansporter ZnT2 (Slc30a2) is localized to the zymogen granules and that dietary zinc restriction in mi
27 as degeneration of exocrine cells, decreased zymogen granules, and alterations in the endoplasmic ret
28 teins found on synaptic vesicles, pancreatic zymogen granules, and chromaffin granules, suggests GAIP
30 t the amount of endogenous Rab3D on purified zymogen granules as assessed by either Western blotting
31 etagogue carbamylcholine, a subpopulation of zymogen granules became coated with filamentous actin.
32 ced in the pancreas where they are stored in zymogen granules before secretion into the intestine.
33 h Rap1 and Epac1 colocalized with amylase in zymogen granules, but only Rap1 was integral to the zymo
34 Hemagglutinin-tagged Rab3D was localized to zymogen granules by immunohistochemistry, and was shown
35 ycerol, and cAMP activate the release of the zymogen granule content in a manner that is poorly under
37 in bound directly at mildly acidic pH to the zymogen granule content proteins amylase, prolipase, pro
41 in understanding the proteins present on the zymogen granules, especially Rabs and SNARE proteins, an
42 we describe characteristics of fusion during zymogen granule exocytosis in exocrine pancreatic acinar
44 y, we have investigated the possibility that zymogen granules express InsP3 receptors and are thus Ca
49 l cellular polarity and inability to secrete zymogen granules in pancreatic acinar exocrine cells.
51 g disruption of retinal cell layers, lack of zymogen granules in the pancreas, and dilated Golgi in i
53 oad that results from the exocytic fusion of zymogen granules is significantly blunted by HCO3 (-) bu
54 ding to exocytosis of pancreatic acinar cell zymogen granules is the inositol 1,4,5-trisphosphate (In
55 also because the majority of them lacked the zymogen granule marker rab3D, a small GTPase implicated
56 not alphas or alphao, to be localized to the zymogen granule membrane along with G-protein beta-subun
57 stigation has focused on the proteins of the zymogen granule membrane, and several novel proteins hav
59 The small GTPase Rab27B localizes to the zymogen granule membranes and plays an important role in
60 stochemistry, and was shown to be present on zymogen granule membranes by Western blotting; both resu
61 f these v-SNARE proteins are associated with zymogen granule membranes in pancreatic acinar cells.
65 he pancreatic pro-enzymes, packaged into the zymogen granules of acinar cells, become activated and c
68 ish apical-basal polarity, properly position zymogen granules, or communicate with adjacent cells, di
69 as significant keratin overexpression alters zymogen granule organization and causes aging-associated
73 pical-basal polarity, increasing the size of zymogen granules, reorganizing the cytoskeletal network,
74 bules showed that alphaq/11 localized to the zymogen granule-rich apical region of acinar cells toget
78 were able to study the dynamics of isolated zymogen granules, the secretory vesicles in exocrine pan
79 that while the wild-type Rab3D localized to zymogen granules, the two dominant negative mutants did
80 rticipates in zinc transport into pancreatic zymogen granules through a glucocorticoid pathway requir
82 sms whereby intracellular messengers mediate zymogen granule transport and exocytosis in the pancreat
84 on in pancreatic acinar cells, exocytosis of zymogen granules was quantified by continuous, time-diff
88 le preparation consisted of essentially pure zymogen granules, whereas the granules prepared without
92 ar cells contain two distinct populations of zymogen granules (ZGs) expressing either VAMP 2 or VAMP
93 treated) exhibit normal apical exocytosis of zymogen granules (ZGs) in response to physiologic stimul
96 in increased cytoplasmic zinc and decreased zymogen granule zinc that further demonstrated that ZnT2
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