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1 differential regulation of TLR7-mediated Ab-forming cell (AFC) and germinal center (GC) responses, a
3 functions of the vast majority of adenylate-forming enzymes are unknown without tools available to a
5 e used machine learning to predict adenylate-forming enzyme function and substrate specificity from p
6 ggested divergent evolution of the adenylate-forming superfamily from a core enzyme scaffold most rel
8 eve their chaperone activity against amyloid-forming clients and how cells defend against pathologica
14 ly dispersed sites outside a prion's amyloid-forming region can contribute to prion character, and al
15 opensity and seeding ability of this amyloid-forming segment were modulated by site-specific phosphor
16 al center formation via short-lived antibody-forming cells (AFCs) localized to extrafollicular region
17 ral and safe 'antimicrobial' against biofilm-forming bacteria in food systems vis-a-vis other convent
19 h antimicrobial peptide-inducing and biofilm-forming capacities outcompeted pathogenic bacteria durin
20 ic resistance genes characterized by biofilm-forming and human-microbiome-influenced environments wit
21 rt a reference genome for the marine biofilm-forming diatom Seminavis robusta, showing that gene fami
23 (DeltarexB > USA300 > DeltasarA) of biofilm-forming ability were used to infect full-thickness porci
25 ombination significantly reduced the biofilm-forming abilities of the tested Candida species by up to
27 ent and iStent Supra), and conjunctival bleb-forming procedures (Xen gel stent and InnFocus microshun
28 f vascular endothelial cells to become blood-forming, or hemogenic, and the subsequent endothelial-to
29 ons regarding the effects of ageing on blood-forming stem cells; we suggest instead that changes in t
34 this intermediate leveraged additional bond-forming chemistry and enabled the one-pot synthesis of k
35 aradigm decouples the bond-breaking and bond-forming steps of the catalytic cycle to enable the use o
36 By harnessing the stereoselective C-C bond-forming activity of Fub7, we established a chemoenzymati
38 t two steps and use of an efficient C-C bond-forming reaction, this radical-based protocol enables th
40 eophile that engages in dearomative C-C bond-forming reactions with allylpalladium(II) electrophiles
44 eral decades, limiting the types of C-C bond-forming transformations possible through biocatalytic me
46 in the transition state; two concurrent bond-forming events; and a spatiotemporal-base rate accelerat
47 with a spectrum of heterolytic covalent-bond-forming activity (that is, reacting diversely with small
48 pparent regioselectivity of the desired bond-forming event is a convergent process that is initiated
49 r-catalysed C-C, C-N, C-B, C-Si and C-F bond-forming reactions using unactivated alkyl electrophiles.
50 in carbon-carbon and carbon-heteroatom bond-forming reactions, these have numerous crucial limitatio
53 elopment of efficient and selective C-N bond-forming reactions from abundant feedstock chemicals rema
54 one of the most commonly practiced C-N bond-forming reactions in pharmaceutical and laboratory synth
57 capture represents the key C(sp)-C(sp3) bond-forming step in the copper-catalyzed C-H functionalizati
59 nvolves extensive communication between bone-forming osteoblasts and bone-resorbing osteoclasts to or
60 Sun and Solar System accreted within the CAI-forming epoch, which lasted less than 200,000 years.
63 hese data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved a
64 iour of bone tumours, particularly cartilage-forming tumours, and tumours are now further subdivided
68 ed to the periplasmic leaflet by the channel-forming WzmWzt ABC transporter for ligation to the core
72 d in penetrance in B and T cells; (2) colony-forming units (CFUs) revealed clonal evolution or multip
74 ntranasally with S. pneumoniae (1,500 colony-forming units) or vehicle (phosphate-buffered saline) at
75 mice were supplemented with 1 x 10(9) colony-forming units of L lactis subsp cremoris ATCC 19257 or L
79 stromal cells [MSCs] and endothelial colony-forming cells [ECFCs]) may potentially result in in vivo
80 Founding populations are small, a few colony-forming units, and infections are rapid, lasting roughly
84 ficient mice displayed an increase in colony-forming unit-erythroid progenitors and in all erythrobla
85 n was required for SAMD14 to increase colony-forming activity, c-Kit signaling, and progenitor surviv
87 d, and medians were reported as log10 colony-forming units (CFUs) per gram of bone or log10 CFUs per
90 ation size converted to the number of colony-forming units establishing infection in wild plains zebr
91 ion typically requires measurement of colony-forming units, which is labor intensive and takes at lea
94 red for UM7F8's capacity to block the colony-forming ability of murine leukemia-initiating cells.
99 of polymerization of the stabilizer and core-forming blocks, PISA provides rapid access to a wide ran
100 y, block copolymers with crystallizable core-forming blocks and functional coronal segments were coas
101 amide reduced the number of intestinal crypt-forming enteroids without affecting their structure, ASM
103 ndent DNA strand-breaks occur near the Z-DNA-forming region in human cell extracts, and we model thes
104 Both ERCC1-XPF and MSH2-MSH3 bind to Z-DNA-forming sequences, though ERCC1-XPF recruitment to Z-DNA
106 er in citridone B is catalyzed by an epoxide-forming P450 enzyme, followed by carbon skeletal rearran
107 sfer (FRET) dual DNA probes with the excimer-forming pyrene pair as a donor and sulfo-Cy3 dye as an a
110 the repertoire of known prokaryotic filament-forming CCRPs and demonstrate that cyanobacterial CCRPs
111 RPs) that are predicted as putative filament-forming proteins, we observed a higher proportion of CCR
112 tion, S173I, that is located at the filament-forming interface, and further show that a previously re
113 ing mode of H-NS proteins), whereas filament-forming proteins significantly increase the stiffness of
114 ances (PFASs) are identified in aqueous film-forming foam (AFFF) concentrates and AFFF-impacted sites
115 orooctanesulfonamide (FOSA), or aqueous film-forming foam (AFFF) formulations at concentrations rangi
116 amination related to the use of aqueous film-forming foam (AFFF) has been documented at hundreds of m
117 PFAS exposure resulting from aqueous film-forming foam (AFFF) ingestion is poorly understood due t
119 Soil and groundwater from an aqueous film-forming foam (AFFF)-impacted site were sampled at high r
120 luoroalkyl substances (PFAS) at aqueous film-forming foam (AFFF)-impacted sites is limited by various
121 , ADONA, 9Cl-PF3ONS), and three aqueous film-forming foam (AFFF)-related zwitterionic PFASs (AmPr-FHx
125 sed to Ansulite and Arctic Foam aqueous film-forming foams (AFFFs), the BSAF was related to perfluori
129 ition of baboon semen containing 10(6) focus-forming units (FFU) of ZIKV (n = 3 for FP isolate H/PF/2
131 Red Sea has favorable habitats for framework-forming DWC species and highlights the need for conducti
132 show that the dynamics of the two framework-forming units, polyatomic anions and pyrazines, govern b
133 aintaining processive replication through G4-forming sequences, and exhibits partial redundancy with
134 upregulation of the succinate-CoA ligase GDP-forming beta subunit (SUCLG2), which regulates succinate
137 The pH-shift process for isolation of gel-forming proteins from fish processing by-products was ex
139 lites in pure Se and in binary AsSe(4) glass-forming liquids near their glass transition temperature.
144 ndant facilitation cascade involving habitat-forming marsh cordgrass and aggregations of ribbed musse
145 damage range from the rapid loss of habitat-forming organisms, through to a reduction in the service
146 quences of shifts and losses in such habitat-forming species for associated communities and ecosystem
148 reaks (DSBs) revealed that long-stem hairpin-forming sequences could form foldback inversions when pr
149 istal to the DSB, whereas short-stem hairpin-forming sequences formed foldback inversions when proxim
158 highlights the potential success of hydrogel-forming microneedle arrays as a transdermal drug deliver
164 ophila, both the visual system and non-image-forming photoreceptors contribute to circadian clock res
167 the systems-level organization of the image-forming, nonimage forming, oculomotor, and accessory opt
168 psin ganglion cell types do project to image-forming brain targets, it is important to note that this
170 oligomerization of the upstream inflammasome-forming sensor and proceeds through a multistep process
171 the carbon backbone, presumably via lactone-forming Baeyer-Villiger oxidation and subsequent intramo
174 rgoes a developmental transition from a leaf-forming vegetative SAM to an inflorescence- and flower-f
175 omprehensive time-scaled phylogeny of lichen-forming fungi (LFF) to date (over 3,300 species), we ide
176 protein Dumpy is spatially expanded in lobe-forming species, connecting the posterior lobe to the an
177 sement membrane protein, collagen IV, in LVV-forming endothelial cells (EC), and could be partially o
179 d with n-dodecyl-beta-d-maltoside, a micelle-forming detergent, we are able to discern the dissociate
181 rpenoid biosynthetic pathways: the multibond-forming polyene cyclizations catalyzed by the yet poorly
185 nge of synthetic building blocks and network-forming reactions offers an enormous variety of CMPs wit
186 el of unselected patient-derived neurosphere-forming cells and found that GBM cells can be distinguis
188 found that transgenic expression of nonchain-forming P/rds generated abundant high-curvature OS membr
189 ly into a unique monophyletic group of odour-forming staphylococci about 60 million years ago, and ha
190 f-tensioned Maxwell fluid exhibits a pattern-forming instability that was studied by analytical tools
192 variability inevitably exists within pattern-forming systems on both microscopic and macroscopic scal
193 ths received 1 intranasal dose of 105 plaque-forming units (PFU) of LID/DeltaM2-2/1030s (n = 21) or p
194 onths received 1 intranasal dose (105 plaque-forming units [PFUs] of D46/NS2/N/DeltaM2-2-HindIII [n =
195 l (vaccine-placebo ratio, 2:1) at 106 plaque-forming units (PFU) in 15 RSV-seropositive children and
196 s to yield on average 23 mL of 10(11) plaque-forming units (PFUs) per milliliter for Pseudomonas, Kle
198 ated PrP (Prnp187N) challenged with a plaque-forming prion strain showed a phenotype reversal, with a
199 e challenged with 2 subfibrillar, non-plaque-forming prion strains instead developed plaques highly e
201 (v)2 Ca(2+) channels are comprised of a pore-forming alpha(1) subunit (Ca(v)1.1-1.4, Ca(v)2.1-2.3) an
203 okines such as IL-1beta and IL-18 and a pore-forming protein, gasdermin D, which triggers pyroptosis,
205 denylyl cyclase (AC) domain linked to a pore-forming RTX cytolysin (Hly) moiety, binds the complement
208 MRSA strains encoding alpha-toxin(4)-a pore-forming toxin that binds the metalloprotease ADAM10 on t
209 ing repeats-in-toxin (MARTX) toxins are pore-forming bacterial toxins that translocate multiple funct
210 esterol-dependent cytolysins (CDCs) are pore-forming proteins that serve as major virulence factors f
211 esterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target membrane
212 ltage-gated sodium (Na(V)) channels are pore-forming transmembrane proteins that play essential roles
213 y, we show that the membrane-associated pore-forming protein Perforin-2 (P2) is critical for LPS-indu
216 aureus produces an array of bicomponent pore-forming toxins that target and kill leukocytes, known co
222 pylori (Hp) secrete VacA, a diffusible pore-forming exotoxin that is epidemiologically linked to gas
223 exhibits behavior typically observed in pore-forming proteins, such as porins and ionic transporters.
226 ly by the recently identified family of pore-forming proteins known as gasdermins, the best character
231 mbinatorial libraries from which potent pore-forming peptides have been derived, optimized to work un
232 ge of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cel
233 the membrane selectivity of a prolific pore-forming peptide, melittin, based on experimental observa
235 port the structures of a staphylococcal pore-forming cytotoxin, leukocidin GH (LukGH), in complex wit
237 in D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved by ac
238 cking and biophysical properties of the pore-forming alpha1 subunit and trigger excitatory synaptogen
239 e generally, treatment with H2A and the pore-forming antibiotic polymyxin B completely eradicates bac
240 surface of podocytes, with most of the pore-forming domain (PFD) and C terminus of the Serum Resista
242 Recent studies have suggested that the pore-forming group A colicin N (ColN) instead uses lipopolysa
244 lex) contains four core components: the pore-forming MCU protein, the gatekeepers MICU1 and MICU2, an
245 lipopolysaccharide (LPS) activated the pore-forming protein Gasdermin D, which formed mitochondrial
246 tosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the anti-
248 a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectif
252 tically evaluate the candidates for the pore-forming unit of the PTP and discuss recent data suggesti
253 N-terminal region, scaffolds the L-type pore-forming alpha1 subunit and, through its C-terminal regio
254 ability, thermal stability, and uniform pore-forming capability, which endow the resultant frameworks
255 s a rapid age-hardening response during post-forming artificial aging treatment at 210 degrees C for
256 ge is implicated as the critical C-N product-forming event, in which a postulated oxazaphosphirane in
259 assay, we show that a putative G-quadruplex-forming sequence (PQFS) in the first intron of the Atg7
260 wever, we identified a specific G-quadruplex-forming sequence at the heavy-strand promoter (HSP1) tha
262 skeletons from six species spanning all reef-forming coral morphologies: Branching, encrusting, massi
264 e broad active site observed for the retinal-forming Synechocystis apocarotenoid oxygenase (SynACO) b
265 en approach to enable the prediction of ring-forming reactions, for which we have demonstrated its ut
268 orrelated with its structural role; scaffold-forming Nups exchange slowly, whereas flexible connector
270 oblasts as the main cellular sources of scar-forming myofibroblasts during human kidney fibrosis.
271 pre-formed biosynthetic buttons and in situ-forming matrices that strive to achieve the transparency
277 idioides difficile is a Gram-positive, spore-forming, anaerobic bacterium that infects the human gast
279 AdOx1 nCoV-19 (18-55 years: median 1187 spot-forming cells [SFCs] per million peripheral blood mononu
280 responses peaked on day 14 (median 856 spot-forming cells per million peripheral blood mononuclear c
281 RB source(6), FRB 180916.J0158+65, to a star-forming region in a nearby (redshift 0.0337 +/- 0.0002)
283 anosulfur chemistry can be initiated in star-forming regions via the elementary gas-phase reaction of
285 ucture comprises the majority of nearby star-forming regions, has an aspect ratio of about 1:20 and c
286 gher-metallicity, massive elliptical or star-forming galaxies, suggesting that perhaps the repeating
288 nsequences of the presence of long structure-forming repeats at the molecular level: somatic and inte
289 ected molecular recognition in the structure-forming step and which are reconfigured in an enzymatic
292 apy of vessel-forming cells and renal tubule-forming cells aimed at alleviating renal hypoxia and enh
293 Notably, after renal injury, renal tubule-forming cells and vessel-forming cells infused into the
297 njury, renal tubule-forming cells and vessel-forming cells infused into the renal artery did not pene
299 acillus brevis (Lb)NOX(1), a bacterial water-forming NADH oxidase, to assess the metabolic consequenc
300 haracterized CLE genes expressed in the wood-forming zone, PttCLE47 appears to be active at its site