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6 that the complexes block the G34E amantadine-resistant mutant despite some crowding in the binding si
9 t antibiotic but with HGT from an antibiotic-resistant isolate of H. pylori We find that HGT increase
10 otic-resistant bacteria (ARB) and antibiotic-resistant genes (ARGs) in human gut microbiota have sign
11 tries to track patients who carry antibiotic-resistant bacteria, including carbapenem-resistant Enter
12 tence of phylogenetically diverse antibiotic-resistant lineages, widespread geographical mixing, and
14 eaks on surgical units, involving antibiotic-resistant organisms and enteric outbreaks, as well as th
17 microbial pathogens including two antibiotic-resistant species [methicillin-sensitive Staphylococcus
19 e changes in infection rates with antibiotic-resistant organisms in the 2 to 6 years post-implementat
21 bits asexual growth of multiple antimalarial-resistant strains of Plasmodium falciparum (half maximal
23 nce, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution
25 gulls are mobile and can shed antimicrobial-resistant bacteria for extended periods, gulls may facil
26 dienone compounds are cytotoxic to apoptosis-resistant tumor cells and show activity in animal tumor
27 -stage survival of wild-type and artemisinin-resistant parasites harboring the PfKelch13:C580Y mutati
35 These findings were confirmed on bortezomib-resistant multiple myeloma cells as well as on bone marr
36 d YAP1, are activated in the Rho(High) BRAFi-resistant cell lines, and resistant cells are more sensi
38 (from 24.15 to 15.76 per 10,000), carbapenem-resistant acinetobacter species infection (from 3.33 to
39 As a case study, we multiplexed 3 carbapenem-resistant genes to show the impact of this approach on g
41 f beta-lactam antibiotics against carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistan
44 nem-resistant Enterobacteriaceae, carbapenem-resistant acinetobacter species, and MDR Pseudomonas aer
45 bal evolution of pathogenicity in carbapenem-resistant K. pneumoniae, resulting in the repeated conve
47 stant bacteria strains (including carbapenem-resistant Escherichia coli and methicillin-resistant Sta
48 ametrized via a novel analysis of carbapenem-resistant Enterobacteriaceae data reported to the Nation
49 beta-lactamase (ESBL) production, carbapenem-resistant Enterobacteriaceae, carbapenem-resistant acine
51 udomonas aeruginosa isolates were carbapenem-resistant preimplementation compared with 25.0% postimpl
53 enty-eight patients infected with carbapenem-resistant P. aeruginosa isolates susceptible to TOL-TAZ
54 temic therapy alone can result in a castrate-resistant state; therefore, increasing focus is being pl
58 hat RUNX1(+) PLCs is an intrinsic castration-resistant and self-sustained lineage that emerges early
61 vival of patients with metastatic castration-resistant prostate cancer and liver metastases assigned
62 ients with progressing metastatic castration-resistant prostate cancer taken prior to starting a stan
66 apy among men with nonmetastatic, castration-resistant prostate cancer and a rapidly rising PSA level
67 Among men with nonmetastatic, castration-resistant prostate cancer, the percentage of patients wh
68 ntravenously for the treatment of castration-resistant prostate cancer (CRPC) as the oral administrat
69 n extremely aggressive variant of castration-resistant prostate cancer (CRPC), is increasing in incid
71 as developed for the treatment of castration-resistant prostate cancer but was dropped in phase III c
74 tients with CRPC-NE compared with castration-resistant adenocarcinoma, supporting greater intraindivi
76 tions caused by 3rd-generation cephalosporin-resistant Enterobacterales (3GC-R-BSI) leads to a trade-
77 s anti-cancer agents to inhibit chemotherapy-resistant tumor growth by consuming intracellular glutat
81 ociated with the prevalence of ciprofloxacin-resistant Escherichia coli in cattle and to determine if
82 gement strategy to help reduce ciprofloxacin-resistant E. coli in cattle within the United States.
85 egression to examine associations between co-resistant phenotypes, patient and healthcare facility ch
87 -b-PDM12 sensitizes carbapenem- and colistin-resistant GNB to multiple antibiotics in vitro and in vi
89 plied in developing tough, impact- and crush-resistant materials for joining dissimilar materials.
90 n independently derived, lab-selected Cry2Ab-resistant pink bollworm strain from the United States (B
91 g directed evolution, we engineered a 'decoy-resistant' IL-18 (DR-18) that maintains signalling poten
92 r its interacting partner malin, degradation-resistant abnormally structured insoluble glycogen accum
93 on incubation method, we measure degradation-resistant glycogen in as little as 30 mg of skeletal mus
94 d to reduce CD40 relocation to the detergent-resistant membrane domain and to inhibit CD40-induced ph
95 derived cholesterol into transient detergent-resistant membrane domains (DRMs) within the ER, also ca
96 ype of PSCs and are overactivated at disease-resistant NMJs [soleus muscle (SOL)] in SOD1(G37R) mice.
104 yl)ethyl sulfide (BPTES) selected for a drug-resistant population with increased endogenous GLS2 and
105 Notably, the emergence of additional drug-resistant species, such as Candida auris and Candida gla
106 showed better activity profiles against drug-resistant influenza A strains, as well as influenza B, a
107 that PDAC consists of ALDH+/CD133+ and drug-resistant (MDR1+) subtypes of CSCs with specific metabol
108 infectious cause of death globally, and drug-resistant TB strains pose a serious threat to controllin
110 0 experimentally supported circulating, drug-resistant and prognosis-related lncRNA biomarkers; (ii)
111 the mechanisms remain poorly clarified, drug-resistant strains are widely believed to be less infecti
112 new agents against the most extensively drug-resistant (XDR) and pan-drug-resistant (PDR) Gram-negati
113 ne antibiotics and 60% were extensively drug-resistant (XDR), resistant to first-line antibiotics, fl
114 nst multidrug-resistant and extensively drug-resistant bacteria, including ESBL, carbapenem- and coli
116 independent acquisitions of extensively drug-resistant/multidrug-resistant-inducing plasmids, probabl
119 provides significant insights into how drug-resistant strains of Mtb differentially impact immunomet
120 ced on the cortex, is typically used in drug-resistant epilepsy patients, and is increasingly being u
122 7-48 which exhibited greater potency in drug-resistant NSCLC cells (IC(50) = 17 nM) and in mice with
124 GN) cases increased owing to a surge in drug-resistant Staphylococcus aureus infections, both in the
125 which degrades the ERalpha receptor in drug-resistant tumors and has been approved for the treatment
127 s against two clinically isolated multi-drug-resistant bacteria strains (including carbapenem-resista
132 tabolic reprogramming in the context of drug-resistant Mtb infection, previous literature examining h
133 HAI) resulting from the transmission of drug-resistant pathogens affect hundreds of millions of patie
136 gest a mechanism for the development of drug-resistant tumors and a target for overcoming resistance.
139 seven major bacterial species and their drug-resistant variants in a network of 357 hospital wards.
141 d differences in the immune response to drug-resistant Mtb provides significant insights into how dru
142 id and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest
144 device in adults (age >=18 years) with drug-resistant focal epilepsy followed at 35 centres across t
145 e presurgical evaluation, patients with drug-resistant focal epilepsy were instructed to overtly expl
146 nsuring that all persons diagnosed with drug-resistant TB are started on an appropriate treatment reg
148 and in neocortical parenchyma of young, drug-resistant epilepsy patients (18-28 years old) who underw
152 s (SEs) that are abnormally activated in Enz-resistant CRPC cells and associated with enhanced transc
153 ine-27 acetylation (H3K27ac) ChIP-seq in Enz-resistant CRPC cells, we identified a group of super enh
154 ro and in vivo growth responses of Abi-/Enza-resistant LNCaP-95 cells in which CRISPR-Cas9 was used t
160 induced necrosis in several mutant and FLT3-resistant AML cell lines and primary blasts from AML pat
161 strategies to design next-generation fouling-resistant RO membranes via structural optimization: firs
162 ampin-susceptible TB accounted for 50% of FQ-resistant TB in South Africa and 83% in Southeast Asia.
163 launch a 2nd wave of spreading via an FTY720-resistant pathway after the 1st wave of spreading is inh
164 h could explain why the 20rDNA line is hyper-resistant to both bacterial and nematode infections.
168 ly, we showed that tyrosine kinase inhibitor-resistant tumors, with EGFRT790M and EGFRC797S mutations
171 e presented for the selection of insecticide-resistant vectors and the spread of resistance through r
174 -1 system is known to be impaired in insulin-resistant conditions, and we sought to understand the co
175 mice; and hyperglycemic and markedly insulin-resistant KKAy mice were used for ozone exposure studies
176 L/6J mice; hyperglycemic, but mildly insulin-resistant, KK mice; and hyperglycemic and markedly insul
177 pplementation in middle-aged, obese, insulin-resistant men affects mitochondrial respiration, content
178 (p = 0.0005) and are more type I interferon-resistant (p = 0.007) than those transmitted to males.
179 diagnosis and optimal treatment of isoniazid-resistant TB are urgently needed to avert the de novo em
181 Meta-analysis of patients with isoniazid-resistant tuberculosis (TB) given standard first-line an
182 treatment regimen for people with isoniazid-resistant, rifampicin-susceptible TB (Hr-TB), which incl
183 Here we show that inappropriate, learning-resistant fear behavior results from disruption of brain
184 1 or GFP in the parkinsonian striatum of LID-resistant Lewis or LID-prone Fischer-344 (F344) male rat
185 , since the detection of the first macrolide-resistant isolate in 1998, three epidemic waves of macro
186 uencing of all 1,575 available GAS macrolide-resistant clinical isolates of all infection types colle
187 e in 1998, three epidemic waves of macrolide-resistant GAS infections have occurred, with peaks in 19
190 pension can help individuals with medication-resistant tremor, worsening symptoms when the medication
192 gistic in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA) and bolsters the
195 unity-onset infections caused by methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resis
197 NFs (n = 584) were surveyed for methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resis
198 am-positive pathogens, including methicillin-resistant Staphylococcus aureus, a common cause of human
199 tly hastened healing in ischemic methicillin-resistant Staphylococcus aureus infected delayed healing
201 ve Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resis
202 Jails may facilitate spread of methicillin-resistant Staphylococcus aureus (MRSA) in urban areas.
205 otic classes with activity against multidrug-resistant (MDR) Gram-negative pathogens as the pipeline
206 spectrum in vitro activity against multidrug-resistant and extensively drug-resistant bacteria, inclu
207 emergence of deadly pathogens and multidrug-resistant bacteria at an alarmingly increased rate, bact
209 stant Enterobacteriaceae (CRE) are multidrug-resistant pathogens for which new treatments are despera
210 irst case of belatacept-associated multidrug-resistant Cytomegalovirus retinitis in a kidney transpla
213 is an opportunistic and frequently multidrug-resistant Gram-negative bacterial pathogen that primaril
216 olates of N. gonorrhoeae including multidrug-resistant strains at a concentration as low as 0.03 ug/m
217 aluated the accuracy of the BD MAX multidrug-resistant (MDR)-TB assay (BD MAX) in South Africa, Ugand
218 recommended a shorter (9-12 month) multidrug-resistant tuberculosis (MDR-TB) treatment regimen (as co
219 e antibiotics for the treatment of multidrug-resistant bacterial infections, particularly the ESKAPE
220 ith respect to the transmission of multidrug-resistant gastrointestinal pathogens and the risk of tre
223 aracterized genomic variability of multidrug-resistant Rhodococcus equi isolated from soil samples fr
224 ent indicated an increased risk of multidrug-resistant TB (MDR-TB) emerging (8%), compared to drug-se
225 ions of extensively drug-resistant/multidrug-resistant-inducing plasmids, probably facilitated by hor
226 kill clinical isolates of several multidrug-resistant bacteria-including those from the genera Acine
227 to colonization and infection with multidrug-resistant organisms, including vancomycin-resistant Ente
229 y on the contacts of patients with multidrug-resistant tuberculosis.Methods: In a prospective cohort
231 her the in vitro susceptibility of multi-NAI-resistant AIVs is associated with in vivo susceptibility
234 st of Essential Medications for treating non-resistant malaria, rheumatoid arthritis (RA) and systemi
235 use of PARPi in BRCA-competent and olaparib-resistant cancers, making fully small-molecule-induced s
239 nically relevant platinum and acquired PARPi-resistant patient-derived xenografts (PDXs) models.
242 d the conversion of the mutated C1 into a PK-resistant and infectious form perpetuating the biochemic
243 ucted a genomic survey of clinical polymyxin-resistant (PR) Klebsiella pneumoniae to determine the mo
245 schedule self-administration and punishment-resistant responding, food reward tolerance and escalati
246 ld as toxic as permethrin in four pyrethroid-resistant strains and not significantly less toxic than
247 ction against clinical malaria in pyrethroid-resistant areas compared to standard pyrethroid-only LLI
248 uito populations that are largely pyrethroid-resistant, often with elevated levels of P450s that can
253 ons have been reported in rpoB in rifampicin-resistant clinical isolates of Mycobacterium tuberculosi
257 rom all six Tau isoforms as well as Sarkosyl-resistant Tau aggregates extracted from cell cultures an
258 cyst nematode (SCN) relies on the use of SCN-resistant soybean cultivars, a strategy that has been fa
259 nds C3 with low nanomolar affinity in an SDS-resistant complex, and the nanobody is demonstrated to b
262 llent activity against several streptogramin-resistant strains of Staphylococcus aureus, exhibits dec
264 /4 [BMP2/4], osteocalcin [OCN], and tartrate-resistant acid phosphatase [TRAP]) analyses were perform
265 ts of PRF membranes as indicated by tartrate-resistant acid phosphatase (TRAP) staining and pit forma
266 ng/BH), number of cells stained for tartrate-resistant acid phosphatase (TRAP) and immunohistochemica
267 is driven by tumor heterogeneity and therapy-resistant populations that can reinitiate growth and pro
268 cute myeloid leukaemia owing to both therapy-resistant disease and treatment-related toxicities.
269 was itself regulated by MDM2, and in therapy-resistant melanoma cell lines, nuclear accumulation of M
270 Wnt ligand that drives a metastatic, therapy-resistant phenotype, stabilizes the half-life of p53 and
272 g of mutation kinetics demonstrated that TKI-resistant low-level mutations are invariably selected if
276 approximately 15%-20% of advanced treatment-resistant prostate cancers, and this may manifest clinic
284 n 34 individuals (ages 18-65) with treatment-resistant depression (TRD) who received a single ketamin
286 of treatment for 33 patients with treatment-resistant schizophrenia and 31 controls, and processed u
287 increase in bla(TEM-1B) copy number, the TZP-resistant isolate does not incur a fitness cost compared
291 ant Staphylococcus aureus (MRSA), vancomycin-resistant enterococcus (VRE), extended-spectrum cephalos
292 ant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), Pseudomonas aeruginosa (PA
293 ant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis/faecium (VREfc/VREfm), a
295 d CDI (CO-HCFA-CDI), incidence of vancomycin-resistant Enterococci (VRE) colonization after receiving
296 about the population structure of vancomycin-resistant Enterococcus faecium (VREfm) in Latin America
297 l acquisition and transmission of vancomycin-resistant Enterococcus faecium (VREfm) is the driver for