ライフサイエンスコーパス: -substituted

1 alyzed ring-opening reaction of various C(1)-substituted unsymmetrical oxabenzonorbornadienes (OBD) w

2 acile access to a single regioisomer of N(1)-substituted 2-aminobenzimidazoles as well as fused tetra

3 1-Substituted and 1,1-disubstituted tetrahydro-beta-carbol

4 1-Substituted derivatives of the carbene (R != H) are sens

5 ide access to several different classes of 1-substituted azulenes, including a conjugated ketone and

6 A mild, direct C-H arylation of 1-substituted tetrazoles to 5-aryltetrazoles is developed

7 We also evaluated a series of C(10)-substituted cytisine derivatives, using two-electrode vo

8 hosphinines, starting from a 3-N(CH(3) )(2) -substituted 2-pyrone and (CH(3) )(3) Si-C=P.

9 were performed on a series of bicyclic C(2)-substituted pyranoside models to isolate and analyze fac

10 el process delivers medicinally relevant 1,2-substituted cyclobutyl boronic esters with high levels o

11 tion) provided access to a wide variety of 2-substituted and 2,3-disubstituted pyrroles from the avai

12 rature, protecting-group-free oxidation of 2-substituted anilines has been developed to generate an e

13 The exposure of 2-substituted anilines to PIFA and trifluoroacetic acid or

14 s employed for the metal-free synthesis of 2-substituted benzo[b]thiophenes from 2-haloalkynyl (heter

15 efficiency in catalyzing the synthesis of 2-substituted benzothiazoles and quinazolines in excellent

16 The reaction is tolerant of 2-substituted resorcinols (R' = OH, Cl, Br, Me), allowing

17 tic imidazolate frameworks (ZIFs) based on 2-substituted imidazolate linkers.

18 zed by [Ir(cod)Cl](2) (4 mol %) to provide 2-substituted indoles (up to 70% yield) in just one step.

19 The less reactive 2-substituted ethynylphosphonates required gold complexes

20 We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a ne

21 20 degrees C in a sealed tube delivers the 2-substituted-2H-indazoles in a single synthetic step with

22 verted N-monosubstituted OPD substrates to 2-substituted benzimidazoles; however, electron-poor subst

23 d selectivity and showed that while the C(3)-substituted indoles are selective, high affinity NOP lig

24 A novel series of C(3)-substituted piperdinylindoles were developed as nocicept

25 This new protocol enabled access to 6-CF(3)-substituted 1,3-thiazine beta-secretase inhibitor 2.

26 The hydrodefluorination of CF(3)-substituted alkenes can be catalyzed by a nickel(II) hyd

27 Interestingly, a CF(3)-substituted BODIPY, known for forming J-type aggregates,

28 carbene-metal-amide photoemitters with CF(3)-substituted ligands to show sky-blue to deep-blue photol

29 orimidazolide chemistry afford various CF(3)-substituted mono- and dinucleoside oligophosphates in go

30 unsaturated delta-lactones featuring a CF(3)-substituted quaternary stereocenter in high yields with

31 r differences in reactivity between 2- and 3-substituted pyridines.

32 acid, MAR reduced only one double bond in 3-substituted muconic acids.

33 Dimerization of 3-substituted 2-oxindoles has been developed under a mild

34 ilyl bromide (TMSBr) to a broad variety of 3-substituted and 3,3-disubstituted oxetanes.

35 xperimental side, the hydride reduction of 3-substituted cyclobutanones was proven to be highly selec

36 oselective intermolecular C2-allylation of 3-substituted indoles is reported for the first time.

37 an be considered as elongated analogues of 3-substituted piperidines.

38 The nucleophilic substitution on 3-substituted 2-methoxytropones to form azulenes is depend

39 shown to be convenient precursors to other 3-substituted 1,2-oxazine derivatives using Lewis/Bronsted

40 4-Substituted 2,4-dioxobutanoic acids inhibit influenza vi

41 A collection of 42 novel alkyl 4-substituted-2-methyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]

42 via radical addition to the C4 position of 4-substituted quinoline substrates, with subsequent Hantzs

43 re inert exocyclic double bond of the same 4-substituted Delta1-pyrroline-2-carboxylic acid substrate

44 However, the photochromism of 3(5)-substituted-1H-pryazoles has not yet been investigated,

45 We designed a 2,5-substituted benzoic acid scaffold that displayed equipot

46 oxidovanadium(V) complexes derived from 3,5-substituted-N-salicylidene-l-tert-leucine were used as c

47 roviding access to 4-, 1,4-, 1,5-, and 1,4,5-substituted triazoles in excellent yield.

48 are developed to selectively obtain 4- and 5-substituted azulenes based on the nature of bases and nu

49 thoxide, and aromatic nucleophiles to form 5-substituted 3,4-eta(2)-1,3-cyclohexadiene complexes in g

50 sation of MeP(SiMe(3))(2) with a series of 5-substituted isophthaloyl chlorides (5-R'C(6)H(3)-2,6-{C(

51 ng pyrroloisoquinolone, leads to variously 5-substituted 3H-pyrrolo[2,3-c]isoquinolines in excellent

52 morphous phase transitions of prepared 1,3,6-substituted pentafulvenes showed the expected reversible

53 A series of 6-substituted 7-deazapurines and the corresponding nucleos

54 eta-keto esters led to the biosynthesis of 6-substituted l-pipecolates.

55 An efficient access to 6-substituted 7-deazapurine and the corresponding nucleosi

56 A method for the synthesis of 2,3,6,7-substituted anthracene derivatives, one of the most chal

57 Here, differently 8-substituted 3-arylcoumarins are complementarily studied

58 A series of 8-substituted 1-methyl-1,4-dihydropyrazolo[3',4':4,5]pyrro

59 9-Substituted 2-chloro-6-sulfonylpurines provide 6-azido-2

60 A series of 5,7,9-substituted 2-azapyrenes were synthesized for the first

61 selective, and direct C-H peroxidation of 9-substituted fluorenes has been achieved using a Mn-2,2'-

62 C) vaccination with tumor-encoded amino acid-substituted (AAS) peptides revealed diverse neoantigen-s

63 chromone derivatives into challenging 3-acyl-substituted chromones in excellent yield.

64 and efficient synthetic routes toward 3-acyl-substituted chromones ranging from readily available chr

65 This suppressor variant and an Ala-substituted beta-hairpin PriA variant displayed wildtype

66 Expression of alanine-substituted, phosphodeficient GFP-gle1A(6A) promoted SG

67 Using alanine-substituted BigDyn analogs, we find that the BigDyn modu

68 pot procedure for the preparation of 2-alkyl-substituted N-arylindoles is described.

69 ed allylic substitution of challenging alkyl-substituted secondary allylic carbonates with benzylzinc

70 loped, enabling efficient synthesis of alkyl-substituted acylsilanes in high yield.

71 ng blocks for isosteric replacement of alkyl-substituted isoxazole and pyrazole was shown by the synt

72 he steric demand of the electron-rich, alkyl-substituted double bond determines the reaction pathway,

73 2) and formic acid, similar to smaller alkyl-substituted CIs, and by contrast, slow removal in the pr

74 from primary, secondary, and tertiary alkyl-substituted alkynes, thus demonstrating divergent regios

75 Various alkyl-substituted cis- and trans-epoxides can be reduced to tr

76 ies, and cytoprotective nature of alkylamine-substituted perthiocarbamates.

77 Using this dually reactive alkylamine-substituted perthiocarbamate platform, the generation of

78 nd aryl-, heteroaryl-, alkenyl-, and alkynyl-substituted homoallylic alpha-tertiary NH(2) -amines is

79 metallacycle becomes possible when an alpha-substituted enoate is used.

80 The chiral alpha-substituted allylboronic acids were reacted with aldehyd

81 Chiral alpha-substituted allylboronic acids were synthesized by asymm

82 der mild aqueous and basic conditions, alpha-substituted enone-aldehydes and 1,3-carbonyls undergo a

83 ty would be attained and the resulting alpha-substituted NH-ketimines, wherein there is strong C=N ->

84 The yet unknown 2-amino-substituted lambda(3) ,sigma(2) -phosphinines are phosph

85 For example, the OH stretch of an amino-substituted analogue is red-shifted by roughly 50 cm(-1)

86 eveloped a series of synthetic aminopyrazole-substituted resorcylate amides with broad, potent, and f

87 lectronic properties of the Si-adsorbed and -substituted monolayer graphene systems are studied by a

88 nce spectroscopy reveals that the anthracene-substituted derivatives fluoresce poorly (Phi < 0.01).

89 to accompany these reactions, the anthracene-substituted derivatives resist direct photoinduced oxida

90 t rapid nonradiative decay of the anthracene-substituted derivatives, perhaps because of inter-arene

91 emical oxidative switching of an antioxidant-substituted resorcinarene macrocycle is reported.

92 The reaction of aroyl-substituted donor-acceptor (D-A) cyclopropanes with two

93 d for the regioselective synthesis of 2-aryl-substituted 2H-indazoles is reported.

94 ctive and fully selective, leading to 3-aryl-substituted imidazopyridines in moderate to high yields

95 development of the rearrangement for 7-aryl-substituted oxazolo[5,4-b]pyridines treated with aluminu

96 mple method generates the corresponding aryl-substituted cyclic amines, typically, with good conversi

97 protocol to selectively prepare (hetero)aryl-substituted naphthofurans via a Suzuki-coupling-ring-con

98 A proprietary library of novel N-aryl-substituted amino acid derivatives bearing a hydroxamate

99 led to the synthesis of compound 7j (N-aryl-substituted valine derivative) that possesses dual PPARg

100 Cloke-Wilson-type ring expansion of the aryl-substituted cyclopropane carbaldehydes with the hydroxyl

101 nd thiols to afford 3-alkoxy- and 3-arylthio-substituted 1,2-diphenylcyclopropenes, which can be capt

102 ates in the asymmetric synthesis of backbone-substituted scaffolds similar to 3,3'-disubstituted BINO

103 ion at room temperature, affording the AD,BC-substituted 2-methoxycarbonyl-2-propenone.

104 n developed for the synthesis of beta-benzyl-substituted 5-membered heterocyclic carbaldehydes via tr

105 ctical approach for the synthesis of N(beta)-substituted alpha,beta-diamino acids, such as 1-isohisti

106 -Diels-Alder (rDA) reaction to afford a beta-substituted furan/pyrrole derivative and a stable triazo

107 ma-substituted alcohols and amines from beta-substituted ketones.

108 ich can be processed further to furnish beta-substituted, alpha,beta-disubstituted, or alpha,beta,alp

109 icient procedure for the preparation of beta-substituted furans/pyrroles is presented.

110 etric Wagner-Meerwein rearrangements of beta-substituted styrenes are catalyzed by the C(2)-symmetric

111 Bicyclic-substituted piperidine ring derivatives of naphthalene a

112 ine Greek cross (+)-assembly of 6,13-bisaryl-substituted pentacene derivatives.

113 nd monomeric solution state for 6,13-bisaryl-substituted pentacene derivatives.

114 A 2D array of bismuth-substituted iron-garnet nanopillars on an ultrathin iron

115 h an array of 2-alkyl-, 2-aryl-, and 2-boryl-substituted 1,1-diboryl alkenes, giving rise to enantioe

116 ouple with alkynes, generating various boryl-substituted homoallylic alcohol motifs with good stereos

117 The late-stage derivatization of a bromine-substituted, tetracyclic indoline derivative with alkyl

118 symmetry such that the chlorine- and bromine-substituted structures are non-centrosymmetric.

119 may contain an alkyl-, a chloro-, or a bromo-substituted Z-alkene, can either be purchased or prepare

120 e precursor for selective formation of bromo-substituted B,N,B-benzo[4]helicenes 2 a/2 b via intramol

121 -coupling reactions to be performed on bromo-substituted naphthopyrans without the ring-contraction s

122 ound that this activator, the bromothiophene-substituted small molecule GAT1508, is specific for brai

123 rehensive experimental study of a di-t-butyl-substituted cyclooctatetraene-based molecular balance to

124 higher than that of the silyl and tert-butyl-substituted analogues because of attractive dispersion i

125 The di-t-butylphosphino-substituted species are ineffective for such substrates;

126 the previously reported di-t-butylphosphino-substituted species.

127 nt of homoallylic alcohols bearing a Z-F(3)C-substituted alkene can also be prepared with similar hig

128 s of chromane is metal-free generation of C1-substituted glucal from d-mannose, which was further con

129 the development of three types of smNBEs: C1-substituted, C2-substituted, and C5-substituted or C5,C6

130 of three types of smNBEs: C1-substituted, C2-substituted, and C5-substituted or C5,C6-disubstituted N

131 C3-substituted 1H-indazoles are useful and important substr

132 N), leading to the selective formation of C3-substituted imidazo[1,2-a]pyridines, an heterocyclic moi

133 ophilic C1 carbon was also alkylated when C3-substituted indolizines were employed as the substrate.

134 NBEs: C1-substituted, C2-substituted, and C5-substituted or C5,C6-disubstituted NBEs, as well as thei

135 led hydroxypyromorphite but rather a calcium-substituted hydroxypyromorphite.

136 A broad scope with all six-carbon-substituted arene motifs, control experiments, and gram-

137 of ester-, amide-, carbamate-, and carbonate-substituted 2-phenyl-2-oxazolines with mixed lithium-mag

138 Chloride-substituted variants of the Lindqvist vanadium-oxide clu

139 More specifically, Z-chloro-substituted allylic pinacolatoboronate is first obtained

140 ed spongian diterpenoids harboring a concave-substituted cis-2,8-dioxabicyclo[3.3.0]octan-3-one fragm

141 ivotal in fashioning the challenging concave-substituted cis-dioxabicyclo[3.3.0]octanone fragment.

142 The fluorescent nature of core-substituted naphthalene diimide monomers has been furthe

143 The fluorescent nature of the core-substituted naphthalene diimide (cNDI) monomers enables

144 and S-arylation to give the ortho-cyanamide-substituted diaryl thioether intermediate.

145 In addition, 8-p-anisyl-5-p-cyanophenyl-substituted psoralen exhibits aggregation-induced emissi

146 re, however, limited to diamino- and dialkyl-substituted species.

147 ynoic acid, a precursor to the trans-dialkyl-substituted AD dihydrodipyrrin.

148 on reaction of various unsymmetrical dialkyl-substituted alkenes.

149 A class of dialkylamino-substituted dibenzodiazepines and their hetero analogues

150 unsubstituted DBCOD to 68 kJ/mol for diamide-substituted DBCOD.

151 presents a series of four new diarylethynyl-substituted long acenes-three tetracenes and one anthrad

152 tilization of an electron-deficient difluoro-substituted secondary amine catalyst and the intrinsic r

153 t-dependent manner whereas difluoromethylene-substituted 1H-isochromen-1-ones are generated under the

154 ond at the C3 position afforded dihydrofuryl-substituted indole.

155 ybenzyl-, and alpha-3,4-dihydroxybenzylidene-substituted derivatives, exhibited complex and varying s

156 ary route employs reaction of a gem-dimethyl-substituted dihydrodipyrrin-carboxaldehyde (AD half) and

157 zoate transfer from the bis(4-dimethylamino)-substituted benzhydryl benzoate Ar(2)CH-OBz to the pheny

158 A versatile synthetic route to distannyl-substituted polyarenes was developed via double radical

159 ifferent rotamer conformations; b) bulky Dur-substituted phosphasilene forms two radicals (Si- and P-

160 In contrast, a sulfonyl, ester-substituted alkyne is reactive enough that it couples wi

161 ing methyl, methoxy, dimethoxy, benzyl ether-substituted iodo-benzenes, other iodoarenes, such as iod

162 violet neutral complexes, which carry an EWG-substituted dinegatively charged catecholate ligand.

163 dichloride complexes having a bis-ferrocenyl-substituted pyridinediimine ligand was systematically sy

164 ed, and evaluated a novel series of fluorine-substituted cyclohexene analogues, thereby identifying 8

165 side chain for incorporation of fluoroalkyl-substituted azoles into the structures of biologically a

166 ere functionalized on the surface by a furyl-substituted carbene through an insertion reaction.

167 ow that expression of either N196K- or G301D-substituted U2AF2 can subtly alter splicing of represent

168 wild-type (WT) compared with N196K- or G301D-substituted U2AF2 proteins, each bound to a prototypical

169 decreased RNA-binding affinity of the G301D-substituted protein.

170 We found that expression of the G301D-substituted U2AF2 protein reduces splicing of a minigene

171 lation of alkynes to access alpha,beta,gamma-substituted allylic amines in an atom-economic fashion i

172 astereo- and enantioselectivities from gamma-substituted enol diazoacetates, while their geometrical

173 oconvergent syntheses of stereodefined gamma-substituted alcohols and amines from beta-substituted ke

174 d stereocontrol from silyl-protected Z-gamma-substituted enoldiazoacetates and imido-sulfur ylides by

175 ity and catalytic efficiency of the germanyl-substituted ligands is higher than that of the silyl and

176 n alternating copolymer from the same glycol-substituted cyanostar macrocycle and phenylene-linked di

177 Using only proline catalysis, heteroaryl-substituted acetaldehydes are fluorinated and then direc

178 Heteroatom-substituted (such as yttrium and phosphorus) transition-

179 , providing ready access to alpha-heteroatom-substituted cyclobutyl boronic esters.

180 f the tridimensional compounds in heteroatom-substituted species.

181 Use of prochiral, heteroatom-substituted radicals results in stereocenters being form

182 (3)H]PSB-1584) by hydrogenation of a hexenyl-substituted precursor with tritium gas.

183 The employment of the hexyl-substituted anion [HexCB(11) Cl(11) ](-) allowed the syn

184 Information on replicative fitness of PA-I38-substituted viruses remains sparse.

185 s leads to the synthesis of alkoxy/imidazole-substituted 1,3-dihydrofuro[3,4-b]quinolines via C-O and

186 14, pK(aH) 12.6) and the 2-imidazoliummethyl-substituted pyrrolidine A21 (pK(aH) 11.1) are outside th

187 ramework (COF), which contains 2,5-di(imine)-substituted 1,4-dihydroxybenzene (diiminol) moieties, un

188 d alpha,beta-unsaturated esters, beta-indole-substituted diazo esters, and dienes are obtained with g

189 can be directed towards either tin- or iodo-substituted product formation, giving complementary choi

190 of the linkers and the barrier for isopropyl-substituted derivative 10 was experimentally estimated t

191 lesser crowding of the di-isopropylphosphino-substituted catalysts.

192 is also found that the di-isopropylphosphino-substituted complexes catalyze dehydrogenation of severa

193 Di-isopropylphosphino-substituted pincer-ligated iridium catalysts are found t

194 he latter and a gem-dimethyl, beta-ketoester-substituted BC dihydrodipyrrin afforded the enone (E, 70

195 utants with glycan extensions beyond lactose-substituted HepI (lactose alone, LNnT, or GalNAc-LNnT) a

196 We also show that the leucine-substituted variant no longer functions as a two-electro

197 ctric oxides including insulating Nb-lightly-substituted [Formula: see text], [Formula: see text] (BT

198 other remarkable trait of the new Tm- and Lu-substituted compounds.

199 two radicals (Si- and P-centred); and c) Mes-substituted phosphasilene mainly forms one species of ra

200 organic substrates, including para- and meta-substituted styrenes, substituted conjugated dienes, and

201 junctions, including destructive QI in meta-substituted phenyl rings and constructive QI in para-sub

202 zinc-bound native CA II and non-native metal-substituted CA IIs, we demonstrate that the characterist

203 of synthetically highly versatile metalloid-substituted alkenes, which are key building blocks on ro

204 report a new mechanoacid based on 2-methoxy-substituted gem-dichlorocyclopropane (MeO-gDCC).

205 vide alpha-aryl and alpha-alkyl alpha-methyl-substituted nitriles, respectively.

206 re made possible by a self-assembled, methyl-substituted carbazole monolayer as the hole-selective la

207 sis to show that all-syn contiguously methyl-substituted hydrocarbons, with chain lengths from C6 to

208 For methyl-substituted phenols, the presence of methyl substituents

209 led to each other via para-phenylene, methyl-substituted para-phenylenes, or a bicyclo[2.2.2]octane r

210 Unlike the methyl-substituted analogue, the phenyl analogue exhibits a dua

211 tane was efficiently synthesized from a mono-substituted cyclobutane through sequential C-H arylation

212 In addition, mono-substituted patulin-glutathione adducts were identified

213 The treatment of mono-substituted activated arenes led to para-brominated prod

214 rt the synthesis and characterization of a N-substituted, bisphenalenyl pai-radical cation [3(OTf)] t

215 Considering N-substituted 2-pyridone acts as a biologically-active str

216 We have identified different N-substituted 2-pyridones as inbuilt directing groups for

217 eloped to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileg

218 densation of Asmic with imines to generate N-substituted dihydroimidazoles.

219 and reports the biological activity of new N-substituted colchicine derivatives.

220 A wide variety of N-substituted 7-amino coumarin analogues was prepared in g

221 which include the preparative synthesis of N-substituted beta-amino ester derivatives via a dynamic k

222 Peptoids (oligomers of N-substituted glycines) demonstrate proteolytic stability

223 In addition, the use of N-substituted nitriles, namely cyanamides, leads to the fa

224 The hydrogenation of N-substituted vinylphosphonates using rhodium complexes de

225 gressive series of torsionally restrictive N-substituted non-NIR fluorescent rosol dyes based on dens

226 cks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

227 1-keto macrocyclic systems, as well as two N-substituted ixabepilone analogues in which the 12,13-epo

228 d apparent RNA-binding affinity of the N196K-substituted protein.

229 The 2-naphthyl-substituted (R)-imidazolinone was the best inhibitor of

230 es connected to oxazole, imidazole, or nitro-substituted pyrrole.

231 The nitro-substituted quinazolin-4(3 H)-one 2k inhibited NLRP3 inf

232 g precursors for the novel backbone nitrogen-substituted N(2)[8](A)GNRs 2a,b.

233 t enantioselectivity is achieved even with o-substituted substrates, which are particularly challengi

234 A series of tetra- and octa-substituted hexa-cata-hexabenzocoronenes (cata-HBCs) wer

235 trocyclization in the case of methoxy (-OMe)-substituted indoles.

236 diisopropenylbenzene) to yield a alpha,omega-substituted polypropylene.

237 studies have focused on the effect of ortho'-substituted nucleophilic groups such as OH, NH(2), CH(2)

238 nt study extends the investigation to ortho'-substituted vinyl and formyl groups.

239 helating and donating properties of an ortho-substituted closo-carborane (1,2-(Ph(2)PO)(2)-1,2-C(2)B(

240 the chlorination of phenol, para- and ortho-substituted chlorophenols (2-Cl, 4-Cl, 2,4-diCl-, 2,6-di

241 roducts including sterically demanding ortho-substituted heteroarenes.

242 are possible, the more crowded (doubly ortho-substituted) product is formed preferably or exclusively

243 ntense Cotton effects are observed for ortho-substituted derivatives, which undergo a rapid decomposi

244 tution and heteroaromatic and hindered ortho-substituted arenes on the azomethine ylide.

245 vides ready access to a broad range of ortho-substituted benzamides.

246 e second case, the poor performance of ortho-substituted cinnamyl electrophiles in the enantioselecti

247 ication in medicinal chemistry programs as p-substituted aniline bioisosteres.

248 iments led to the characterization of both p-substituted phenoxy radical and substituted 2-benzoylcyc

249 nt motifs in drug design as surrogates for p-substituted arenes and alkynes.

250 facile and efficient two-step synthesis of p-substituted tris(2-pyridylmethyl)amine (TPMA) ligands to

251 stituent on the N-tert-butyl moiety and para-substituted phenyl or naphthlyl moieties were synthesize

252 ted phenyl rings and constructive QI in para-substituted phenyl rings containing terminal oxazole gro

253 nes (BCPs) are valuable bioisosteres of para-substituted aromatic rings.

254 Direct irradiation of para-substituted phenols under N(2) atmosphere in homogeneous

255 the para-substituted phenol radical-cations and the corresponding

256 The binding constants (K(b)) of the para-substituted phenols with the surfactant were also measur

257 r, in the crystal, the triarylmethanol, para-substituted with the chiral moiety, shows a propensity f

258 Ozonides with para-substituted carboxymethoxy and N-benzylglycine substitue

259 ed by replacing the P1 Tyr residue with para-substituted Phe derivatives, generating new inhibitors w

260 tra, and direct magnetoelectric tensor of Pd-substituted lead titanate and lead zirconate-titanate.

261 oscopy, and magnetization measurements of Pd-substituted room-temperature magnetoelectric multiferroi

262 o acylation reactions for constructing penta-substituted arene cores, including the development of a

263 se range of pharmaceutically important penta-substituted pyrroles.

264 Working with a model, a pentamethyl-substituted derivative, we found that the mutual orienta

265 rticular, some of the obtained perfluoroaryl-substituted 2H-imidazoles were found to be of particular

266 dol condensation with the pentamethyl phenyl-substituted ketone to form an enone containing the vinyl

267 d a slightly twisted geometry for the phenyl-substituted cisoid squaraine derivative, whereas the n-p

268 The phenylimine-substituted rhodium complex (eta(5)-C(5)Me(5))Rh((Me)PhI

269 The resulting alpha-phosphorus-substituted oximes can be considered as useful P-, N-, a

270 d squaraine derivative, whereas the n-propyl-substituted derivative possessed the expected planar geo

271 The new pyridyl-substituted 3H-naphtho[2,1-b]pyrans display good photoch

272 ically linked in proline and its pyrrolidine-substituted analogues.

273 tly, two piperidinyl- and two quinuclidinium-substituted biphenyl carbamates OFH243 (13n), OFH244 (13

274 alize the different reactivities of O- and S-substituted heteroallenes.

275 antimycobacterial activity of the present S-substituted thioquinazolinones is likely due to modulati

276 determine the influence of wild-type or S34F-substituted U2AF1 on the conformational dynamics of U2AF

277 d, length as m-dash]C, SiH) and alpha-di-SiH-substituted alkynes (hetero-tri-functional: SiH, C[tripl

278 We used triisopropyl silane-substituted alkynes for the alkynylation reaction, which

279 nd high reactivity of the heteroleptic silyl-substituted stannylene in contrast to the previously rep

280 experimentally, and it was found that silyl-substituted benzenes provide the most rapid access to bi

281 hotophysical studies reveal that the Bu(3)Sn-substituted PAHs are moderately fluorescent, and their p

282 well as DFT calculations on a sulfoximinoyl-substituted model system to explain the pronounced solve

283 ends were introduced efficiently via a TEMPO-substituted initiator and chain-terminating agent, respe

284 Tetra-substituted alkenyl nitriles are obtained providing usef

285 Di-, tri-, and tetra-substituted acrylic acid derivatives with various substi

286 fication of the potent antitubercular 2-thio-substituted quinazolinone 26.

287 for the synthesis of 3-[(4-nitrophenyl)thio]-substituted 4-methylene-1-pyrrolines is described.

288 -mediated condensation to afford thioimidoyl-substituted 2,5-dihydrooxazoles.

289 e electron-donor NMe(2) and the bulkiest Tip-substituted phosphasilenes form several muoniated radica

290 Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorinat

291 nantioselective synthesis of trifluoromethyl-substituted and aryl-, heteroaryl-, alkenyl-, and alkyny

292 thesis of various classes of trifluoromethyl-substituted organic molecules in both academic and indus

293 Stereogenic trifluoromethyl-substituted carbon centers are highly sought-after moiet

294 nalized and highly versatile trifluoromethyl-substituted alpha-tertiary boronic esters.

295 ns a phosphine ligand bearing trimethylsilyl-substituted aryl groups and a triflimide counteranion, a

296 iCl affords the corresponding trimethylsilyl-substituted (Me(3)Si)(2)Si(5)R(4).

297 fluorophore is composed of a triphenylamine-substituted cyanostar macrocycle, and it exhibits a rema

298 Trityl-substituted alkynylpyridines 3-5 react with Pd(II) to fo

299 The combination of a vinyl-substituted aromatic or heteroaromatic and an alkyl brom

300 Ylide-substituted phosphines have been shown to be excellent l