ライフサイエンスコーパス: 1,25-dihydroxyvitamin D3

1 glutaminase promoter activity in response to 1,25-dihydroxyvitamin D3.

2 M, or IL-1 but not by parathyroid hormone or 1,25-dihydroxyvitamin D3.

3 hormones especially parathyroid hormone and 1,25-dihydroxyvitamin D3.

4 /kg dose for mice proved less effective than 1,25-dihydroxyvitamin D3.

5 at Cdk6 and Cdk2 activities are regulated by 1,25-dihydroxyvitamin D3.

6 e pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.

7 tory activity of the receptor independent of 1,25-dihydroxyvitamin D3.

8 ed by Salmonella stimulation, independent of 1,25-dihydroxyvitamin D3.

9 of stimulation with the hormonal VDR ligand, 1,25-dihydroxyvitamin D3.

10 200 genes were identified to be regulated by 1,25-dihydroxyvitamin D3.

11 e that is present in most tissues to produce 1,25-dihydroxyvitamin D3.

12 the kidney to its biologically active form, 1,25-dihydroxyvitamin D3.

13 vated extracellular calcium concentration or 1,25-dihydroxyvitamin D3.

14 ablished GADD45 as a primary target gene for 1,25-dihydroxyvitamin D3.

15 C family in keratinocytes and is induced by 1,25-dihydroxyvitamin D3.

16 n markers involucrin and transglutaminase to 1,25-dihydroxyvitamin D3.

17 ects of IL-1, but not parathyroid hormone or 1, 25-dihydroxyvitamin D3.

18 The ability of 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3) and structural a

19 Transcriptional activation in response to 1, 25-dihydroxyvitamin D3 (1,25-(OH)2D3) was virtually e

20 ial amounts of NO on stimulation with LPS or 1, 25-dihydroxyvitamin D3 (1,25-D3) in the absence of ac

21 time-dependent manner above that induced by 1,25 dihydroxyvitamin D3 (1,25 vitamin D3) in cultures o

22 on in human leukemia HL60 cells treated with 1,25 dihydroxyvitamin D3 (1,25D3) at low to moderately h

23 owing that microRNA-498 (miR-498) induced by 1,25-dihydroxyvitamin D3 (1,25(OH)(2)D(3)) decreases the

24 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by t

25 The hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) elicits the progr

26 1alpha-hydroxylase, the enzyme required for 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) hormone biosynthe

27 ex, plays a fundamental role in induction by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the transcript

28 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays a major rol

29 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays an integral

30 itamin D3 (2MD) is a highly potent analog of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) whose actions are

31 lase (24(OH)ase), a key metabolic enzyme for 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is up-regulated

32 way against intracellular M. tuberculosis by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form

33 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metab

34 The ability of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), to transcription

35 GF)-23, a bone-derived hormone that inhibits 1,25-dihydroxyvitamin D3 (1,25(OH)2D3; calcitriol) forma

36 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) down-modulates a

37 tein kinase C (PKC) plays a critical role in 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) promotion of HL-

38 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) suppresses c-myc

39 A quantitative method for measuring 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) was developed ut

40 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), a key regulator

41 Vitamin D3 supports 1,25-dihydroxyvitamin D3 (1,25-[OH]2D3) synthesis in the

42 Treatment with 1,25-dihydroxyvitamin D3 (1,25-D3) normalized TRPC6 expr

43 laboratory has previously demonstrated that 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) rapidly stimulate

44 vity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D(3)), which incorporate a

45 1,25-dihydroxyvitamin D3 (1,25D), the biologically activ

46 we show that functional AP-1 is required for 1,25-dihydroxyvitamin D3 (1,25D)-induced monocytic diffe

47 e reporter gene transcription in response to 1,25-dihydroxyvitamin D3 (1,25D).

48 n potentiate the transcriptional activity of 1,25-dihydroxyvitamin D3 (1,25D).

49 tic differentiation-inducing steroid hormone 1,25-dihydroxyvitamin D3 (1,25D3) and found that growth

50 We hypothesized that 1,25-dihydroxyvitamin D3 (1,25D3) and its analogues may

51 gical activities and mechanisms of action of 1,25-dihydroxyvitamin D3 (1,25D3) and nine potent 1,25D3

52 In contrast, the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D3), is predominantly immu

53 ere cultured with parathyroid hormone (PTH), 1,25-dihydroxyvitamin D3 (1,25D3), or PTH+1,25D3.

54 lated with all-trans retinoic acid (ATRA) or 1,25-dihydroxyvitamin D3 (1,25D3), the biologically acti

55 sms of acquired drug resistance we developed 1,25-dihydroxyvitamin D3 (1,25D3)-resistant sublines of

56 ll (HSNEC) conversion of 25(OH)D3 (25VD3) to 1,25-dihydroxyvitamin D3 (1,25VD3) and, furthermore, tha

57 Vitamin D3 [1,25-dihydroxyvitamin-D3 (1,25(OH)2D3)] modulates the pr

58 Up-regulation of MKP5 mRNA by 1,25-dihydroxyvitamin-D3 (1,25D) was dependent on the vi

59 that AXII gene expression is upregulated by 1,25-dihydroxyvitamin D3 [1, 25-(OH)2D3] and that additi

60 ts in elevated serum phosphate, calcium, and 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D] levels; vascular

61 We investigated the capacity of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and all-trans-ret

62 ne is regulated by extracellular calcium and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and GHS rats have

63 ifferentiate normally under the influence of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] despite the prese

64 single known regulatory mediator of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in higher vertebr

65 nce between bioactivation and degradation of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is critical for e

66 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] is the biological

67 The 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is the physiologi

68 estinal Ca hyperabsorption with normal serum 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] levels, elevation

69 le diet (WD) and supplemental calcium and/or 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the colorectal

70 e potential functional significance of human 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] receptor (hVDR) p

71 higher levels of the osteoregulatory steroid 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] than whites.

72 ll stimuli and transcriptional repression by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] through the vitam

73 In experimental models and clinical trials, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] was shown to exer

74 itamin D deficiency, and its bioactive form, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], has been shown t

75 The active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], has been shown t

76 The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is able to promo

77 High doses of the active form of vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], prevent diabetes

78 The receptors for 9-cis retinoic acid and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], RXR and VDR, res

79 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active metab

80 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the hormonal lig

81 (CYP24A1) with 25(OH)D3, 3-epi-25(OH)D3, and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]; and 1alpha-hydro

82 asing renal phosphate excretion and reducing 1,25-dihydroxyvitamin D3 [1,25(OH)2D] production.

83 ndex over the naturally occurring VDR ligand 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in an in vivo pr

84 ompletely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].

85 nal vitamin D receptor (VDR) is required for 1,25-dihydroxyvitamin D3-[1,25(OH)2D3]-induced renal rea

86 The active form of vitamin D3 (1,25-dihydroxyvitamin D3; 1,25(OH)2D3) inhibits prolifer

87 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 (2MD) is a highly potent analog

88 cidence of ACR compared to no treatment with 1,25-dihydroxyvitamin D3 (5.1% vs. 13.0%, P=0.099).

89 nor-1,25-dihydroxyvitamin D2 (200 ng/day) or 1,25-dihydroxyvitamin D3 (50 ng/mouse/day) orally throug

90 retinoid exposure was potently attenuated by 1,25-dihydroxyvitamin D3, a metabolic vitamin derivative

91 The hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, acting through its cognate nuc

92 To understand the molecular mechanism of 1,25-dihydroxyvitamin D3 action, we profiled the hormone

93 Retinoic acid and 1, 25-dihydroxyvitamin D3 activate both a genomic fragme

94 e transient gene expression system augmented 1, 25-dihydroxyvitamin D3-activated transcription, but i

95 verts 25-hydroxyvitamin D3 (storage form) to 1,25-dihydroxyvitamin D3 (active form).

96 Furthermore, CsA causes bone loss, whereas 1,25-dihydroxyvitamin D3 actually increases bone mass.

97 To support this belief, we have found that 1,25-dihydroxyvitamin D3 administration to mice increase

98 m and inositol triphosphate levels following 1,25-dihydroxyvitamin D3 administration were markedly re

99 intracellular calcium mobilization following 1,25-dihydroxyvitamin D3 administration.

100 e C-gamma1 construct were measured following 1,25-dihydroxyvitamin D3 administration.

101 extremely high serum levels of phosphate and 1,25-dihydroxyvitamin D3, along with abnormal bone miner

102 The use of 1,25-dihydroxyvitamin D3 and its analogs to increase tra

103 r patients to benefit from therapy with both 1,25-dihydroxyvitamin D3 and ligands for death receptors

104 Because of the role of 1,25-dihydroxyvitamin D3 and retinoic acid working throu

105 aT1 in the intestine is highly responsive to 1,25-dihydroxyvitamin D3 and shows both fast and slow ca

106 Our findings reveal a novel activity of 1,25-dihydroxyvitamin D3 and the VDR in regulation of pr

107 data in the literature support the idea that 1,25-dihydroxyvitamin D3 and the vitamin D receptor (VDR

108 In this study, we show that 1,25-dihydroxyvitamin D3 and three of its analogs induce

109 The role for 1,25-dihydroxyvitamin D3 and/or calcium in hair follicle

110 orbol-13-acetate [TPA], gamma interferon, or 1, 25-dihydroxyvitamin D3) and then challenged with HGE.

111 aride (LPS), estradiol, progesterone, and/or 1,25-dihydroxyvitamin D3; and transcriptional activity o

112 tudying the regulation of gene expression by 1,25-dihydroxyvitamin D3, as well as for examining facto

113 ne resorption in organ culture stimulated by 1,25-dihydroxyvitamin D3 at concentrations as low as 75

114 We find that 1,25 dihydroxyvitamin D3 binding favors both VDR-RXR het

115 Previously we demonstrated that 1,25-dihydroxyvitamin D3 blocks the progression of relap

116 We now propose that 1,25-dihydroxyvitamin D3 blocks these autoimmune symptom

117 Here, we found that 1,25-dihydroxyvitamin D3-bound [1,25(OH)2D3-bound] vitam

118 ic acid attenuates the stimulating effect of 1,25-dihydroxyvitamin D3 by decreasing the rate of VDR-R

119 ulture-derived HCV were exposed to bioactive 1,25-dihydroxyvitamin D3 (calcitriol) with or without IF

120 monstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), has a profound in

121 These results suggest that 1,25-dihydroxyvitamin D3 can be used as an effective age

122 Results show that 1,25-dihydroxyvitamin D3 can either prevent or markedly

123 The present study showed that 1,25-dihydroxyvitamin D3 causes cell cycle arrest at the

124 (PTH) significantly (p=0.0172), while serum 1,25-dihydroxyvitamin D3 concentration was not changed b

125 were immunized with pWW65 alone, pWW65 plus 1,25-dihydroxyvitamin-D3 (D3), or pRSVnt.

126 on of the death receptors, pretreatment with 1,25-dihydroxyvitamin D3 decreased apoptosis induced by

127 that endogenous NCoA62/SKIP associated in a 1,25-dihydroxyvitamin D3-dependent manner with VDR targe

128 at associate with the receptor in a strictly 1,25-dihydroxyvitamin D3-dependent manner.

129 ver, EVs from osteoclast precursors promoted 1,25-dihydroxyvitamin D3-dependent osteoclast formation

130 eract with the AF-2 domain of VDR to augment 1,25-dihydroxyvitamin D3-dependent transcription.

131 1,25-Dihydroxyvitamin D3 (DHVD3) coadministered with mon

132 1,25-Dihydroxyvitamin D3 does not suppress basal promote

133 1,25-Dihydroxyvitamin D3 enhanced LTBP1 cleavage, result

134 We also observed that 1,25-dihydroxyvitamin D3 enhanced the inhibition of T ce

135 1,25-Dihydroxyvitamin D3 exerts its effects by binding t

136 DNA or GADD45-null mouse embryo fibroblasts, 1,25-dihydroxyvitamin D3 failed to induce G2/M arrest.

137 The hormone 1,25-dihydroxyvitamin D3 has been most extensively studi

138 In the 1,25-dihydroxyvitamin D3 HL60 cell system, G1 arrest has

139 how that p21 is transcriptionally induced by 1,25-dihydroxyvitamin D3 in a VDR-dependent, but not p53

140 diator for the tumor-suppressing activity of 1,25-dihydroxyvitamin D3 in human ovarian cancer cells.

141 The efficacy of 1,25-dihydroxyvitamin D3 in prolonging graft survival in

142 ependent induction of luciferase activity by 1,25-dihydroxyvitamin D3 in reporter assays.

143 by an absent response of her fibroblasts to 1,25-dihydroxyvitamin D3 in vitro.

144 opriate splicing of transcripts derived from 1,25-dihydroxyvitamin D3-induced expression of a growth

145 important in the signaling pathway mediating 1,25-dihydroxyvitamin-D3-induced keratinocyte differenti

146 in the signal transduction pathway mediating 1,25-dihydroxyvitamin-D3-induced keratinocyte differenti

147 -II and RA 4-hydroxylase, but did not affect 1,25-dihydroxyvitamin D3 induction of the vitamin D rece

148 n A (all-trans retinoic acid) and vitamin D (1,25-dihydroxyvitamin D3) inhibited P. acnes-induced Th1

149 Thus, like cyclosporin A, 1,25-dihydroxyvitamin D3 inhibits TCR-driven activation,

150 The active metabolite of vitamin D, 1,25 dihydroxyvitamin D3, is an important immunoregulato

151 nd normalized serum 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 levels, as well as mineral and

152 nti-human CD14 Abs blocked the activation of 1,25-dihydroxyvitamin D3-matured human myelomonocytic TH

153 These studies suggest that 1,25-dihydroxyvitamin D3 may be effective in prolonging

154 of these two anti-inflammatory cytokines by 1,25-dihydroxyvitamin D3 may be responsible for the abil

155 Locally produced 1,25-dihydroxyvitamin D3 may have pleiotropic effects ou

156 y important roles in mediating the action of 1,25-dihydroxyvitamin D3 on involucrin expression, but t

157 pproach to overcome the protective effect of 1,25-dihydroxyvitamin D3 on the apoptosis of ovarian can

158 ed transcriptional repression in response to 1,25-dihydroxyvitamin D3 or 17beta-estradiol.

159 The provision of exogenous 1,25-dihydroxyvitamin D3 or an analog, 19-nor-1,25-dihyd

160 he induction of osteoclastogenesis by either 1,25-dihydroxyvitamin D3 or dexamethasone.

161 ced osteoclast-like MNC formation induced by 1,25-dihydroxyvitamin D3 or PTH-related protein in mouse

162 9-cis or all-trans retinoic acid, 1,25 dihydroxyvitamin D3, or the PPARgamma ligands prost

163 Recently, we have shown that 1,25-dihydroxyvitamin D3 prolongs graft survival in mice

164 Our results suggest that 1,25-dihydroxyvitamin D3 prolongs graft survival without

165 At followup, levels of 1,25-dihydroxyvitamin D3, PTH, OC, and urine phosphorus

166 Many nuclear receptors, including the human 1,25-dihydroxyvitamin D3 receptor (VDR), bind cooperativ

167 clear hormone receptors, including the human 1,25-dihydroxyvitamin D3 receptor (VDR), bind cooperativ

168 veloping fetal rat which immunostain for the 1,25-dihydroxyvitamin D3 receptor (VDR).

169 nt studies suggest that growth inhibition by 1,25-dihydroxyvitamin D3 represents an innovative approa

170 esponse element provides specificity for the 1,25-dihydroxyvitamin D3 response lacking at the AP-1 si

171 nhibitor p27 in U937 cells in the absence of 1,25-dihydroxyvitamin D3 results in the cell-surface exp

172 on of Fas relieved the suppressive effect of 1,25-dihydroxyvitamin D3, showing that molecular manipul

173 rived EVs to inhibit osteoclast formation in 1,25-dihydroxyvitamin D3-stimulated marrow cultures.

174 AP-1 site reduced basal activity and blocked 1,25-dihydroxyvitamin D3 stimulation of the involucrin p

175 udy both elements proved to be important for 1,25-dihydroxyvitamin D3 stimulation of the involucrin p

176 n of involucrin gene expression, but blocked 1,25-dihydroxyvitamin D3 stimulation.

177 1,25-Dihydroxyvitamin D3 supplementation initiated withi

178 the first year of kidney transplantation and 1,25-dihydroxyvitamin D3 supplementation may help reduce

179 ancer cells express vitamin D3 receptors and 1,25-dihydroxyvitamin D3 suppressed growth of these cell

180 1,25-Dihydroxyvitamin D3 suppresses the growth of multip

181 1,25-Dihydroxyvitamin D3, the hormonal form of vitamin D

182 These results support the hypothesis that 1, 25-dihydroxyvitamin D3, through interactions with the

183 sity, femurs were collected from nontreated, 1,25-dihydroxyvitamin D3-treated (50 ng/mouse/day), or C

184 were higher in the central nervous system of 1,25-dihydroxyvitamin D3-treated mice compared with cont

185 of cells recoverable from the lymph nodes of 1,25-dihydroxyvitamin D3-treated mice was only 50% that

186 cell line with probes generated from either 1,25-dihydroxyvitamin D3-treated or untreated cells.

187 We compared the ability of 1,25-dihydroxyvitamin D3-treated, nontreated, or cyclosp

188 Overall, 1,25-dihydroxyvitamin D3 treatment causes a net loss in

189 Here we show that 1,25-dihydroxyvitamin D3 treatment does not increase the

190 Because persistent 1,25-dihydroxyvitamin D3 treatment has been shown to ind

191 of ovalbumin (OVA) model allergen, CpG, and 1,25-dihydroxyvitamin D3 (VD3).

192 the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactiva

193 However, 1,25-dihydroxyvitamin D3 (vitamin D3)-induced endogenous

194 rvival of the transplants brought about with 1,25-dihydroxyvitamin D3 was not accompanied by hypercal

195 n D3 and convert it to the most active form, 1,25-dihydroxyvitamin D3, which regulates keratinocyte p

196 To test the hypothesis that 1,25-dihydroxyvitamin D3 would prolong allograft surviva