ライフサイエンスコーパス: 12-lipoxygenase

1 onic acid rather than enhanced expression of 12-lipoxygenase.

2 elet-type 12-lipoxygenase and leukocyte-type 12-lipoxygenase.

3 e dinucleotide phosphate (NADPH) oxidase and 12-lipoxygenase.

4 etabolite of arachidonic acid synthesized by 12-lipoxygenase.

5 -HPODE by a stoichiometric amount of ferrous 12-lipoxygenase.

6 In this paper, human platelet 12-lipoxygenase (12-hLO) and human reticulocyte 15-lipox

7 lipoxygenase-1 (15-hLO-1) and human platelet 12-lipoxygenase (12-hLO) have been implicated in a numbe

8 Induction of eicosanoid (12-lipoxygenase (12-LO) and cyclooxygenase 2 (COX2))- an

9 was synthesized and tested as inhibitors of 12-lipoxygenase (12-LO) from porcine leukocyte cytosol.

10 Leukocyte 12-lipoxygenase (12-LO) gene expression in pancreatic be

11 12-lipoxygenase (12-LO) has been shown to be a factor in

12 for the arachidonic acid-metabolizing enzyme 12-lipoxygenase (12-LO) in LTP at CA3-CA1 hippocampal sy

13 12-Lipoxygenase (12-LO) is activated by high-fat diets a

14 ery few compounds selectively inhibiting the 12-lipoxygenase (12-LO) pathway are known.

15 The 12-lipoxygenase (12-LO) pathway of arachidonic acid meta

16 way that requires activation by the platelet 12-lipoxygenase (12-LO) pathway to fragment platelets.

17 Evidence suggests that leukocyte type 12-lipoxygenase (12-LO) plays an important role in cell

18 ivation of the platelet NADPH oxidase by the 12-lipoxygenase (12-LO) product 12(S)-HETE.

19 12-Lipoxygenase (12-LO) products of arachidonate metabol

20 nt in inflammatory fluids, and platelet-type 12-lipoxygenase (12-LO), expressed by platelet MPs.

21 approximately 5-fold decreased expression of 12-lipoxygenase (12-LO, gene ALOX12), which catalyzes 12

22 ascribed in part to increased expression of 12-lipoxygenase (12-LOX) and its arachidonate metabolite

23 tion between the expression of platelet-type 12-lipoxygenase (12-LOX) and the progression of human pr

24 In neurons the 12-lipoxygenase (12-LOX) arachidonic acid (AA) metabolit

25 e first demonstrate that human platelet-type 12-lipoxygenase (12-LOX) can directly catalyze the regio

26 Platelet-type 12-Lipoxygenase (12-LOX) has beenshown to regulate growt

27 cortical neurons suggests a central role of 12-lipoxygenase (12-LOX) in executing glutamate-induced

28 12-Lipoxygenase (12-LOX) is a key enzyme in arachidonic

29 Human 12-lipoxygenase (12-LOX) is a key enzyme involved in pla

30 The platelet isoform of 12-lipoxygenase (12-LOX) is expressed in a variety of hu

31 tion, metabolism of arachidonic acid (AA) by 12-lipoxygenase (12-LOX) may play a significant role in

32 [12-HETrE]) over cyclooxygenase-1 (COX-1) or 12-lipoxygenase (12-LOX) metabolized prothrombotic and p

33 PMN chemoattractant and a metabolite of the 12-lipoxygenase (12-LOX) pathway.

34 Arachidonic acid is metabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic a

35 ALOX12 is a gene encoding arachidonate 12-lipoxygenase (12-LOX), a member of a nonheme lipoxyge

36 yeicosatrienoic acid (12-HETrE), produced by 12-lipoxygenase (12-LOX), and prostaglandins and thrombo

37 itrite toxicity was blocked by inhibitors of 12-lipoxygenase (12-LOX), p38 mitogen-activated protein

38 We previously showed that 12-lipoxygenase (12-LOX), which is required to generate

39 e in GSH triggers the activation of neuronal 12-lipoxygenase (12-LOX), which leads to the production

40 ory epithelium induces the production of the 12-lipoxygenase (12-LOX)-dependent lipid inflammatory me

41 intraplantar carrageenan are metabolites of 12-lipoxygenases (12-LOX), particularly hepoxilins (HXA(

42 ests that the arachidonic acid metabolite of 12-lipoxygenase, 12(S)-hydroxyeicosatetraenoic acid (12(

43 genes encoding 12-lipoxygenase (arachidonate 12-lipoxygenase, 12S type [Alox12]) or 12/15-lipoxygenas

44 re consistent with a model for inhibition of 12-lipoxygenase activity in which OPP slows the oxidatio

45 pSE380 yielded the highest level of 12-lipoxygenase activity when these vectors were tested

46 oid hepoxilin A(3), an endogenous product of 12-lipoxygenase activity, is secreted from the apical su

47 CDC, 10 microM) was used to block endogenous 12-lipoxygenase activity.

48 ave significantly increased arachidonic acid 12-lipoxygenase (ALOX12) expression and elevated levels

49 ethylation at a CpG site in the arachidonate 12-lipoxygenase (ALOX12) gene in children having persist

50 acid pathway, in particular the arachidonate 12-lipoxygenase (ALOX12) gene, was closely correlated wi

51 ics' analysis, we identified an arachidonate 12-lipoxygenase (ALOX12)-12-hydroxyeicosatetraenoic acid

52 treat NASH by interrupting the arachidonate 12-lipoxygenase (ALOX12)-acetyl-CoA carboxylase 1 (ACC1)

53 (4) Pharmacological inhibition of 12-lipoxygenase also blocked induction of mGluR-LTD.

54 12-Lipoxygenase and 12/15-lipoxygenase are related but d

55 demonstrate in mice genetically deficient in 12-lipoxygenase and 15-lipoxygenase (Alox15(-/-) mice) t

56 d expression of the SPM biosynthetic enzymes 12-lipoxygenase and 15-lipoxygenase.

57 The detection of 12-lipoxygenase and cyclooxygenase-1 in single bovine co

58 d is selective for the leukocyte form of the 12-lipoxygenase and inhibits the purified recombinant en

59 characterized: 5-lipoxygenase, platelet-type 12-lipoxygenase and leukocyte-type 12-lipoxygenase.

60 n chirality to the product of the well-known 12S-lipoxygenase and heretofore in mammals is known only

61 SPM biosynthesis, including 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase-1.

62 -6-phosphatase, fructose-1,6-bisphosphatase, 12-lipoxygenase, and cyclooxygenase 2.

63 lation of ERK42/44, inhibiting activation of 12-lipoxygenase, and eliminating the accumulation of rea

64 ar signal-regulated kinase 42/44 (ERK42/44), 12-lipoxygenase, and generation of reactive oxygen speci

65 patients had a lower level of expression of 12-lipoxygenase ( approximately 30%) and reduced MaR1 (L

66 lobal genetic deletion of the genes encoding 12-lipoxygenase (arachidonate 12-lipoxygenase, 12S type

67 OPP was not metabolized by 12-lipoxygenase as evidenced by its quantitative recover

68 synaptic transmission, because inhibitors of 12-lipoxygenase as well as lipoxygenases and PLA(2) larg

69 ylethanolamine-specific phospholipase D, and 12-lipoxygenase, as well as type I metabotropic glutamat

70 The 12-lipoxygenase blocker, baicalein, prevents epidermal g

71 tatus, or its purported target, arachidonate 12-lipoxygenase, but does require caspase activation and

72 mechanism of inhibition of porcine leukocyte 12-lipoxygenase by 4-(2-oxapentadeca-4-yne)phenylpropano

73 Porcine leukocyte 12-lipoxygenase cDNA was cloned into the expression vect

74 ll death was not observed with inhibitors of 12-lipoxygenase, cyclooxygenase, or cytochrome P450 path

75 aenoic acid, in the skin using platelet-type 12-lipoxygenase-deficient mice generated by gene targeti

76 Platelet-type 12-lipoxygenase-deficient mice lacked immunodetectable p

77 ation response was apparent in platelet-type 12-lipoxygenase-deficient mice.

78 ent on the combined effects of TNF-alpha and 12-lipoxygenase-derived arachidonic acid metabolites.

79 or that displays high affinity for the human 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14

80 ertaken to delineate the mechanisms by which 12-lipoxygenase enhances angiogenesis.

81 cript level in PC-3 cells transfected with a 12-lipoxygenase expression construct.

82 se chromosome 11 closely linked with the two 12-lipoxygenase genes (Alox12p and Alox12l).

83 Increased expression of 12-lipoxygenase has been documented in a number of carci

84 14-lipoxygenation of DHA by human macrophage 12-lipoxygenase (hm12-LOX) gave 14-hydro(peroxy)-docosah

85 Human platelet 12-lipoxygenase (hp-12LOX, 662 residues+iron nonheme cof

86 Overexpression of 12-lipoxygenase in PC-3 cells resulted in a 3-fold incre

87 t mice lacked immunodetectable platelet-type 12-lipoxygenase in platelets and epidermis, appeared gro

88 Platelet-type 12-lipoxygenase in wild-type mice was localized to the s

89 We evaluated the role of 5- and 12-lipoxygenases in the development of diabetic retinopa

90 Finally, inhibition of 12-lipoxygenase induced apoptosis of A431 cells, which w

91 ker 4-aminopyridine (4-AP; 100 microM) and a 12-lipoxygenase inhibitor, baicalein (5 microM), suggest

92 The 12-lipoxygenase inhibitor, cinnamyl-3,4-dihydroxy-alpha-

93 ehaviorally in rats in vivo, NRM infusion of 12-lipoxygenase inhibitors significantly reduced DOR-ind

94 that displays 60% identity with both murine 12-lipoxygenase isozymes and 40% identity to 5-lipoxygen

95 weaver-Burk analysis of the effect of OPP on 12-lipoxygenase kinetics with arachidonic acid indicated

96 sly, we isolated the murine "leukocyte-type" 12-lipoxygenase (L-12LO) cDNA from RNA of peritoneal-eli

97 ons that cyclooxygenase-2 and leukocyte-type 12-lipoxygenase (LOX) efficiently oxygenate 2-arachidony

98 we observed significant increases in spinal 12-lipoxygenase (LOX) metabolites, in particular, hepoxi

99 ynthesize various eicosanoids, including the 12-lipoxygenase (LOX) product 12(S)-hydroxyeicosatetraen

100 e demonstrated previously that platelet-type 12-lipoxygenase (LOX) regulates the growth and survival

101 methionine residues in the porcine leukocyte 12-lipoxygenase (M338L, M367V, and M562L) were targeted

102 cellular signal-regulated kinase (ERK) via a 12-lipoxygenase-mediated pathway.

103 suggesting VEGF as an important effector for 12-lipoxygenase-mediated stimulation of tumor angiogenes

104 istamine and Phe-Met-Arg-Phe-amide, activate 12-lipoxygenase metabolism in isolated identified Aplysi

105 homogenates were capable of synthesizing the 12-lipoxygenase metabolite of arachidonic acid, 12(S)-hy

106 Hydroxyeicosatetraenoic acid (12(S)-HETE), a 12-lipoxygenase metabolite of arachidonic acid, has mult

107 -Hydroxyeicosatetraenoic acid (12(S)HETE), a 12-lipoxygenase metabolite of arachidonic acid, is requi

108 Z, 10E, 14Z-tetraenoic acid (12(S)-HPETE), a 12-lipoxygenase metabolite of arachidonic acid, satisfie

109 cGMP signalling activated by an arachidonate 12-lipoxygenase metabolite suppresses LCC activity trigg

110 e, as well as increased concentration of the 12-lipoxygenase metabolites hepoxilin A(3) and 12-hydrox

111 l a novel requirement for macrophage-derived 12-lipoxygenase metabolites in lung fibroblast MMP induc

112 etic approach to examine the function of the 12-lipoxygenase metabolites of arachidonic acid in long-

113 tors revealed increased arachidonic acid and 12-lipoxygenase metabolites.

114 12-lipoxygenase mRNA and protein were detected in HLECs

115 12-lipoxygenase mRNA was detected by reverse transcripti

116 poxygenase, cyclooxygenase, and epoxygenase, 12-lipoxygenase of the lipoxygenase pathway primarily me

117 O-releasing compound does not activate islet 12-lipoxygenase or PLA2 activities.

118 Furthermore, these 12-lipoxygenase-overexpressing cells displayed significa

119 tance of arachidonic acid metabolism via the 12-lipoxygenase (P-12LO) pathway to 12-hydro(pero)xyeico

120 These findings suggest the PLA(2)-AA-12-lipoxygenase pathway as a primary signaling cascade f

121 hese results indicate that the platelet-type 12-lipoxygenase pathway in mice is partly responsible fo

122 We found that the 12-lipoxygenase pathway is required for the induction of

123 The 12-lipoxygenase pathway of arachidonic acid metabolism i

124 thesis by EGF-insulin was inhibited when the 12-lipoxygenase pathway was blocked by CDC.

125 gation, but by analogy to the well-described 12-lipoxygenase pathway, we suggest that (8R)-HPETE and

126 onitored eicosanoids in cyclooxygenase-1 and 12-lipoxygenase pathways.

127 xilin A(3), including phospholipase A(2) and 12-lipoxygenase, potently interfere with P. aeruginosa-i

128 that IL-1 increases islet production of the 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid

129 The 12-lipoxygenase product hepoxilin A3 mediates the migrat

130 lowing heparin, levels of the major platelet 12-lipoxygenase product, 12-HETE, rose significantly.

131 xpressed in human prostate or breast cancer, 12-lipoxygenase promotes tumor angiogenesis and growth i

132 cancers also express 12-lipoxygenase RNA and 12-lipoxygenase protein and biosynthesize 12(S)-hydroxye

133 the facts that IL-1 does not increase islet 12-lipoxygenase protein or mRNA levels and does not enha

134 The 12-lipoxygenase protein was detected by immunoblotting.

135 ases and baicalein, a selective inhibitor of 12-lipoxygenase, reduced VEGF expression in human prosta

136 e adenine dinucleotide phosphate oxidase and 12-lipoxygenase releasing reactive oxygen species.

137 d -66 of the VEGF promoter was identified as 12-lipoxygenase responsive using VEGF promoter-based luc

138 Many lung cancers also express 12-lipoxygenase RNA and 12-lipoxygenase protein and bios

139 d Sp1 as a transcription factor required for 12-lipoxygenase stimulation of VEGF.

140 opyl 4-hydroxylase alpha, MT-1, MKP-1, CELF, 12-lipoxygenase, t-PA, CAR-1, and an expressed sequence

141 (3) A mouse in which the leukocyte-type 12-lipoxygenase (the neuronal isoform) was deleted throu

142 quence comparisons between mammalian 15- and 12-lipoxygenases, three methionine residues in the porci

143 cosahexaenoic acid was converted by platelet 12-lipoxygenase to 13S,14S-epoxy-maresin, which was furt

144 The released arachidonate is metabolized by 12-lipoxygenase to active second messengers.

145 ody activation of platelet NADPH oxidase and 12-lipoxygenase to release reactive oxygen species, whic

146 ibody significantly decreased the ability of 12-lipoxygenase-transfected PC-3 cells to stimulate endo

147 0-fold increase in VEGF promoter activity in 12-lipoxygenase-transfected PC-3 cells.

148 12-Lipoxygenase utilizes arachidonic acid to synthesize

149 r beta), and 12-HETE synthesis (arachidonate 12-lipoxygenase) were significantly up-regulated.

150 , we have examined the role of platelet-type 12-lipoxygenase which converts arachidonic acid to the o

151 reduced by inhibitors of cyclooxygenase and 12-lipoxygenase, which metabolize arachidonic acid to ge