ライフサイエンスコーパス: 13C

1 13C and 15N MAS spectra of both nanocrystals and fibrils

2 13C detected 2D 13C-13C spectroscopy is performed in the

3 13C flux analysis studies have become an essential compo

4 13C isotropic chemical shifts and backbone (phi, psi) to

5 13C labeling has been shown to greatly minimize matrix e

6 13C labeling studies performed in G. sulfurreducens indi

7 13C metabolic flux analysis (13C-MFA) has been widely us

8 13C NMR and stopped-flow kinetic experiments reveal that

9 13C relaxivity in C60 induced by nitroxide has also been

10 13C steady-state metabolic flux analysis showed that oxi

11 13C-Based metabolic flux analysis provides valuable info

12 13C-Glucose was dissolved in the test meal and 13CO2 det

13 13C-Isotopologue compositions of amino acids from bacter

14 [13C]-cyanocobalamin was completely decyanated to [13C]-m

15 sotope effects (AKIEs) of 1.0070 +/- 0.0002 (13C-AKIE, oxidation), 1.068 +/- 0.001 (13C-AKIE, S(N)2),

16 0002 (13C-AKIE, oxidation), 1.068 +/- 0.001 (13C-AKIE, S(N)2), and 1.0087 +/- 0.0002 (37Cl-AKIE, S(N)

17 amines directly in aqueous medium with 1,1'-13C(2) acetic anhydride is a simple method that creates

18 hese findings demonstrate hyperpolarized ([1-13C])pyruvate MRI as a tool for accurately assessing the

19 ization of approximately 20% in seconds in 1-13C-succinic-d2 acid.

20 m the (13)C incorporation from of infused [1-13C] glucose into glutamate [4-13C] relative to alanine

21 alanine, l-[ring-3,5-2H2]-tyrosine, and l-[1-13C]-leucine and ingested 45 g carbohydrate with either

22 trinsically l-[1-13C]-phenylalanine and l-[1-13C]-leucine labeled milk protein after endurance exerci

23 PRO), or 45 (45 g PRO) g intrinsically l-[1-13C]-phenylalanine and l-[1-13C]-leucine labeled milk pr

24 ncorporation of dietary protein-derived l-[1-13C]-phenylalanine into de novo mitochondrial protein in

25 icator amino acid oxidation (IAAO; with l-[1-13C]leucine).

26 direct amino acid oxidation (DAAO; with l-[1-13C]phenylalanine) and indicator amino acid oxidation (I

27 S, SPS, respectively) by incorporation of [1-13C]proline (using gas chromatography-mass spectrometry)

28 intermediates formed with the substrates, [1-13C]ethanolamine, [2-13C]ethanolamine, and unlabeled eth

29 e and exchange interactions as well as the 1-13C hyperfine splitting tensor were analyzed via spectra

30 the molecular addition of parahydrogen to 1-13C-fumaric acid-d2 and the subsequent transfer of spin

31 Feeding experiments using (1-13C)Glc followed by analysis of labeling patterns by 13C

32 ps were performed on separate days, using [1-13C]glucose infusion to increase plasma 13C enrichment.

33 g in EPR spectra of samples prepared with [1-13C]ethanolamine and the absence of such splitting in sp

34 ning, leveraging data from approximately 100 13C-MFA papers on heterotrophic bacterial metabolisms.

35 Approximately 100% 13C-labeled graphite was made and converted to 13C-label

36 r correlation experiments involving 1H, 11B, 13C, 19F, 29Si, and 31P nuclei.

37 ized a stable isotope-labeled vitamin B-12, [13C]-cyanocobalamin, using Salmonella enterica by provid

38 A large 12C/13C (k(12C)/k(13C)) isotope effect of approximately equa

39 n of cyclohexenone, while a much smaller 12C/13C isotope effect of 1.010 was observed at the C2 (alph

40 Carbon-13 (13C) solid-state nuclear magnetic resonance (SSNMR) spec

41 in-spin couplings 13Calpha-1Halpha, 13Calpha-13C', 15N-13C', and 15N-1HNu.

42 uplings 13Calpha-1Halpha, 13Calpha-13C', 15N-13C', and 15N-1HNu.

43 equence and exploiting differences in 1J 15N-13C coupling patterns to filter selected 15N resonances

44 Two-dimensional 13C-13C and 15N-13C solid state NMR spectra of a uniformly 15N- and 13C-

45 ed at specific sites and two-dimensional 15N-13C and 13C-13C NMR spectra of samples that are uniforml

46 that allowed only the fungus access to a 15N/13C-labeled organic patch; in some cases, one plant was

47 o acids in the B chain were labeled with 15N/13C.

48 ide chain, including isotope reporters (19F, 13C) that can be used in biophysical experiments such as

49 1H, 13C, and 15N resonance assignments revealed very similar

50 region of two-dimensional heteronuclear 1H, 13C NMR spectra of natural organic matter and related ma

51 ches the data reported for neopeltolide (1H, 13C, HRMS, IR, NOESY, [alpha]), thereby establishing the

52 mbines the experimental determination of 1H, 13C, and 15N chemical shifts by magic-angle spinning (MA

53 1H-13C correlations of target analytes at < or = 25 microg/

54 oved to be superior for detecting analyte 1H-13C correlations.

55 Two-dimensional 1H-13C HSQC (heteronuclear single quantum correlation) and

56 es, we have recorded ultrahigh-resolution 1H-13C HSQC NMR spectra of cell extracts, which exhibit spe

57 allows recording of ultrahigh resolution 1H-13C HSQC spectra in a fraction of the time needed for re

58 the hydroxyphenyl ring determined by the 1H-13C DIPSHIFT experiment indicate that the bond between t

59 ned in the medium and cell extract using 1H-{13C}-NMR.

60 The subjects were administered [2-13C]acetate for 2 hours and scanned throughout that time

61 with the substrates, [1-13C]ethanolamine, [2-13C]ethanolamine, and unlabeled ethanolamine were acquir

62 ability and fractional absorption of R-(+)[2-13C]equol were higher than those of S-(-)[2-13C]equol or

63 The pharmacokinetics of racemic (+/-)[2-13C]equol were different from those of the individual en

64 -13C]equol were higher than those of S-(-)[2-13C]equol or the racemate.

65 tting in spectra of samples prepared with [2-13C]ethanolamine show that the unpaired electron is loca

66 13C detected 2D 13C-13C spectroscopy is performed in the usual manner.

67 temperature-jump methods to develop a new 2D 13C-13C NMR experiment that yields a factor of 100-170 i

68 Detection using either 1D or 2D 13C NMR experiments produces highly resolved spectra wit

69 In this study, 1H, 2H, 13C, 15N NMR and liquid/liquid intermolecular transfer d

70 bisphosphonate drugs to human bone using 2H, 13C, 15N, and 31P nuclear magnetic resonance spectroscop

71 present, Envelope supports labeling with 2H, 13C, and 15N, and supports adjustments for baseline corr

72 nto glutamate [4-13C] relative to alanine [3-13C] assessed by LC-tandem MS in muscle biopsies.

73 ed rates of alanine turnover, assessed by [3-13C]alanine, in a subgroup of participants under similar

74 Analysis of the 5J(HH) and 3J(13C-H) coupling constants in the NMR spectra showed an a

75 of infused [1-13C] glucose into glutamate [4-13C] relative to alanine [3-13C] assessed by LC-tandem M

76 [6-13C], [6-15N], and [1-15N]adenosines reported intrinsic

77 of BACUS to the structure determination of a 13C unenriched protein for which no prior experimental 3

78 hnique, using [U-13C] spirulina protein or a 13C-algal IAA mixture as the standard.

79 referenced to [U-13C] spirulina protein or a 13C-algal IAA mixture did not differ significantly (63.2

80 (SSNMR) spectra of GO for natural abundance 13C have poor signal-to-noise ratios.

81 Accordingly, 13C-labeled glutamine was incorporated into 2HG in cells

82 nhanced nuclear alignment) method to achieve 13C polarization of approximately 20% in seconds in 1-13

83 ltransferase (ST6Gal-I) to enzymatically add 13C-N-acetylneuraminic acid (NeuAc or sialic acid) to gl

84 ntration (cumulative percent of administered 13C dose recovered) in expiratory breath samples taken a

85 e found through 13C Metabolic Flux Analysis (13C MFA) for central carbon metabolism but, additionally

86 ntegrated using 13C Metabolic Flux Analysis (13C MFA) to provide quantitative metabolic maps of flux

87 ellular fluxes, 13C Metabolic Flux Analysis (13C MFA), uses the labeling pattern obtained from metabo

88 uring fluxes by 13C metabolic flux analysis (13C-MFA) has become a key activity in chemical and pharm

89 13C metabolic flux analysis (13C-MFA) has been widely used to measure in vivo enzyme

90 tabolites using 13C-Metabolic Flux Analysis (13C-MFA).

91 ecific sites and two-dimensional 15N-13C and 13C-13C NMR spectra of samples that are uniformly 15N- a

92 15N and 13C stable isotope tracing revealed that glucose but not

93 y with 15N, species B uniformly with 15N and 13C, and species C uniformly with 15N but selectively wi

94 nd RNA with the NMR-active isotopes, 15N and 13C, opened the door to detailed analyses of macromolecu

95 was achieved by low-temperature 1H, 15N, and 13C NMR from FSO3H-SbF5-SO2ClF solutions.

96 -15N HSQC spectra were recorded for 15N- and 13C-labeled murine amelogenin as a function of increasin

97 id state NMR spectra of a uniformly 15N- and 13C-labeled sample indicate that a relatively small frac

98 ectra of samples that are uniformly 15N- and 13C-labeled.

99 opy was essentially eliminated, while 1H and 13C chemical shift information could be derived quickly

100 c matter and related materials (e.g., 1H and 13C chemical shifts ranging from approximately 5 to 10 a

101 Specifically, the 1H and 13C NMR assignments are inconsistent with an N-terminal

102 uctural investigations in solution by 1H and 13C NMR clearly showed scalar coupling of fluorine with

103 Low-temperature 1H and 13C NMR spectra of formic acid (1) showed separate signa

104 tural elucidation by multidimensional 1H and 13C NMR spectroscopy revealed the accumulated metabolite

105 31P and 13C NMR studies using isotopically labeled substrates as

106 roups in the 6 position are shown by 6Li and 13C NMR spectroscopic studies to be monomers in THF.

107 xic or hypoxic (120 min only) conditions and 13C enrichment determined in the medium and cell extract

108 The use of metabolite derivatization and 13C NMR spectroscopy produces data suitable for metaboli

109 the integration of extracellular fluxes and 13C enrichment measurements, HepatoDyn predicted that th

110 ion, with input of the molecular formula and 13C NMR spectrum of the isolated compound.

111 Metabolite tracing with 13C-glucose and 13C-glutamine following MCT1 inhibitor treatment reveale

112 as made and converted to 13C-labeled GO, and 13C SSNMR was used to reveal details of the chemical bon

113 monomer to ligand was confirmed by GC/MS and 13C NMR after quenching.

114 simultaneously because the observed NOEs and 13C(alpha) chemical shifts correspond to a dynamic ensem

115 knot structure, dynamics analyzed by RDC and 13C relaxation measurements, and base pair stability.

116 nt-infusion protocol with [15N]arginine and [13C]- and [2H]citrulline.

117 Plasma and urinary [13C]R-equol and [13C]S-equol concentrations were measured by tandem mass

118 e chemistry was slowed for both [2H]PNP and [13C, 15N]PNP in proportion to their altered protein mass

119 rmative data to predict metabolic fluxes are 13C based metabolomics, which provide information about

120 dipole-dipole couplings in samples that are 13C-labeled at specific sites and two-dimensional 15N-13

121 in a form that exploits heteronuclei such as 13C.

122 sing a curated metabolic model and available 13C-labeling distributions under multiple genetic and en

123 way as through the standard amino acid based 13C MFA, and quantify the amount of information lost as

124 hemical shift and that of the directly bound 13C or 15N, is subsequently mapped to specific atoms in

125 In vivo brain 13C magnetic resonance spectroscopy was used to measure

126 n of E-1 in this solvent mixture was 4.3% by 13C NMR.

127 sured extracellular fluxes as constrained by 13C labeling data.

128 ment of lactate production, as determined by 13C magnetic resonance spectroscopy (MRS) of hyperpolari

129 Measuring fluxes by 13C metabolic flux analysis (13C-MFA) has become a key a

130 ard to both real-time noninvasive imaging by 13C MRS as well as therapeutic response.

131 d maritime Antarctic regions, as informed by 13C and 18O signals in organic material.

132 ction fluxes than experimentally measured by 13C-metabolic flux analysis (MFA) and the appearance of

133 ne containing peptides that were modified by 13C iodoacetic acid showed a molecular weight that was 2

134 bile sites, most of which can be observed by 13C solid-state NMR even without magic-angle spinning.

135 followed by analysis of labeling patterns by 13C-NMR, confirmed an MVA-dependent biosynthesis; howeve

136 e inhibitor cyanide (CN-) was also probed by 13C NMR.

137 complex, the citrate central carboxylate C6 13C peak moves upfield, indicating diminution of negativ

138 ens TC1 (i) delivered highly characteristic (13C/12C, 15N/14N) fractionation trends for pathway ident

139 straints together with observed and computed 13C(alpha) chemical shifts, is applied to determine the

140 Consecutively 13C urea breath tests results were extracted from the fi

141 sites of mechanistic interest also contains 13C at all carbon positions, whereas the 16 O-labeled nu

142 ar couplings, C-H and N-H dipolar couplings, 13C chemical shift anisotropies, and 1H T1rho relaxation

143 which usually requires a combination of 2-D 13C NMR spectroscopy and GC/MS.

144 are manifested in the temperature-dependent 13C and 15N spectra, 13C-1H and 15N-1H dipolar couplings

145 We describe 13C NMR studies demonstrating a CODH-catalyzed steady-st

146 Two-dimensional 13C-13C and 15N-13C solid state NMR spectra of a uniform

147 y 3 and 4 times, respectively, versus direct 13C and 15N detection.

148 ar magnitude but opposite sign for the donor 13C and acceptor 15N nuclei.

149 allinity of all salts was documented by DSC, 13C CP-MAS NMR, and XRPD.

150 m metabolites (typically amino acids) during 13C labeling experiments to derive intracellular fluxes.

151 Dynamic 13C labeling experiments indicate the presence of distin

152 or sham operation (sham; n=8) using dynamic 13C-nuclear magnetic resonance.

153 were perfused with buffer containing either 13C-palmitate plus glucose or (13)C glucose plus palmita

154 The high-field 13C multiplets are observed as a function of pH, and the

155 ve method of measuring intracellular fluxes, 13C Metabolic Flux Analysis (13C MFA), uses the labeling

156 to prepare chemically modified graphenes for 13C SSNMR analysis with enhanced sensitivity and for fun

157 The resulting value of R1 for 13C is substantially smaller relative to the 1H relaxati

158 ed on an isotope ratio mass spectrometer for 13C enrichment.

159 lF2/CHCl2F/(CH3)2O) was larger than that for 13C-labeled methyl formate in the same solvent (0.2%), w

160 lic engineering, that incorporates data from 13C labeling experiments and genome-scale models.

161 The data from 13C labeling experiments provide strong flux constraints

162 ing HepatoDyn to integrate data derived from 13C based experiments.

163 we use NMR distance restraints derived from 13C dipolar recoupling measurements to guide the simulat

164 unassigned distance restraints derived from 13C- and 15N-edited NOESY spectra.

165 timate intracellular flux distributions from 13C measurements and transcriptomics data.

166 The 13C line widths measured from 13C-13C 2D chemical shift correlation spectra are approx

167 experimental order parameters obtained from 13C relaxation measurements.

168 arrangement of stable isotope tracers (e.g., 13C or 15N) that can be detected by mass spectrometry (M

169 here there is a spin-active X-nucleus (e.g., 13C, 15N, 31P) label present.

170 However, shorter tail ADs (G2-15C and G2-13C) and lower generation (G0 and G1) dendrimers failed

171 However, 13C MFA might be unable to reduce the solution space tow

172 rientation and dynamics of A-form helices in 13C/15N isotopically enriched RNA samples using NMR resi

173 s study was to use the natural variations in 13C:12C ratio (carbon-13 isotopic abundance [delta13C])

174 ate the presence of an anionic intermediate, 13C isotope effect studies have been performed using the

175 Measurements of intermolecular 13C-13C dipole-dipole couplings in selectively carbonyl-

176 Using the stable isotope 13C-labeling technique, we analyzed the carbon fluxes th

177 contain synthetically incorporated isotopes (13C, 15N, etc) generating a distinct isotope pattern.

178 d (188)Os) and three unique 13C isotopomers (13C in ethylene, axial, and equatorial positions) were o

179 A large 12C/13C (k(12C)/k(13C)) isotope effect of approximately equal to 1.032 was

180 gment following helix E, experiences a large 13C shift corresponding to a conformational change of Il

181 nsion of this approach to accurately measure 13C-31P and 1H-31P couplings from phospholipids, which a

182 Critically, the dispersion is at natural 13C abundance; this matches typical pharmaceutical resea

183 spectroscopy of the brain to observe natural 13C abundance of N-acetylaspartate (NAA) and the appeara

184 bed including X-ray crystallography, 1H NMR, 13C NMR, HMQC, UV-visible, HPLC, MALDI-MS, and electroch

185 luble and have been characterized by 1H NMR, 13C NMR, MALDI-TOF, and UV-vis spectroscopy.

186 omposition products, because hyphae were not 13C-enriched.

187 The complex .Cr(13CO)2(O=13C=CHSiMe3)(C5Me5) has been studied by electron spin re

188 ; A(53Cr) = 125 MHz; A(13CO) = 22.5 MHz; A(O=13C=CHSiMe3) = 12.0 MHz.

189 the agreement between predicted and observed 13C(beta) chemical shifts, and some stereochemical quali

190 After addition of 13C or deuterated analogues to a sediment sample, the is

191 -acetylaspartate (NAA) and the appearance of 13C-labeled glutamate, glutamine, and acetate.

192 been derived that allows the calculation of 13C/12C ratios from the whole isotopic distributions, gi

193 scopy was used to measure the time course of 13C label incorporation into different metabolites and t

194 s the 16 O-labeled nucleotide is depleted of 13C.

195 sensitivity, for which inverse detection of 13C and 15N signals with 1H is one promising approach.

196 itting within a single standard deviation of 13C-MFA estimated values.

197 4-bromostyrene) (PS/P4BrS), the diffusion of 13C-labeled PS has been investigated near the respective

198 the basis of the smaller magnetic moment of 13C.

199 (Poverfeeding = 0.034) and the oxidation of 13C-labeled glucose load (Poverfeeding = 0.038).

200 Correlation plots of 13C and 18O values show that species (Chorisodontium aci

201 surements did not fully utilize the power of 13C-MFA.

202 ches can dramatically improve the quality of 13C-MFA results with important applications in metabolic

203 f fluxes using only relative quantitation of 13C-labeled metabolites.

204 The site of 13C substitution is at a meso-position, either the site

205 d sensitivity and for fundamental studies of 13C-labeled graphite and graphene.

206 Nuclear magnetic resonance studies of 13C-labeled RH as a function of experimental conditions

207 Here we propose a new type of 13C MFA that infers fluxes based on peptide labeling, in

208 The approach makes use of 13C(alpha) chemical shifts, computed at the density func

209 rms and extends recognition determinants of -13C.

210 study was to measure the bioavailability of [13C]-cyanocobalamin in humans and to assess the effect o

211 rient containing 3-O-methylglucose (3-OMG), [13C]triolein, and [(99m)Tc]sulfur colloid was administer

212 problem can be resolved after more papers on 13C-MFA are published for non-model species.

213 modification by iodoacetic acid with 12C or 13C.

214 opy, and a dual intravenous [6,6-2H2]-, oral 13C-labeled glucose tolerance test and a polysomnographi

215 Our 13C- and 1H-chemical exchange saturation transfer (CEST)

216 (13C) = 25.8 +/- 5.1% (when produced) and %P(13C) = 14.2 +/- 0.7% (when imaged), T1 = 74 +/- 3 s), an

217 zed 1-(13)C-succinate-d2 (30 mM in water, %P(13C) = 25.8 +/- 5.1% (when produced) and %P(13C) = 14.2

218 Here we present parsimonious 13C MFA (p13CMFA), an approach that runs a secondary opt

219 Investigations of dual pathway 13C-13C couplings, 3+3JC1,C4 and 3+3JC2,C5, revealed an

220 directed isotope labeling scheme that places 13C with high efficiency and specificity at the nucleoti

221 g [1-13C]glucose infusion to increase plasma 13C enrichment.

222 Plasma [13C]equol concentration appearance and disappearance cur

223 site chemistry in isotopically labeled PNP (13C, 15N, and 2H).

224 ulse to yield a sample with highly polarized 13C spins.

225 ts is reflected in the carbon isotope ratio (13C/12C) in GTP or GDP, which is determined by the use o

226 g carbon and nitrogen stable isotope ratios [13C/12C (CIR) and 15N/14N (NIR)] are promising dietary b

227 on predicted by our model agrees with recent 13C fluxomics experiments, and that our model largely re

228 Resolved 13C hyperfine splitting in EPR spectra of samples prepar

229 d by the experiments of TOCSY, NOESY, ROESY, 13C HSQC 2D NMR, and ESI-MS and GC.

230 cating mutations in vacuolar protein sorting 13C (VPS13C).

231 The residue-specific 13C' CSA tensor principal components, sigma(11), sigma(2

232 However, the analysis of the site-specific 13C IR signals reveals distinct unfolding thermodynamics

233 rared spectroscopy (FTIR) with site-specific 13C isotopic labeling.

234 e temperature-dependent 13C and 15N spectra, 13C-1H and 15N-1H dipolar couplings and 1H rotating-fram

235 our in-house developed isotopic steady-state 13C MFA software.

236 nance assignment that combines new strategic 13C labeling technologies with filter/edit type NOESY ex

237 affinity column, and addition of synthesized 13C-CMP-NeuAc to the desialylated ST6Gal-I.

238 er 6 wk, a 75-g oral-glucose-tolerance test (13C-labeled) and a subsequent fasting challenge were per

239 We also show that 13C' CSA tensors are sensitive to hydrogen-bond length b

240 The 13C chemical shifts of the primary visual photointermedi

241 The 13C line widths measured from 13C-13C 2D chemical shift

242 The 13C splitting from C1 persists from 10 ms throughout the

243 The 13C' CSA principal components cluster about the average

244 The 13C-enriched ketone substrate, dihydroxyacetone phosphat

245 The 13C=18O isotopic label shifted the carbonyl stretching f

246 relation between experimental shifts and the 13C NMR shifts calculated with density functional theory

247 ch that runs a secondary optimization in the 13C MFA solution space to identify the solution that min

248 Changes in the 13C NMR line shapes show that the diphenyl compound 8 un

249 Variations in the 13C:12C ratio (delta13C) of palmitate (16:0) and linolea

250 MR and quantum chemical investigation of the 13C gamma NMR chemical shifts in phenylalanine and tyros

251 0 ns), remains fast on the time scale of the 13C hyperfine clock ( approximately 50 ns).

252 The orientation of the principal axes of the 13C hyperfine splitting tensor shows that the long axis

253 The unique IR signature of the 13C=18O label was exploited to probe the equilibrium the

254 The comparisons to the 13C study showed improvement upon inclusion of the corre

255 tric emptying of solids was analysed by the [13C]octanoic acid breath test.

256 Subsequently, these 13C-prelabeled amoebae were infected with L. pneumophila

257 Through 13C-labeled isotope labeling experiments we elucidate th

258 ew method are similar to those found through 13C Metabolic Flux Analysis (13C MFA) for central carbon

259 C-labeled graphite was made and converted to 13C-labeled GO, and 13C SSNMR was used to reveal details

260 ling experiments is of central importance to 13C-MFA as it determines the precision with which fluxes

261 We then apply rKFP to 13C-labeled glucose time series data collected from cell

262 cyanocobalamin was completely decyanated to [13C]-methylcobalamin describing metabolic utilization, a

263 Our results show that as few as two 13C labeled residues can be detected in a 40 residue pro

264 Furthermore, the observation of two 13C peaks in solid-state NMR indicates very stable dicho

265 ng the conversion of hyperpolarized [U-2H, U-13C]glucose to lactate using 13C magnetic resonance spec

266 e study also aimed to validate the use of [U-13C] spirulina as a reference protein in this method.

267 chnique referenced to a standard protein ([U-13C] spirulina).

268 stibility of mung bean when referenced to [U-13C] spirulina protein or a 13C-algal IAA mixture did no

269 the dual-isotope tracer technique, using [U-13C] spirulina protein or a 13C-algal IAA mixture as the

270 ributions at each position for the uncoupled 13C=O modes.

271 tic coupling among ring carbons in uniformly 13C-labeled samples.

272 g frame spin relaxation (R1rho) in uniformly 13C/15N labeled RNA samples.

273 NMR spectra were collected on uniformly 13C and 15N isotopically enriched, polyethylene glycol p

274 chemes using the fully protonated, uniformly 13C,15N-labeled protein GB1 at 40 kHz MAS rate with 1.6-

275 mall-cell lung cancer (NSCLC) with uniformly 13C-labeled glucose before tissue resection and determin

276 ine global secondary structure in uniformly (13C,15N)-enriched systems by simultaneously measuring di

277 2)Os, (190)Os, and (188)Os) and three unique 13C isotopomers (13C in ethylene, axial, and equatorial

278 Plasma and urinary [13C]R-equol and [13C]S-equol concentrations were measure

279 This study used 13C magnetic resonance spectroscopy to test whether chro

280 Using 13C tracer labeling and two model systems, polystyrene/p

281 Using 13C,15N-labeled PSA, we applied a combination of heteron

282 Such data can be integrated using 13C Metabolic Flux Analysis (13C MFA) to provide quantit

283 arized [U-2H, U-13C]glucose to lactate using 13C magnetic resonance spectroscopy and spectroscopic im

284 aining 74 reactions and 61 metabolites using 13C-Metabolic Flux Analysis (13C-MFA).

285 amics at the level of a single residue using 13C=18O isotope-edited infrared spectroscopy.

286 a gastric emptying test by breath test using 13C octanoic acid coupled to a solid meal and answered a

287 ng mosquitoes was investigated in vivo using 13C solid-state NMR.

288 etics of S-(-)equol and R-(+)equol by using [13C] stable-isotope-labeled tracers to facilitate the op

289 Chemical shift dispersion due to the various 13C-NeuAc adducts on ST6Gal-I was observed in a 3D exper

290 of isocitrate dehydrogenase (IDH); and, via 13C-labeling studies, demonstrated that autocrine type I

291 epatic metabolism was analyzed using in vivo 13C/31P/1H and ex vivo 2H magnetic resonance spectroscop

292 The line shape analysis of VT 13C CPMAS and broad-band 2H NMR data were in remarkable

293 For this purpose, A. castellanii was 13C-labeled by incubation in buffer containing [U-(13)C(

294 of disulfide bonds, was then alkylated with 13C iodoacetic acid.

295 thynylbiphenyl at natural abundance and with 13C[triple bond]13CH and 15N[triple bond]C labeling is d

296 ess integration of gene expression data with 13C data.

297 d melanotic melanoma cells were labeled with 13C precursors and changes in their metabolism was analy

298 tyl groups in isolated native oligomers with 13C labeled acetyl groups and the extraction of orientat

299 es C uniformly with 15N but selectively with 13C' or 13Calpha.

300 Metabolite tracing with 13C-glucose and 13C-glutamine following MCT1 inhibitor t