ライフサイエンスコーパス: 2-oxoglutarate

1 droxylases via enzyme-catalysed oxidation to 2-oxoglutarate.

2 ine, which is an analogue of the cosubstrate 2-oxoglutarate.

3 nic acid, N-acetylglucosamine, and decreased 2-oxoglutarate.

4 small effectors, most notably glutamine and 2-oxoglutarate.

5 does not prevent the binding of the cofactor 2-oxoglutarate.

6 ethylase activity dependent on both iron and 2-oxoglutarate.

7 w carbon/nitrogen and depleted in starch and 2-oxoglutarate.

8 es the oxidative deamination of glutamate to 2-oxoglutarate.

9 amino-terminal GAF domain of NifA that binds 2-oxoglutarate.

10 ng the release of 14CO2 from labeled [1-14C]-2-oxoglutarate.

11 ible oxidative deamination of L-glutamate to 2-oxoglutarate.

12 ylate, Ala:glyoxylate, Glu:pyruvate, and Ala:2-oxoglutarate.

13 e trimethylamine N-oxide (TMAO), citrate and 2-oxoglutarate.

14 sugar phosphate levels, and lower content of 2-oxoglutarate.

15 eoxy-d-GlcNAc to form UDP-4-amino-FucNAc and 2-oxoglutarate.

16 interactions are modulated by ADP, ATP, and 2-oxoglutarate.

17 2-oxoglutarate (2-OG or alpha-ketoglutarate) relates mit

18 their ability to bind the effector molecules 2-oxoglutarate (2-OG) and ATP or ADP.

19 These 2-oxoglutarate (2-OG) and non-heme iron-dependent oxygen

20 es co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, includin

21 talytic domain in complex with the substrate 2-oxoglutarate (2-OG) and the inhibitor N-oxalylglycine

22 ynthetase/glutamate synthase system requires 2-oxoglutarate (2-OG) as a carbon precursor.

23 fector and cellular nitrogen level indicator 2-oxoglutarate (2-OG) inhibited the formation of the PII

24 Levels of 2-oxoglutarate (2-OG) reflect nitrogen status in many ba

25 oxoglutarate dehydrogenase (2-OGDH) converts 2-oxoglutarate (2-OG) to succinyl-CoA concomitant with t

26 Recently, members of the 2-oxoglutarate (2-OG)-dependent dioxygenase family have

27 ins (JBP1 and JBP2) homologous to the Fe(2+)/2-oxoglutarate (2-OG)-dependent dioxygenase superfamily

28 of sigE and that this binding is enhanced by 2-oxoglutarate (2-OG).

29 hich was corrected by provision of exogenous 2-oxoglutarate (2-OG).

30 of the enzyme in complex with the substrate 2-oxoglutarate (2-OG).

31 2-Oxoglutarate (2OG) and Fe(II)-dependent oxygenase doma

32 ALKBH5 is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic

33 range of Bacteria and Archaea sense cellular 2-oxoglutarate (2OG) as an indicator of nitrogen limitat

34 h NrpR, nifOR(1), nifOR(2), and the effector 2-oxoglutarate (2OG) combine to regulate nif expression,

35 al human homologues belong to a subfamily of 2-oxoglutarate (2OG) dependent oxygenases (2OG oxygenase

36 The human 2-oxoglutarate (2OG) dependent oxygenases belong to a fa

37 member of the Jumonji C family of Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases.

38 he presence of NifI(1) and NifI(2), and that 2-oxoglutarate (2OG), a potential signal of nitrogen lim

39 the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that c

40 translocation (TET) proteins are Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenases that success

41 Escherichia coli DNA repair enzyme AlkB is a 2-oxoglutarate (2OG)-dependent Fe(2+) binding dioxygenas

42 FTO is a 2-oxoglutarate (2OG)-dependent N-methyl nucleic acid dem

43 mjC domain-containing protein 6 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to vario

44 ember of the mononuclear nonheme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase superfamily.

45 tate/asparagine-beta-hydroxylase (AspH) is a 2-oxoglutarate (2OG)-dependent oxygenase that catalyzes

46 2-Oxoglutarate (2OG)-dependent oxygenases catalyze a wid

47 Mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases comprise a lar

48 2-Oxoglutarate (2OG)-dependent oxygenases have important

49 enome sequences predict the presence of many 2-oxoglutarate (2OG)-dependent oxygenases of unknown bio

50 The JmjC KDMs are Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenases, some of which

51 f prolyl and lysyl residues, as catalyzed by 2-oxoglutarate (2OG)-dependent oxygenases, was first ide

52 tion hydroxylation as catalyzed by iron- and 2-oxoglutarate (2OG)-dependent prolyl and asparaginyl hy

53 The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eu

54 talyze the interconversion of isocitrate and 2-oxoglutarate (2OG).

55 cytosolic alpha-ketoglutarate, also known as 2-oxoglutarate (2OG).

56 ppression increased levels of the metabolite 2-oxoglutarate (2OG).

57 ascorbate, and the Kreb's cycle intermediate 2-oxoglutarate (2OG).

58 Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) encodes the only

59 ssion of the crosslinker procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), in sarcomas has

60 PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine resi

61 alpha-ketoglutarate (alphaKG, also known as 2-oxoglutarate), a metabolite that also serves as an obl

62 inhibition is antagonised by the binding of 2-oxoglutarate, a key metabolic signal of the carbon sta

63 The electron acceptor for 2-oxoglutarate:acceptor oxidoreductase was determined to

64 tarate respiration is mediated by the enzyme 2-oxoglutarate:acceptor oxidoreductase; mutagenesis of t

65 ially vulnerable, as it employs pyruvate and 2-oxoglutarate:acceptor oxidoreductases (Por and Oor), w

66 One such enzyme is the 2-oxoglutarate (alpha-ketoglutarate) oxidoreductase (OOR

67 2OGDDs all require oxygen, reduced iron and 2-oxoglutarate (also known as alpha-ketoglutarate) to fu

68 logical role of the NADH-dependent glutamine-2-oxoglutarate aminotransferase (NADH-GOGAT) enzyme was

69 the urea and glutamine synthetase/glutamine 2-oxoglutarate aminotransferase pathways and redirected

70 rs, nitrate/nitrite reductases and glutamine:2-oxoglutarate aminotransferase.

71 tein phosphotransferase, and diaminobutyrate-2-oxoglutarate aminotransferase.

72 With the carbon skeleton provided by 2-oxoglutarate, ammonia/ammonium (NH(4)(+)) is assimilat

73 ion using the isoquinolone Roxadustat or the 2-oxoglutarate analog dimethyloxalylglycine (DMOG).

74 prolyl hydroxylase inhibitors are lipophilic 2-oxoglutarate analogues (2OGAs) that are widely taken u

75 A set of human 2-oxoglutarate analogues were screened using a unified a

76 o an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that me

77 te shunt is a major contributor to flux from 2-oxoglutarate and glutamate to succinate in Synechocyst

78 tors (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enz

79 Unlike classical 2-oxoglutarate and iron-dependent dioxygenases, which in

80 plasmic reticulum and belong to the group of 2-oxoglutarate and iron-dependent dioxygenases.

81 es of ADP-stimulated (State 3) and uncoupled 2-oxoglutarate and succinate oxidation increased in para

82 tinguish between the C5-carboxylate group of 2-oxoglutarate and the epsilon-ammonium group of l-lysin

83 mpounds (iron, ascorbate, hydrogen peroxide, 2-oxoglutarate, and succinate) influenced by cellular ox

84 beta-Phe, (R)-3-amino-5-methylhexanoic acid, 2-oxoglutarate, and the inhibitor 2-aminooxyacetic acid,

85 a form that contained iron, the co-substrate 2-oxoglutarate, and the reaction product of EctD, 5-hydr

86 Both Tet and AlkB enzymes are 2-oxoglutarate- and Fe(II)-dependent dioxygenases.

87 that Jumonji domain-containing 4 (Jmjd4), a 2-oxoglutarate- and Fe(II)-dependent oxygenase, catalyze

88 ydroxymethyl-cytosine (hmC) by the action of 2-oxoglutarate- and Fe(ii)-dependent oxygenases of the T

89 The Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate- and Fe(II)-dependent oxygenases.

90 arboxyl-terminal domain corresponding to the 2-oxoglutarate- and iron-dependent dioxygenase domains s

91 s (the flavin-dependent KDM1 enzymes and the 2-oxoglutarate- and oxygen-dependent JmjC KDMs, respecti

92 inishes AmtB/GlnK association, and sites for 2-oxoglutarate are evaluated.

93 previously described TET enzymes, which use 2-oxoglutarate as a co-substrate(4), CMD1 uses L-ascorbi

94 ses depends on iron as the activating metal, 2-oxoglutarate as a co-substrate, and ascorbic acid as a

95 requirement for iron(II) as a co-factor and 2-oxoglutarate as a co-substrate.

96 xoadipate and pyruvate substitute poorly for 2-oxoglutarate as a cosubstrate.

97 using flavin (amine oxidases) or Fe(II) and 2-oxoglutarate as cofactors (2OG oxygenases) has changed

98 of alpha-ketoglutarate (alternatively termed 2-oxoglutarate) as a co-substrate in so many oxidation r

99 onsume the metabolite alphaKG (also known as 2-oxoglutarate) as an obligate cosubstrate and are inhib

100 Mutation of Arg-275 resulted in impaired 2-oxoglutarate binding.

101 e AML-associated mutations in the Fe(2+) and 2-oxoglutarate-binding residues increased the Km values

102 e-dependent dioxygenases, putative iron- and 2-oxoglutarate-binding residues, typical of such enzymes

103 ll core with both Fe(II) and the cosubstrate 2-oxoglutarate bound in the active site.

104 acids, AOX1A and AOX1D are both activated by 2-oxoglutarate, but only AOX1A is additionally activated

105 hemical carbon-carbon bond formation to make 2-oxoglutarate by coupling CO(2) with a succinyl group.

106 f mitochondrial transport of 2OG through the 2-oxoglutarate carrier (OGC) participates in control of

107 ylnicotinamide, methionine, acetylcarnitine, 2-oxoglutarate, choline, and creatine.

108 lytic iron center is exposed to solvent, the 2-oxoglutarate co-substrate likely adopts an inactive co

109 These enzymes use an Fe(II) cofactor and 2-oxoglutarate co-substrate to oxidize organic substrate

110 ine 8 or 5-carboxy-8-hydroxyquinoline 9, two 2-oxoglutarate competitive templates developed for JmjC

111 NJ-42041935, was a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective in

112 ess should be amenable to the assay of other 2-oxoglutarate-consuming enzymes and to the discovery of

113 Severe decreases were also seen in 2-oxoglutarate content, a key indicator of cellular carb

114 eir primary substrates while decomposing the 2-oxoglutarate cosubstrate to form succinate and CO(2).

115 ymes that orchestrate nitrogen flow, such as 2-oxoglutarate decarboxylase (KGD).

116 r1022 and combinations thereof, deficient in 2-oxoglutarate decarboxylase (Sll1981), succinate semial

117 Genes encoding a novel 2-oxoglutarate decarboxylase and succinic semialdehyde d

118 Independent of the 2-oxoglutarate decarboxylase bypass, the gamma-aminobuty

119 The Deltasll1981 strain, lacking 2-oxoglutarate decarboxylase, exhibited a succinate leve

120 olite flux to succinate than the pathway via 2-oxoglutarate decarboxylase.

121 The tricarboxylic acid cycle enzyme 2-oxoglutarate dehydrogenase (2-OGDH) converts 2-oxoglut

122 succinyltransferase (Dlst), a subunit of the 2-oxoglutarate dehydrogenase (alpha-KGDH) complex.

123 (a) Functionally competent 2-oxoglutarate dehydrogenase (E1o-h) and dihydrolipoyl s

124 However, the 2-oxoglutarate dehydrogenase (OGDH), branched-chain 2-ox

125 redundancy with the ubiquitous OGDH-encoded 2-oxoglutarate dehydrogenase (OGDH).

126 quire the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH).

127 complete in many other anaerobes (absence of 2-oxoglutarate dehydrogenase activity), isotopic labelin

128 acid as a cofactor (pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and glycine decarboxylase).

129 e to succinate and thus functionally replace 2-oxoglutarate dehydrogenase and succinyl-CoA synthetase

130 arboxylic acid (TCA) cycle because they lack 2-oxoglutarate dehydrogenase and thus cannot convert 2-o

131 The 2-oxoglutarate dehydrogenase complex (OGHDC) (also known

132 -dependent E1o component (EC 1.2.4.2) of the 2-oxoglutarate dehydrogenase complex catalyses a rate-li

133 t of the gene encoding the E1 subunit of the 2-oxoglutarate dehydrogenase complex in the antisense or

134 A traditional 2-oxoglutarate dehydrogenase complex is missing in the c

135 cle enzymes, pyruvate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex, NAD-malic enzyme,

136 2-oxo-acid dehydrogenase, and E2 subunit of 2-oxoglutarate dehydrogenase complex.

137 We report that the intact pyruvate and 2-oxoglutarate dehydrogenase complexes specifically copu

138 inyl CoA ligase, aconitase, and pyruvate and 2-oxoglutarate dehydrogenase complexes.

139 ith engineered variants of the E2 subunit of 2-oxoglutarate dehydrogenase indicate that binding sites

140 are reported unique properties of the human 2-oxoglutarate dehydrogenase multienzyme complex (OGDHc)

141 bunit binding domain from Escherichia coli's 2-oxoglutarate dehydrogenase multienzyme complex (termed

142 te interactions with other components of the 2-oxoglutarate dehydrogenase multienzyme complex.

143 amine diphosphate-dependent Escherichia coli 2-oxoglutarate dehydrogenase, which is a key component o

144 al OPN knockout or AAV9-mediated delivery of 2-oxoglutarate dehydrogenase-like (Ogdhl) to the heart.

145 lding domain of a large multienzyme complex, 2-oxoglutarate dehydrogenase.

146 Pyruvate and 2-oxoglutarate dehydrogenases are substituted by 'ancien

147 d, and small molecule inhibitors of MAPK and 2-oxoglutarate dependent collagen IV modifying enzymes r

148 Feruloyl-CoA 6'-hydroxylase (F6'H), a 2-oxoglutarate dependent dioxygenase (2OGD), catalyzes a

149 Three mononuclear nonheme iron and 2-oxoglutarate dependent enzymes, l-Ile 4-hydroxylase, l

150 The human 2-oxoglutarate dependent oxygenase aspartate/asparagine-

151 The Fe(II) and 2-oxoglutarate dependent oxygenase Jmjd6 has been shown

152 gamma-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the fi

153 conserved eukaryotic subfamily of Fe(II) and 2-oxoglutarate dependent oxygenases; their catalytic dom

154 ation catalyzed by the nonheme iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenase, AsqJ.

155 Iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases generate ir

156 and heterologous expression, we identified a 2-oxoglutarate-dependent dioxygenase (BX13) that catalyz

157 The protein level of a probable 2-oxoglutarate-dependent dioxygenase 2-ODD2, involved in

158 dioxygenase (HtxA) is a novel member of the 2-oxoglutarate-dependent dioxygenase enzyme family.

159 The TET enzymes are members of the 2-oxoglutarate-dependent dioxygenase family and comprise

160 sis, homozygous mutations in the Fe(II)- and 2-oxoglutarate-dependent dioxygenase family gene F6'H1 a

161 Tpa1 is a member of the Fe(II) and 2-oxoglutarate-dependent dioxygenase family, and we show

162 EPO and VEGF), certain members of the oxygen/2-oxoglutarate-dependent dioxygenase family, including t

163 In a mutant screening, we identified 2-oxoglutarate-dependent dioxygenase Feruloyl-CoA 6'-Hyd

164 -5-hydroxylation catalyzed by the Fe(II) and 2-oxoglutarate-dependent dioxygenase Jumonji domain-6 pr

165 mber of the non-heme-containing iron(II) and 2-oxoglutarate-dependent dioxygenase superfamily and is

166 oxidase cluster of the Arabidopsis thaliana 2-oxoglutarate-dependent dioxygenase superfamily tree.

167 otein (JMJD6) is a JmjC-containing iron- and 2-oxoglutarate-dependent dioxygenase that demethylates h

168 also known as Egl nine homolog 1 (EGLN1), a 2-oxoglutarate-dependent dioxygenase that hydroxylates H

169 AlkB is a bacterial Fe(II)- and 2-oxoglutarate-dependent dioxygenase that repairs a wide

170 he bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkyl

171 ICU11 encodes a 2-oxoglutarate-dependent dioxygenase, an activity associ

172 a coli that DES has the characteristics of a 2-oxoglutarate-dependent dioxygenase.

173 4-hydroxylase isoform 1 (PHD1), an iron and 2-oxoglutarate-dependent dioxygenase.

174 2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a sup

175 yloxalylglycine, an inhibitor of Fe(II)- and 2-oxoglutarate-dependent dioxygenases also inhibited AhR

176 d synthases, cytochrome P450 monooxygenases, 2-oxoglutarate-dependent dioxygenases and UDP-dependent

177 The Fe(II)/2-oxoglutarate-dependent dioxygenases are a catalyticall

178 Iron- and 2-oxoglutarate-dependent dioxygenases are a diverse fami

179 itamin C serves as a cofactor for Fe(II) and 2-oxoglutarate-dependent dioxygenases including TET fami

180 scription factor alpha subunit by oxygen and 2-oxoglutarate-dependent dioxygenases promotes decay of

181 enerated by a series of non-haem Fe(II)- and 2-oxoglutarate-dependent dioxygenases that catalyse the

182 signal is generated by a series of iron and 2-oxoglutarate-dependent dioxygenases that catalyze post

183 The oxygen-sensitive signal is generated by 2-oxoglutarate-dependent dioxygenases that deploy molecu

184 lyl 4-hydroxylases are a family of iron- and 2-oxoglutarate-dependent dioxygenases that negatively re

185 Like other iron/2-oxoglutarate-dependent dioxygenases, AlkB employs a tw

186 The FNSI class comprises soluble Fe(2+)/2-oxoglutarate-dependent dioxygenases, and FNSII enzymes

187 Gibberellin (GA) 3-oxidase, a class of 2-oxoglutarate-dependent dioxygenases, catalyzes the con

188 ncometabolites and competitive inhibition of 2-oxoglutarate-dependent dioxygenases, particularly, hyp

189 low amino acid sequence homology with known 2-oxoglutarate-dependent dioxygenases, putative iron- an

190 e kinetic parameters of two bacterial Fe(II)/2-oxoglutarate-dependent dioxygenases.

191 , it will be a valuable tool to study Fe(II)/2-oxoglutarate-dependent dioxygenases.

192 These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases.

193 The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA

194 is generated by the TET family of Fe(II) and 2-oxoglutarate-dependent enzymes through oxidation of 5-

195 tructural characteristics of non-heme Fe(II) 2-oxoglutarate-dependent enzymes, although key enzymatic

196 substantiated by the pioneering discovery of 2-oxoglutarate-dependent flavone demethylase activity in

197 While a handful of Fe(II)- and 2-oxoglutarate-dependent halogenases (2ODHs) have been f

198 tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enz

199 directly decreased the activity of a Fe(II)-2-oxoglutarate-dependent histone H3K9 demethylase in nuc

200 n-dependent aromatic amino acid hydroxylase, 2-oxoglutarate-dependent hydroxylase, Rieske dioxygenase

201 ve TH domain related to the family of Fe(2+)/2-oxoglutarate-dependent hydroxylases.

202 JMJD6 catalyses the iron- and 2-oxoglutarate-dependent hydroxylation of lysyl residues

203 The 2-oxoglutarate-dependent iron enzyme ALKBH3 is an antitu

204 eport that recombinant PHF8 is an Fe(II) and 2-oxoglutarate-dependent N(epsilon)-methyl lysine demeth

205 2-Oxoglutarate-dependent nucleic acid demethylases are o

206 in C synthase (DAOC/DACS) is an iron(II) and 2-oxoglutarate-dependent oxygenase involved in the biosy

207 sporin C synthase (DAOCS) is an iron(II) and 2-oxoglutarate-dependent oxygenase that catalyzes the co

208 The AlkB family of nonheme Fe(II)/2-oxoglutarate-dependent oxygenases are essential regula

209 A widely used generic assay for 2-oxoglutarate-dependent oxygenases relies upon monitori

210 xylase domain enzymes (PHDs) are Fe(II)- and 2-oxoglutarate-dependent oxygenases that act as hypoxia-

211 of the HIF system is provided by Fe(II) and 2-oxoglutarate-dependent oxygenases that catalyse the po

212 us iron binding residues that are present in 2-oxoglutarate-dependent oxygenases.

213 FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases.

214 d cocontrolled by PHD2 and PHD3, oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regu

215 ated by using wild-type and variant forms of 2-oxoglutarate-dependent taurine dioxygenase.

216 2-Oxoglutarate-dependent versions appear to have further

217 vely, Grob-type oxidative fragmentation of a 2-oxoglutarate-derived intermediate occurs to give ethyl

218 2-Oxoglutarate did not affect activity in DeltanifI(1)ni

219 2-Oxoglutarate diminishes AmtB/GlnK association, and sit

220 uence comparisons suggest that hypophosphite:2-oxoglutarate dioxygenase (HtxA) is a novel member of t

221 BCDEFGHIJKLMN operon encodes a hypophosphite-2-oxoglutarate dioxygenase (HtxA), whereas the predicted

222 Whereas the Fe-2-oxoglutarate dioxygenase core matches that in other su

223 f vitamin C, a potential cofactor for Fe(II) 2-oxoglutarate dioxygenase enzymes such as Tet enzymes.

224 ochondrial poison cyanide or the nonspecific 2-oxoglutarate dioxygenase inhibitor dimethyloxalylglyci

225 nder the tested conditions, a broad-spectrum 2-oxoglutarate dioxygenase inhibitor is a better mimic o

226 Ofd1, a prolyl 4-hydroxylase-like 2-oxoglutarate dioxygenase, controls the oxygen-dependen

227 ation of ATF3 under anoxia is independent of 2-oxoglutarate dioxygenase, HIF-1 and p53, presumably in

228 s also striking enrichment for the family of 2-oxoglutarate dioxygenases, including the jumonji-domai

229 The Arabidopsis DMR6 gene encodes a putative 2-oxoglutarate Fe(II)-dependent oxygenase (2OGO) and has

230 This reaction is catalyzed by iron(II) and 2-oxoglutarate (Fe/2OG) dependent enzymes.

231 an uncharacterized prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase, accelerates Sre1N deg

232 These findings further highlight the role of 2-oxoglutarate/Fe(II) oxygenases in fundamental cellular

233 n morphine biosynthesis are catalyzed by the 2-oxoglutarate/Fe(II)-dependent dioxygenases, thebaine 6

234 DhpJ, a 2-oxoglutarate/Fe(II)-dependent enzyme, introduces the v

235 report the identification of four paralogous 2-oxoglutarate/Fe(II)-dependent oxygenases in Arabidopsi

236 dmium sulfide nanorods (CdS NRs) transfer to 2-oxoglutarate:ferredoxin oxidoreductase from Magnetococ

237 tricarboxylic acid cycle, ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and pyruvate:f

238 phosphite in a process strictly dependent on 2-oxoglutarate, ferrous ions, and oxygen.

239 no acid directly competes with the substrate 2-oxoglutarate for binding within the active site of HCS

240 iological function of NADH-GDH is to provide 2-oxoglutarate for the tricarboxylic acid cycle.

241 We examine the dependence of 2-oxoglutarate formation on a variety of factors and, us

242 anti-correlation between 2-hydroxyglutarate, 2-oxoglutarate, fructose, hexadecanoic acid, hypotaurine

243 s a two-step mechanism in which oxidation of 2-oxoglutarate generates a highly reactive enzyme-bound

244 artate and reintroduced in the TCA cycle via 2-oxoglutarate/glutamate.

245 rginine in a nonoxidized conformation and of 2-oxoglutarate in an unprecedented high-energy conformat

246 organisms includes demonstrating the role of 2-oxoglutarate in regulating the activity of the transcr

247 DH and OGDH to oxidation of 2-oxoadipate and 2-oxoglutarate in vitro.

248 The P(II) effector 2-oxoglutarate, in the presence of Mg-ATP, inhibited Dra

249 Extraction and quantification of 2-oxoglutarate indicated concentrations 10-fold higher i

250 ln, glutamate, and the anaplerotic substrate 2-oxoglutarate, inhibiting MM cell growth.

251 To determine pathways that convert 2-oxoglutarate into succinate in the cyanobacterium Syne

252 t an alternative assay in which depletion of 2-oxoglutarate is monitored by its postincubation deriva

253 The iron and 2-oxoglutarate ligands are bound within the EctD active

254 , pyruvate, orthophosphate dikinase, and the 2'-oxoglutarate/malate transporter are expressed in oat

255 hosphorylation pathway and those involved in 2-oxoglutarate metabolic processes.

256 eveal that 2-hydroxyglutarate is oxidized to 2-oxoglutarate non-enzymatically, likely via iron-mediat

257 Deficiency in 2-oxoglutarate occurred despite increased citrate and ma

258 in resonance upon reaction of the E1o-h with 2-oxoglutarate (OG) by itself or when assembled from ind

259 ess multiple oxygen-dependent enzymes called 2-oxoglutarate (OG)-dependent dioxygenases (2-OGDDs), bu

260 However, the dicarboxylate (DIC) and 2-oxoglutarate (OGC) carriers localized to the inner mit

261 ntial for function of the pyruvate (PDH) and 2-oxoglutarate (OGDH) dehydrogenases and thus for aerobi

262 ability to override the allosteric effect of 2-oxoglutarate on NifA activity.

263 eine, histidine, and ferrous iron but not by 2-oxoglutarate or oxygen.

264 should not solely rely upon PAHX assays for 2-oxoglutarate or phytanoyl-CoA oxidation.

265 hondria also inhibited State 3 succinate and 2-oxoglutarate oxidation by 30 %, but not that of palmit

266 tion rather than activation of succinate and 2-oxoglutarate oxidation.

267 In one branch, an apparently typical 2-oxoglutarate oxygenase reaction to give succinate, car

268 endoplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-terminal oxygenase and

269 of 2-hydroxyglutarate-enabled activation of 2-oxoglutarate oxygenases, including prolyl hydroxylase

270 , at levels supporting in vitro catalysis by 2-oxoglutarate oxygenases.

271 olic flux using (13)C labelling; acetate and 2-oxoglutarate production was reduced in the light.

272 e stimulated and inhibited, respectively, by 2-oxoglutarate, providing a mechanistic link between PII

273 tilizing the typical keto-acid cosubstrates, 2-oxoglutarate, pyruvate, and oxaloacetate, Ab-ArAT4 pos

274 es the adrenal release of adrenaline through 2-oxoglutarate receptor 1 (OXGR1) expressed in adrenal g

275 a variety of nitrogen assimilation genes by 2-oxoglutarate-reversible binding to conserved palindrom

276 Pyruvate and oxaloacetate bind to the 2-oxoglutarate site of HIF-1alpha prolyl hydroxylases, b

277 id cycle intermediates (citrate, isocitrate, 2-oxoglutarate, succinate, fumarate, malate, and oxaloac

278 air yields slow but substantial oxidation of 2-oxoglutarate that is inefficiently coupled to nucleoti

279 iring for activity both molecular oxygen and 2-oxoglutarate that, under normoxia, selectively hydroxy

280 of a novel enzymatic activity that converts 2-oxoglutarate to D-2-hydroxyglutarate.

281 in fungi by condensing acetyl-coenzyme A and 2-oxoglutarate to form 3R-homocitrate and coenzyme A.

282 eversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate, and there

283 tion, but via the four-electron oxidation of 2-oxoglutarate to give ethylene in an arginine-dependent

284 Pyl is also able to ligate 2-oxoglutarate to other 4-amino-sugar derivatives to for

285 Together, these two enzymes convert 2-oxoglutarate to succinate and thus functionally replac

286 tarate dehydrogenase and thus cannot convert 2-oxoglutarate to succinyl-coenzyme A (CoA).

287 hat, in the presence of ATP and Mg(II), adds 2-oxoglutarate to the 4-amino moiety of UDP-4-amino-FucN

288 rates that this mutation prevents binding of 2-oxoglutarate to the GAF domain.

289 Addition of 2-oxoglutarate to wild-type extracts enhanced activity u

290 DeltaR306 mutant complexed with iron(II) and 2-oxoglutarate (to 2.10 A) and the DeltaR306A mutant com

291 ansamination enzymes, namely 4-aminobutyrate-2-oxoglutarate transaminase (GABA-T) and alanine-glyoxyl

292 alian transaminating enzymes 4-aminobutyrate-2-oxoglutarate transaminase and alanine-glyoxylate trans

293 mature quenching by solvent, which uncouples 2-oxoglutarate turnover from nucleobase oxidation.

294 lved in the synthesis of UDP-FucNAc-4-amido-(2)-oxoglutarate (UDP-Yelosamine), a modified UDP-sugar n

295 ole in counteracting the response of NifA to 2-oxoglutarate, under conditions that are inappropriate

296 ible oxidative deamination of l-glutamate to 2-oxoglutarate using NAD(P)(+) as coenzyme.

297 Oxidation of 2-oxoglutarate was significantly uncoupled from oxidatio

298 e apparent K(m) values for hypophosphite and 2-oxoglutarate were 0.58 +/- 0.04 mm and 10.6 +/- 1.4 mi

299 ivity that is counteracted by high levels of 2-oxoglutarate, which acts as a signal of nitrogen limit

300 deamination activity of GDH might regenerate 2-oxoglutarate, which is a cosubstrate that facilitates