ライフサイエンスコーパス: 2-oxoglutarate dehydrogenase

1 lding domain of a large multienzyme complex, 2-oxoglutarate dehydrogenase.

2 ction by inhibiting the mitochondrial enzyme 2-oxoglutarate dehydrogenase.

3 The tricarboxylic acid cycle enzyme 2-oxoglutarate dehydrogenase (2-OGDH) converts 2-oxoglut

4 istae, activation of mitochondrial AMPK, and 2-oxoglutarate dehydrogenase, a rate-liming enzyme in tr

5 complete in many other anaerobes (absence of 2-oxoglutarate dehydrogenase activity), isotopic labelin

6 succinyltransferase (Dlst), a subunit of the 2-oxoglutarate dehydrogenase (alpha-KGDH) complex.

7 acid as a cofactor (pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and glycine decarboxylase).

8 e to succinate and thus functionally replace 2-oxoglutarate dehydrogenase and succinyl-CoA synthetase

9 arboxylic acid (TCA) cycle because they lack 2-oxoglutarate dehydrogenase and thus cannot convert 2-o

10 Pyruvate and 2-oxoglutarate dehydrogenases are substituted by 'ancien

11 organisms in which three enzymes compose the 2-oxoglutarate dehydrogenase complex (ODH), actinobacter

12 acid dehydrogenase complex (BCOADC), and the 2-oxoglutarate dehydrogenase complex (OGDC).

13 nsensitive and -sensitive E1 subunits of the 2-oxoglutarate dehydrogenase complex (OGDHC) regulate ti

14 cinate selectively reduced the expression of 2-oxoglutarate dehydrogenase complex (OGDHc), the enzyme

15 The 2-oxoglutarate dehydrogenase complex (OGHDC) (also known

16 -dependent E1o component (EC 1.2.4.2) of the 2-oxoglutarate dehydrogenase complex catalyses a rate-li

17 dehydrogenase complex E (BCOADC-E2), and the 2-oxoglutarate dehydrogenase complex E (OGDC-E2).

18 -E2) in 6 of 19 patients (31.6%), and to the 2-oxoglutarate dehydrogenase complex E2 (OGDC-E2) in 1 o

19 2 (BCOADC-E2) in 4 of 49 (8%), to PDC-E2 and 2-oxoglutarate dehydrogenase complex E2 (OGDC-E2) in 9 o

20 t of the gene encoding the E1 subunit of the 2-oxoglutarate dehydrogenase complex in the antisense or

21 A traditional 2-oxoglutarate dehydrogenase complex is missing in the c

22 ) regenerated by Complex I is reduced by the 2-oxoglutarate dehydrogenase Complex yielding succinyl-C

23 cle enzymes, pyruvate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex, NAD-malic enzyme,

24 2-oxo-acid dehydrogenase, and E2 subunit of 2-oxoglutarate dehydrogenase complex.

25 us 2-oxoglutarate decarboxylase (E1o) of the 2-oxoglutarate dehydrogenase complex.

26 onents of pyruvate dehydrogenase complex and 2-oxoglutarate dehydrogenase complex.

27 We report that the intact pyruvate and 2-oxoglutarate dehydrogenase complexes specifically copu

28 inyl CoA ligase, aconitase, and pyruvate and 2-oxoglutarate dehydrogenase complexes.

29 (a) Functionally competent 2-oxoglutarate dehydrogenase (E1o-h) and dihydrolipoyl s

30 show nuclear localization of aconitase 2 and 2-oxoglutarate dehydrogenase in mouse embryonic stem cel

31 ith engineered variants of the E2 subunit of 2-oxoglutarate dehydrogenase indicate that binding sites

32 in this organism, even though a traditional 2-oxoglutarate dehydrogenase is lacking.

33 The 2-oxoglutarate dehydrogenase-like (OGDHL) protein is a r

34 al OPN knockout or AAV9-mediated delivery of 2-oxoglutarate dehydrogenase-like (Ogdhl) to the heart.

35 are reported unique properties of the human 2-oxoglutarate dehydrogenase multienzyme complex (OGDHc)

36 bunit binding domain from Escherichia coli's 2-oxoglutarate dehydrogenase multienzyme complex (termed

37 e succinyltransferase (E2o) component of the 2-oxoglutarate dehydrogenase multienzyme complex is comp

38 succinyltransferase polypeptide chain of the 2-oxoglutarate dehydrogenase multienzyme complex of Esch

39 te interactions with other components of the 2-oxoglutarate dehydrogenase multienzyme complex.

40 se (E2p, E2o) components of the pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes are s

41 : see text]-fatty acid oxidation pathway and 2-oxoglutarate dehydrogenase of the citric acid cycle, r

42 However, the 2-oxoglutarate dehydrogenase (OGDH), branched-chain 2-ox

43 Inhibition of 2-oxoglutarate dehydrogenase (OGDH), the E1 subunit of t

44 d mouse models and organoids, we reveal that 2-oxoglutarate dehydrogenase (OGDH), the enzymatic subun

45 redundancy with the ubiquitous OGDH-encoded 2-oxoglutarate dehydrogenase (OGDH).

46 quire the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH).

47 alpha-ketoglutarate dehydrogenase (kdh), and 2-oxoglutarate dehydrogenase (sucA), were responsive to

48 amine diphosphate-dependent Escherichia coli 2-oxoglutarate dehydrogenase, which is a key component o