ライフサイエンスコーパス: 20-hydroxyecdysone

1 soforms are induced as a primary response to 20-hydroxyecdysone.

2 chromosomes initiated by the molting hormone 20-hydroxyecdysone.

3 y to become pupally committed in response to 20-hydroxyecdysone.

4 ersion of cholesterol to the molting hormone 20-hydroxyecdysone.

5 one that includes the insect steroid hormone 20-hydroxyecdysone.

6 ing mutant larvae the insect steroid hormone 20-hydroxyecdysone.

7 NMR, IR, and mass spectra not only for pure 20-hydroxyecdysone (100-400 microg on column) but also t

8 gnificantly up-regulated after stimulated by 20-hydroxyecdysone (20-E) in vivo.

9 infections and find that the steroid hormone 20-hydroxyecdysone (20-HE) can regulate the quality of t

10 and influential roles of the steroid hormone 20-hydroxyecdysone (20-HE) during development, we tested

11 lly by the prepupal peak of the ecdysteroid, 20-hydroxyecdysone (20-HE).

12 culating titer of the insect molting hormone 20-hydroxyecdysone (20-HE).

13 e (Kc167) that differentiates in response to 20-hydroxyecdysone (20-HE).

14 -hydroxyecdysone-3-O-beta-D-glycopyranoside, 20-hydroxyecdysone, 20-hydroxyecdysone-3-O-beta-D-xylose

15 ogenesis is regulated by the steroid hormone 20 hydroxyecdysone (20E).

16 ated wing disk growth in vitro requires both 20-hydroxyecdysone (20E) and either brain extract or bom

17 embryos have very low titers of ecdysone and 20-hydroxyecdysone (20E) and fail to express IMP-E1 and

18 l-autonomous response to the steroid hormone 20-hydroxyecdysone (20E) and involves mitochondrial demi

19 we show that the Drosophila steroid hormone 20-hydroxyecdysone (20E) and its nuclear receptor direct

20 h induction of BR-C mRNA in the epidermis by 20-hydroxyecdysone (20E) and its suppression by JH were

21 crosstalk between two major insect hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH) to el

22 o maximal levels within 12h by low levels of 20-hydroxyecdysone (20E) and repressed by physiologicall

23 culture, AaFTZ-F1 expression is inhibited by 20-hydroxyecdysone (20E) and superactivated by its withd

24 th and developmental hormones, the steroidal 20-hydroxyecdysone (20E) and the sesquiterpenoid juvenil

25 mosquito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) appears to have evolved to both

26 ector genes activated by the steroid hormone 20-hydroxyecdysone (20E) are dually controlled by the ec

27 tion occurs as levels of the steroid hormone 20-hydroxyecdysone (20E) are rising during the pupal sta

28 mis of the tobacco hornworm Manduca sexta by 20-hydroxyecdysone (20E) during larval and pupal molts,

29 Remarkably, 20-hydroxyecdysone (20E) has opposite effects on USP iso

30 Blood feeding triggers a 20-hydroxyecdysone (20E) hormonal cascade, which activat

31 Here, we investigate the role of 20-hydroxyecdysone (20E) in CW assessment and pupation t

32 a competence factor for the steroid hormone 20-hydroxyecdysone (20E) in Drosophila melanogaster meta

33 in day 2 fifth larval epidermis in vitro by 20-hydroxyecdysone (20E) in the absence of JH with dose-

34 r hormone receptor family that is induced by 20-hydroxyecdysone (20E) in the epidermis of the tobacco

35 te a key requirement for the steroid hormone 20-hydroxyecdysone (20E) in the maintenance of numerous

36 When day 2 fourth epidermis was exposed to 20-hydroxyecdysone (20E) in vitro, MHR4 mRNA appeared be

37 and the Manduca GV1 cell line is induced by 20-hydroxyecdysone (20E) in vitro.

38 The steroid hormone 20-hydroxyecdysone (20E) initiates metamorphosis in inse

39 ow that the male-transferred steroid hormone 20-hydroxyecdysone (20E) is a key regulator of monandry

40 ng insect metamorphosis, the steroid hormone 20-hydroxyecdysone (20E) is responsible for coordinating

41 The steroid 20-hydroxyecdysone (20E) is the primary regulatory hormo

42 r knowledge, because exposure to the steroid 20-hydroxyecdysone (20E) leads to a robust regulated sec

43 upon successive phases of rising and falling 20-hydroxyecdysone (20E) levels, leading to a cascade of

44 Tonic exposure to moderate levels of 20-hydroxyecdysone (20E) or its precursor, ecdysone, are

45 activates transcription in complex with the 20-hydroxyecdysone (20E) receptor (EcR).

46 revealed that pulses of the steroid hormone 20-hydroxyecdysone (20E) regulate ganglionic fusion, but

47 rt that the ecdysone receptor (EcR)-mediated 20-hydroxyecdysone (20E) signaling regulates miRNA expre

48 stablished that fat-body remodeling requires 20-hydroxyecdysone (20E) signaling.

49 ca sexta in a pattern-specific manner as the 20-hydroxyecdysone (20E) titer rises for the larval molt

50 that includes the principal molting hormone, 20-hydroxyecdysone (20E), and ecdysone (E), which is the

51 The mechanism of 20-hydroxyecdysone (20E), but not of JH action, is well

52 are activated in larval organs cultured with 20-hydroxyecdysone (20E), consistent with EcR/USP acting

53 Upon blood feeding, a steroid hormone, 20-hydroxyecdysone (20E), initiates a reproductive progr

54 ncipally orchestrated by the steroid hormone 20-hydroxyecdysone (20E), remains largely unknown.

55 hat converts ecdysone (E) to the more active 20-hydroxyecdysone (20E), specifically in mature follicl

56 Here, we show that 20-hydroxyecdysone (20E), the active metabolite of ecdys

57 mmonly thought to be a hormone precursor and 20-hydroxyecdysone (20E), the physiologically active ste

58 The ecdysteroid hormone 20-hydroxyecdysone (20E), transferred from male to femal

59 n in direct response to the prepupal rise in 20-hydroxyecdysone (20E), whereas APR(4)s survive throug

60 ated by the male-synthetized steroid hormone 20-hydroxyecdysone (20E), which is packaged together wit

61 pression of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional casca

62 motes vitellogenesis through the function of 20-hydroxyecdysone (20E).

63 ikely candidate for sexual selection is male 20-hydroxyecdysone (20E).

64 t development and metamorphosis regulated by 20-hydroxyecdysone (20E).

65 uggests its regulation by a steroid hormone, 20-hydroxyecdysone (20E).

66 metamorphosis through its active metabolite 20-hydroxyecdysone (20E).

67 rphosis is controlled by the steroid hormone 20-hydroxyecdysone (20E).

68 sis under the control of the steroid hormone 20-hydroxyecdysone (20E).

69 I), and the JH I induction is suppressed by 20-hydroxyecdysone (20E).

70 and cell autonomously by the steroid hormone 20-hydroxyecdysone (20E).

71 to a blood-meal-initiated, elevated titer of 20-hydroxyecdysone (20E).

72 nes, juvenile hormone (JH) and ecdysteroids (20-hydroxyecdysone, 20E, is the most active form) govern

73 stasis and is essential for molting hormone (20-hydroxyecdysone; 20E) biosynthesis.

74 ed that the most prevalent phytoecdysteroid, 20-hydroxyecdysone (20HE), was secreted (leached) from i

75 ined and used to identify four ecdysteroids: 20-hydroxyecdysone-3-O-beta-D-glycopyranoside, 20-hydrox

76 -beta-D-glycopyranoside, 20-hydroxyecdysone, 20-hydroxyecdysone-3-O-beta-D-xylose and a hydroxyecdyst

77 After ingestion of blood, 20-hydroxyecdysone activates yolk protein precursor (YPP

78 We conclude that 20-hydroxyecdysone acts through the Broad-Complex to con

79 optimal concentration of the steroid hormone 20-hydroxyecdysone and with hemolymph taken from growing

80 exposure to the hormone and lower levels of 20-hydroxyecdysone, and by being sensitive to either 20-

81 We examine the role of juvenile hormone, 20-hydroxyecdysone, and insulin/insulin-like growth fact

82 been used for the analysis of a standard of 20-hydroxyecdysone- and ecdysteroid-containing plant ext

83 cid residues were identified as critical for 20-hydroxyecdysone binding.

84 ctly induced in larval epidermis in vitro by 20-hydroxyecdysone, but EcR-B1 mRNA accumulated more rap

85 Specifically, we show that the 20-hydroxyecdysone (commonly referred to as "ecdysone")

86 The holoreceptor of 20-hydroxyecdysone consists of two nuclear receptors (NR

87 The steroid hormone 20-hydroxyecdysone coordinates the stages of Drosophila

88 iption in Drosophila Schneider S2 cells in a 20-hydroxyecdysone-dependent manner, via its interaction

89 The steroid hormone 20-hydroxyecdysone (ecdysone) activates a relatively sma

90 la development is regulated by two hormones, 20-hydroxyecdysone (ecdysone) and juvenile hormone.

91 Following an increase in the steroid 20-hydroxyecdysone (ecdysone) at the end of larval devel

92 In Drosophila, pulses of the steroid hormone 20-hydroxyecdysone (ecdysone) control the timing of the

93 metamorphosis, pulses of the steroid hormone 20-hydroxyecdysone (ecdysone) direct the destruction of

94 The steroid hormone 20-hydroxyecdysone (ecdysone) is the key regulator of po

95 which is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone recep

96 In Drosophila melanogaster, fluctuations in 20-hydroxyecdysone (ecdysone) titer coordinate gene expr

97 orphological response to the steroid hormone 20-hydroxyecdysone (ecdysone).

98 The insect steroid hormone 20-hydroxyecdysone enhanced BrdU incorporation into the

99 rge in the production of the steroid hormone 20-hydroxyecdysone from the prothoracic gland, the prima

100 us studies have suggested that production of 20-hydroxyecdysone in Drosophila and other arthropods in

101 an elevated response to the steroid hormone 20-hydroxyecdysone in mosquitoes in a state of arrest.

102 ons of premoult concentrations (10(-6) M) of 20-hydroxyecdysone in the epidermal and muscle tissue of

103 central nervous system, the steroid hormone 20-hydroxyecdysone induces a wide spectrum of cellular r

104 The steroid hormone 20-hydroxyecdysone is a key regulatory factor, controlli

105 The steroid insect molting hormone 20-hydroxyecdysone is believed to control critical aspec

106 he most abundant phytoecdysteroids including 20-hydroxyecdysone is yet to be clarified.

107 gulatory mechanism upon a hormonal stimulus (20-hydroxyecdysone) is to influence pause-release rather

108 of exogenous and endogenous compounds, like 20-hydroxyecdysone (natural ligand of the ecdysone recep

109 Precocious application of 20-hydroxyecdysone on the first day of pupal life accele

110 increasing the levels of the steroid hormone 20-hydroxyecdysone or by decapitation.

111 xyecdysone, and by being sensitive to either 20-hydroxyecdysone or its precursor, ecdysone.

112 ding the mutants the steroid molting hormone 20-hydroxyecdysone, or the precursors of ecdysone biosyn

113 elements stimulating direct development (the 20-hydroxyecdysone pathway: Ecr, Shd, Broad; the Wnt pat

114 ocally identified in these extracts included 20-hydroxyecdysone, polypodine B, and integristerone A.

115 The steroid hormone 20-hydroxyecdysone (referred to here as ecdysone) direct

116 The Broad-Complex, a 20-hydroxyecdysone-regulated gene, is essential for the

117 Broad-Complex (BR-C) is a key member of the 20-hydroxyecdysone regulatory hierarchy that coordinates

118 uced in vitro by the insect molting hormone, 20-hydroxyecdysone, suggesting that this, or some relate

119 Although 20-hydroxyecdysone titers were elevated under heat shock

120 on depends on ecdysone signaling, as feeding 20-hydroxyecdysone to PTTH mutants reverses the effect.

121 Bombyxin evidently acts together with 20-hydroxyecdysone to stimulate cell division and growth

122 Importantly, AaGATAr can override the 20-hydroxyecdysone transactivation of YPP genes, and its

123 cultured fat body became less abundant after 20-hydroxyecdysone treatment.

124 Later, high levels of 20-hydroxyecdysone trigger a wave of apoptosis within th

125 We have shown that the fly steroid hormone 20-hydroxyecdysone triggers both the elongation itself a

126 ered and orchestrated by the steroid hormone 20-hydroxyecdysone, which initiates a cascade of coordin

127 The insect steroid hormone 20-hydroxyecdysone works through a ligand-activated nucl