ライフサイエンスコーパス: 3' end

1 f the position of this motif relative to the 3' end.

2 late variants with addition of A or U at the 3' end.

3 of nucleic acids beginning directly at their 3' end.

4 trend in TS repair with time from the 5' to 3' end.

5 with telomeric sequences on either the 5' or 3' end.

6 acylated (charged) with an amino acid at its 3' end.

7 significantly lower SSM density than at the 3' end.

8 se RNAs is an accessible, protein-free 5' or 3' end.

9 e density which increases from the 5' to the 3' end.

10 ween states with one TR hanging at the 5' or 3' end.

11 moving AGO-associated miRNAs with an exposed 3' end.

12 ication of the Upper Stem, first Hairpin and 3' end.

13 f their transcripts share the annotated mRNA 3' end.

14 e azide-modified nucleotide analogues at the 3' end.

15 proficient state, possibly aided by the RNA 3'-end.

16 cation relative to transcription around gene 3' ends.

17 eIF4E4-PABP1-poly(A) bridges the mRNA 5' and 3' ends.

18 small fraction of analyzed RNAs had extended 3' ends.

19 as opened to make azide groups accessible at 3' ends.

20 stable RNA structures devoid of free 5' and 3' ends.

21 x essential for formation of eukaryotic mRNA 3' ends.

22 , as well as 1628 processed 5' ends and 1299 3' ends.

23 de mapping of translation and of mRNA 5' and 3' ends.

24 y factor involved in the processing of snRNA 3' ends.

25 th joint molecules with incompletely invaded 3' ends.

26 upstream polyadenylation sites to annotated 3' ends.

27 gher error frequencies at nascent transcript 3' ends.

28 ally carry a CCA nucleotide triplet at their 3'-ends.

29 tructure of the nsP2h bound to the conserved 3'-end 14 nucleotides of the CHIKV genome and the nonhyd

30 As at the 2'-hydroxyl group on the ribose at 3'-end (2'-O-methylation, 2'Ome) is critical for miRNA f

31 ial use of exons and previously unidentified 3' ends across development, new primary microRNAs and te

32 echanism that generates mRNAs with different 3'-ends, allowing them to interact with different sets o

33 ide arising from incisions at 15 nt from the 3' end and 9 nt from the 5' end flanking the damage.

34 the Pat1/Lsm1-7 complex engages mRNA at the 3' end and promotes hydrolysis of the cap structure by D

35 ntergenic region between the prophage at the 3' end and the bacterial gene.

36 that recognize ncRNAs with accessible 5' or 3' ends and/or increase the availability of these ends.

37 ur base pair DNA (GAAG to 5' end and CTTC to 3' end) and covalently bound to gold nanoparticles (AuNP

38 g 2-5 nucleotide long RNA oligomers from the 3' end, and longer RNA substrates from the 5' end.

39 posttranscriptional oligo(A) tails, trimming 3' ends, and preventing nuclear exosome targeting.

40 nucleotide additions and deletions at 5' and 3' ends; and nucleotide substitutions.

41 miRNA 3' ends are subject to frequent sequence modifications,

42 sequencing synthetic RNAs with varied 5' and 3' ends, as well as human plasma exRNA Analyzing phospho

43 5' end-bound pyrophosphohydrolase MERS1 and 3' end-associated KPAF4 to enable mRNA circularization.

44 nsight into the biochemical basis of 5'- and 3'-end biases in RNA-seq and suggest general approaches

45 omputational methods for remediating 5'- and 3'-end biases, the latter based on a random forest regre

46 TDP1 also removes DNA 3' end blocking lesions generated by chain-terminating n

47 ivities of Apn2 in resolving a wide range of 3' end blocks and identify a role for Apn2 in maintainin

48 suggest preferential formation of GQs at the 3' end both in K+ and Na+ solutions, with minor populati

49 complex bridges the 5' end-bound PPsome and 3' end-bound polyadenylation complexes.

50 has been exonucleolyticly shortened from the 3' end by the exosome complex.

51 pendent histone pre-mRNAs are cleaved at the 3' end by U7 snRNP consisting of two core components: a

52 nger RNAs (pre-mRNAs) are processed at their 3' ends by the 1-megadalton multiprotein cleavage and po

53 addition, the extent of pairing to the miRNA 3' end can influence the stability of the miRNA itself.

54 nscript usage: promoter choice, splicing and 3' end choice.

55 m traditional linear RNAs (containing 5' and 3' ends), circular RNAs (circRNAs) are a special type of

56 suppress transcription-terminating premature 3' end cleavage and polyadenylation (PCPA) from cryptic

57 Generated by 3' end cleavage and polyadenylation at alternative polya

58 human genes have multiple sites at which RNA 3' end cleavage and polyadenylation can occur, enabling

59 Most eukaryotic pre-mRNAs must undergo 3'-end cleavage and polyadenylation prior to their expor

60 structure explains how Pno1 coordinates the 3'end cleavage of the 18S rRNA by Nob1 and how the late

61 lay by changing linker flexibility, changing 3' end complementarity, or mutationally inducing 3' end

62 nt feature was the clustering of both 5' and 3' ends, contrasting with the prevailing description of

63 or recruiting Prp43p to the spliceosome, the 3' end cross-links directly to Prp43p in an RNA-dependen

64 Using specialized 3' end deep sequencing methods, we undertook a comprehen

65 an ATP binding-dependent manner, preventing 3' end degradation.

66 Interestingly, 3' end degraded transcripts are also subject to re-adeny

67 t ventricular ejection fraction was 14.5+/-5.3%, end-diastolic diameter was 7.33+/-0.89 cm, end-systo

68 e links of the ligand with respect to the 5'-3'-ends; dictate the preferred orientation of lexitropsi

69 ncover the mechanism driving TDMD and reveal 3' end display as a key determinant regulating miRNA act

70 Altering 3' end display by changing linker flexibility, changing

71 Furthermore, native extensions on the 5' and 3' ends do not interfere with cooperative core folding.

72 TL has 16 nucleotides of the 3' end duplicated at the 5' end and a 3' end produced by

73 leads to DNA damage at the primer terminus (3-end) during the succeeding insertion event.

74 e into the aldolase gene FBA1, replacing its 3' end each time they integrate.

75 ration of post-natal keratinocytes while its 3' end eclipses the stimulatory effect.

76 M2A and the shorter form N782 that lacks the 3' end encoding F-box and LRR.

77 The data also indicate that RNA 3' end engagement with the active site is a determinant

78 ells with reduced levels of TOE1 accumulated 3'-end-extended pre-snRNAs, and the immunoisolated TOE1

79 its relationship to 5' end resection and/or 3' end extension is poorly understood.

80 mmed piwi-interacting RNA intermediates with 3' end extension, leading to severe reduction of mature

81 stability, with the addition and removal of 3' end extensions controlling miRNA levels in the cell.

82 A 3'-end-focused library approach cannot detect differenti

83 to bend at the linker and display the miRNA 3' end for enzymatic attack.

84 that in mammalian cells, the formation of a 3' end for noncoding RNAs can be a complex process gover

85 ndergo cleavage and polyadenylation at their 3'-end for maturation.

86 ' end) and T oligo (carrying a T-tail at the 3' end), for efficient ligation to target DNA and subseq

87 ative transcript abundance and defective RNA 3' end formation.

88 of the processing activities involved in RNA 3'-end formation in Eukarya.

89 lation specificity factor (CPSF) complex for 3'-end formation of mRNA, but it still has no clear func

90 or how PAS sequences are recognized for mRNA 3'-end formation.

91 e ability of ArcZ to be processed to a 50 nt 3'- end fragment is essential for its regulation of pecT

92 oped so far for capturing and sequencing RNA 3' ends from a variety of cell types and species.

93 se activity that cleaves the single-stranded 3'-end from tRNAs that contain guanine discriminator nuc

94 The cleavage of rNMPs by Top1 produces 3' ends harboring terminal adducts, such as 2',3'-cyclic

95 Novel methods to sequence RNA 3' ends have generated comprehensive catalogues of polya

96 (CRS overlapping) enhancer RNAs and extended 3' ends have significantly increased expression levels o

97 xoN excises nucleotide mismatches at the RNA 3'-end in vitro, and its inactivation in vivo jeopardize

98 ntly methylated bases accumulate towards the 3'end in regions enriched for BER enzymes AAG and APE1,

99 RNAs with highly structured 3' ends, including snRNAs and histone mRNAs, are natural

100 Although conserved sequence at the 3' end is not required, 2' hydroxyls are, paralleling re

101 The RNA primer 3' end is positioned 5 angstrom away from the polymerase

102 he dihydroquinolizinone RG7834, rescued TERC 3' end maturation and telomere length.

103 The pnp mutant exhibited multiple defects in 3' end maturation as well as other qualitative changes i

104 er nuclear exosome targeting as an essential 3' end maturation mechanism that vertebrate TR shares wi

105 by poly(A) polymerase (PAP) is important for 3' end maturation of almost all eukaryotic mRNAs.

106 munoisolated TOE1 complex was sufficient for 3'-end maturation of snRNAs.

107 ighly dysregulated, showing accumulation and 3' end misprocessing of other low-abundance RNAs, includ

108 U6 snRNA undergoes post-transcriptional 3' end modification prior to incorporation into the acti

109 undergo internal changes by RNA editing and 3' end modifications.

110 sing events such as alternative splicing and 3 end mRNA processing.

111 These results highlight the significance of 3' end mRNA processing in expression of genes important

112 regions encompassing nucleotides 5-44 at the 3 end of mature 18S rRNA.

113 (i) DP-rcDNA and rcDNA possess an identical 3' end of (-)strand DNA; (ii) compared to rcDNA, DP-rcDN

114 y forming base-pairing interactions with the 3' end of 16S rRNA, mRNA Shine-Dalgarno (SD) sequences p

115 es to initiate DNA synthesis directly at the 3' end of a DNA strand while simultaneously attaching a

116 rase can cleave a phosphodiester bond at the 3' end of a nascent RNA in the presence of pyrophosphate

117 ative polyadenylation (polyA) sites near the 3' end of a pre-mRNA create multiple mRNA transcripts wi

118 We find de novo cohesin peaks often at the 3' end of a subset of active genes.

119 ently from the 5' end of one template to the 3' end of another with little or no complementarity betw

120 ddition of a complementary nucleotide to the 3' end of cDNAs synthesized from natural templates.

121 Our work shows that, by paring the 5' and 3' end of each RNA, TIF-Seq2 can improve the annotation

122 ad, a putative SRSF1 binding sequence at the 3' end of exon 2 directs CD33 exon 2 inclusion into the

123 A polymerase II (Pol II) accumulation at the 3' end of genes, correlating with its role in APA regula

124 leads to readthrough transcription past the 3' end of genes, which can result in novel transcripts,

125 of Pob3, the FACT Spt16 subunit controls the 3' end of genes.

126 BE)-anchored chromatin loop domain(2) at the 3' end of Igh contains an internal subdomain that spans

127 The HGE starts from the 3' end of intron 19 and extends into intron 22, possesse

128 sed frequency of nonsense errors towards the 3' end of mRNAs was observed, suggesting a Nonsense-Medi

129 Hfq, including 44 sRNAs originating from the 3' end of mRNAs.

130 rcDNA, DP-rcDNA has an extended but variable 3' end of plus strand [(+)strand] DNA, most of which is

131 insertion of a transposable element into the 3' end of ppzA We demonstrate here that these truncated

132 end of the Trk fused Gene (TFG) fused to the 3' end of RET tyrosine kinase leading to a TFG-RET fusio

133 ce [SD]) and a complementary sequence in the 3' end of the 16S rRNA (anti-Shine-Dalgarno sequence [aS

134 y an important role in the processing of the 3' end of the 16S rRNA in Escherichia coli.

135 rt a model whereby purine motifs towards the 3' end of the 5'UTR are associated with increased riboso

136 ed elements are located predominantly at the 3' end of the 5'UTR.

137 ng the "foot" structure assembled around the 3' end of the 7S pre-rRNA.

138 itching rate, even when complementary to the 3' end of the acceptor template.

139 vered a critical role for nucleotides at the 3' end of the catalytic U6 small nuclear RNA in splicing

140 vated this decay pathway hybridized near the 3' end of the coding regions.

141 e interface formed by Cas6 and Cas7 near the 3' end of the CRISPR RNA (crRNA).

142 rom nucleotides 889 to 1289 encompassing the 3' end of the delta protein-coding gene.

143 e (capture DNA) that is complementary to the 3' end of the expected runoff RNA effectively prevents s

144 ich connect the 5' end, the enhancer and the 3' end of the gene, and are stabilized by RNA early afte

145 s Ser-5 at the promoter and Ser-2 toward the 3' end of the gene.

146 er and Bur1/Ctk1 phosphorylates Ser-2 at the 3' end of the genes.

147 The stem-loop at the 3' end of the genome interacts extensively with the matu

148 This observation reveals that the 3' end of the genome is largely exposed in fully assembl

149 and an intact T (porA) or no T (porA) at the 3' end of the gfp coding sequence revealed that both the

150 synthesis, the heteroduplex must be near the 3' end of the initiating strand.

151 e extent of DNA sequence conservation at the 3' end of the leader.

152 The cleavage reaction defines the 3' end of the mature mRNA, and thus the activity of the

153 ied PABPN1-dependent ALYREF binding near the 3' end of the mRNA.

154 ification of cDNA ends (RACE), we mapped the 3' end of the N and NSs mRNAs, showing that the mRNAs te

155 We show that the 3' end of the N mRNA terminates upstream of a 5'-GCCAGCC

156 At the 3' end of the porA transcript, there is a Rho-independen

157 the brain, where alternative splicing of the 3' end of the pre-mRNA leads to the production of 3 vali

158 is dictated by the sequence that flanks the 3' end of the RNA target site (called the PFS).

159 rved at 8.9-kDa open reading frame 4a at the 3' end of the spike gene.

160 When exchange reaches the 3' end of the ssDNA, a DNA polymerase can add nucleotide

161 n polyadenylated RNA, sequencing of only the 3' end of the transcript, an exuberant fraction of reads

162 es were identified, predominantly toward the 3' end of the viral genome.

163 ion of non-templated uridine residues to the 3' end of transcripts.

164 tsRNAs are fragments originating from the 3' end of tRNA precursors and do not contain mature tRNA

165 is Usb1, which removes nucleotides from the 3' end of U6 and, in humans, leaves a 2',3' cyclic phosp

166 Although the 3' end of U6 is not required for recruiting Prp43p to th

167 To elucidate the 3' ends of all EBV transcripts genome-wide, we performed

168 ' ends of uncapped, polyadenylated mRNAs and 3' ends of capped mRNAs from the same input RNA.

169 al activity redistributes the complex to the 3' ends of convergently oriented gene pairs.

170 it also led to an increase of H3K14ac in the 3' ends of GCN5 up-regulated targets.

171 At the 3' ends of genes, treatment with THZ1 suppressed RNA pol

172 ced nucleosome occupancy particularly at the 3' ends of genes.

173 , able to sequence simultaneously the 5' and 3' ends of individual RNA molecules at single-nucleotide

174 of the GU and AG dinucleotides at the 5' and 3' ends of introns and provides insight into the catalyt

175 regulation of H3K14ac levels in their 5' and 3' ends of its target genes.

176 e is an RNA-protein complex that extends the 3' ends of linear chromosomes, using a unique telomerase

177 e sites marking proximal promoters, but also 3' ends of maize genes.

178 non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs.

179 um tuberculosis functions to both define the 3' ends of mRNAs and silence substantial fragments of th

180 ing and local chromatin organization, 5' and 3' ends of nascent capped transcripts and the locations

181 Polymerases and exonucleases act on 3' ends of nascent RNAs to promote their maturation or d

182 The complex oligouridylates the 3' ends of pre-let-7 molecules, leading to their degrada

183 rate 'mixed tails' of diverse nucleotides at 3' ends of RNAs via nontemplated nucleotide addition to

184 t (or very inefficiently) transferred to the 3' ends of single-stranded and (fully) double-stranded a

185 would be able to form in the single-stranded 3' ends of telomeres.

186 of one or more nucleotides at the 5' and/or 3' ends of the canonical miRNA sequence.

187 or transcript is extended on both the 5' and 3' ends of the cloverleaf core, and these extensions get

188 nsitive antisense RNAs located at the 5' and 3' ends of the E(2)-induced transcription unit which sta

189 nal nucleotides because the promoters at the 3' ends of the genomes and antigenomes are almost identi

190 ecBCD creates a gap between the sequences at 3' ends of the initiating strands.

191 a group of 3' -> 5' exonucleases mature the 3' ends of the majority of tRNAs with few exceptions.

192 results in a spurious polyadenylation of the 3' ends of the mitochondrial (mt-) rRNA and mt-tRNA.

193 R-loops at the 5' and 3' ends of the RA or E(2)-target genes were demonstrated

194 ats, with the breakpoint located near 5' and 3' ends of the spike (S) protein gene.

195 atalyze the attachment of amino acids to the 3' ends of their cognate tRNAs.

196 e diverse accessory proteins, encoded in the 3' ends of their genomes, that often act as host cell an

197 dels GTP.EF-Tu.aa-tRNA complexes to free the 3'-end of aa-tRNA for entry into the nuclease active sit

198 mall interfering (si)RNAs against the common 3'-end of all HBV transcripts were used to knock down an

199 The 3'-end of cleaved RNA(3'-rA) consists of 2',3'-cyclic ph

200 nhanced by employing a 3'-amino group at the 3'-end of each oligonucleotide, in combination with an N

201 Specifically, PARN cleaves the 3'-end of immature, polyadenylated hTR to form the matur

202 However, most of these methods focus on the 3'-end of polyadenylated transcripts and provide only a

203 vered a P2-family prophage integrated at the 3'-end of ssrA in the deep-sea bacterium S. putrefaciens

204 AAT motif, i.e. occasionally overlapping the 3'-end of the bipartite binding site.

205 DNA, from MCM2 at the 5'-end to MCM5 at the 3'-end of the DNA spiral, but only MCM6, 4, 7 and 3 make

206 dogenous antisense RNA, transcribed from the 3'-end of the human CD39/ENTPD1 gene.

207 f three protruding nucleotides (+CCC) to the 3'-end of the nascent cDNA, which can then anneal to the

208 l 12 possible noncanonical base pairs at the 3'-end of the nicked repair intermediate.

209 ation, selective nucleotides included at the 3'-end of the PCR primers result in additional genome re

210 ce for recombination events encompassing the 3'-end of the Rep ORF in the unclassified CRESS DNA viru

211 which can then anneal to the matching rGrGrG 3'-end of the template-switching oligo (TSO), allowing t

212 sterification of specific amino acids to the 3'-end of their cognate tRNAs and therefore play a pivot

213 ugh allowing ribosomes to translate into the 3-end of mRNAs.

214 ut do not significantly affect the 5' TAGGGT 3'-ending overhangs, indicating that telomerase-mediated

215 to RNA:DNA hybrid strength and promotes RNA 3' end pairing/annealing with the template.

216 rocess governed by the activities of various 3'-end polymerases and exonucleases.

217 LAV globally regulates all sites of neuronal 3' end processing and directly binds to proximal polyade

218 Previous studies indicated that 3' end processing and mRNA export are intertwined in gen

219 on with CBC-ARS2 and NELF/DSIF, and promotes 3' end processing by enhancing recruitment of Integrator

220 in cancer through ubiquitination of the mRNA 3' end processing complex protein, PCF11, by the cancer-

221 1, resulting in loss of CFIm25 from the mRNA 3' end processing complex.

222 poly(A) site choice is regulated by core RNA 3' end processing factors, such as cleavage factor I and

223 Our results suggest that hTR 3' end processing likely involves multiple exonucleases

224 tions of different functional modules of the 3' end processing machinery and reveal additional contac

225 ether, our data suggest that the active mRNA 3' end processing machinery is a dynamic assembly that i

226 tion at Ser2, and control recruitment of the 3' end processing machinery to the vicinity of pA sites.

227 s regions in the Sm proteins and U7 snRNA in 3' end processing of histone pre-mRNAs.

228 In budding yeast, the 3' end processing of mRNA and the coupled termination of

229 omplex, which has a well-established role in 3' end processing of small nuclear RNAs (snRNAs), attenu

230 previously unknown sequence determinants of 3' end processing, and integrates these features into a

231 F1 in coordinating transcriptional dynamics, 3' end processing, and nuclear export of long 3' UTR tra

232 This review focuses on alternative splicing, 3' end processing, miRNA-mediated mRNA repression, of AR

233 co-transcriptionally via splicing but before 3' end processing.

234 an important role of ALYREF in coordinating 3'-end processing and nuclear export of non-polyadenylat

235 ALYREF promotes histone pre-mRNA 3'-end processing by facilitating U7-snRNP recruitment t

236 terminal region binds FLASH, an RDH-specific 3'-end processing factor, which keeps the kinase on the

237 tes that FCA nuclear bodies compartmentalize 3'-end processing factors to enhance polyadenylation at

238 The 3'-end processing machinery for metazoan replication-dep

239 e polymerase and nuclease modules of the RNA 3'-end processing machinery.

240 complex (INT) has important functions in the 3'-end processing of noncoding RNAs, including the uridi

241 F plays key roles in nuclear export and also 3'-end processing of polyadenylated mRNAs, but whether s

242 sibility that mRNA structures facilitate the 3'-end processing of thousands of human mRNAs by juxtapo

243 Moreover, we show that 3'-end processing promotes ALYREF recruitment and histon

244 s showed increased read-through of the snRNA 3'-end processing signal, leading to continuation of tra

245 n chromatin remodeling, actin assembly, mRNA 3'-end processing, gene looping and mRNA decay, but they

246 ins in several complexes participate in this 3'-end processing, including cleavage and polyadenylatio

247 typical CNA isoform generated by alternative 3'-end processing, whose divergent C terminus shares the

248 ations for understanding canonical and snRNA 3'-end processing.

249 s required for further RNAPII elongation and 3'-end processing.

250 og of CPSF-73, the endonuclease for pre-mRNA 3'-end processing.

251 lecular factors, some of which belong to the 3'end processing complex, suggesting they might impact t

252 ial selection of proximal polyA sites by the 3'end processing complex.

253 erase RNA and related noncoding RNAs require 3' end-processing steps, including oligoadenylation.

254 oss-link repair gene SNM1 family and in mRNA 3'-end-processing endonuclease CPSF-73, containing metal

255 The mammalian pre-mRNA 3'-end-processing machinery consists of cleavage and pol

256 of the 3' end duplicated at the 5' end and a 3' end produced by self-cleavage of a delta ribozyme.

257 elated with changes in H3K9ac at both 5' and 3' ends, providing evidence for a molecular link between

258 t that TOE1 is positioned at the center of a 3' end quality control pathway that selectively promotes

259 l mapping of mRNA and of long non-coding RNA 3' ends, quantification of the resulting isoforms and th

260 tes hTR maturation by precisely defining the 3' end, recruiting poly(A)polymerase activity, and confe

261 containing G4 structures, preferentially at 3'-end regions of expressed genes, which are partially l

262 d to be more prevalent within these extended 3'-end regions than within PAS-upstream regions and inde

263 nd complementarity, or mutationally inducing 3' end release impacts TDMD efficiency, leading to produ

264 tecture of the CTD in complex with Rtt103, a 3'-end RNA-processing and transcription termination fact

265 t the expression levels of APA isoforms from 3'-end RNA-Seq data by exploiting both paired-end reads

266 in mammals, consists of 12 Mg(2+)-dependent 3'-end RNases with substrate specificity that is mostly

267 nucleotides is possible based on foldback of 3' ends, self-priming, and concatemerization, especially

268 Each of these 3'-end sequences is immediately adjacent to or even fuse

269 In Saccharomyces cerevisiae, the 3'-end sequences of at least three intron-lacking mitoch

270 In the present study, simultaneous 5' and 3' end sequencing (SEnd-seq)-a high-throughput and unbia

271 Here, we report 14-nt 3' end-shortened variants of let-7a, miR-27a, and specif

272 n vitro and in human A549 cells, appending a 3'-end single-stranded pyrimidine (3'-ssPy) can strongly

273 s (5' GCTGGTGG 3'), RecB's nuclease cuts the 3'-ended strand and loads RecA strand-exchange protein o

274 d strand and its slower RecB helicase on the 3'-ended strand.

275 uridylation, and guanylation of U6 and Y RNA 3' ends, suggesting that in mammalian cells, the formati

276 stent with a role for ZCCHC8 in mediating TR 3' end targeting to the nuclear RNA exosome.

277 By contrast, mRNA isoforms with 3' ends that lie within annotated 5'-UTRs were overrepre

278 n contrast, we find that RelE yields precise 3'-ends that for the first time reveal reading frame in

279 which Prp43p translocates along U6 from the 3' end to disassemble the spliceosome and thereby releas

280 ation and to permit telomerase access to the 3' end to solve the end-replication problem.

281 es and energetic cost of bringing the primer 3' end to the priming site are hypothesized to explain t

282 cording to our results, the proximity of the 3' end to the ribosomal recruitment site of the mRNA cou

283 At higher ratio, BMVC also binds the 3'-end to form a second complex.

284 s a 3'-to-5' exoribonuclease whose catalytic 3'-end trimming activity impacts microRNA (miRNA) and PI

285 TD) and exonucleolytic domain (EXO) in miRNA 3'-end trimming.

286 tabilizes viral RNAs by uridylation of their 3' end; ubiquitin protein modifications and turnover; an

287 olymerase II as precursors, and whose 5' and 3' ends undergo processing to release mature, functional

288 Upon DIS3L2 loss, sustained 3'-end uridylation of aberrant 7SL RNA impacts ER-target

289 but also observe significant alterations in 3' end usage across orthologs.

290 ctly quantified promoter usage, splicing and 3' end usage.

291 ular vise that clamps the tRNA, captures its 3' end using an elaborate 'discriminator' structure, and

292 nked by 3C(pro) cleavage sites at the 5' and 3' ends, was found in the 2C/3A junction region of the v

293 Through deep sequencing of 3' ends, we provide evidence that PARN can also deadenyl

294 We found that promoters, splicing and 3' ends were predominantly controlled by independent gen

295 th end resection, leading to single-stranded 3' ends, which require microhomology upstream and downst

296 Aptamer tagged at the 3' end with 40 nucleotide bases exhibited the maximum af

297 Targeting the transcript 3' end with ASOs, however, allows transcript knockdown w

298 ve a well-defined 5' end and a more flexible 3' end with the possibility of 3' tailing events, such a

299 RNAs with 3' ends within protein-coding regions and introns were l

300 lation (APA) produces isoforms with distinct 3'-ends, yet their functional differences remain largely