ライフサイエンスコーパス: 5' end

1 wo nucleotides (12th and 16th bases from the 5' end).

2 lytic degradation of uncapped mRNAs from the 5' end.

3 ed positive-strand RNAs corresponding to the 5' end.

4 e 3' end, and longer RNA substrates from the 5' end.

5 rand breaks (DSBs) that carry adducts at the 5' end.

6 four unpaired nucleotides are present at the 5' end.

7 ear the likely exit site for the product RNA 5' end.

8 orms a covalent phosphotyrosyl bond with the 5' end.

9 pecifically affected by the cofactors on its 5'-end.

10 iption and replication, particularly at gene 5' ends.

11 taining cytosine at the second position from 5'-end (5'-xCx DNA).

12 post-transcriptional modifications at their 5' end: an inverted methylated guanosine and a unique 2'

13 tions in any one of seven nucleotides in the 5' end and 3' extension alter the processing of pre-U8,

14 nucleotides of the 3' end duplicated at the 5' end and a 3' end produced by self-cleavage of a delta

15 In brief, miRNAs usually have a well-defined 5' end and a more flexible 3' end with the possibility o

16 ion constructs with the porA promoter at the 5' end and an intact T (porA) or no T (porA) at the 3' e

17 le helix stem of four base pair DNA (GAAG to 5' end and CTTC to 3' end) and covalently bound to gold

18 amer A1-949 was fluorescently labeled at the 5' end and hybridized with a short quencher DNA strand t

19 at contain a conserved UGU sequence at their 5' end and lack specificity for cytosine.

20 at least two unpaired nucleotides at the RNA 5' end and prefers three or more such nucleotides.

21 unknown base-pairing interaction between the 5' end and the 3' extension of human pre-U8.

22 The optimal spacing between the 5' end and the scissile phosphate appears to be eight nu

23 start sites (TSS), as well as 1628 processed 5' ends and 1299 3' ends.

24 ation are generally inferred from transcript 5' ends and are thought to be either locally dispersed o

25 mRNAs identified recapping events at native 5' ends and downstream of the TOP sequence of EIF3K and

26 ,919 human lncRNA genes with high-confidence 5' ends and expression profiles across 1,829 samples fro

27 confirmed that Integrator is bound to their 5' ends and negatively regulates their transcription via

28 g P oligo (carrying a phosphate group at the 5' end) and T oligo (carrying a T-tail at the 3' end), f

29 only a single nucleotide (12th base from the 5' end), and miR-10c, which differs by only two nucleoti

30 ethyl (H3K36me3) shifted within genes toward 5' ends, and histone H3 lysine 4 dimethyl (H3K4me2) exte

31 enosine (A) bases, a fluorophore unit at the 5'-end, and a quencher at the 3'-end.

32 Their distinctive 5' ends are accommodated by a small, mobile arch in the

33 le and poly thymine sequences on both 3' and 5' ends as a template for Cu-nanocluster supraparticle f

34 ing tiRNAs bear oligoguanine motifs at their 5'-ends, assemble G-quadruplex-like structures and inter

35 ight be incomplete with the lack coverage of 5' ends assessed by CAGE peaks.

36 ckdown inhibited detection of free HIV-1 RNA 5' ends at all time points.

37 diting substrate binding complex bridges the 5' end-bound PPsome and 3' end-bound polyadenylation com

38 (RESC) mediates the interaction between the 5' end-bound pyrophosphohydrolase MERS1 and 3' end-assoc

39 ly 20-60 nt in length, often having the same 5' ends but differing in 3' ends by 1-nt steps.

40 Many of these arrays have multiple Helitron 5' ends, but a single 3' end.

41 f the role of the sequence and nature of its 5'-end (capped versus noncapped) in these biases.

42 homologs are a crucial component of the mRNA 5'-end capping quality control mechanism.

43 on within the active site negatively affects 5'-end capping surveillance properties of DXO1, but has

44 DXO catalyzes the elimination of incomplete 5'-end caps (including pyrophosphate) and the non-canoni

45 locus that differ in terms of editing state, 5' end cleavage position, and poly(U) tail addition.

46 The Qbeta hairpin on the 5 end confers affinity for the Qbeta coat protein (CP).

47 mation of chromatin loops that juxtapose the 5' end (containing the promoter) with the enhancer and t

48 liana as a model, we catalogued >215 primary 5' ends corresponding to transcription start sites (TSS)

49 m the 3' end created by the ribozyme and the 5' end created from an endolytic cleavage by yeast at a

50 3' -> 5' exonuclease that is responsible for 5' end degradation in vivo.

51 y induced recombination by cotransfection of 5'-end-deleted and 3'-end-deleted and replication-defici

52 ap-filling DNA synthesis and lyase-dependent 5'-end deoxyribose phosphate removal.

53 rial transcripts to a monophosphate triggers 5' end-dependent degradation by RNase E.

54 sphate-to-monophosphate conversion to induce 5' end-dependent RNA degradation is a two-step process i

55 Besides its role as the master regulator of 5'-end-dependent mRNA decay, RppH is important for the a

56 These properties are also manifested during 5'-end-dependent mRNA degradation in E. coli.

57 ia coli Nudix hydrolase RppH, which triggers 5'-end-dependent RNA degradation by removing orthophosph

58 5'-End-dependent RNA degradation impacts virulence, stre

59 Eukaryotic mRNAs are modified at their 5' end early during transcription by the addition of N7-

60 Truncation of guide RNA (gRNA) from the 5' end enables the application of a nuclease competent C

61 -beta promoter sequence, and dGMP favors the 5'-end fill-in.

62 s at 15 nt from the 3' end and 9 nt from the 5' end flanking the damage.

63 gh disrupting the weaker G-quadruplex at the 5'-end, followed by the stronger G-quadruplex at the 3'-

64 bers of the Potyviridae family rely on their 5' end for translation.

65 effective protocol for sequencing capped RNA 5' ends from as little as 50 ng total RNA.

66 is likely determined by the stability of the 5'-end hairpin that the ribosome first encounters during

67 Finally, the 5'-end hairpin unravels, producing an extended state (Er

68 all effect, whereas most mismatches near the 5' end impede strand exchange dramatically.

69 is by binding two sites (S1 and S2) near its 5' end in association with Ago2.

70 he difference in detection of free HIV-1 RNA 5' ends in infected DBR1 knockdown versus control cells

71 nome to a greater extent than those from the 5' end, indicating that it inhibits transcription initia

72 f both enzymes for decay intermediates whose 5' end is monophosphorylated.

73 rovides a long-distance interaction with the 5' end is unique.

74 raded from both the 3' end but also from the 5' end, likely after decapping.

75 Transcripts with processed 5'-ends mapping approximately 70 nucleotides upstream of

76 by one of several ribonucleases followed by 5' end maturation by ribonuclease P.

77 The 5' end maturation of mRNAs ascribed to the combined acti

78 bonuclease P (mt:RNase P) is responsible for 5'-end maturation and is comprised of three proteins; mi

79 to generate pre-tRNA species, which undergo 5'-end maturation by the ribozyme RNase P.

80 Surprisingly, the failure of 5'-end maturation elicits increased polyadenylation of s

81 sible for the final steps of 5S and 23S rRNA 5'-end maturation have remained unknown.

82 ibonuclease P (RNase P) is essential for the 5'-end maturation of tRNAs in all kingdoms of life.

83 onuclease, performs the last step of 5S rRNA 5'-end maturation.

84 data reveal that mammalian RNAs can harbor a 5' end modification distinct from the classical m(7)G ca

85 iation with the unnatural analogue, yielding 5'-end modified transcripts that can be mono-phosphoryla

86 ic messenger RNAs (mRNAs) normally possess a 5' end N(7)-methyl guanosine (m(7)G) cap, a non-canonica

87 es translation initiation independent of the 5' end N(7)-methylguanosine cap.

88 Eukaryotic mRNAs generally possess a 5' end N7 methyl guanosine (m(7)G) cap that promotes the

89 However, mammalian mRNAs can also carry a 5' end nicotinamide adenine dinucleotide (NAD(+)) cap th

90 p-0) and a 2'-O-methyl (2'-OMe) group to the 5'-end nucleotide ribose (Cap-1).

91 mimic 5-(E)-vinylphosphonate stabilizes the 5 end of the guide strand by protecting it from phosphat

92 ts Ago2 to tandem sites (S1 and S2) near the 5 end of the HCV genome, stabilizing it and promoting it

93 ditionally, RNase AM was found to mature the 5' end of 16S rRNA, a reaction previously attributed to

94 ase AM was also found to generate the mature 5' end of 23S rRNA, subsequent to a newly identified pri

95 that addition of a 20 nt RNA hairpin to the 5' end of a gRNA still supported RNP formation but produ

96 pression in inflammatory states, maps to the 5' end of an intergenic region on Chr11p13 that is impli

97 An atypical +1 shift site, UUC C at the 5' end of CAG repeats, which has some resemblance to the

98 using a strategy of specifically tagging the 5' end of capped RNA by first decapping and then recappi

99 n the presence of an oligo(U) stretch at the 5' end of coronavirus minus-strand RNAs, it is tempting

100 , 10, 30, and 50 consecutive adenines at the 5' end of DNA sequence, Poly A10/A30/A50), producing the

101 onal stabilising function of a region at the 5' end of env.

102 bally repress antisense transcripts near the 5' end of genes and inside gene bodies, respectively.

103 periments revealed that H3K36ac peaks at the 5' end of genes, mainly on the two nucleosomes immediate

104 ulation of RNA polymerase II (Pol II) at the 5' end of genes.

105 GS and de novo heterozygous mutations in the 5' end of GMNN, encoding the DNA replication inhibitor g

106 ing and adding a non-matching guanine to the 5' end of gRNA influenced unwinding in a sequence-contex

107 ion of a lariat-like structure involving the 5' end of HIV-1 RNA during an early step in infection an

108 a premature termination codon present at the 5' end of intron 2 leads to nonsense-mediated decay of t

109 liver-specific microRNA-122 (miR-122) to the 5' end of its genome.

110 res at least two unpaired nucleotides at the 5' end of its substrates and prefers three or more but h

111 of copies of a 150 kb region containing the 5' end of KANSL1, a gene that is important for epigeneti

112 cts were due to altered CDK7 activity at the 5' end of long genes, and were likely to be due to slowe

113 aryotic initiation factor 4F (eIF4F)] at the 5' end of messenger RNA (mRNA) to form the 48S initiatio

114 ost prevalent modified bases is found at the 5' end of mRNA, at the first encoded nucleotide adjacent

115 Initiation complexes formed even at the very 5' end of mRNA, implying that Met-tRNAi (Met) inspects m

116 4F, anchors the preinitiation complex at the 5' end of mRNAs and regulates translation initiation.

117 -dependent RNA polymerase (RdRP) cleaves the 5' end of nascent capped host RNAs and uses the capped R

118 nscriptionally with the cap structure at the 5' end of nascent mRNA to protect it from exonucleolytic

119 nit (SSU) processome, can be observed at the 5' end of nascent pre-rRNA.

120 N7-methylated guanosine cap structure on the 5' end of nascent RNA polymerase II transcripts.

121 orporates dinucleoside polyphosphates at the 5' end of nascent transcripts in vitro and the percentag

122 able to template-switch efficiently from the 5' end of one template to the 3' end of another with lit

123 composite RNA-binding site and captures the 5' end of pre-ribosomal RNA.

124 w that mutations in three nucleotides at the 5' end of pre-U8 alter the processing of the 3' extensio

125 sing enzymes that catalyze maturation of the 5' end of precursor tRNAs in Eukaryotes.

126 (rs12425376-rs10843047-rs42294) covering the 5' end of PTHLH was associated with postmenopausal osteo

127 s this dramatic stabilization by capping the 5' end of RAD-51-ssDNA filaments.

128 -fiber isolation with Switching Mechanism at 5' end of RNA Template (SMART) technology.

129 ared three protocols: Switching Mechanism at 5' End of RNA Template technology (SMART) with two diffe

130 Alyref is recruited to the 5' end of RNAs by CBC, and our data reveal subsequent bi

131 recruited by the cap binding complex to the 5' end of RNAs, as part of TREX.

132 of the methyl-7-guanosine (m(7)G) cap on the 5' end of RNAs.

133 stically increased ribosome occupancy at the 5' end of specific mRNAs under nutrient-limited conditio

134 lthough ANA residues were detrimental at the 5' end of the antisense strand, the siRNAs with ANA at p

135 New spacers are added invariably to the 5' end of the array; therefore, the first spacer matches

136 king a D-loop or a hairpin structure, on the 5' end of the blocking primer inhibited Pol epsilon from

137 and the cleavage sites are measured from the 5' end of the DNA substrate's RNA-paired region.

138 a phosphate or hydroxyl group; and (iv) the 5' end of the DP-rcDNA (-)strand is unblocked at nucleot

139 leotide composition; moreover, flanks at the 5' end of the exons have significantly lower SSM density

140 tide, instead using the template base at the 5' end of the gap to direct nucleotide binding and incor

141 to a genome-wide decrease of H3K14ac in the 5' end of the GCN5 down-regulated targets, it also led t

142 gnizes the destruction box sequence near the 5' end of the geminin protein.

143 inatorial alternative splicing events at the 5' end of the gene allow for the generation of eight mRN

144 Thus, the variability observed in this 5' end of the genomic region of divergent HIV-1 strains

145 influenza and the bunyavirus La Crosse, the 5' end of the genomic RNA binds as a hook-like structure

146 tical role of the regulatory elements at the 5' end of the HIV-1 genome in controlling the life cycle

147 his effect, we evaluated the topology of the 5' end of the HIV-1 RNA genome during early infection wi

148 les (AuNPs) using a thiol spacer attached to 5' end of the hpDNA.

149 e 7-methylguanylate (m(7)G) cap found on the 5' end of the majority of mRNAs.

150 covalently linked viral polymerase from the 5' end of the minus strand [(-)strand] of viral relaxed

151 IC, in an open conformation, attaches to the 5' end of the mRNA and scans to locate the start codon,

152 o studies, ALYREF binds to a region near the 5' end of the mRNA in a CBP80-dependent manner.

153 xt specificity, i.e. flanking purines at the 5' end of the mutated nucleotide.

154 binding of cap-binding complex (CBC) to the 5' end of the nascent U1 snRNA, which ultimately influen

155 ained the RNA primer that is attached to the 5' end of the plus strand in RC DNA, suggesting that min

156 -guanosine is adjacent to the complex at the 5' end of the quadruplex core.

157 by a modified HIV-switching mechanism at the 5' end of the RNA template (SMART) method to obtain full

158 ecognizes its cognate aptamer encoded on the 5' end of the RNA under study and beta-lactamase, which

159 strongly suppressed Nun cross-linking to the 5' end of the RNA, suggesting that GreA and GreB can ent

160 We reveal that the G-dC base pair at the 5' end of the RNA-DNA hybrid interferes with RNAP transl

161 a GG or GA dinucleotide genomic match at the 5' end of the sgRNA.

162 acer-blocking hairpin (SBH) structure at the 5' end of the single guide RNA (sgRNA), which abrogates

163 sence of a fluorescent label tethered to the 5' end of the solution-phase target.

164 The addition of three guanosines at the 5' end of the substrate significantly inhibited the degr

165 nt is faster if the toehold is placed at the 5' end of the substrate; and that the displacement slows

166 stry we show that CsrA binds directly to the 5' end of the transcript encoding AcrAB.

167 new gene fusion involves exons 1-4 from the 5' end of the Trk fused Gene (TFG) fused to the 3' end o

168 een the 5' splice site of a pre-mRNA and the 5' end of the U1 snRNA.

169 Terminal deletions at the 5' end of the viral genome involving an RNA secondary st

170 ence captured in this analysis mapped to the 5' end of the viral genome, distinct patterns of enhance

171 n internal ribosome entry site (IRES) at the 5' end of their RNA, which, unlike most cellular mRNAs,

172 molecular explanation for codon bias at the 5' end of this essential determinant of pathogenesis.

173 Furthermore, R-loops are enriched at the 5' end of those genes with promoter-proximal RNA polymer

174 This site maps to the 5' end of transcripts that fail to accumulate in ppr103

175 emnants lacking proteins associated with the 5' end of transcripts.

176 e and the Ulvale clade of Ulvophyceae at the 5' end of triphosphorylated atpH mRNA.

177 In fact, the same two SNPs located at the 5' end of TSHR showed the most significant association w

178 antisense morpholino that base-pairs to the 5' end of U1 snRNA blocks splicing in the coupled system

179 ked protein (VPg) is covalently bound to the 5' end of viral genomic RNA (gRNA) and associates with h

180 perfect inverted repeats of ~100 bp near the 5' end of vlsE, and an exceedingly high concentration of

181 s to robustly silence transcription, and the 5' end of Xist harbors SPEN-independent transcriptional

182 high-throughput sequencing to determine the 5' ends of A/WSN/33 (H1N1) influenza mRNAs.

183 OR 4 (RPF4) supports the generation of extra 5' ends of ccmB transcripts in Landsberg erecta (Ler) an

184 Whereas the 5' ends of ebolavirus RNAs are highly conserved with the

185 e motifs at the transcription start site and 5' ends of first introns (false discovery rate < 0.001)

186 We also show that GC-rich motifs at the 5' ends of footprints are found in yeast, calling into q

187 bound to nucleosome-depleted regions at the 5' ends of genes containing high levels of activating hi

188 hyperphosphorylation of CTD Ser2 residues at 5' ends of genes that is conserved in yeast.

189 P1 and PP4 complexes that localize to 3' and 5' ends of genes, respectively, and have overlapping but

190 t OGA maps to the transcriptional start site/5' ends of genes, showing considerable overlap with RNA

191 upancy and positioning of nucleosomes at the 5' ends of genes.

192 FIT1 for RNA oligonucleotides resembling the 5' ends of IAV gene segments.

193 In plant mitochondria, the 5' ends of many transcripts are generated post-transcrip

194 pyrimidine (TOP) motifs are sequences at the 5' ends of mRNAs that link their translation to the mTOR

195 ion on 2-O-methylated adenine located at the 5' ends of mRNAs.

196 IF4A, eIF4B, and Ded1 primarily targeted the 5' ends of mRNAs.

197 ease P (mt-RNase P) complex that cleaves the 5' ends of mt-tRNAs from polycistronic precursor transcr

198 or part by nucleotides that flank the 3' and 5' ends of nairoviral genes, called nontranslated region

199 expression (NET-CAGE), to sensitively detect 5' ends of nascent RNAs in diverse cells and tissues, in

200 Here we report that the 5' ends of Okazaki fragments have significantly increase

201 atin by the SWR-C complex, is found near the 5' ends of protein-coding genes, and has been implicated

202 High-throughput approaches for profiling the 5' ends of RNA degradation intermediates on a genome-wid

203 specifically designed for sequencing capped 5' ends of RNA derived from FFPE samples.

204 Mapping of 5' ends of rpoE mRNA identified five new transcriptional

205 how supernumerary guanine nucleotides at the 5' ends of single guide RNAs (sgRNAs) account for dimini

206 cumulation of ribosomes with immature 3' and 5' ends of the 16S rRNA.

207 hs of guanine-repeats are added at the 3' or 5' ends of the cytosine-repeats.

208 izes the replication origins, placed at both 5' ends of the linear chromosome, and initiates replicat

209 f two TOP2 subunits covalently linked to the 5' ends of the nicked DNA.

210 oes promoter-proximal transcript slippage at 5' ends of transcription units, adding quasitemplated AU

211 all ribonucleic acids (sRNAs), primarily the 5' ends of transfer RNAs (tRNAs) termed tRNA fragments (

212 method that captures in parallel the native 5' ends of uncapped, polyadenylated mRNAs and 3' ends of

213 nhancement of nascent RNA signal towards the 5'-end of genes promoting the identification of transcri

214 , observing that ribosomes accumulate on the 5'-end of genes through dynamic cycles of mRNA cleavage,

215 ing site by facilitating fluctuations in the 5'-end of helix P1.

216 ired at least one unpaired nucleotide at the 5'-end of its substrates, with the 5'-terminal nucleotid

217 (eIF4E) binds the m7GTP cap structure at the 5'-end of mRNAs, stimulating the translation of proteins

218 BMVC first binds the 5'-end of MycG4 to form a 1:1 complex with a well-define

219 in the absence of TSO and observed that the 5'-end of RNA template influences the terminal transfera

220 e a broad range of functional handles at the 5'-end of RNA.

221 , NDPs and (p)ppGpp, which each resemble the 5'-end of RNA.

222 Modifications at the 5'-end of RNAs play a pivotal role in determining their

223 s a primary nucleation binding step near the 5'-end of the aptamer followed by a directional folding

224 e base pairing transfers this complex to the 5'-end of the mRNA, where translation initiates.

225 zle has been why the AU dincucleotide at the 5'-end of the U1 snRNA is highly conserved, despite the

226 ), in conjunction with nsp10, methylates the 5'-end of virally encoded mRNAs to mimic cellular mRNAs,

227 cription factor Rex and binds to the extreme 5'-end of yflS mRNA.

228 nd that in the follicle cells of ovaries the 5'-ends of flam transcripts are usually located in close

229 The peak uracilated regions were in the 5'-ends of genes and operons mainly containing tRNA gene

230 By extending the 3'- or 5'-ends of the crRNA with different lengths of ssDNA, ss

231 and binds both the highly conserved 3'- and 5'-ends of the vRNA segment.

232 results due to incomplete sequencing of the 5'-ends of transcripts during RNA-seq library preparatio

233 Spliced Leader (SL) sequence is added to the 5'end of each mRNA by trans-splicing.

234 Small RNAs that map to the 5'end of psaC RNA in the wild type but not in the mac1 m

235 kb region spanning the 3'end of MLH1 and the 5'end of the neighboring LRRFIP2, and marked by an isole

236 cing (5P-seq) that specifically captured the 5-end of processed transcripts and mapped the genome-wid

237 gh-baseline carbon emission scenarios (RCP 8.5), end-of-century (2075-2100) pollock and Pacific cod f

238 method (HIV-SMART [i.e.,switchingmechanismat 5' end ofRNAtranscript]) for next-generation sequencing

239 We also found evidence that the 5 end pairs alternatively with two different regions of

240 rthermore, we show that DUSP11 modulates the 5' end phosphate group and/or steady-state level of seve

241 pool of miR-34 is rapidly activated through 5'-end phosphorylation in an ATM- and Clp1-dependent man

242 Functionalization of the 5'-end position by a chemical label, a polydA tail, a pr

243 Among these XRN4 substrates that have 5' ends precisely at cap sites, those associated with ph

244 xpected cases of clade-specific variation in 5' end precision, occasional antisense loci, and putativ

245 ly on mitochondrial transcripts that are not 5' end processed.

246 ng that Pol delta and FEN1 dissociate during 5' end processing and that LigI engages PCNA at the DNA

247 Pet111p binds directly and specifically to a 5'-end proximal region of the COX2 transcript.

248 of proteins participates in eukaryotic mRNA 5'-end quality control, removal of non-canonical NAD+ ca

249 as a function of the fragment's size and its 5' end reading frame in Ribo-Seq data generated from S.

250 Remarkably, 5' end recognition and pyrophosphate hydrolysis by the P

251 er-specific oligonucleotides (TRs) via their 5'-end regions and to a capture probe-magnetic micropart

252 nd Nuc2 were positioned slightly more to the 5' end relative to their position in integrated DNA.

253 creates the structure that Exo1 requires for 5' end resection and HR initiation.

254 Meiotic DSB processing entails 5' end resection and preferred strand exchange with the

255 ogous recombination, but its relationship to 5' end resection and/or 3' end extension is poorly under

256 e for plant homeodomain finger 11 (PHF11) in 5' end resection at DNA double-strand breaks (DSBs).

257 The regulation of 5' end resection at DSBs and telomeres prevents genome i

258 sting that PHF11 acts (in part) by promoting 5' end resection at RPA-bound sites of DNA damage.

259 ir proteins and suggests that PHF11 mediates 5' end resection by negotiating RPA-coated DNA repair in

260 a previously unknown DDR factor involved in 5' end resection, ATR signaling, and HR.

261 logous recombination (HR), which begins with 5' end resection, mediated by exonuclease complexes, one

262 f MRE11 and CtIP, and protects the DSBs from 5' end resection.

263 lease 1 (Exo1), a 5'-exonuclease crucial for 5'-end resection to mediate DNA processing at stalled fo

264 Thus, mammalian cells have two distinct 5' end-resection pathways that are regulated by DNA dama

265 ups at nucleotide positions 1 and 5 from the 5 end, resulting in four methyl groups symmetrically pos

266 raightforward method for making high-quality 5' end RNA-seq libraries from FFPE-derived RNA.

267 DXO/Rai1 family of enzymes removes numerous 5'-end RNA modifications, thereby regulating RNA turnove

268 r the first time that the T. brucei telomere 5' end sequence - an important feature of the telomere t

269 To generate a free 5' end, stalled replication forks must therefore be clea

270 le-stranded region, but surprisingly, also a 5'-end stem-loop structure.

271 winds DNA with its fast RecD helicase on the 5'-ended strand and its slower RecB helicase on the 3'-e

272 nucleolytic degradation (resection) of their 5'-ending strands, we investigated the contribution of r

273 se structure with a bound complementary cRNA 5' end that exhibits a major rearrangement of the subdom

274 s, facilitated a global analysis of internal 5' ends that are generated or acted upon by these enzyme

275 A. marginale, which contains repeats at the 5' ends that are useful for genotyping strains.

276 diate with both 5'- and 2'-phosphates at its 5'-end that inhibit 5'->3' decay and suggesting that Ire

277 RA or E(2)-induced loops which connect the 5' end, the enhancer and the 3' end of the gene, and are

278 of 15 conserved RNA elements located at the 5' end, the ribosomal frameshift segment and the 3'-untr

279 sis of the cap structure by Dcp1/Dcp2 at the 5' end through an unknown mechanism.

280 er, H5' abstraction can lead DNA cleavage at 5' end through the formation of C5'=O5' ketone and break

281 bonucleases that degrade RNA either from the 5' end to the 3' end, such as XRN4, or in the opposite d

282 base pairing-that disrupt the path from the 5' end to those sites and prolong mRNA lifetimes.

283 t impedes scanning from a monophosphorylated 5' end to those sites by the regulatory endonuclease RNa

284 ing the Ctgf gene from 15 kb upstream of its 5'-end to 10 kb downstream of its 3'-end to determine SO

285 olding of the aptamer around its target from 5'-end to 3'-end.

286 l MCM subunits contact DNA, from MCM2 at the 5'-end to MCM5 at the 3'-end of the DNA spiral, but only

287 at A, a conserved RNA element located in its 5' end, to induce gene silencing during X-chromosome ina

288 Herein, we globally identify the 5' end transcriptome of B. burgdorferi grown in culture

289 identified a new activity for these enzymes, 5'-end triphosphonucleotide hydrolase (TPH) instead of P

290 We investigated the effects of 5'-end truncated CRISPR RNA-guided Cas9 nuclease (tru-RG

291 ntly, 1,293 lincRNAs were corrected at their 5' ends using the putative lincRNA TSS regions predicted

292 cGMP binds both the 3'- and 5'-end vG4s and forms two fill-in G4s with similar popul

293 Intriguingly, an equilibrium of 3'- and 5'-end vG4s is present in the PDGFR-beta promoter sequen

294 nd remains covalently bound to its substrate 5'-end via a phosphotyrosine linkage.

295 An Oligonucleotide with ANA at the 5' end was more stable in the presence of 5'-exonuclease

296 s programmed with mRNAs containing different 5'-ends, we show that an MNK inhibitor, CGP57380, affect

297 ne or two non-matching guanines added to the 5' end were used, Sniper1-Cas9 showed the lowest promisc

298 rtion of cellular RNAs being 'capped' at the 5' end with NAD+, reminiscent of eukaryotic cap.

299 BMVC binds the more accessible 5'-end with higher affinity, whereas sequence specificit

300 GE, a method for the detection of transcript 5'-ends with an original sample multiplexing strategy in