ライフサイエンスコーパス: 5-formyltetrahydrofolate

1 in pemetrexed activity in growth medium with 5-formyltetrahydrofolate.

2 n a complex with uridine monophosphate and N-5-formyltetrahydrofolate.

3 he conversion of methenyltetrahydrofolate to 5-formyltetrahydrofolate.

4 nversion of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.

5 was catalytically inactive and did not bind 5-formyltetrahydrofolate.

6 rolysis of 5, 10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.

7 lted in over a 6-fold increase in [(13)C(5)]-5-formyltetrahydrofolate ([(13)C(5)]-5-formylTHF) concen

8 loligase (5-FCL) catalyzes the conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu(n)) to 5,10-m

9 thermodynamic parameters for the binding of 5-formyltetrahydrofolate (5-CHO-H4PteGlun) and its polyg

10 With 5-formyltetrahydrofolate (5-CHO-THF) as the folate sourc

11 istant L1210 clonal variant in which MTX and 5-formyltetrahydrofolate (5-CHO-THF) influx was markedly

12 5-Formyltetrahydrofolate (5-CHO-THF) is formed by a side

13 5-Formyltetrahydrofolate (5-CHO-THF) is formed via a sec

14 5-Formyltetrahydrofolate (5-formylTHF) is the only folat

15 s of the tight-binding dimer are occupied by 5-formyltetrahydrofolate (5-formylTHF), whose N5-formyl

16 Transport of 5-formyltetrahydrofolate (5-FTHF) into primary cultured

17 dministered unnatural carbon-6 isomers, (6R)-5-formyltetrahydrofolate (5-HCO-THF) and (6S)-5,10-methe

18 he respiration of mitochondria, whereas (6S)-5-formyltetrahydrofolate (5-HCO-THF) was inactive.

19 asured by 5-methyltetrahydrofolate (5MeTHF), 5-formyltetrahydrofolate (5FoTHF), and folic acid concen

20 olate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substitut

21 forms of folates - 5-methyltetrahydrofolate, 5-formyltetrahydrofolate and 10-formyltetrahydrofolate -

22 THFS) is the only enzyme known to metabolize 5-formyltetrahydrofolate and catalyzes the conversion of

23 a approximately 50% decrease in the EC50 for 5-formyltetrahydrofolate and folic acid and the MTX IC50

24 atic production of 5-methyltetrahydrofolate, 5-formyltetrahydrofolate and tetrahydrofolate after 48 h

25 -formylfolic acid, 5-methyltetrahydrofolate, 5-formyltetrahydrofolate and tetrahydrofolate were deter

26 roxymethyltransferase-catalyzed formation of 5-formyltetrahydrofolate, and 5, 10-hydroxymethylenetetr

27 AR resulted in augmentation of methotrexate, 5-formyltetrahydrofolate, and 5-methyltetrahydrofolate i

28 d E45K all 1) increased carrier affinity for 5-formyltetrahydrofolate approximately 4-fold, 2) increa

29 other antifolates in HepG2 cells grown with 5-formyltetrahydrofolate at physiological pH.

30 etrahydrofolate synthase (MTHFS; also called 5-formyltetrahydrofolate cyclo-ligase; EC 6.3.3.2) activ

31 5-Formyltetrahydrofolate cycloligase (5-FCL) catalyzes t

32 We have identified the 5-formyltetrahydrofolate cycloligase gene (FTL_0724) as

33 nd how much of a physiologic dose of [(13)C5]5-formyltetrahydrofolate delivered in a pH-sensitive ent

34 of [(3)H]5-methyltetrahydrofolate and [(3)H]5-formyltetrahydrofolate (di- through heptaglutamates).

35 ed transport, subsequent pemetrexed and (6S)-5-formyltetrahydrofolate export into the cytosol was mar

36 The folate derivative 5-formyltetrahydrofolate (folinic acid; 5-CHO-THF) was d

37 thenyltetrahydrofolate is hydrolyzed to only 5-formyltetrahydrofolate if reducing agents are present

38 ahydrofolate, 5'-methyltetrahydrofolate, and 5'-formyltetrahydrofolate in human plasma.

39 oxyl group of serine and the formyl group of 5-formyltetrahydrofolate in complexes of these species w

40 In order to address the function of 5-formyltetrahydrofolate in mammalian cells, intracellul

41 rganisms, the addition of p-aminobenzoate or 5-formyltetrahydrofolate in the external medium restored

42 drolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate in vivo, and there is no requir

43 duce large quantities of folate, and [(13)C5]5-formyltetrahydrofolate infused during colonoscopy is a

44 These results suggest that 5-formyltetrahydrofolate inhibits serine hydroxymethyltr

45 The metabolic role of 5-formyltetrahydrofolate is not known; however, it is an

46 whereas folE thyA mutants supplemented with 5-formyltetrahydrofolate (lacking pterins and depleted i

47 ydrofolate in mammalian cells, intracellular 5-formyltetrahydrofolate levels were depleted in human 5

48 sent in mouse liver and kidney does not bind 5-formyltetrahydrofolate, nor does it oligomerize with t

49 ermined the effects of depleting cytoplasmic 5-formyltetrahydrofolate on cellular folate concentratio

50 the N terminus of slr0642) enabled growth on 5-formyltetrahydrofolate or folic acid but not on 5-form

51 A in the presence and absence of glycine and 5-formyltetrahydrofolate pentaglutamate.

52 that results from the binding of glycine and 5-formyltetrahydrofolate polyglutamate, a slow tight-bin

53 s replaced with the more physiological 25 nM 5-formyltetrahydrofolate, R5 cells were 2-fold collatera

54 and was purified from the culture medium by 5-formyltetrahydrofolate-Sepharose affinity chromatograp

55 R-luciferase mRNA binds to the cSHMT.glycine.5-formyltetrahydrofolate ternary complex with an apparen

56 ahydrofolate and catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolat

57 r that catalyzes the oxidative catabolism of 5-formyltetrahydrofolate to p-aminobenzoylglutamate and

58 myltetrahydrofolate or folic acid but not on 5-formyltetrahydrofolate triglutamate, demonstrating tha

59 Folic acid was a much better substrate, and 5-formyltetrahydrofolate was a poorer substrate for tran

60 c acid, (6S)5-methyltetrahydrofolate, or (6S)5-formyltetrahydrofolate was not detected.

61 ahydrofolate, 5'-methyltetrahydrofolate, and 5'-formyltetrahydrofolate were 1250, 400, and 360 pmol/L

62 e degradation in vitro with the exception of 5-formyltetrahydrofolate, which may be a storage form of

63 ze folinic acid (also known as leucovorin or 5-formyltetrahydrofolate), whose metabolic function rema