ライフサイエンスコーパス: 9-cis-retinoic acid

1 en troglitazone was given with estradiol and 9-cis retinoic acid.

2 n the granulocytic pathway after exposure to 9-cis retinoic acid.

3 tic agonist but not by the endogenous ligand 9-cis retinoic acid.

4 all-trans retinol, but not the stereo-isomer 9-cis retinoic acid.

5 ar diffusion barrier against fluorescein and 9-cis retinoic acid.

6 fect similar to that of triiodothyronine and 9-cis-retinoic acid.

7 transcription in response to the RXR ligand 9-cis-retinoic acid.

8 hat is activated by the vitamin A derivative 9-cis-retinoic acid.

9 of RXR were modestly enhanced by its ligand, 9-cis-retinoic acid.

10 regulates gene transcription in response to 9-cis-retinoic acid.

11 hat is activated by the vitamin A metabolite 9-cis-retinoic acid.

12 rticipation of CRAD3 in the biogeneration of 9-cis-retinoic acid.

13 clear receptors for 1alpha,25(OH)(2)D(3) and 9-cis-retinoic acid.

14 oid and similar to those for the pan-agonist 9-cis-retinoic acid.

15 to detect significant levels of all-trans or 9-cis retinoic acids.

16 roglitazone (2.7 A), felodipine (2.3 A), and 9-cis-retinoic acid (2.6 A) were determined to examine l

17 monolayers to fluorescein (20 microg/mL) and 9-cis retinoic acid (3 x 10(-4) M) were also determined.

18 We utilized [20-methyl-(3)H]-9-cis-retinoic acid ([(3)H]9-cis-RA) as a direct photoaf

19 We report that 9-cis retinoic acid (9-cis RA) and all trans retinoic ac

20 (PPs), 3,3',5-triiodo-L-thyronine (T3), and 9-cis retinoic acid (9-cis RA) induce hepatocyte prolife

21 leukemia line), because they were induced by 9-cis retinoic acid (9-cis RA) to differentiate towards

22 The effects of 13-cis RA, 9-cis retinoic acid (9-cis RA), and all-trans retinoic a

23 h efficacy and high potency equal to that of 9-cis-retinoic acid (9-c-RA).

24 a,25-dihydroxyvitamin D3 (1, 25-[OH]2D3) and 9-cis-retinoic acid (9-c-RA).

25 dy was conducted to evaluate the activity of 9-cis-retinoic acid (9-cis-RA) as an inhibitor of prosta

26 SCD mRNA expression was also increased by 9-cis-retinoic acid (9-cis-RA) as well as 4-(E-2-(5,6,7,

27 9-cis-retinoic acid (9-cis-RA) has shown potential chemo

28 In this study we demonstrate that 9-cis-retinoic acid (9-cis-RA) is a negative regulator o

29 ha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and 9-cis-retinoic acid (9-cis-RA) ligands in the binding of

30 and synergistically activating RXRalpha with 9-cis-retinoic acid (9-cis-RA), a natural ligand binding

31 Here we have discovered that 9-cis-retinoic acid (9-cis-RA), a RXRalpha-specific liga

32 C) in combination with its obligate partner, 9-cis-retinoic acid (9-cis-RA), decreased surfactant pho

33 inding domain in the presence and absence of 9-cis-retinoic acid (9-cis-RA).

34 mediates stimulation of promoter activity by 9-cis-retinoic acid (9-cis-RA).

35 We have previously demonstrated that 9-cis-retinoic acid (9-cisRA) has the potential to be re

36 9-cis-Retinoic acid, 9-trans-retinoic acid, and MC1288,

37 olution structure of the TRalpha*T3:RXRalpha*9-cis retinoic acid (9c) ligand binding domain heterodim

38 cid (RA), all-trans retinoic acid (t-RA) and 9-cis retinoic acid (9c-RA).

39 amine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke.

40 rway inflammation mouse model in response to 9-cis retinoic acid (9cRA) and after lymphocyte-specific

41 rway inflammation mouse model in response to 9-cis retinoic acid (9cRA) and after lymphocyte-specific

42 Wild-type RXR has an EC50 of 500 nM for 9-cis retinoic acid (9cRA) and an EC50 of >10 microM for

43 Two RXRalpha ligands, 9-cis retinoic acid (9cRA) and LG268, induced SUMOylatio

44 We have shown that 9-cis retinoic acid (9cRA) inhibits acinar differentiati

45 The effect of the endogenous metabolite 9-cis retinoic acid (9cRA) on allergic sensitization is

46 e chemopreventive efficacy of two retinoids, 9-cis-retinoic acid (9cRA) and 4-(hydroxyphenyl)retinami

47 tinoid X receptor (RXRalpha) is activated by 9-cis-retinoic acid (9cRA) and regulates transcription a

48 9-cis-retinoic acid (9cRA) binds retinoic acid receptors

49 Previously, 9-cis-retinoic acid (9cRA) was defined as a potent RXR a

50 Although RXRs bind 9-cis-retinoic acid (9cRA) with high affinity, in vitro

51 is in multiple tissues, with abnormally high 9-cis-retinoic acid (9cRA), a pancreas autacoid that att

52 The all-trans-retinoic acid (atRA) isomer, 9-cis-retinoic acid (9cRA), activates retinoic acid rece

53 RXR, which is activated by 9-cis-retinoic acid (9cRA), can modulate several signali

54 XR), a nuclear receptor that is activated by 9-cis-retinoic acid (9cRA), can regulate transcription a

55 tive fashion by 22(R)-hydroxycholesterol and 9-cis-retinoic acid (9CRA), suggesting induction by nucl

56 nd RXRalpha LBDs complexed to the RXR ligand 9-cis-retinoic acid (9cRA), the PPARgamma agonist rosigl

57 The 9-cis-retinoic acid (9cRA)-inducible enhancer of the rat

58 vation of its heterodimeric partner RXR with 9-cis-retinoic acid (9cRA).

59 alpha LBD (T223-T462) with and without bound 9-cis-retinoic acid (9cRA).

60 Recently, 9-cis retinoic acid, a high affinity ligand for retinoic

61 , is affected by treatment of the cells with 9-cis retinoic acid, a treatment that activates the reti

62 In support of this hypothesis, we show that 9-cis-retinoic acid, acting through RXR, inhibits both t

63 9-cis-Retinoic acid activates retinoid X receptors, whic

64 ever, beta-apo-13-carotenone antagonized the 9-cis-retinoic acid activation of RXRalpha.

65 nes, but neither all-trans-retinoic acid nor 9-cis-retinoic acid affected reporter transcription.

66 9-cis-Retinoic acid (ALRT1057), a pan agonist retinoid t

67 g to the retinoic acid receptor (RAR), while 9-cis-retinoic acid also binds to the retinoid X recepto

68 elated retinoids all-trans-retinoic acid and 9-cis-retinoic acid also display slight agonist properti

69 The RXR agonist 9-cis-retinoic acid also increased Bcl2a1 expression, al

70 inol, as well as all-trans retinoic acid and 9-cis retinoic acid, also repressed HIV-1 long terminal

71 MO, tocopherol acetate, selenomethionine, or 9-cis-retinoic acid, although the effects on late-stage

72 with various concentrations of all-trans or 9-cis retinoic acid (an analogue of 11-cis retinoic acid

73 wing cotreatment with PPARgamma agonists and 9-cis-retinoic acid, an RXRalpha agonist.

74 glitazone and ciglitazone, is coactivated by 9 cis-retinoic acid and is inhibited by the PPARgamma an

75 The receptors for 9-cis retinoic acid and 1,25-dihydroxyvitamin D3 [1,25(O

76 inoic acid than control subjects but similar 9-cis retinoic acid and retinol levels.

77 ide evidence that potentiation of ST8SIA2 by 9-cis-retinoic acid and artificial polysialylation of ol

78 Cotreatment with 9-cis-retinoic acid and PPARgamma agonists decreased the

79 receptors (RXRs), which include the natural 9-cis-retinoic acid and synthetic analogs, are potent in

80 l to generate the retinoid X receptor ligand 9-cis-retinoic acid and/or may regenerate dihydrotestost

81 molar concentrations of the RXRalpha ligand (9-cis-retinoic acid) and PPARgamma ligands to CpG-activa

82 d receptor-alpha (RARalpha), including atRA, 9-cis-retinoic acid, and Am580, sequentially increased t

83 ted the in vitro effect of triiodothyronine, 9-cis-retinoic acid, and the retinoid X receptor-selecti

84 All-trans- and 9-cis-retinoic acid are active retinoids for regulating

85 retinoids, like all-trans retinoic acid and 9-cis retinoic acid, are known to affect proliferation a

86 -retinal into the retinoid X receptor ligand 9-cis-retinoic acid as two previously identified ALDHs w

87 In comparison, 9-cis retinoic acid at 30 mg/kg inhibited growth of esta

88 9-cis-Retinoic acid attenuates the stimulating effect of

89 iles between these lineages is distinct with 9- cis-retinoic acid being exclusively detected in Jurka

90 1, CRAD3, or RDH1, to reconstitute a path of 9-cis-retinoic acid biosynthesis in situ.

91 ver, we studied 9-cis-retinol metabolism and 9-cis-retinoic acid biosynthesis in two hepatic-derived

92 y that ALDH12 could function in a pathway of 9-cis-retinoic acid biosynthesis in vivo includes biosyn

93 , type 3), which catalyzes the first step in 9-cis-retinoic acid biosynthesis, the conversion of 9-ci

94 uggest that it could meet specific needs for 9-cis-retinoic acid biosynthesis.

95 ming growth factor beta, lipopolysaccharide, 9-cis-retinoic acid) but not others (e.g., tumor necrosi

96 id X receptor in the presence and absence of 9-cis-retinoic acid by Q(tau) analysis.

97 otene is a subject of recent interest, since 9-cis retinoic acid can apparently be formed from 9-cis

98 The structure of the 9-cis-retinoic acid complex reveals that two substrate m

99 ation and the rate of association of the RXR-9-cis-retinoic acid complex were significantly slower in

100 ent with a retinoid X receptor alpha ligand, 9-cis-retinoic acid, decreased [(3)H]thymidine incorpora

101 gth SHP to the GAL4 DNA binding domain shows 9-cis-retinoic acid-dependent interaction with a VP16-re

102 and synthetic ligands for RXRalpha including 9-cis-retinoic acid, docosahexaenoic acid, and LG100268

103 ximately 35 fmol RAR alpha/mg total protein (9-cis retinoic acid; EC50, approximately 50-100 nM).

104 nsitivity to growth inhibition by retinoids (9-cis-retinoic acid; EC50, approximately 3 nM).

105 Treatment of cells with 9-cis retinoic acid enhanced accessibility to cisplatin

106 re, PPARgamma ligands alone or combined with 9-cis-retinoic acid enhanced CpG-induced expression of C

107 9-cis-retinoic acid enhances ST8SIA2 expression, providi

108 al RXR agonists mimicking the natural ligand 9-cis retinoic acid exhibit poor physicochemical propert

109 oyl dopamine for airway hyperresponsiveness, 9-cis-retinoic acid for lung function, phosphatidylcholi

110 Little is known, however, regarding 9-cis-retinoic acid formation.

111 ehydrogenase, which probably plays a role in 9-cis-retinoic acid formation.

112 iosynthesis in vivo includes biosynthesis of 9-cis-retinoic acid from 9-cis-retinol in cells co-trans

113 animals, whereas all-trans-retinoic acid and 9-cis-retinoic acid function as ligands for nuclear reti

114 of additional pathways for the generation of 9-cis-retinoic acid in specialized tissues.

115 ometric isomers, all-trans retinoic acid and 9-cis retinoic acid, in a focal model of ischemia.

116 atoma cells, whereas RXRalpha and its ligand 9-cis-retinoic acid increased MTP promoter activity by 6

117 t interacts with both RAR and RXR receptors (9-cis-retinoic acid) increases IGFBP-3 levels and suppre

118 9-cis Retinoic acid induced higher rates of apoptosis in

119 recursor protein, 22R-hydroxycholesterol and 9-cis-retinoic acid induced ABCA1 expression and increas

120 nce of a confluent RPE monolayer reduced the 9-cis retinoic acid-induced apoptosis rate (P = 0.002),

121 Cycloheximide did not inhibit 9-cis retinoic acid-induced apoptosis, but phorbol myris

122 9-cis retinoic acid inhibited the accumulation, suggesti

123 9-cis Retinoic acid is an important mediator of vascular

124 9-cis-Retinoic acid is a known biological ligand for ret

125 When the pan-agonist 9-cis-retinoic acid is bound to the receptor, only the d

126 luciferase expression by ciprofibrate and/or 9-cis-retinoic acid is dependent upon cotransfection of

127 A second molecule of 9-cis-retinoic acid is located above the proximal molecu

128 metabolism of all-trans-retinol to at-RA or 9-cis-retinoic acid is observed in these cells.

129 le transcription factor that is activated by 9-cis-retinoic acid, is a member of the superfamily of n

130 nd that, while this activity is regulated by 9-cis-retinoic acid, it is distinct from and independent

131 Like vertebrate RXRs, jRXR binds 9-cis retinoic acid (Kd = 4 x 10(-10) M) and binds to th

132 Hypoxia also diminished the 9-cis-retinoic acid-mediated activation of a reporter co

133 Addition of exogenous ligands, such as 9-cis retinoic acid or all-trans retinoic acid, expands

134 ed with either an RXR agonist (bexarotene or 9-cis retinoic acid) or vehicle (dimethylsulfoxide) for

135 owed an increased growth inhibition by ATRA, 9-cis-retinoic acid, or the synthetic retinoid 6-(5,6,7,

136 CRAD3 contributes to 9-cis-retinoic acid production in intact cells, in conju

137 involved in the first step of all-trans- and 9-cis-retinoic acid production in many tissues.

138 er as homodimers or as heterodimers with the 9-cis retinoic acid (RA) receptor (retinoid X-receptor [

139 However, 1,25(OH)(2) vitamin D(3), 9-cis retinoic acid (RA), and 13-cis RA also induced the

140 We herein show that the combination of 9-cis-retinoic acid (RA) and IFN-alpha induces marked an

141 promoter 150% of control, in the presence of 9-cis-retinoic acid (RA), whereas RXR alpha/T3R beta het

142 y RXR in the presence of its cognate ligand, 9-cis-retinoic acid (RA).

143 The 9-cis retinoic acid receptor (retinoid X receptor, RXR)

144 rization but now forms heterodimers with the 9-cis retinoic acid receptor (RXR) DBD.

145 rms active, heterodimeric complexes with the 9-cis retinoic acid receptor (RXR) on vitamin D response

146 cs through binding as a heterodimer with the 9-cis retinoic acid receptor (RXR) to enhancers in targe

147 function as homo- or heterodimers such as TR:9-cis retinoic acid receptor (RXR).

148 imer of Xenopus thyroid hormone receptor and 9-cis retinoic acid receptor (TR-RXR).

149 heterodimer of thyroid hormone receptor and 9-cis retinoic acid receptor (TR-RXR).

150 heterodimer of thyroid hormone receptor and 9-cis retinoic acid receptor (TR/RXR) to nucleosomal DNA

151 ectively bound PXR as a heterodimer with the 9-cis retinoic acid receptor alpha (NR2B1).

152 s, we demonstrated that TR alone and TR/RXR (9-cis retinoic acid receptor) can bind to the LTR in viv

153 The 9-cis retinoic acid receptor, RXR, binds DNA effectively

154 activated FXR acts as a heterodimer with the 9-cis-retinoic acid receptor (RXR) and regulates the Std

155 tor-activated receptor gamma (PPARgamma) and 9-cis-retinoic acid receptor (RXR) are required for enha

156 mily and functions as a heterodimer with the 9-cis-retinoic acid receptor (RXR).

157 s either homodimers or heterodimers with the 9-cis-retinoic acid receptor (RXR).

158 pogenic target genes by interacting with the 9-cis-retinoic acid receptor alpha (RXRalpha, NR2B1).

159 hat the heterodimers of T3 receptor (TR) and 9-cis-retinoic acid receptor bind to the TRE both in vit

160 All isoforms heterodimerise with the 9-cis-retinoic acid receptor RXR, and play an important

161 Interestingly, although the unliganded TR/9-cis-retinoic acid receptor was able to recruit corepre

162 nd PPARgamma2 alone or as a heterodimer with 9-cis-retinoic acid receptor.

163 imers of thyroid hormone receptors (TRs) and 9-cis retinoic acid receptors (RXRs) are the likely in v

164 To determine whether 9-cis retinoic acid receptors (RXRs) regulate the biolog

165 emonstrated that hADA3 directly binds to the 9-cis retinoic acid receptors alpha and beta, and functi

166 All-trans-retinoic acid receptors (RAR) and 9-cis-retinoic acid receptors (RXR) are nuclear receptor

167 The 9-cis-retinoic acid receptors (RXRalpha, RXRbeta, and RX

168 cription system by introducing TRs and RXRs (9-cis-retinoic acid receptors) into Xenopus oocytes.

169 The vitamin A metabolites all-trans- and 9-cis-retinoic acid regulate gene expression by binding

170 PBP to PPARgamma1 or retinoid-X-receptor for 9-cis-retinoic acid (RXR) is independent of their phosph

171 ,25(OH)(2)D(3) (vitamin D receptor, VDR) and 9-cis-retinoic acid (RXRalpha).

172 Treatment with AGN194204 and 9-cis-retinoic acid significantly decreased apoptosis me

173 Both AGN194204 and 9-cis-retinoic acid significantly increased luciferase a

174 Furthermore, 9-cis-retinoic acid significantly up-regulated NAADP syn

175 c acid (ATRA), retinol, retinalaldehyde, and 9-cis-retinoic acid stimulated release of (45)Ca from ca

176 In Hep G2 cells, 9-cis-retinoic acid synthesis was strongly inhibited by

177 sed as a source for 9-cis-retinol and, thus, 9-cis-retinoic acid synthesis.

178 rs via all-trans retinoic acid metabolism to 9-cis retinoic acid, the natural ligand of retinoid X re

179 Clofibrate and 9-cis-retinoic acid, the partner ligands for binding to

180 Administration of the RXR agonist 9-cis-retinoic acid to demyelinated cerebellar slice cul

181 n surrounding the TATA box in cells prior to 9-cis retinoic acid treatment, which was abolished follo

182 l-trans retinoic acid (atRA), and panagonist 9-cis-retinoic acid-upregulated VSMC ADPR-cyclase; the s

183 9-cis Retinoic acid was undetectable in either leiomyoma

184 nteraction of retinoid X receptor alpha with 9-cis-retinoic acid was studied using stopped-flow fluor

185 Both all-trans-retinoic acid and 9-cis-retinoic acid were able to elevate the expression

186 wth inhibition by all-trans-retinoic acid or 9-cis-retinoic acid, whereas RAR gamma was less effectiv

187 me known to oxidize 9-cis retinaldehyde into 9-cis retinoic acid, which can regulate the expression o

188 ed markedly after exposure to oxysterols and 9-cis-retinoic acid, which are ligands for the nuclear h

189 The compounds are capable of displacing 9-cis-retinoic acid with IC(50) values in the 10 nm and

190 a involves the stoichiometric interaction of 9-cis-retinoic acid with retinoid X receptor alpha monom

191 nd kinetic parameters of the interactions of 9-cis-retinoic acid with RXR and with a deletion mutant