ライフサイエンスコーパス: A(2A) receptor

1 e agonist-promoted change in mobility of the A2A receptor.

2 when PKA was activated through the adenosine A2a receptor.

3 he macrophage response through the adenosine A2A receptor.

4 n PC12 cells, which endogenously express the A2A receptor.

5 ly recruited to folding intermediates of the A2A receptor.

6 perone) were recovered in complexes with the A2A receptor.

7 ss by antagonizing function of the adenosine A2A receptor.

8 by sequence is most similar to the mammalian A2A receptor.

9 cy for the rat A2A receptor versus the human A2A receptor.

10 s most likely by activation of the adenosine A2a receptor.

11 basis of the crystal structure of the human A2A receptor.

12 -resolution structure of the human adenosine A2A receptor.

13 ne had no effect owing to the absence of the A2A receptor.

14 atterns and requires activation of adenosine A2A receptors.

15 a(olf)) coupled to dopamine D1 and adenosine A2A receptors.

16 osine and activation of Gs-coupled adenosine A2A receptors.

17 (hAPP) showed increased levels of astrocytic A2A receptors.

18 uration of the inflammatory response via the A(2A) receptor.

19 n approaches as antagonists of the adenosine A(2A) receptor.

20 a palmitoyl moiety in the C terminus of the A(2A) receptor.

21 nhibition was mediated through the adenosine A(2A) receptor.

22 pha completely inhibits hypoxic induction of A(2A) receptor.

23 es that display functional antagonism of the A(2A) receptor.

24 ich suppresses immune activation through the A(2A) receptor.

25 e hyperaemia is partly mediated by adenosine A(2A)-receptors.

26 Single particle tracking of the A2A receptor(1-311), which lacks the last 101 residues,

27 caffeine (antagonist for A1Rs and adenosine A2A receptors; 4 mg/kg intraperitoneally; dissociation c

28 The adenosine A(2A) receptor (A(2A) R) is a potential drug target for

29 , 7, and 9 agonists, together with adenosine A(2A) receptor (A(2A)R) agonists, switch macrophages fro

30 al interaction between the G protein-coupled A(2A) receptor (A(2A)R) and the receptor tyrosine kinase

31 Adenosine A(2A) receptor (A(2A)R) blockade enhances innate and ada

32 tion between a polymorphism of the adenosine A(2A) receptor (A(2A)R) encoding gene-ADORA2A, and hippo

33 The adenosine A(2A) receptor (A(2A)R) is a G-protein-coupled receptor

34 The adenosine A(2A) receptor (A(2A)R) is increasingly recognized as a

35 auses a 9- and 6-fold induction of adenosine A(2A) receptor (A(2A)R) mRNA in mouse pulmonary iNKT and

36 Pharmacological activation of adenosine A(2A) receptor (A(2A)R) or optogenetic activation of ind

37 We previously reported that the adenosine A(2A) receptor (A(2A)R) specific agonist, ATL146e, decre

38 ial femtosecond crystallography of Adenosine A(2A) receptor (A(2A)R).

39 ures of the thermostabilized human adenosine A(2A) receptor (A(2A)R-GL31) bound to its endogenous ago

40 Blockade of adenosine P1 and A(2A) receptors (A(2A) R) had deleterious effects and de

41 Deletion of adenosine A(2A) receptors (A(2A)ARs) has been reported to activate

42 Adenosine A(2A) receptors (A(2A)Rs) are highly enriched in the str

43 The function of striatal adenosine A(2A) receptors (A(2A)Rs) is well recognized because of

44 e or alterations in the density of adenosine A(2A) receptors (A(2A)Rs) or their degree of functional

45 The adenosine A2A receptor (A(2A)R) plays a key role in transmembrane

46 receptor antagonist) and selective adenosine A2A receptor (A2A R) blockade alleviate neurodegeneratio

47 The duration of action of adenosine A2A receptor (A2A) agonists is critical for their clinic

48 Adenosine A(2A) receptor (A2AR) activation triggers Akt signaling

49 We previously demonstrated that adenosine A2A receptor (A2AR) agonism attenuates lung ischemia-rep

50 Adenosine A2A receptor (A2AR) agonists are known to potently atten

51 Adenosine A2A receptor (A2AR) agonists reduce invariant natural ki

52 ptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 receptor (CB1R),

53 mutants and this was dependent on adenosine A2A receptor (A2AR) and tropomyosin-related kinase B sig

54 the striatum was blunted by ENT1 deletion or A2A receptor (A2AR) antagonism.

55 sion and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as candidate ther

56 the spontaneous reconstitution of adenosine A2A receptor (A2AR) during the de novo formation of synt

57 We produced mice with a floxed adenosine A2A receptor (A2AR) gene, Adora2a, and show that either

58 The adenosine A2A receptor (A2AR) has long been implicated in cardiova

59 -fold upregulation of mRNA for the adenosine A2A receptor (A2AR) in WT allografts compared with WT is

60 The adenosine A2A receptor (A2AR) is a particularly interesting exampl

61 uced sleep using C57BL/6Slac mice, adenosine A2A receptor (A2AR) knockout mice, and their wild-type l

62 Both D4R and A2a receptor (A2aR) mRNAs were present in photoreceptors

63 Activation of adenosine A2A receptor (A2AR) promotes fibrosis and collagen synth

64 Adenosine A2a receptor (A2aR) signaling acts as a barrier to autoi

65 ve previously demonstrated that occupancy of A2A receptor (A2AR) stimulates collagen production, so w

66 adenosine resulting in diminished adenosine A2A receptor (A2AR) stimulation and altered chondrocyte

67 Adenosine A2A receptor (A2AR) stimulation promotes wound healing a

68 Circulating T cells predominantly expressed A2a receptor (A2aR) transcripts.

69 Adenosine, acting at its A2A receptor (A2AR), is a critical autocrine factor for

70 ounteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human f

71 oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by

72 synaptic transmission and enhanced adenosine A2A receptor (A2AR)-dependent synaptic plasticity as the

73 Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromer

74 orphology, and upregulation of the adenosine A2A receptor (A2AR).

75 Adenosine A2A receptors (A2AR) modulate dopamine and glutamate sig

76 Striatal adenosine A2A receptors (A2AR) play an essential role in both etha

77 previously found that adenosine, acting via A2A receptors (A2AR) promotes wound healing and inhibits

78 lthough T cells express inhibitory adenosine A2A receptors (A2AR) that suppress their activation and

79 everal modulators, among which are adenosine A(2A) receptors (A2ARs) and Wingless/Integrated-beta-cat

80 Cerebral adenosine A2A receptors (A2ARs) are attractive therapeutic targets

81 Adenosine A2A receptors (A2ARs) are enriched in the striatum but a

82 Adenosine A2A receptors (A2ARs) are highly expressed in the striat

83 Since adenosine A2A receptors (A2ARs) control lysosome trafficking and p

84 e memory through the antagonism of adenosine A2A receptors (A2ARs) controlling synaptic plasticity pr

85 In contrast, adenosine A2A receptors (A2ARs) did not coprecipitate or colocaliz

86 Activation of adenosine A2A receptors (A2ARs) stimulates bone formation.

87 was developed for mapping cerebral adenosine A2A receptors (A2ARs) with PET.

88 We recently found that adenosine A2A receptors (A2ARs), which control synaptic plasticity

89 disease through the antagonism of adenosine A2A receptors (A2ARs).

90 beta-2 adrenoreceptor (ADRB2), the adenosine A(2A) receptor (AA2AR), and the sphingosine 1-phosphate

91 eactivation mechanism of the human adenosine A2A receptor (AA2AR), a member of the class A GPCRs, we

92 were modulated by dopamine D2 and adenosine A2A receptors, acting through cAMP/PKA.

93 led serotonin 7 (5-HT(7) ) and adenosine 2A (A(2A) ) receptor activation also elicits pMF, but via di

94 creases during hypoxia, we hypothesized that A(2A) receptor activation contributes to acute intermitt

95 -mediated immunosuppressive effects, because A(2A) receptor activation decreased IFN-gamma and IL-4 s

96 In summary, these data demonstrate that A(2A) receptor activation has strong inhibitory actions

97 receptor-deficient mice, we demonstrate that A(2A) receptor activation inhibits Th1- and Th2-cell dev

98 Spinal adenosine 2A (A(2A)) receptor activation also elicits phrenic motor fa

99 A2a receptor activation also increased breathing in unan

100 A2a receptor activation increased phosphorylation and ne

101 Instead, adenosine A2A receptor activation of G alpha(s/olf) seems to initi

102 We demonstrate that A2a receptor activation of NR4A1-3 receptor synthesis is

103 However, the combination of adenosine A2A receptor activation with either isoflurane precondit

104 better neuroprotective effect than adenosine A2A receptor activation, isoflurane preconditioning, or

105 Through adenosine A2A receptor activation, MTX promotes reverse cholestero

106 II inhibition, but may not involve adenosine A2A receptor activation.

107 eral subdivision of the central amygdala via A2A receptor activation.

108 -induced TNF-alpha and CXCL10 production via A2A-receptor activation.

109 d quinpirole, suggesting that removing tonic A(2A) receptor activity enables behaviors mediated by do

110 Accordingly, reducing adenosine A2A receptor activity in Adk(Deltabrain) mice restored n

111 Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-inducible transc

112 th CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA2-selectiv

113 effects via antagonist binding to adenosine A2a receptors (ADORA2A).

114 l and neurochemical effects of the adenosine A(2A) receptor agonist CGS 21680 [2-p-(2-carboxyethyl) p

115 cts of intra-NAc core microinjections of the A(2A) receptor agonist, CGS 21680 (4-[2-[[6-amino-9-(N-e

116 The A(2A) receptor agonist, CGS21680, inhibited osteoclast d

117 carboxamidoadenosine), but not the selective A2A receptor agonist CGS21680 [2-p-(2-carboxyethyl) phen

118 ptor antagonist), and it was mimicked by the A2A receptor agonist CGS21680.

119 l vessel response to CGS-21680, an adenosine A2A receptor agonist, but did not alter the concentratio

120 The effect of D1 receptor and A2A receptor agonists on the phosphorylation of protein

121 Here we demonstrate that spinal A2a receptor agonists transactivate TrkB receptors in th

122 Thus, we hypothesized that A2a receptor agonists would elicit phrenic long-term fac

123 A(2A) receptors also contributed to the adenosine augmen

124 es aPL Ab-mediated NETosis via the adenosine A(2A) receptor and mitigates venous thrombosis in mice.

125 A(2A) receptor and osteoclast marker expression levels w

126 Complex formation between the A2A receptor and HSP90alpha (but not HSP90beta) and HSP7

127 induced chemotaxis by adenosine requires the A2a receptor and is mediated via up-regulation of the cy

128 The adenosine A2A receptor and PDE2, 3, 4, and 7 are important for act

129 enosine inhibits KCa3.1 in human T cells via A2A receptor and PKAI, thereby resulting in decreased T

130 Complex formation between the A2A receptor and SAP102 was verified by coimmunoprecipit

131 ed by genetic polymorphisms of the adenosine A2A receptors and alpha(2)-adrenergic receptors.

132 0% (P<0.01), whereas inhibition of adenosine-A2a receptors and epoxyeicosatrienoic acids had minimal

133 powerful immunosuppressant (mainly acting at A2A receptors) and a modulator of cell growth (mainly ac

134 mbens also contain high numbers of adenosine A(2A) receptors, and, for that reason, the behavioral an

135 A selective A(2A) receptor antagonist (MSX-3, 8 microg kg(-1), 12 mi

136 A second A(2A) receptor antagonist (ZM2412385, 7 microg kg(11), 7

137 cal treatment of ADA-deficient mice with the A(2A) receptor antagonist ZM-241385 prevented the develo

138 (PD) pathophysiology, a selective adenosine A(2A) receptor antagonist, istradefylline, shows promise

139 enzenepropanoic acid hydrochloride), and the A(2A) receptor antagonist, MSX-3 (3,7-dihydro-8-[(1E)-2-

140 Groups 2 and 4, which received the selective A(2A)-receptor antagonist ZM241385 before the third and

141 utamate release by perfusion of an adenosine A2A receptor antagonist in the pmNAc shell blocked the d

142 nesthetized rats pretreated with intrathecal A2A receptor antagonist injections before mASH (PaO2 = 4

143 stream of CD39 using the selective adenosine A2a receptor antagonist istradefylline.

144 Different doses of an adenosine A2A receptor antagonist MSX-3 [3,7-dihydro-8-[(1E)-2-(3-

145 ant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor function in

146 hibition was reversed by SCH58261 (selective A2A receptor antagonist), but not by MRS1754 (A2B recept

147 ffects were reduced by addition of adenosine A2A receptor antagonist.

148 ceptor agonist and ZM 241385 as an adenosine A2A receptor antagonist.

149 A(2A) receptor antagonists (such as caffeine) may exert

150 Adenosine A(2A) receptor antagonists are psychomotor stimulants th

151 ic role for adenosine in the skin and reveal A(2A) receptor antagonists as novel therapeutic agents f

152 nizes dopamine signaling at D2 receptors and A(2A) receptor antagonists have been tested as therapeut

153 d indirect-pathway MSNs, we demonstrate that A(2A) receptor antagonists potentiate 2-AG release and i

154 Adenosine A(2a) receptor antagonists reduce symptom severity in Pa

155 discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1-methylcyc

156 he preferential presynaptic and postsynaptic A2A receptor antagonists SCH-442416 [2-(2-furanyl)-7-[3-

157 l information for the discovery of adenosine A2A receptor antagonists that have potential to treat mu

158 inhibited by Src family tyrosine kinase and A2A receptor antagonists.

159 Adenosine, via activation of A(2A) receptors, antagonizes dopamine signaling at D2 re

160 Thus, accumbens adenosine A(2A) receptors appear to regulate behavioral activation

161 The adenosine A(2A) receptor appears required for neurotoxicity in a m

162 ults of biophysical mapping of the adenosine A(2A) receptor are presented.

163 A(2A) receptors are a major class of G-protein-coupled r

164 Adenosine A(2A) receptors are colocalized with D(2) receptors on n

165 Adenosine A(2A) receptors are preferentially expressed in rat stri

166 specific alkaline phosphatase, and adenosine A2a receptors are significantly increased in diabetic ra

167 In resting neutrophils, we found that A2A receptors are uniformly distributed across the cell

168 s effect of adenosine was mainly mediated by A2A receptors, as KCa3.1 inhibition was reversed by SCH5

169 Loss of actin stress fibers occurs via the A2a receptor at adenosine concentrations above 10 muM, w

170 ignaling via P2Y2 receptors at the front and A2a receptors at the back of cells regulate chemotaxis.

171 e results reveal that the microbiota-inosine-A2A receptor axis might represent a potential avenue for

172 Here we report the crystal structure of A2A receptor bound to compound 1 (Cmpd-1), a novel A2AR/

173 ke nitric oxide (NO) release via endothelial A(2A)-receptors, but the role for NO in exercise hyperae

174 wing melanoma growth in mice lacking myeloid A2A receptors, but tumor suppression mediated by CD8(+)

175 Moreover, activation of accumbens A(2A) receptors by local injections of CGS 21680 increas

176 as a candidate interactor that bound to the A2A receptor C terminus.

177 Our results suggest that the A(2A) receptor-C/EBPbeta axis is critical for IL-10 prod

178 Autocrine stimulation of A2a receptors causes cyclic adenosine monophosphate accu

179 port that selective agonism of the adenosine A(2A) receptor (CGS21680) suppresses aPL Ab-mediated NET

180 In conclusion, A(2A) receptors constrain the expression of serotonin-de

181 s show that selectively blocking presynaptic A2A receptors could provide a new pharmacological approa

182 A2A receptor deficiency led to increased numbers of allo

183 Using A(2A) receptor-deficient mice, we demonstrate that A(2A)

184 efficacious in augmenting TIMP-1 release by A(2A) receptor-deficient than control macrophages.

185 eceptors confirmed that wild type and mutant A(2A) receptor differed in diffusivity and diffusion mod

186 Stimulation of accumbens adenosine A(2A) receptors disrupted performance of an instrumental

187 -MNI-444 regional uptake was consistent with A(2A) receptor distribution in the brain.

188 Herein we describe adenosine A2A receptor distribution, signaling pathways, pharmacol

189 ivity (e.g. ARL67156) and antagonists of the A(2a) receptor (e.g. ZM241385) blocked Treg-mediated imm

190 (51% +/- 8%, P > 0.05), indicating specific A(2A) receptor effects.

191 ainst tumor metastasis, indicating that host A2A receptors enhanced tumor metastasis.

192 dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (MSNs) to d

193 denosine A1 receptor and decreased adenosine A2A receptor expression in the NAc.

194 the most suitable PET ligand for quantifying A2A receptor expression in the rat brain.

195 the most suitable PET ligand for quantifying A2A receptor expression in the rat brain.

196 A2A receptor expression was effectively removed from K56

197 Blockade of adenosine 2A (A(2A)) receptors facilitates dopamine D(2) receptor func

198 identify a critical role for AC 5 and 7 and A2A receptors for up-regulation of AGS3 in morphine with

199 Analysis of the A(2A) receptor gene promoter revealed a hypoxia-responsi

200 oupled receptors (GPCR), the human adenosine A(2A) receptor (hA(2A)AR) remains an attractive drug tar

201 ray crystal structure of the human adenosine A2A receptor (hA2AAR), in which the allosteric sodium io

202 In addition, we demonstrate that A(2A) receptor has angiogenic potential, as assessed by

203 Antagonism of the human A(2A) receptor has been implicated as a point of therape

204 nd agonist-bound structures of the adenosine A(2A) receptor have revealed much about how a ligand may

205 data with CD73 antagonists and inhibitors of A(2A) receptors have demonstrated the therapeutic potent

206 lly enabled homology models of the adenosine A(2A) receptor, identifying a diverse range of ligand ef

207 at many more proteins must interact with the A2A receptor, if the trafficking trajectory of the recep

208 ect to the ventral pallidum showed adenosine A(2A) receptors immunoreactivity.

209 Additional data show increased expression of A(2A) receptor in human lung tumor cancer samples relati

210 determined whether deletion of the adenosine A(2A) receptor in knockout (KO) mice protects against do

211 alpha but not HIF-1alpha regulates adenosine A(2A) receptor in primary cultures of human lung endothe

212 modulin (CaM) to the carboxy-terminus of the A(2A) receptor in the A(2A)-D(2) receptor heteromer.

213 ed on osteoclasts, we determined the role of A(2A) receptor in the regulation of osteoclast different

214 We investigated the role of A(2A) receptors in regulating T helper (Th)1- and Th2-ce

215 ested the hypothesis that adenosine A(1) and A(2A) receptors in the prefrontal cortex contribute to t

216 The results showed that adenosine A(1) and A(2A) receptors in the prefrontal cortex modulate cortic

217 f-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and other organs, elucidating

218 and, thus, promoted the accumulation of the A2A receptor in the compartment with slow mobility.

219 phate hydrolysis and adenosine signaling via A2A receptors in vitro.

220 s to adenosine, which dilates arterioles via A(2A) receptors, in a nitric oxide-independent manner.

221 ust interact with adenosine tone, via D2 and A2a receptor, in direct and indirect pathway neurons, re

222 constraints between 5-HT(2A) and 5-HT(7) or A(2A) receptor-induced pMF are mediated by PKCdelta and

223 immunosuppressive nucleoside, and adenosine A(2A) receptors inhibit T-cell activation.

224 e groups of anaesthetized rats the effect of A(2A)-receptor inhibition with ZM241385 on femoral vascu

225 spite the safe clinical profile of adenosine A2A receptor inhibitors (A2ARi) in Parkinson disease.

226 Surprisingly, blockade of adenosine 2A (A2A ) receptors inhibits both of these responses.

227 Thus, adenosine, acting via the A(2A) receptor, inhibits macrophage colony-stimulating f

228 These data also demonstrate that A(2A) receptor is regulated by hypoxia and HIF-2alpha in

229 The A2A receptor is a class A/rhodopsin-like G protein-coupl

230 The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that

231 The adenosine A2A receptor is a prototypical rhodopsin-like G protein-

232 The cerebral adenosine A2A receptor is an attractive therapeutic target for neu

233 he pharmacologic activation of the adenosine A2A receptor is protective.

234 p-cAMPS), prostaglandin E1, or the adenosine A2A receptor is sufficient to cause epsilonPKC transloca

235 ggest that AD-linked increases in astrocytic A2A receptor levels contribute to memory loss.

236 erapeutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selective propert

237 Adenosine and its precursors, via A2A receptors, likely suppress TNF-alpha and CXCL10 prod

238 We observed that the striatal adenosine A2A receptor links adenosine tone and psychomotor respon

239 dose was related to blockade of postsynaptic A2A receptors localized in striatopallidal neurons.

240 muscle arterioles, we show that ADO acts via A2A receptors located on ECs to produce vasodilation via

241 Medications targeting the A(2A) receptor may have utility in the treatment of mala

242 ammation through signaling via the adenosine A2A receptor may limit tissue damage but may also favor

243 rther demonstrate the nonselective nature of A(2A) receptor-mediated immunosuppressive effects, becau

244 y is sustained, after initial activation, by A(2A) receptor-mediated signalling.

245 o the development of OA; targeting adenosine A2A receptors might treat or prevent OA.

246 s were to determine the effects of adenosine A(2A) receptor modulation in the NAc on cocaine seeking

247 A(2A) receptor mRNA expression in both Th1 and Th2 effec

248 in adenosine A(2A) receptor-positive but not A(2A) receptor-negative cells.

249 d preladenant may have different profiles of A(2A) receptor occupancy in humans.

250 hat tozadenant will provide a more sustained A(2A) receptor occupancy than preladenant in humans at c

251 into AMP and adenosine, which then binds to A(2a) receptors on effector T cells, suppressing their f

252 These data demonstrate a critical role for A(2A) receptors on striatopallidal medium spiny projecti

253 res independently of NO and acts directly on A(2A)-receptors on the vascular smooth muscle to cause v

254 es indicate that adenosine and the adenosine A2A receptor play a role in hepatic fibrosis by a mechan

255 Because both, D1 and A2A receptors, play major roles in the cellular response

256 ce a larger hyperaemia, adenosine acting via A(2A)-receptors plays a greater role in the hyperaemia a

257 endogenously generated adenosine, acting at A(2A) receptors, plays a role in toxin-induced hepatic f

258 ine can trigger a cAMP response in adenosine A(2A) receptor-positive but not A(2A) receptor-negative

259 r increasing or decreasing activity at D2 or A2A receptors prevents the aversive motivational respons

260 at interact with and retain partially folded A2A receptor prior to ER exit.

261 cently reported that activation of adenosine A(2A) receptors promotes collagen synthesis by human der

262 In polarized cells, A2A receptors redistributed to the back where their stim

263 Thus, A(2A) receptors represent a target for reducing enhanced

264 (NMDA) receptors, or activation of adenosine A2A receptors resulted in reduction of the OGD and simul

265 onstrate that beta2-adrenergic and adenosine A2A receptors scramble lipids, suggesting that rhodopsin

266 reas the other half were pretreated with the A2A receptor-selective antagonist KW-6002, inducing full

267 Treatments that blocked endogenous A2A receptor signaling impaired the polarization and mig

268 gatively regulates dopamine D1 and adenosine A2A receptor signaling in the striatum.

269 754, ARL67156, an ecto-ATPase inhibitor, and A2A receptor siRNA, suggesting that in contrast to ATP,

270 human A(2A) adenosine receptor bound to the A(2A) receptor-specific antagonist, ZM241385, was recent

271 ylase and ABCA1 was blocked by the adenosine A2A receptor-specific antagonist ZM241385.

272 (18)F-FPSCH, respectively) were developed as A2A receptor-specific PET ligands.

273 Thus, A(2A) receptor stimulation by adenosine, a breakdown pro

274 Taken together, these findings suggest that A(2A) receptor stimulation reduces, while A(2A) blockade

275 A(2A)-receptor stimulation suppressed the development of

276 Inhibition of PANX1 blocked A2A receptor stimulation and cAMP accumulation in respon

277 odulation is primarily through the adenosine A2a receptor subtype.

278 o mediate antinociception through the A1 and A2A receptor subtypes.

279 related to blockade of striatal presynaptic A2A receptors that modulate glutamatergic neurotransmiss

280 In contrast to the wild type A(2A) receptor, the concentration-response curve for ago

281 with known crystal structures: the adenosine A2A receptor, the beta2-adrenergic receptor and rhodopsi

282 utions of endogenous adenosine and adenosine A(2A) receptors to skin fibrosis.

283 ession of SAP102 precluded the access of the A2A receptor to a compartment with restricted mobility.

284 ) plays a role in olfaction, coupling D1 and A2a receptors to adenylyl cyclase, and histone H3 phosph

285 The unique action of A2A receptors to function directly as G proteins and in

286 , despite having reduced potency for the rat A2A receptor versus the human A2A receptor.

287 cells, suggesting that signaling through the A2A receptor via CD73-generated adenosine is a significa

288 Among the P1 receptors, only the A2a receptor was significantly upregulated after TAC.

289 ta(2) adrenergic receptors and the adenosine A(2a) receptor were determined in the antagonist-bound s

290 that mice with striatum-specific deletion of A(2A) receptors were selectively impaired in habit forma

291 9 small molecule agonists/antagonists of the A2a receptor were determined and found to be in agreemen

292 Affinity-tagged versions of the A2A receptor were expressed in HEK293 cells to identify

293 ncreased in striatum after acute blockade of A(2A) receptors, which are highly expressed by striatal

294 inority of microglia expressed the adenosine A2A receptor, which has been linked with process withdra

295 We present evidence for functional A2A receptors, which have a weak modulatory effect on th

296 and Th2 cells in vitro depended on adenosine A2A receptors, which were also required for the efficacy

297 The A2A receptor with a cytochrome b562-RIL (BRIL) fusion (A

298 vitro as antagonist ligands of cloned human A2A receptor with affinities (Ki 7.5-53 nM) comparable t

299 monstrate the following: (1) blocking spinal A2A receptors with MSX-3 reveals mASH-induced pMF; and (

300 In contrast, a mutated A2A receptor (with (383)DVELL(387) replaced by RVRAA) wa