ライフサイエンスコーパス: AAA-ATPase

1 isingly, without the involvement of the Vps4 AAA-ATPase.

2 ocess and may shed light on studies of other AAA ATPases.

3 bl1) and Reptin (Ruvbl2) are closely related AAA ATPases.

4 ly applicable to other protein-translocating AAA ATPases.

5 g ATPase cycle, which is likely conserved in AAA-ATPases.

6 veals an additional regulatory mechanism for AAA+ ATPases.

7 licative hexameric helicases onto origins by AAA+ ATPases.

8 gnition of genomic sites, termed origins, by AAA+ ATPases.

9 the presence of RuvBL1-RuvBL2, two essential AAA+ ATPases.

10 lpB, are Clp/Hsp100 molecular chaperones and AAA+ ATPases.

11 of protein translocation by Cdc48 and other AAA+ ATPases.

12 tion mechanism is likely conserved for other AAA+ ATPases.

13 ay reflect an entirely new characteristic of AAA + ATPases.

14 sinA, an endoplasmic reticulum (ER) resident AAA(+) ATPase.

15 ndent on clpV, a gene that likely encodes an AAA(+) ATPase.

16 uding dynamic conformations similar to other AAA(+) ATPases.

17 lexes that require activation by specialized AAA(+) ATPases.

18 rotein (RIME) assay, we identified RuvB-like AAA ATPase 1 (RUVBL1/Pontin) and enhancer of rudimentary

19 ponents are investigated including HSP101 (a AAA(+) ATPase), a protein of no known function termed PT

20 Dynein contains four AAA+ ATPases (AAA: ATPase associated with various cellul

21 motor domain of dynein contains three active AAA+ ATPases (AAA1, 3, and 4), only the functions of AAA

22 p97, a AAA+ ATPase, accumulates on mitochondria upon uncoupling

23 complexes through its remodelling by cognate AAA+ ATPase activators.

24 a single-stranded DNA coil, akin to the way AAA+ ATPases (adenosine triphosphatases) unfold peptides

25 f substrate translocation proposed for other AAA+ ATPases (adenosine triphosphatases).

26 The evolutionarily conserved AAA ATPase ANCCA (AAA nuclear coregulator cancer-associa

27 independent mechanism that requires only 19S AAA ATPases and 20S proteasome.

28 The AAA(+) ATPase and bromodomain factor ATAD2/ANCCA is over

29 Since Yta7(ATAD2) is an AAA(+) ATPase and potential hexameric unfoldase, our res

30 Finally, the p97 AAA(+)-ATPase and its cofactor UFD1 are required for pro

31 associated with diverse cellular activities (AAA) ATPase and to evaluate its potential to be a therap

32 ANCCA is an AAA+ ATPase and a bromodomain-containing nuclear coactiv

33 Potentiated variants of Hsp104, a hexameric AAA+ ATPase and protein disaggregase from yeast, have be

34 er-order assembly and client engagement by a AAA+ ATPase and suggest a mechanistic model where IstB b

35 DnaA is an AAA+ ATPase and the conserved replication initiator in b

36 Like other AAA+ ATPases and self-compartmentalising proteases, Lon

37 o VI is necessary for the full activation of AAA-ATPase and a set of (1)O(2)-responsive transcripts i

38 Topo VI binds to the promoter of the AAA-ATPase and other (1)O(2)-responsive genes, and hence

39 d from MCC by the joint action of the TRIP13 AAA-ATPase and the Mad2-binding protein p31(comet) Now w

40 associated with diverse cellular activities (AAA+ ATPase) and forms ATP-dependent filaments with or w

41 Homohexameric ring AAA(+) ATPases are found in all kingdoms of life and are

42 The p97 AAA (ATPase associated with diverse cellular activities)

43 massive (>500 kDa) protein has an N-terminal AAA (ATPase associated with diverse cellular activities)

44 The AAA (ATPase associated with diverse cellular activities)

45 The FIGL-1 protein contains an AAA (ATPase associated with various activities) domain a

46 Mutations in p97, a major cytosolic AAA (ATPases associated with a variety of cellular activ

47 Yme1, an AAA (ATPases associated with diverse cellular activities

48 Proteins of the AAA (ATPases associated with various cellular activities

49 The AAA(+) (ATPases associated with a variety of cellular ac

50 charomyces cerevisiae) is a highly conserved AAA(+) (ATPases associated with multiple cellular activi

51 nding proteins (bEBPs) are a subclass of the AAA(+) (ATPases Associated with various cellular Activit

52 Escherichia coli is carried out by ClpB, an AAA(+) (ATPases associated with various cellular activit

53 ctor (NSF) is a homo-hexameric member of the AAA(+) (ATPases associated with various cellular activit

54 p97/VCP is a member of the AAA+ (ATPase associated with a variety of activities) pr

55 sed of four heptameric rings, and one or two AAA+ (ATPase associated with a variety of cellular activ

56 t is predicted to adopt a fold resembling an AAA+ (ATPase associated with a variety of cellular activ

57 l channel of the OEM, and CDC48, a cytosolic AAA+ (ATPase associated with diverse cellular activities

58 DnaA protein, a member of the AAA+ (ATPase associated with various cellular activities

59 e report that the nuclear envelope-localized AAA+ (ATPase associated with various cellular activities

60 The AAA+ (ATPases associated with a variety of cellular acti

61 bacterium tuberculosis collaborates with the AAA+ (ATPases associated with a variety of cellular acti

62 rom the Orc1-5 subunits sits atop a layer of AAA+ (ATPases associated with a variety of cellular acti

63 TorsinA is a membrane-associated AAA+ (ATPases associated with a variety of cellular acti

64 gradation in vivo, and LonA is the principal AAA+ (ATPases associated with diverse cellular activitie

65 he bromodomain region of human ATPase family AAA+ (ATPases associated with diverse cellular activitie

66 We find that purified Pch2 is an AAA+ (ATPases associated with diverse cellular activitie

67 of chemical energy into mechanical force by AAA+ (ATPases associated with diverse cellular activitie

68 AAA+ (ATPases associated with diverse cellular activitie

69 p97/VCP, a member of the AAA+ (ATPases associated with diverse cellular activitie

70 Midasin, an essential approximately 540-kDa AAA+ (ATPases associated with diverse cellular activitie

71 all organisms, initiator proteins possessing AAA+ (ATPases associated with various cellular activitie

72 ancer binding protein (bEBP), members of the AAA+ (ATPases Associated with various cellular Activitie

73 binding domains, cellular initiators possess AAA+ (ATPases associated with various cellular activitie

74 bEBPs are members of the AAA+ (ATPases associated with various cellular activitie

75 ase with distinct N-terminal, transmembrane, AAA+ (ATPases associated with various cellular activitie

76 Dynein contains four AAA+ ATPases (AAA: ATPase associated with various cellular activities)

77 t targeted deletion of the gene encoding the AAA+-ATPase Atad3a hyperactivated mitophagy in mouse hem

78 xameric protein p97, a very abundant type II AAA ATPase (ATPase associated with various cellular acti

79 VPS4B, an AAA ATPase (ATPase associated with various cellular acti

80 dentify Msp1, a conserved, membrane-anchored AAA-ATPase (ATPase associated with a variety of cellular

81 cated AAA+ ATPase (Mycobacterium proteasomal AAA+ ATPase; ATPase forming ring-shaped complexes).

82 Meiotic clade AAA ATPases (ATPases associated with diverse cellular ac

83 sly, we and others have reported that TRIP13 AAA-ATPase binds to the mitotic checkpoint-silencing pro

84 ring-shaped cylindrical oligomer like other AAA(+) ATPases, but this has been difficult to directly

85 Msp1 is a transmembrane AAA-ATPase, but its role in TA protein clearance is not

86 st-fusion, the complex is disassembled by an AAA+ ATPase called N-ethylmaleimide-sensitive factor (NS

87 asis of phylogenetic classification of their AAA ATPase cassette, include four relatively well charac

88 and trafficking) domain followed by a single AAA ATPase cassette.

89 also relieves autoinhibition and primes the AAA ATPase cassettes for substrate binding.

90 1 (LAP1), an activator of ER-resident Torsin AAA+-ATPases, causes a failure in membrane removal from

91 Raman et al. and Franz et al. establish the AAA ATPase CDC-48/p97 as an essential regulator of eukar

92 rms a SUMO-specific ternary complex with the AAA ATPase Cdc48 and an adaptor, Doa1.

93 rate that UBXN-2, a substrate adaptor of the AAA ATPase Cdc48/p97, is required to coordinate centroso

94 We identify the AAA(+) ATPase Cdc48 and its cofactors as the Ub receptor

95 stress induces selective recruitment of the AAA(+) ATPase Cdc48/p97 to catalyze dissociation of the

96 associated with diverse cellular activities (AAA(+)) ATPase Cdc48.

97 ese processes are catalyzed by the conserved AAA-ATPase Cdc48 (also known as p97).

98 The AAA-ATPase Cdc48 and the Hsp70 chaperone Ssa1 are crucia

99 The yeast AAA-ATPase Cdc48 and the ubiquitin fusion degradation (U

100 g anaphase B, Imp1-mediated transport of the AAA-ATPase Cdc48 protein at the MMD allows this disassem

101 ylation, we demonstrated that Rbd2 binds the AAA-ATPase Cdc48 through a C-terminal SHP box.

102 found associated, together with Ltn1 and the AAA-ATPase Cdc48, to 60S ribosomal subunits.

103 nd functionally interacts with the conserved AAA-ATPase Cdc48.

104 0 and serves as a recruitment signal for the AAA-ATPase Cdc48/p97, which actively disassembles the co

105 c complementation to a gene encoding a novel AAA-ATPase/CDC48 family member called TgNoAP1.

106 The hexameric AAA-ATPase, Cdc48p, catalyzes an array of cellular activ

107 regulator of Arabidopsis CDC48, an essential AAA-ATPase chaperone that mediates diverse cellular acti

108 AAA+ ATPase ClpB is a promising target for the developme

109 The AAA(+) ATPase ClpV disassembles the contracted sheath, w

110 Here, we show that the RuvBL1 and RuvBL2 AAA+ ATPases co-purify with FA core complex isolated und

111 nknown, but it is thought to involve the p97 AAA-ATPase complex and bears a topological equivalence t

112 Moreover, we found involvement of the Cdc48 AAA-ATPase complex members Ufd1 and Npl4, as well as the

113 n addition to a role for the Cdc48-Npl4-Ufd1 AAA-ATPase complex, Doa1 and a mitochondrial pool of the

114 heat shock protein 101 (HSP101), a ClpB-like AAA+ ATPase component of PTEX.

115 t vaccinia virus (VACV) to identify the VACV AAA+ ATPase D5 as the poxvirus uncoating factor.

116 Dedicated AAA+ ATPases deposit hexameric ring-shaped helicases ont

117 In cells, dedicated AAA+ ATPases deposit hexameric, ring-shaped helicases on

118 An AAA+ ATPase, DnaC, delivers DnaB helicase at the E. coli

119 echanistically, this is dependent on SAF-A's AAA(+) ATPase domain, which mediates cycles of protein o

120 leQ, the second messenger interacts with the AAA+ ATPase domain at a site distinct from the ATP bindi

121 Crystal structures of FleQ's AAA+ ATPase domain in its apo-state or bound to ADP or A

122 The viral protein binds to the loader's AAA+ ATPase domain, allowing binding of the host replica

123 eted ORC5, the protein would lack 80% of the AAA+ ATPase domain, including the Walker A motif.

124 Previous studies of AAA(+) ATPase domains from sigma(54) activators have sho

125 s) DNA are bound within the C-tier of MCM2-7 AAA+ ATPase domains.

126 Here we identify the AAA-ATPase Drg1 as a target of diazaborine.

127 The AAA-ATPase Drg1 is essential for the release of several

128 ubiquitin-system or a HORMA domain-PCH2-like AAA+ ATPase dyad.

129 The transcription factor FleQ is a bacterial AAA+ ATPase enhancer-binding protein that is the master

130 ionarily conserved microtubule (MT)-severing AAA-ATPase enzyme Katanin is emerging as a critical regu

131 ved and essential residue in many GTPase and AAA+ ATPase enzymes that completes the active site from

132 mutated in the ubiquitin-binding domain, the AAA ATPase factor p97/VCP mediates rapid inactivation of

133 s a highly abundant protein belonging to the AAA ATPase family involved in a number of essential cell

134 ein (VCP), also known as p97, is a member of AAA ATPase family that is involved in several biological

135 t GENERAL CONTROL NONREPRESSIBLE4 (GCN4), an AAA(+)-ATPase family protein, as one of the key proteins

136 Many members of the AAA+ ATPase family function as hexamers that unfold thei

137 ATPases are the only representatives of the AAA+ ATPase family that reside in the lumen of the endop

138 is a highly expressed member of the type II AAA+ ATPase family.

139 The flagella export AAA+ ATPase FliI was identified as a result of this scre

140 uch as Mu, Tn7, and IS21, require regulatory AAA+ ATPases for function.

141 Many AAA+ ATPases form hexamers that unfold protein substrate

142 RUVBL1 and RUVBL2 AAA-ATPases form an hetero-hexameric ring that is part o

143 aplegia protein M1 Spastin, a membrane-bound AAA ATPase found on LDs, coordinates fatty acid (FA) tra

144 It is not understood how Hsp104, a hexameric AAA+ ATPase from yeast, disaggregates diverse structures

145 Meiotic clade AAA ATPases function as hexamers that can cycle between

146 trol of the promoter of a (1)O(2)-responsive AAA-ATPase gene (At3g28580) and isolating second-site mu

147 me, above the N-terminal coiled coils of the AAA-ATPase heterodimers Rpt4/Rpt5 and Rpt1/Rpt2, respect

148 eals previously unidentified features of the AAA-ATPase heterohexamer.

149 onserved bromodomain-containing protein with AAA-ATPase homology originally implicated in heterochrom

150 TorsinA is a membrane-tethered AAA+ ATPase implicated in nuclear envelope dynamics as w

151 Msp1 is a conserved AAA ATPase in budding yeast localized to mitochondria wh

152 ay could shed light on a general role of 19S AAA ATPases in processing tight protein-DNA complexes du

153 A AAA+ ATPase in the clamp loader clade, RarA protein is p

154 Each RP is believed to include six different AAA+ ATPases in a heterohexameric ring that binds the CP

155 97 or N-ethylmaleimide-sensitive factor (two AAA ATPases involved in membrane fusion) and their cofac

156 identify a new VBP1 binding partner, p97, an AAA(+) ATPase involved in protein degradation and DNA da

157 p97 is an essential hexameric AAA+ ATPase involved in a wide range of cellular process

158 actly where the arginine finger of canonical AAA+ ATPases is found.

159 r DNA damage, little is known about how this AAA-ATPase is involved in the transcriptional process.

160 served nonstructural protein 2C, which is an AAA+ ATPase, is a promising target for drug development.

161 now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its target

162 The AAA ATPase katanin severs microtubules.

163 Receptor Interacting Protein 13 (TRIP13), an AAA-ATPase known to interact with p31(comet).

164 The structure establishes that type II AAA-ATPases lacking the aromatic-hydrophobic motif withi

165 Msp1 is a conserved eukaryotic AAA+ ATPase localized to the outer mitochondrial membran

166 TorsinA is an AAA+ ATPase located within the lumen of the endoplasmic

167 striking, unifying feature of meiotic clade AAA ATPases may be their MIT domain, which is a module t

168 erved, opening up the possibility that other AAA+ ATPases may respond to c-di-GMP.

169 ations indicate a general mechanism by which AAA+ ATPases may translocate a variety of substrates tha

170 for the construction of atomic models of the AAA(+) ATPase module as it progresses through the functi

171 ase of the RP is formed by a heterohexameric AAA(+) ATPase module, which unfolds and translocates sub

172 Its AAA-ATPase module adopts essentially the same topology t

173 amer, which connects to the CP and roofs the AAA-ATPase module, positioning the Rpn8/Rpn11 heterodime

174 nd a regulatory particle (RP) containing the AAA-ATPase module.

175 mmitment and prior to their unfolding by the AAA-ATPase module.

176 a 20S proteolytic core particle (CP), and an AAA-ATPase module.

177 Valosin-containing protein (VCP)/p97 is an AAA ATPase molecular chaperone that regulates vital cell

178 by mutations in the evolutionarily conserved AAA-ATPase molecular chaperone, CDC48A, homologous to ye

179 tered abundance of transport proteins having AAA-ATPase motifs.

180 The AAA+ ATPase motor cytoplasmic dynein regulates ciliary t

181 The mitochondrial AAA ATPase Msp1 is well known for extraction of mislocal

182 We show that the AAA+ ATPase Msp1 limits the accumulation of mislocalized

183 The mitochondrial AAA-ATPase Msp1 removes mislocalized TA proteins from th

184 s are recognized and unfolded by a dedicated AAA+ ATPase (Mycobacterium proteasomal AAA+ ATPase; ATPa

185 on, the SNARE complex is disassembled by the AAA-ATPase N-ethylmaleimide-sensitive factor that requir

186 in of Rpn11 is positioned directly above the AAA-ATPase N-ring suggesting that Rpn11 deubiquitylates

187 solically dislocated, in cells deficient for AAA-ATPases of the proteasome 19 S regulatory particle.

188 The human AAA ATPase p97 is a molecular chaperone essential in cel

189 The essential and highly abundant hexameric AAA ATPase p97 is perhaps the best studied AAA protein,

190 TRIM21 or chemical inhibition of either the AAA ATPase p97/valosin-containing protein (VCP) or the p

191 rough the activity of the proteasome and the AAA ATPase p97/VCP in a similar manner to infectious vir

192 y described as inhibitor leads for the human AAA+ ATPase p97, an antitumor target.

193 he unexpected collaboration of the cytosolic AAA-ATPase p97 and the luminal quality control factor UD

194 t was unclear whether they would require the AAA-ATPase p97 chaperone complex that retrotranslocates/

195 The AAA-ATPase p97 plays vital roles in mechanisms of protei

196 that DNA-locked Ku rings are released by the AAA-ATPase p97.

197 the cytosol in a manner that depends on the AAA-ATPase p97/VCP [3].

198 ting inhibition of a conserved Dictyostelium AAA ATPase, p97, a homolog of the human transitional end

199 The AAA+ ATPase, p97, also referred to as VCP, plays an esse

200 an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes b

201 We show that an AAA-ATPase, p97, is required for the proteasomal degrada

202 rm a complex with Derlin-1 and an associated AAA-ATPase, p97.

203 tures of the archaeal CP in complex with the AAA-ATPase PAN (proteasome-activating nucleotidase).

204 We show that the conserved AAA-ATPase PCH-2/TRIP13, which remodels the checkpoint e

205 Signaling is attenuated by a homolog of the AAA+ ATPase Pch2/TRIP13, which binds and disassembles th

206 Exclusion requires the AAA+-ATPase Pch2 and is directly coupled to synaptonemal

207 The traffic AAA-ATPase PilF is essential for pilus biogenesis and na

208 Our results suggest that 19S AAA ATPases play a dual role in sensing the Top2beta cle

209 tly phosphorylates parasite RPT1, one of six AAA(+) ATPases present in the 19S regulatory particle of

210 report that Isu is degraded by the Lon-type AAA+ ATPase protease of the mitochondrial matrix, Pim1.

211 is dependent on the conserved inner-membrane AAA+ ATPase/protease, FtsH.

212 13 ortholog PCH-2, revealing a new family of AAA+ ATPase protein remodelers.

213 pendent Esigma(54) and its cognate activator AAA+ ATPase protein, before ADP+P(i) formation, using a

214 uvBL1/RuvBL2 or pontin/reptin) are enigmatic AAA(+) ATPase proteins that are present in multiple cell

215 The AAA + ATPase R2TP complex facilitates assembly of a numb

216 mingly incompatible symmetries-the hexameric AAA+ ATPase RavA and the decameric inducible lysine deca

217 until remodeling of the pre-ribosome by the AAA-ATPase Rea1 (Midasin).

218 show that p37/UBXN2B, a cofactor of the p97 AAA ATPase, regulates spindle orientation in mammalian c

219 ent ubiquitylation also involves VCP/p97, an AAA ATPase regulating the folding of various cellular su

220 Multimeric AAA ATPases represent a structurally homologous yet func

221 VPS4 proteins are AAA(+) ATPases required to form multivesicular bodies, r

222 Pex1 and Pex6 are Type-2 AAA+ ATPases required for the de novo biogenesis of pero

223 mily; Bro1, a homolog of Alix; and Vps4, the AAA-ATPase required for ESCRT function in all contexts/o

224 Rix7 is an essential type II AAA-ATPase required for the formation of the large ribos

225 E) mutation in TOR1A, which encodes torsinA, AAA(+) ATPase resident in the lumen of the endoplasmic r

226 Torsins are membrane-tethered AAA+ ATPases residing in the nuclear envelope (NE) and e

227 ns between the lid subunit Rpn5 and the base AAA+ ATPase ring are important for stabilizing the subst

228 roteasome contains a heterohexameric ring of AAA-ATPases (RPT1-6) that unfolds and inserts substrates

229 function of the subunit regulatory particle AAA ATPase (RPT2a) causes a weak defect in 26S proteasom

230 2/p27, binds to the C-terminal region of the AAA-ATPase Rpt5.

231 f the GABAB2 C terminus with the proteasomal AAA-ATPase Rpt6.

232 We have tested this method on the AAA+ ATPase Rubisco activase (Rca).

233 proteins as follows: Pih1D1, RPAP3, and the AAA(+)-ATPases RUVBL1 and RUVBL2.

234 ing known regulators, we discovered that the AAA+ ATPase RUVBL1 is necessary for Nrf1's transcription

235 ing 14 different polypeptides, including the AAA+ ATPases Rvb1 and Rvb2.

236 hancer-binding protein (bEBP) with a central AAA+ ATPase sigma(54)-interaction domain, flanked by a C

237 The AAA ATPase Spastin severs microtubules along their lengt

238 The AAA+ ATPase spastin remodels microtubule arrays through

239 ve NADH binding motif (GxGxxG) including the AAA-ATPase subunit, Psmc1 (Rpt2).

240 easome, the 20S particle is regulated by six AAA ATPase subunits and, in archaea, by a homologous rin

241 and may guide the development of additional AAA+ ATPase superfamily inhibitors.

242 a bacterial enhancer-binding protein of the AAA+ ATPase superfamily, is inhibited by an unprecedente

243 en five RavA rings is unique for the diverse AAA+ ATPase superfamily.

244 id deletion in torsinA (TA), a member of the AAA+ ATPase superfamily.

245 in the SF3 helicase family, a subset of the AAA+ ATPase superfamily.

246 TorsinA is an unusual AAA + ATPase that needs an external activator.

247 r protein sorting 4 (Vps4), which encodes an AAA ATPase that interacts with the ESCRT-III complex to

248 Spastin is a hexameric ring AAA ATPase that severs microtubules.

249 uble-stranded DNA (dsDNA) viruses contain an AAA(+) ATPase that assembles into oligomers, often hexam

250 Magnesium chelatase is an AAA(+) ATPase that catalyzes the first committed step in

251 Magnesium chelatase is an AAA(+) ATPase that catalyzes the first step in chlorophy

252 charomyces cerevisiae) is a highly conserved AAA(+)-ATPase that regulates a wide array of cellular pr

253 transcriptional activators forms a hexameric AAA+ ATPase that acts through conformational changes bro

254 DnaA is the widely conserved bacterial AAA+ ATPase that functions as both the replication initi

255 p97/VCP is an essential, abundant AAA+ ATPase that is conserved throughout eukaryotes, wit

256 p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellula

257 This study identifies an AAA+ ATPase that plays a critical role in regulating the

258 n (DeltaE) at position 302/303 of TorsinA, a AAA+ ATPase that resides in the endoplasmic reticulum.

259 LAP1 binds to and activates torsinA, an AAA+ ATPase that resides in the perinuclear space and co

260 equires the activity of Rubisco activase, an AAA+ ATPase that utilizes chemo-mechanical energy to cat

261 Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/

262 s tubular lysosomal network requires VCP, an AAA-ATPase that, when mutated, causes degenerative disea

263 s - katanin, spastin, fidgetin - are related AAA-ATPases that cut microtubules into shorter filaments

264 Pex1 and Pex6 are two AAA-ATPases that play a crucial role in peroxisome bioge

265 Here we describe and characterize the AAA+ ATPase Thorase, which regulates the expression of s

266 erstood endoplasmic reticulum (ER)-localized AAA+ ATPases, through a conserved, perinuclear domain.

267 The AAA-ATPase thyroid hormone receptor interacting protein

268 Pase domain, the Ies2 and Ies6 proteins, the AAA(+) ATPases Tip49a and Tip49b, and the actin-related

269 glutamic acid codon in the gene encoding the AAA+ ATPase TorsinA (TorA).

270 Saunders et al. show that the AAA+ ATPase torsinA and its partner LAP1 are required fo

271 In turn, the AAA+ ATPase torsinA is thought to regulate force transmi

272 The AAA+ ATPase TRIP13 regulates both MAD2 and meiotic HORMA

273 Here, we report that the conserved AAA+ ATPase TRIP13(PCH-2) localizes to unattached kineto

274 Here we describe a mechanism where the AAA-ATPase TRIP13 promotes treatment resistance.

275 ive oxidase1a, NADH dehydrogenaseB2, and the AAA ATPase Ubiquinol-cytochrome c reductase synthesis1),

276 strates depends on its being partnered by an AAA+ ATPase/unfoldase, ClpA or ClpX.

277 ugh poorly defined reactions mediated by the AAA-ATPase valosin-containing protein (VCP)/p97 and augm

278 C1orf124 also binds to the AAA-ATPase valosin-containing protein via its SHP domain

279 protein that we termed VWA interacting with AAA+ ATPase (ViaA) containing a von Willebrand Factor A

280 The hexameric AAA ATPase Vps4 drives membrane fission by remodeling an

281 The AAA ATPase Vps4 is recruited to membrane necks shortly b

282 sport III (ESCRT-III) subunit CHMP2A and the AAA ATPase VPS4, but their regulatory mechanisms remain

283 A component of this pathway, the AAA ATPase Vps4, provides energy for pathway progression

284 in disassembly of ESCRT-III polymers by the AAA ATPase Vps4.

285 The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking

286 e effects of inhibiting the ESCRT-associated AAA+ ATPase VPS4 on EV release from cultured cells using

287 rsions of peptides bind to the S. cerevisiae AAA+ ATPase Vps4 with similar affinities, and determined

288 The AAA-ATPase Vps4 is required for ESCRT function, and its

289 The AAA-ATPase Vps4 is required for ESCRT-III disassembly, h

290 r transport (ESCRT)-III subunit Snf7 and the AAA-ATPase Vps4 to destabilize and clear defective NPC a

291 their disassembly requires the action of the AAA-ATPase Vps4.

292 The vacuolar protein sorting 4 AAA-ATPase (Vps4) recycles endosomal sorting complexes r

293 dodecamer, and argue that, like other type I AAA ATPases, Vps4 functions as a single ring with six su

294 As an AAA-ATPase, Vps4 is important for function of multivesic

295 ssociated with various cellular activities" (AAA(+)) ATPases, which use mechanical forces powered by

296 s the formation of a heterohexameric ring of AAA-ATPases, which is guided by at least four RP assembl

297 This reaction is catalyzed by VPS4, an AAA-ATPase whose activity is tightly regulated by a host

298 TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results i

299 ), also named p97, is an essential hexameric AAA+ ATPase with diverse functions in the ubiquitin syst

300 p97 is a AAA-ATPase with multiple cellular functions, one of whic