ライフサイエンスコーパス: ABCG1

1 ABCG1 expression and cholesterol efflux are reduced in p

2 ABCG1 has a lesser role in cholesterol efflux and a negl

3 ABCG1 is highly expressed in macrophages and probably me

4 ABCG1 plays a crucial role in maintaining intracellular

5 ABCG1 transcripts are induced in vivo in multiple tissue

6 ABCG1 was present in macrophages from control subjects b

7 ABCG1, a member of the ATP-binding cassette transporter

8 t ATP-binding cassette subfamily G member 1 (ABCG1), cholesterol transporters in this process.

9 xpression of LXR target genes such as ABCA1, ABCG1, APOE, SCD-1, and SREBP-1c in THP-1 differentiated

10 Peritoneal macrophages deficient in ABCA1, ABCG1, or both show enhanced expression of inflammatory

11 volved in lipid metabolism, including ABCA1, ABCG1, and sterol regulatory element-binding protein-1c

12 e identified a new beneficial role of ABCA1, ABCG1 and HDL in dampening the oxidative burst and prese

13 XRbeta, resulting in the induction of ABCA1, ABCG1, and apolipoprotein E expression.

14 r (LXR) agonist induced expression of ABCA1, ABCG1, and cholesterol efflux in both LDLR(-/-) and wild

15 crophages had reduced basal levels of ABCA1, ABCG1, and cholesterol efflux.

16 The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoieti

17 ved in reverse cholesterol transport (ABCA1, ABCG1 and 27-hydroxylase) and scavenger receptors, respo

18 ABCA1/ABCG1 show high expression in medial and low expression

19 apolipoprotein E (apoE) or increasing ABCA1/ABCG1-induced apoE lipoprotein association/lipidation.

20 terol (by activating the PPARgamma-LXR-ABCA1/ABCG1 pathway), thereby reducing inflammation and apopto

21 lipidation of apoE4, then induction of ABCA1/ABCG1 may be beneficial.

22 SPCs to promote cholesterol efflux via ABCA1/ABCG1 and decrease cell proliferation, monocytosis, and

23 transporters, including ABCC3, ABCB6, ABCD1, ABCG1, ABCG4, ABCG5, ABCG8, ABCE1, ABCF1, ABCF2, and ABC

24 cine residue in the Walker A motif abolished ABCG1-dependent cholesterol efflux and esterification an

25 A 638-amino acid ABCG1, which lacked the 40 N-terminal amino acids of the

26 for the first time a major role of adipocyte ABCG1 in adiposity and fat mass growth and suggests that

27 nd fat mass growth and suggests that adipose ABCG1 might represent a potential therapeutic target in

28 ction and active eNOS dimer disruption in an ABCG1-dependent manner.

29 ote cholesterol efflux from foam cells in an ABCG1-dependent pathway due to an increased content of L

30 ransporters ATP binding cassette (ABC)A1 and ABCG1.

31 ABCA1 and ABCG1 (ATP-binding cassette transporter A1 and G1) media

32 Combined deficiency of ABCA1 and ABCG1 also resulted in significant islet inflammation as

33 phages had decreased expression of ABCA1 and ABCG1 and reduced lipid efflux.

34 Deletion of ABCA1 and ABCG1 causes an increased cholesterol content on the inn

35 ABCA1 and ABCG1 control the proliferation of hematopoietic stem an

36 activation and increased levels of ABCA1 and ABCG1 could be useful in the treatment of human apoE4 ca

37 ith isolated macrophages, combined ABCA1 and ABCG1 deficiency resulted in impaired cholesterol efflux

38 ATP binding cassette transporters ABCA1 and ABCG1 displayed a dramatic increase in HSPC mobilization

39 These data suggest that ABCA1 and ABCG1 each make complimentary and important contribution

40 ABCA1 and ABCG1 export excess cellular cholesterol into the HDL pa

41 crophage RCT from cells where both ABCA1 and ABCG1 expression were knocked down than from ABCG1-knock

42 by increased PPARalpha, LXRalpha, ABCA1 and ABCG1 expressions in the liver.

43 ABCA1 and ABCG1 facilitate macrophage chemotaxis by promoting PM t

44 ABCA1 and ABCG1 facilitate the efflux of cholesterol from macropha

45 ed at doses in which they elevated ABCA1 and ABCG1 gene expression in duodenum and liver at equal lev

46 ATP-binding cassette transporters ABCA1 and ABCG1 have a major role in promoting cholesterol efflux

47 To determine whether ABCA1 and ABCG1 have complementary roles in beta-cells, mice lacki

48 efflux-promoting ABC transporters ABCA1 and ABCG1 in BM cells.

49 ses the mRNA and protein levels of ABCA1 and ABCG1 in hippocampal neurons, but has no effect on the c

50 ting a dose-dependent induction of ABCA1 and ABCG1 in human monocyte-derived macrophages by cholester

51 radation of endogenously expressed ABCA1 and ABCG1 in human THP-1 macrophages.

52 ggest that the combined effects of ABCA1 and ABCG1 in mediating macrophage sterol efflux are central

53 ts were independent of any role of ABCA1 and ABCG1 in mediating oxidized phospholipid efflux but were

54 letion of cholesterol transporters ABCA1 and ABCG1 in microglia, leading to inflammaraft formation, i

55 tudy was to determine the roles of ABCA1 and ABCG1 in preserving the viability of macrophages during

56 addressing the individual roles of ABCA1 and ABCG1 in the development of atherosclerosis have produce

57 Thus, lack of both ABCA1 and ABCG1 induces greater defects in beta-cell function than

58 Turnover of ABCA1 and ABCG1 is strongly inhibited by proteasomal inhibitors an

59 l in post-translational control of ABCA1 and ABCG1 protein expression.

60 ent, post-translational control of ABCA1 and ABCG1 protein levels, mediated through a specific and st

61 inding cassette (ABC) transporters ABCA1 and ABCG1 regulate macrophage cholesterol efflux and hence p

62 rol efflux from macrophages by the ABCA1 and ABCG1 transporter systems hold great promise and may be

63 g cassette transporters A1 and G1 (ABCA1 and ABCG1) in macrophages (MAC-ABC(DKO) mice) but not in hem

64 nding cassette (ABC) transporters (ABCA1 and ABCG1) involved in cholesterol efflux is not affected in

65 ATP-binding cassette transporters (ABCA1 and ABCG1) that mediate cellular cholesterol efflux.

66 cholesterol uptake (LDLR), efflux (ABCA1 and ABCG1), and inflammation (DHCR24).

67 These results demonstrate that ABCA1 and ABCG1, but not SR-BI, promote macrophage RCT in vivo and

68 Two macrophage ABC transporters, ABCA1 and ABCG1, have a major role in promoting cholesterol efflux

69 ATP-binding cassette transporters, ABCA1 and ABCG1, in beta-cells (beta-DKO mice).

70 g cassette transporters A1 and G1 (ABCA1 and ABCG1, respectively) are the most important apoE-lipidat

71 dentify sequences in the 3' UTR of ABCA1 and ABCG1, sterol transporter genes both previously shown to

72 inding cassette (ABC) transporters ABCA1 and ABCG1, which are membrane lipid translocases.

73 ATP-binding cassette transporters ABCA1 and ABCG1, which are responsible for initiating reverse chol

74 inding cassette (ABC) transporters ABCA1 and ABCG1, which promote cholesterol efflux from macrophages

75 ATP-binding cassette transporters ABCA1 and ABCG1, which promote efflux of cholesterol and oxysterol

76 nding cassette (ABC) transporters, ABCA1 and ABCG1.

77 xpression of the ABC transporters, ABCA1 and ABCG1.

78 ATP-binding cassette transporters ABCA1 and ABCG1.

79 anol, also caused up-regulation of ABCA1 and ABCG1.

80 n of the cholesterol transporters, ABCA1 and ABCG1.

81 anisms by which RAGE downregulates ABCA1 and ABCG1.

82 tivation upregulated the levels of ABCA1 and ABCG1.

83 loading inhibits ubiquitination of ABCA1 and ABCG1.

84 ng cassette subfamily A member 1 (ABCA1) and ABCG1.

85 binding cassette transporter A1 (ABCA1) and ABCG1.

86 ased scavenger receptor AI, CD36, ABCA1, and ABCG1 expression which led to suppression of cholesterol

87 he coordinate regulation of apoE, ABCA1, and ABCG1 expression.

88 mRNA and protein levels of apoE, ABCA1, and ABCG1 in young, naive apoE3- and apoE4-targeted replacem

89 sm, such as the ATP transporters, ABCA1, and ABCG1, and the scavenger receptor, SRB1.

90 -bound pool, where it acted in an ABCA1- and ABCG1-dependent fashion to decrease cell proliferation.

91 This occurs through an ABCA1- and ABCG1-dependent mechanism and is reversible by intervent

92 ake while concomitantly promoting ABCA1- and ABCG1-mediated reverse cholesterol transport.

93 ing lipoprotein lipase, CD36, LXR alpha, and ABCG1 in thioglycolate-elicited peritoneal macrophages.

94 sterol transport (PPAR-gamma, LXR-alpha, and ABCG1) and macrophage emigration from lesions (CCR7) in

95 from wild-type, ABCA1(-/-), SR-BI(-/-), and ABCG1(-/-) adipocytes to apolipoprotein A-I (apoA-I) and

96 avenger receptor class B type I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to e

97 gh the various pathways (ABCA1-, SR-BI-, and ABCG1-mediated efflux); however, these subjects had no c

98 CETP and ABCG1 may be important mediators of these effects throug

99 CETP and ABCG1, both of which participate in the HDL-mediated rev

100 es in the recently reported HIF3A, CPT1A and ABCG1 regions.

101 CAV-1, CYP2b10, and ABCG1 were significantly induced in ABCA1-overexpressing

102 s between triglyceride levels and SREBF1 and ABCG1 were also found in adipose tissue of the Multiple

103 ated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.

104 , SC4MOL), and efflux ( downward arrowABCA1, ABCG1), producing a molecular profile expected to increa

105 ion analysis revealed an association between ABCG1 methylation and lipid levels that might be partly

106 Because both ABCG1 and LPL are expressed in adipose tissue, we hypoth

107 Lack of both ABCG1 and beta-cell ABCA1 resulted in increased fasting

108 in intracellular cholesterol homeostasis by ABCG1 profoundly impact iNKT cell development and functi

109 ipid levels that might be partly mediated by ABCG1 expression.

110 In transfected 293 cells, ABCG1 and ABCG4 stimulate cholesterol efflux to both sma

111 Consistent with these data, ABCG1 had a major role in promoting efflux of cholestero

112 with type 2 diabetes mellitus had decreased ABCG1 and/or ABCA1, impaired cholesterol efflux, and inc

113 lso studied and were found to have decreased ABCG1 expression without an increase in CD36.

114 ophage cholesterol efflux and that decreased ABCG1 function can facilitate foam cell formation in Typ

115 lucidation of the various roles of different ABCG1 isoforms will be important for our understanding o

116 zation to the endosome pathway distinguishes ABCG1 and/or ABCG4 from all other mammalian members of t

117 nt in glucose tolerance compared with either ABCG1 deletion or loss of ABCA1 in beta-cells alone.

118 ly obese individuals indicated that elevated ABCG1 expression in adipose tissue was associated with i

119 eritoneal macrophages showed that endogenous ABCG1 is intracellular and undetectable at the cell surf

120 ues in the TM domains that are important for ABCG1 to alter sterol efflux, induce sterol regulatory e

121 have demonstrated an intracellular role for ABCG1 in beta cells.

122 These findings indicate a specific role for ABCG1 in promoting efflux of 7-ketocholesterol and relat

123 Analysis of two frequent ABCG1 single nucleotide polymorphisms (rs1893590 [A/C] a

124 ABCG1 expression were knocked down than from ABCG1-knockdown cells.

125 at two ABC transporters of unknown function, ABCG1 and ABCG4, mediate isotopic and net mass efflux of

126 harbored C-phosphorus-G dinucleotides (e.g., ABCG1/cg06500161), which overlapped Encyclopedia of DNA

127 ing cassette transporters A1 (ABCA1) and G1 (ABCG1) in macrophages, thus promoting efflux of choleste

128 ing cassette transporters A1 (ABCA1) and G1 (ABCG1), and a consequent decrease in cellular cholestero

129 esterol transporter ATP binding cassette G1 (ABCG1) have pulmonary lipidosis and enhanced innate immu

130 The role of the ATP-binding cassette G1 (ABCG1) transporter in human pathophysiology is still lar

131 ing the ATP-binding cassette transporter G1 (ABCG1) develop chronic inflammation in the lungs, which

132 ATP-binding cassette transporter G1 (ABCG1) effluxes cholesterol from macrophages and plays a

133 The ATP-binding cassette transporter G1 (ABCG1) has been shown to play a role in cholesterol effl

134 ATP binding cassette transporter G1 (ABCG1) mediates the transport of cholesterol from cells

135 ATP-binding cassette transporter G1 (ABCG1) plays a role in the intracellular transport of ch

136 ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol accumulation and alters T ce

137 ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regula

138 te that ATP-binding cassette transporter G1 (ABCG1) regulates cholesterol homeostasis in thymocytes a

139 riphosphate-binding cassette transporter G1 (ABCG1).

140 Cg06500161 in gene ABCG1 associated both with serum triglycerides (P = 5.36

141 -dependent expression of other target genes, ABCG1 and SREBP-1c.

142 ABCG1 degradation via lysosomes and hampered ABCG1-mediated cholesterol efflux and reverse cholestero

143 Last, we found that higher ABCG1 expression in Tregs was associated with a higher f

144 mice that express both the murine and human ABCG1 genes.

145 E1 and NEDD4-1 in cells overexpressing human ABCG1 significantly increased levels of the ABCG1 monome

146 Here we show that human ABCG1 overexpressed in baby hamster kidney cells in the

147 In conclusion, the human ABCG1 gene contains multiple promoters, spans more than

148 omic organization and structure of the human ABCG1 gene demonstrates that: (i) the gene consists of 2

149 The human ABCG1 gene encodes a member of the ATP-binding cassette

150 Using microarray analyses, we identified ABCG1, encoding an ABC transporter, as a gene responsive

151 These findings identify ABCG1 as a novel integrator of cholesterol homeostasis a

152 and emphasizes recent studies that identify ABCG1 as a key regulator of cellular lipid homeostasis.

153 geted to endosomes and functional, and (iii) ABCG1 colocalizes with multiple proteins that mark late

154 This impaired ABCG1-mediated cholesterol efflux significantly correlat

155 These results implicate ABCG1 as an important negative regulator of lymphocyte p

156 Thymic iNKT cells deficient in ABCG1 had reduced membrane lipid raft content, and showe

157 the lungs of aged chow-fed mice deficient in ABCG1 show distinctive signs of inflammation that includ

158 e, indicating that the ATP binding domain in ABCG1 is essential for both lipid transport activity and

159 DL was largely derived from these domains in ABCG1 transfectants but not in cells lacking ABCG1.

160 CpG cg06500161, located in ABCG1, was associated in opposite directions with both h

161 es, respectively, with no effect observed in ABCG1(-/-) adipocytes.

162 rol content and rescued insulin secretion in ABCG1-deficient islets.

163 Methylation of a CpG site in ABCG1 on chromosome 21 was significantly associated with

164 G sites annotated to various genes including ABCG1, MIR33B/SREBF1, and TNIP1 were identified.

165 In addition, ligase silencing increased ABCG1-mediated cholesterol export to HDL in cells overex

166 k293 cells with plasmids encoding individual ABCG1 isoforms.

167 other LXR target genes were weakly induced (ABCG1 and SREBP-1c) or not induced (apoE and LXRalpha).

168 Furthermore, islet ABCG1 expression was reduced in diabetic mice and restor

169 , implicating a role for regulation of islet ABCG1 expression in diabetes pathogenesis and treatment.

170 ABCG1 transfectants but not in cells lacking ABCG1.

171 plementary roles in beta-cells, mice lacking ABCG1 and beta-cell ABCA1 were generated and glucose tol

172 nd inflammation, hyperlipidemic mice lacking ABCG1 develop smaller atherosclerotic lesions compared w

173 Like ABCG1, ABCG4 protein levels and cholesterol export activ

174 provide important information that may link ABCG1 to diseases of dysregulated tissue lipid homeostas

175 d provide critical information that may link ABCG1 to the reverse cholesterol transport pathway or di

176 tudies reveal a critical role for macrophage ABCG1 in lung inflammation and homeostasis.

177 We show that increased macrophage ABCG1 expression significantly promoted while knockdown

178 ed while knockdown or knockout of macrophage ABCG1 expression significantly reduced macrophage RCT in

179 To investigate whether macrophage ABCG1 is involved in macrophage RCT in vivo, we used ABC

180 ABCA1 CEC-but not ABCG1 CEC-of small HDL was lower in the subjects with ty

181 implicate adipocyte SR-BI and ABCA1, but not ABCG1, in this process.

182 merase chain reaction, we identified a novel ABCG1 transcript that encodes a putative protein of 786

183 The absence of ABCG1 in CD4 T cells results in hyperproliferation in vi

184 , our study demonstrates that the absence of ABCG1 inhibits tumour growth through modulation of macro

185 In the absence of ABCG1, intracellular cholesterol accumulation led to dow

186 The mechanism of action of ABCG1 is controversial and it has been proposed to act a

187 ular localization studies showed the bulk of ABCG1 protein to be present in insulin granules.

188 eicosatetranoic acid-mediated degradation of ABCG1.

189 d critical residues within the TM domains of ABCG1 that are both essential for sterol transport and c

190 ls was completely dependent on expression of ABCG1 and the presence of HDL in media.

191 tato plants with downregulated expression of ABCG1 display major alterations in both root and tuber m

192 Macrophage expression of ABCG1 in both patients and control subjects was induced

193 RNA interference reduced the expression of ABCG1 in liver X receptor-activated macrophages and caus

194 ear receptor LXR and that over expression of ABCG1 results in increased efflux of cellular cholestero

195 mouse embryos revealed strong expression of ABCG1 transcripts in the olfactory epithelium, hind brai

196 sterol esterification, induced expression of ABCG1, and stimulated HDL-dependent cholesterol efflux i

197 ell ABCA1 have increased islet expression of ABCG1, another cholesterol transporter implicated in bet

198 The in-vivo importance of ABCG1 has recently been demonstrated with both loss-of-f

199 into HEK-293 cells conferred an induction of ABCG1 and SREBP-1c; 2) upon cholesterol loading, CYP27-e

200 l treatment results in >10-fold induction of ABCG1 transcripts that are derived from either exons 8-2

201 esterification and prevented localization of ABCG1 to the cell surface, indicating that the ATP bindi

202 Loss of ABCG1 expression impaired insulin secretion both in vivo

203 ecent studies have demonstrated that loss of ABCG1 has wide-ranging consequences and impacts lymphocy

204 e, we investigated how the selective loss of ABCG1 in T cells impacts atherosclerosis in LDL receptor

205 Loss of ABCG1 led to altered granule morphology and reduced gran

206 Loss of ABCG1 results in increased levels of specific oxysterols

207 Loss of ABCG1 results in severe pulmonary lipidosis in mice, wit

208 b macrophages was due to a selective loss of ABCG1-mediated efflux to high density lipoprotein.

209 DNA methylation of ABCG1 might also play a role in previous hospitalized my

210 Overexpression of ABCG1 also increased cholesterol esterification, which w

211 Genetic knockdown or overexpression of ABCG1 showed that increased cholesterol efflux to CETP-D

212 s type 2, demonstrate that overexpression of ABCG1 specifically stimulates the efflux of cellular cho

213 s the turnover and serine phosphorylation of ABCG1.

214 ymes in the post-translational regulation of ABCG1 and ABCG4 protein levels and cellular cholesterol

215 ceptor activator results in up-regulation of ABCG1 and increases cholesterol efflux to HDL.

216 al inhibitors blocked the down-regulation of ABCG1 expression and resulted in accumulation of phospho

217 ges were resistant to the down-regulation of ABCG1 protein, reduction in efflux, and increase in seri

218 , we were able to confirm down-regulation of ABCG1 using C57BL/6J peritoneal macrophages cultured in

219 e also shown that ABCG4, a close relative of ABCG1, controls platelet production, atherosclerosis, an

220 m macrophages and have evaluated the role of ABCG1 and other factors in this process.

221 Here we demonstrate a role of ABCG1 as a mediator of tumour immunity.

222 val by HDL, consistent with a direct role of ABCG1 in cellular cholesterol transport.

223 offer a comprehensive review on the role of ABCG1 in cellular sterol homeostasis.

224 The critical role of ABCG1 in obesity was further confirmed in independent po

225 (ii) a chimeric protein containing the TM of ABCG1 and the cytoplasmic domains of the nonsterol trans

226 ter luciferase activity and transcription of ABCG1 and ABCA1 through peroxisome proliferator-activate

227 ouse and human macrophages in which ABCA1 or ABCG1 expression was deleted.

228 a HDL, cell lines stably expressing ABCA1 or ABCG1, and both mouse and human macrophages in which ABC

229 cell lines stably expressing human ABCA1 or ABCG1, we observed that the abundance of these proteins

230 a mouse model lacking ABCA1 and its partner ABCG1 specifically in this layer.

231 Genetic variants in SREBF1, PHOSPHO1, ABCG1 and CPT1A were also associated with lipid profile.

232 d resulted in accumulation of phosphorylated ABCG1.

233 aortic CD36 expression and increased plaque ABCG1 expression and signs of plaque stability.

234 Conversely, Epsins promoted ABCG1 degradation via lysosomes and hampered ABCG1-media

235 ave enhanced transporter expression, reduced ABCG1 phosphorylation, and increased cholesterol efflux.

236 phages that overexpress 12/15LO have reduced ABCG1 expression, increased transporter phosphorylation,

237 found that chronic elevated glucose reduces ABCG1 expression.

238 However, lipoproteins regulated ABCG1 expression similarly in LDLR(-/-) and wild type ma

239 ings provide evidence that 12/15LO regulates ABCG1 expression and function through p38- and JNK2-depe

240 te the mechanisms by which 12/15LO regulates ABCG1.

241 Furthermore, T cell-specific ABCG1 deficiency led to a 30% increase in Treg percentag

242 fed a high-cholesterol diet, T cell-specific ABCG1 deficiency protected against atherosclerotic lesio

243 In vitro, RAGE ligands suppressed ABCG1 and ABCA1 promoter luciferase activity and transcr

244 ne genes (SREBF1, SREBF2, PHOSPHO1, SYNGAP1, ABCG1, CPT1A, MYLIP, TXNIP and SLC7A11) and 2 intergenic

245 In mouse macrophages, miR-33 also targets ABCG1, reducing cholesterol efflux to nascent high-densi

246 Our data demonstrate that ABCG1 is an intracellular sterol transporter that locali

247 These observations demonstrate that ABCG1 plays a major role in macrophage cholesterol efflu

248 These results demonstrate that ABCG1 plays critical roles in pulmonary homeostasis, bal

249 In summary, our results demonstrate that ABCG1 plays essential roles in pulmonary lipid homeostas

250 In this study, we demonstrate that ABCG1 regulates iNKT cell development and functions in a

251 Recent studies have also demonstrated that ABCG1 functions as an intracellular lipid transporter, l

252 ssed in adipose tissue, we hypothesized that ABCG1 is implicated in adipocyte TG storage and therefor

253 These studies indicate that ABCG1 and ABCG4 promote cholesterol efflux from cells to

254 Early studies with Abcg1 mice indicated that ABCG1 was crucial for tissue lipid homeostasis, especial

255 More detailed analysis indicated that ABCG1 was expressed primarily in ECs, and that these cel

256 Our study indicates that ABCG1 regulates T cell differentiation into Tregs, highl

257 Previous studies reported that ABCG1 is ubiquitinated and degraded via the ubiquitin pr

258 Further analyses revealed that ABCG1 is expressed in roots and tuber periderm, as well

259 Other studies show that ABCG1 expression is induced following activation of the

260 Here we show that ABCG1 function is dependent on localization to intracell

261 These studies show that ABCG1 redistributes cholesterol to cell-surface domains

262 In conclusion, we have shown that ABCG1 deletion in macrophages causes a striking inflamma

263 These findings suggest that ABCG1 acts primarily to regulate subcellular cholesterol

264 Our data suggest that ABCG1 and HDL maintain EC function in HCD-fed mice by pr

265 in neuronal tissues and the eye suggest that ABCG1-dependent cholesterol efflux may be critical for n

266 (25 mM glucose for 7 days), suggesting that ABCG1 expression in diabetic macrophages is regulated by

267 of RNA interference plants, suggesting that ABCG1 is required for the export of suberin components.

268 The ABCG1 transporter plays a key role in regulating cellula

269 cant reduction in protein levels of both the ABCG1 monomeric and dimeric forms.

270 cellular cholesterol levels mediated by the ABCG1 transporter increase ATP release by volume-regulat

271 ediating free cholesterol efflux to HDL, the ABCG1 transporter equally promotes lipid accumulation in

272 ABCG1 significantly increased levels of the ABCG1 monomeric and dimeric protein forms, however ABCA1

273 r morphology, whereas the aerial part of the ABCG1-RNAi plants appear normal.

274 f a diet high in both fat and cholesterol to ABCG1 mice results in massive cholesterol accumulation i

275 as fully functional and of a similar size to ABCG1 expressed by cholesterol-loaded human monocyte-der

276 Transgenic ABCG1-RNAi potato plants with downregulated expression o

277 decreased expression of the ABC transporter ABCG1 and increased expression of the scavenger receptor

278 The ATP-binding cassette transporter ABCG1 has an essential role in cellular cholesterol home

279 The ATP-binding cassette transporter ABCG1 was recently shown to promote efflux of cholestero

280 cently, the ATP-binding cassette transporter ABCG1, a macrophage liver X receptor (LXR) target, has b

281 Inactivation of the sterol transporter ABCG1 uncouples LXR signaling from proliferation, direct

282 P-binding cassette transmembrane transporter ABCG1 show progressive and age-dependent severe pulmonar

283 ession of a reverse cholesterol transporter (ABCG1; P=7.2E-28) and incident cardiovascular disease ev

284 e levels of another cholesterol transporter, ABCG1.

285 We identified two ABCG1 (ABC subfamily G member 1) variants, which regulat

286 ng to three well-characterized genes (TXNIP, ABCG1 and SAMD12) independently explained 7.8% of the he

287 e MVPs identified previously (near to TXNIP, ABCG1, and SREBF1).

288 t significantly different between wild-type, ABCG1, and hABCG1 transgenic mice.

289 In other cell types, ABCG1 expression is downregulated in diabetes and upregu

290 Strategies to upregulate ABCG1 expression and function in type 2 diabetes mellitu

291 involved in macrophage RCT in vivo, we used ABCG1-overexpressing, -knockdown, and -knockout macropha

292 effects by promoting cholesterol efflux via ABCG1 and ABCA1 with consequent attenuation of signaling

293 and for synthesis of an intact pollen wall (ABCG1 and ABCG16).

294 creased cholesterol efflux to CETP-D HDL was ABCG1 dependent.

295 Whether ABCG1 regulates adaptive immune responses to the environ

296 Elucidation of the mechanisms by which ABCG1 affects intracellular sterol flux/movement should

297 cidation of the molecular mechanism by which ABCG1 controls sterol flux should provide critical infor

298 d two HECT domain E3 ligases associated with ABCG1, named HUWE1 (HECT, UBA, and WWE domain containing

299 These observations are consistent with ABCG1 controlling cellular sterol metabolism.

300 uggest that methylation of a CpG site within ABCG1 is associated with fasting insulin and merits furt