ライフサイエンスコーパス: AMH

1 AMH and inhibin B concentrations were generally higher i

2 AMH can be useful in future studies aiming at improved c

3 AMH correlated with non-transferrin-bound iron (NTBI), s

4 AMH decreased markedly before menopause and remained low

5 AMH emerges as an important biomarker for assessment of

6 AMH evidence from this period is rare and lacks robust c

7 AMH II crystallizes in space-group Pbca with 16 formula

8 AMH is a member of the transforming growth factor beta (

9 AMH is produced by ovarian follicles during their early

10 AMH values ranged from 0.16-35.84 ng/ml and median AMH w

11 AMH was measured in 8507 stored plasma samples.

12 AMH(SCUT) potency (EC(50) 4 ng/mL) was increased 5- or 1

13 AMH, fasting insulin, glucose, HDLc, LDLc, triglycerides

14 AMH-3 is composed of silicate layers containing eight-me

15 l follicles were observed (19 control and 19 AMH) at long-term intervals (>10 weeks).

16 dmixture with Neanderthals, resulting in ~6% AMH ancestry in Neanderthals.

17 In light of these actions, AMH is considered an attractive therapeutic target to ad

18 of the canonical WNT pathway, did not affect AMH signaling activation in the Mullerian duct mesenchym

19 terioration does not appear to have affected AMH subsistence strategies or their capacity to inhabit

20 All non-sub-Saharan African AMHs have genomic regions genetically similar to Neander

21 cing of the AMH-regulated cells using AMHR2 (AMH receptor 2)-Cre:ROSA26 mutant mice indicated the pre

22 ms which might lead consumers to purchase an AMH test in the belief that it can reliably predict fert

23 Furthermore, using an AMH responsive cell-based luciferase assay, we show that

24 GFbeta (transforming growth factor beta) and AMH (anti-Mullerian hormone) expressions were unchanged

25 ust, and inverse association between CRP and AMH in men.

26 dance of Bacteroidetes and Fusobacteria, and AMH showing higher Firmicutes and Proteobacteria.

27 correlating with age, FAI, inflammation and AMH in PCOS, and with BMI, fertilization rate (3 miRNA),

28 AMHs out of Africa and that Neanderthal and AMH gene flow has been bi-directional.

29 archaic hominins, such as Neanderthals, and AMH sequences, and find 766 genes that are likely to hav

30 e contribute to changes in LH, FSH, SHBG and AMH across mid-life in women, and BMI, smoking and parit

31 s in reproductive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (

32 in female gonads induces localised SOX9 and AMH expression.

33 Free testosterone and AMH levels were higher in women with probable than with

34 However, DOX toxicity and AMH rescue mechanisms in the ovary have remained unclear

35 Ossicles of both Neandertals and AMHs appear derived compared with the inferred ancestral

36 pes known to differ between Neanderthals and AMHs, such as the structure of the rib cage and supraorb

37 h was targeted therapeutically using an anti-AMH antibody to successfully repress tumor growth.

38 range (5 to 15 pM), the newly developed anti-AMH B10 antibody decreased by 25% (OVCAR8) to 50% (KGN)

39 Avian AMH cDNA encodes a 644 amino acid protein that is 42% id

40 Antibodies to recombinant avian AMH cross-react with recombinant human AMH and were used

41 t human AMH and were used to show that avian AMH is glycosylated as has been shown for the human form

42 The avian AMH gene is transcribed in both male and female gonads b

43 egression to examine the association between AMH and CRP without and with adjustment for age, race, b

44 No association between AMH and stroke was found.

45 cause mortality, and may be the link between AMH and mortality.

46 imed to investigate the relationship between AMH levels and the development of early-onset VMS among

47 n Asian fossil record, and admixture between AMHs and Neanderthals predating the main Eurasian expans

48 nces in gene regulatory architecture between AMHs and archaic hominins, and provide an avenue for exp

49 their type II receptors, differences in both AMH and AMHR2 account for a highly specific interaction.

50 the gonadal poles of XY embryos lacking both AMH and activin B transdifferentiate into their female c

51 ates Wnt signaling, which are ameliorated by AMH cotreatment.

52 arliest evidence of rainforest occupation by AMH, and underscores the importance of reassessing the t

53 MHR2 lineage-derived cells were regulated by AMH in vitro; whereas, fewer AMHR2-Cre:ROSA26-marked cel

54 volved in the replacement of Neanderthals by AMHs.

55 Our study is the first to characterize AMH residues involved in type I receptor binding and sug

56 ies, the genetic determinants of circulating AMH levels are poorly characterized.

57 we postulate that the decline of circulating AMH levels may be part of the pathophysiology of the inc

58 sted HRs (95% CI) for incident VMS comparing AMH quintiles 4-1 to the highest quintile were 1.02 (0.7

59 Consequently, AMH levels are correlated with ovarian reserve, declinin

60 ith results obtained from the earliest dated AMH sites in Europe, associated with the Uluzzian techno

61 nception were not associated with daughters' AMH levels.

62 the role of genetic variation in determining AMH levels in women of late reproductive age, we carried

63 We showed that during embryonic development, AMH is expressed in migratory GnRH neurons in both mouse

64 content analysis, most websites selling DTC AMH tests included false and misleading claims which mig

65 ution within the genome tells us about early AMH and Neanderthal evolution, we analyzed a dataset of

66 astal corridors as favoured routes for early AMH.

67 sweeps provide a means to reconstruct early AMH population dispersals OoA.

68 creases the areal expansion reached by early AMHs at that time.

69 with cultural materials attributed to early AMHs in western Asia.

70 ition of AFP to the medium inhibited ectopic AMH expression via estrogen, leading to successful folli

71 , physiological concentrations of endogenous AMH improved cancer cell viability.

72 ations using the administration of exogenous AMH show that the transfer of non-growing primordial fol

73 In the context of exogenous AMH, follicles exhibited a decreased ratio of primordial

74 previously shown, incubation with exogenous AMH at concentrations above the physiological range (12.

75 and make comparisons with recent and extinct AMHs as well as African apes.

76 entiation in the fetus, and in adult females AMH is produced by growing ovarian follicles.

77 suggest that in healthy adolescent females, AMH is not associated with cardiometabolic risk factors.

78 Finally, AMH induces Id3, a gene involved in DNA repair, which is

79 Using these SNPs as a genetic proxy for AMH levels, we found no evidence in additional datasets

80 al datasets to support a biological role for AMH in complex traits and diseases in men.

81 Our findings highlight a novel role for AMH in the development and function of GnRH neurons and

82 nor fraction is attributable to the founding AMH settlers.

83 96) Leu) or loss- (Ser(497) Ala) of function AMH variants.

84 cterize the molecular mechanisms that govern AMH synthesis and activity.

85 rameter space; Adaptive Metropolis Hastings (AMH) learns correlations between plausible parameter set

86 active genome of adult C57BL/6 mouse heart (AMH), we used serial analysis of gene expression (SAGE)

87 Here, AMH dose-dependent effect on signaling and proliferation

88 before pregnancy were associated with higher AMH levels in daughter during adolescence.

89 exclusion of 3% of females with the highest AMH values, after excluding those that had not started m

90 exhibit a decrease in antimullerian hormone (AMH) and inhibin B and an increase in FSH with age corre

91 -phase serum level of antimullerian hormone (AMH), follicle-stimulating hormone (FSH), and inhibin B

92 Sertoli cell-derived anti-Mullerian hormone (AMH) and activin B together maintain Sertoli cell identi

93 ozygous mutations in anti-Mullerian hormone (AMH) and its receptor, AMHR2, in 3% of CHH probands usin

94 b-5p correlated with anti-mullerian hormone (AMH) and miR-93-3p correlated with C-reactive protein (C

95 s explore the use of anti-Mullerian hormone (AMH) as a new measurement tool in fecundability studies.

96 ur results show that Anti-Mullerian Hormone (AMH) can be reliably detected in blood samples from neon

97 entile), or elevated anti-Mullerian hormone (AMH) concentration (> 75th percentile).

98 The roles of anti-Mullerian hormone (AMH) continue to expand, from its discovery as a critica

99 ations in either the anti-Mullerian hormone (AMH) gene or its main receptor.

100 by premature loss of anti-Mullerian hormone (AMH) in secondary follicles.

101 nstitutively express anti-mullerian hormone (AMH) induced a greater proportion of quiescent primordia

102 Anti-Mullerian hormone (AMH) is an essential messenger of sexual differentiation

103 Anti-Mullerian hormone (AMH) is produced by growing ovarian follicles and provid

104 Anti-Mullerian hormone (AMH) is required for sexual differentiation in the fetus

105 Anti-Mullerian hormone (AMH) is responsible for regression of the Mullerian duct

106 evel > 11.45 nmol/L, anti-Mullerian hormone (AMH) level > 3.50 ng/ml, frequency of hysteroscopic surg

107 Anti-Mullerian hormone (AMH) levels are increasingly recognized as a biomarker o

108 While serum anti-mullerian hormone (AMH) levels are inversely associated with all-cause mort

109 The role of anti-Mullerian hormone (AMH) levels in incident vasomotor symptoms (VMS) is larg

110 usal associations of anti-Mullerian hormone (AMH) levels, sex hormone-binding globulin (SHBG) levels,

111 Anti-Mullerian hormone (AMH) protects the ovarian reserve from chemotherapy, and

112 incidence of EP was anti Mullerian hormone (AMH) serum concentration (aOR 0.81 95% CI 0.65-1.00, p =

113 ct-to-consumer (DTC) Anti-Mullerian Hormone (AMH) testing in several countries has been contentious,

114 n ovarian carcinoma, anti-Mullerian hormone (AMH) type II receptor (AMHRII) and the AMH/AMHRII signal

115 for associations of Anti-Mullerian hormone (AMH) with cardiometabolic risk factors is lacking.

116 olume, but levels of anti-mullerian hormone (AMH), a sensitive marker for ovarian reserve independent

117 h PCOS, TGFbeta1 and anti-Mullerian hormone (AMH), alone and on the EPS-induced response.

118 cations suggest that anti-Mullerian hormone (AMH), an ovarian reserve marker, plays a physiological r

119 varies, weight gain, Anti-Mullerian Hormone (AMH), hair growth, menstrual irregularity, fast food con

120 Anti-Mullerian hormone (AMH), or Mullerian-inhibiting substance, is a protein ho

121 For the anti-Mullerian hormone (AMH), the hormone-prodomain complex is active, and the p

122 GFbeta family ligand anti-Mullerian hormone (AMH), the prodomain maintains a high-affinity interactio

123 g serial measures of anti-Mullerian hormone (AMH).

124 ) signaling molecule anti-Mullerian hormone (AMH; also known as Mullerian inhibiting substance, MIS)

125 ), concentrations of anti-Mullerian hormone (AMH; women only) and inhibin B (men only), frequencies o

126 rian reserve marker (anti-mullerian hormone [AMH)] to interrogate reproductive aging patterns and ass

127 g substance (MIS) (or anti-Mullerian hormone/AMH), which is produced by granulosa cells of growing fo

128 Overall, our study highlights how AMH engages AMHR2 using a modified paradigm of receptor

129 ognate receptors; however, it is unknown how AMH binds AMHR2 at the molecular level.

130 ng interface, we generated a series of human AMH variants and assessed bioactivity.

131 avian AMH cross-react with recombinant human AMH and were used to show that avian AMH is glycosylated

132 Similarities to human AMH include motifs of sequence identity, a conserved put

133 acid protein that is 42% identical to human AMH overall with increased identity at the carboxyl term

134 erthal genomes to anatomically modern human (AMH) genomes show a history of Neanderthal-to-AMH introg

135 ce suggests that anatomically modern humans (AMH) and various archaic forms coexisted for much of the

136 first settled by anatomically modern humans (AMH) by 50 thousand years ago (kya), with descendent pop

137 ent dispersal of anatomically modern humans (AMH) out of Africa (OoA) and across Eurasia provides a u

138 tic evidence for anatomically modern humans (AMH) out of Africa before 75 thousand years ago (ka) and

139 the dispersal of anatomically modern humans (AMH) out of Africa is a fundamental question in human ev

140 chimpanzees and anatomically modern humans (AMH), with chimpanzees possessing a greater abundance of

141 the emergence of anatomically modern humans (AMH).

142 the emergence of anatomically modern humans (AMH).

143 associated with anatomically modern humans (AMHs) and evidence of a probable Neanderthal-made indust

144 arliest incoming anatomically modern humans (AMHs) in Eurasia are key questions in palaeoanthropology

145 nct expansion of anatomically modern humans (AMHs) out of Africa.

146 Neanderthals and anatomically modern humans (AMHs), and revealed that they interbred.

147 nt from those of anatomically modern humans (AMHs), despite the close relationship between both human

148 Neanderthals by anatomically modern humans (AMHs).

149 nd the spread of anatomically modern humans (AMHs).

150 l structure of ammonia monohydrate phase II (AMH II) employing a combination of ab initio computation

151 t, the reported absence of first pain and II-AMH microneurographical responses when heat stimuli are

152 ack of first pain and microneurographical II-AMH responses following glabrous skin stimulation could

153 mediated by type-II A-fibre nociceptors (II-AMHs).

154 nts, with the physiological properties of II-AMHs, mediate first pain to heat stimulation of glabrous

155 the hand palm has led to the notion that II-AMHs are lacking in this primate glabrous skin.

156 lower increase in LH and FSH and decrease in AMH.

157 ons only led to modest additive increases in AMH potency/efficacy.

158 Mutations in AMH or AMHR2 in humans and mice disrupt signaling, produ

159 ing linear regression, each 10 ng/mL rise in AMH was associated with 0.09 mg/dL (95%CI = -0.14 to -0.

160 panzees and Haemophilus and Streptococcus in AMH.

161 AMH gene that explained 25% of variation in AMH levels in adolescent males but did not identify any

162 Neanderthal haplotypes that do not remain in AMHs.

163 Brain size increase evolved separately in AMHs and Neandertals, leading to differences in the tymp

164 the ligand for either receptor can increase AMH activity beyond the natural level.

165 polycystic ovary syndrome falsely inflating AMH levels (13 websites [48%]) and that it cannot accura

166 ng at least 57 hard sweeps after the initial AMH movement OoA, which have been obscured in modern pop

167 848) at the time of assessment median (IQR) AMH was 3.81 ng/ml (2.55, 5.82) compared with 3.25 ng/ml

168 refore, we investigated whether longitudinal AMH decline trajectories are associated with an increase

169 t hormonal contraceptive use, women with low AMH values (<0.7 ng/mL [n = 84]) did not have a signific

170 Lower AMH levels were statistically significantly associated w

171 d age at menopause was associated with lower AMH levels by 0.18 SD (95% CI [0.14,0.21]) in age-adjust

172 the distribution) was associated with lower AMH levels in daughters.

173 significantly decreased or unchanged in LTM, AMH, HTM, and CMH units.

174 Accordingly, in mammals, AMH is produced at much higher levels in male fetuses th

175 mechanoreceptor (LTM) units, A-mechanoheat (AMH) units, high threshold mechanoreceptor (HTM) units,

176 lues ranged from 0.16-35.84 ng/ml and median AMH was 3.57 ng/ml (IQR: 2.41, 5.49).

177 The median AMH level was 3.67 ng/mL (interquartile range: 2.46-5.57

178 hese data suggest that beta-catenin mediates AMH signaling for Mullerian duct regression during male

179 ore generally associated with pre-menopausal AMH levels.

180 rameters with reproductive aging milestones (AMH <20 pg/mL or >12 months of amenorrhea).

181 Mullerian inhibiting substance (MIS/AMH), produced by granulosa cells of growing follicles,

182 reserve (n = 224) (menses within 12 months; AMH <20 pg/mL; group 2), or postmenopausal (n = 743) (no

183 nopausal (n = 482) (menses within 12 months; AMH level >=20 pg/mL; group 1), premenopausal with reduc

184 pausal (n = 743) (no menses within12 months; AMH <20 pg/mL; group 3).

185 le difference in age-adjusted inverse normal AMH of 0.26 standard deviations (SD) (95% confidence int

186 [0.14,0.21]) in age-adjusted inverse normal AMH per one-year earlier age at menopause.

187 nulosa cells from wild-type control, but not AMH knockout, suppressed epithelial cell growth.

188 These findings reveal the ability of AMH groups to colonize regions hitherto considered uninh

189 Furthermore, the addition of AMH to the culture medium inhibited normal follicle form

190 cent migration, and subsequent admixture, of AMH populations originating from the Levant and North Af

191 rejects the hypothesis that the ancestors of AMH were genetically isolated in Africa, thus providing

192 own archaic population into the ancestors of AMH, likely within the last 30,000 yr.

193 genetic evidence for a pre-60 ka arrival of AMH into ISEA.

194 The association of AMH trajectories with CVD was quantified with joint mode

195 Hence, we examined the association of AMH with serum c-reactive protein (CRP), a biomarker of

196 gression was used to examine associations of AMH with these cardiometabolic outcomes.

197 After comparison of AMH expression profiles obtained by SAGE and cDNA arrays

198 here Neanderthal genomes show a depletion of AMH introgression points to deleterious interactions bet

199 The group mean total number of discharges of AMH units was significantly decreased during tests of al

200 asting insulin changed by 0% per doubling of AMH (95%CI: -3%,+2%) p = 0.70, with identical results if

201 Effect of AMH on mortality may be through amelioration of inflamma

202 Other effects of AMH agonists and antagonists are investigated in the set

203 Ectopic expression of AMH protein was observed in pregranulosa cells of these

204 essing AMH production and mRNA expression of AMH, SOX9, DHH, and COL2A1.

205 n fetuses and unconvered a novel function of AMH as a pro-motility factor for GnRH neurons.

206 ified residues within the wrist pre-helix of AMH (Trp(494) , Gln(496) , Ser(497) , and Asp(498) ) tha

207 ive reserve in women; however, the impact of AMH on folliculogenesis is poorly understood.

208 around day 40 pc, followed by initiation of AMH and steroidogenic genes required for androgen produc

209 zed recipients, including elevated levels of AMH and estradiol.

210 Altogether these mechanisms of AMH protection contribute to sustained fertility in mice

211 ican populations originate from migration of AMH populations from Africa to Eurasia ~250 kya, and sub

212 In the presence of AMH concentrations within the physiological range (5 to

213 the first quantitative expression profile of AMH and serve as a reliable transcriptome reference to i

214 Similarly, men in the highest quartile of AMH had significantly lower CRP compared to those in the

215 e for a novel pro-survival autocrine role of AMH in the context of ovarian cancer, which was targeted

216 dy, we solved the X-ray crystal structure of AMH bound to the extracellular domain of AMHR2 to a reso

217 re we present the synthesis and structure of AMH-3, a silicate with three-dimensionally microporous l

218 creases in group mean response thresholds of AMH units.

219 etic support for the well-established use of AMH as a marker of ovarian reserve.

220 These dates indicate that the arrival of AMHs at the southernmost tip of Iberia was essentially s

221 , functional properties of the middle ear of AMHs and Neandertals are largely similar.

222 there have been multiple migration events of AMHs out of Africa and that Neanderthal and AMH gene flo

223 there was "an express northward expansion of AMHs starting in southern East Asia through the coastal

224 ng from interbreeding after the migration of AMHs from Africa to Eurasia.

225 orphological differences between ossicles of AMHs and Neandertals.

226 to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago.

227 the dependence of prodomain displacement on AMH concentration and analyzed results with respect to t

228 s suggest that the LGM had a major impact on AMH populations in Europe prior to the Neolithic.

229 of AMHR2 and a salt bridge formed by K534 on AMH and D81/E84 of AMHR2 are key to the AMH/AMHR2 intera

230 planted human ovarian cortex with control or AMH-expressing endothelial cells in immunocompromised mi

231 Mullerian inhibiting substance (MIS or AMH) triggers regression by propagating a BMP-like signa

232 Partial AMH depletion by siRNAs was sufficient to reduce cell vi

233 ction data were collected from perdeuterated AMH II using the D2B high-resolution diffractometer at t

234 oth male and female embryonic gonads produce AMH at high levels, although in males it is still respon

235 (306)V(307)P(308) to A(306)M(307)H(308) (RB3-AMH) only partially mimicked the effect of switching the

236 through its own dedicated type II receptor, AMH receptor type II (AMHR2).

237 placed upon binding to its type II receptor, AMH receptor type-2 (AMHR2), on the cell surface.

238 Gonadal function recovery, AMH, and inhibin B were assessed in the patients of chil

239 Mean (SD) AMH was 8.4 (7.2) ng/mL and median (IQR) CRP level was 0

240 e potential regulatable by follicle-secreted AMH.

241 sponded with a dramatic increase in secreted AMH activity.

242 rom websites in multiple countries that sell AMH tests DTC.

243 first genome-wide association study of serum AMH levels across a set of approximately 9 m '1000 Genom

244 results support an independent role of serum AMH levels in predicting incident early-onset VMS among

245 Unlike time to pregnancy, serum AMH level can be assessed regardless of pregnancy-attemp

246 etermining genes, including SOX9, SF1, SOX8, AMH and DMRT1 in an early embryonic development stage at

247 ression was confirmed by IHC for GAGE, SOX9, AMH, CYP17A1, LIN28, WNT2B, ETV5 and GLI1.

248 rian Hormone/Mullerian Inhibitory Substance (AMH/MIS) secreted by granulosa cells of the follicles, a

249 These results suggest that superphysiologic AMH alone may contribute to ovulatory dysfunction by acc

250 en also affected Sertoli cell by suppressing AMH production and mRNA expression of AMH, SOX9, DHH, an

251 Claims that AMH arrived in ISEA before 60 ka have been supported onl

252 This evidence implies that AMH may have been present in South Asia before the Toba

253 d function of GnRH neurons and indicate that AMH signaling insufficiency contributes to the pathogene

254 These results indicate that AMH trajectories in women are independently associated w

255 The authors suggest that AMH measurement can be a valuable addition to traditiona

256 The AMH promoter contains two binding sites for steroidogeni

257 ext, based on species differences across the AMH type II receptor-binding interface, we generated a s

258 mone (AMH) type II receptor (AMHRII) and the AMH/AMHRII signaling pathway are potential therapeutic t

259 ied three genetic variants in and around the AMH gene that explained 25% of variation in AMH levels i

260 Genetic variants at the AMH protein-coding gene showed considerable allelic hete

261 entity of downstream events regulated by the AMH signaling pathway remains unclear.

262 to a 1000-fold increase in the K(d) for the AMH complex, resulting in rapid release of the prodomain

263 cating that the receptor binding site in the AMH complex is fully accessible to AMHR2.

264 Furthermore, by linking the AMH promoter to the luciferase gene, we show that the tr

265 Binding of the AMH complex to a single AMHR2 molecule does not affect t

266 First, we enhanced the processing of the AMH precursor to >90% by introducing more efficient prop

267 Tracing of the AMH-regulated cells using AMHR2 (AMH receptor 2)-Cre:ROS

268 We show here that the AMH prodomain exhibits an atypical two-domain structure,

269 Collectively, this study shows that the AMH prodomain has evolved an atypical binding interactio

270 4 on AMH and D81/E84 of AMHR2 are key to the AMH/AMHR2 interaction.

271 We have cloned an avian homologue to AMH.

272 hree SNPs, we highlight mechanistic links to AMH gene function and demonstrate highly significant sex

273 ant displayed enhanced efficacy, relative to AMH(SCUT) .

274 MH) genomes show a history of Neanderthal-to-AMH introgression stemming from interbreeding after the

275 gy, we show that the teeth are unequivocally AMH.

276 mouse Mullerian duct mesenchyme depends upon AMH signaling, implicating the WNT pathway as a downstre

277 ple feature combinations: * Clinical + USG + AMH: AUC = 0.9947, Precision = 0.9553, F1 Score = 0.9553

278 The former were AMH-positive while some of the latter were 3betaHSD-posi

279 Observing that genomic regions where AMHs show a depletion of Neanderthal introgression are a

280 We aimed to assess whether AMH is associated with cardiometabolic risk factors in a

281 While AMH (30 ng/ml) had no effect, TGFbeta1 (5 ng/ml) induced

282 The structure reveals that while AMH binds AMHR2 in a similar location to Activin and BMP

283 ed 42-52 years free of VMS at baseline whose AMH levels were measured.

284 ing pregnancy were inversely associated with AMH levels.

285 carbon dates align Iberian chronologies with AMH dispersal patterns in Eurasia.

286 In the mesenchyme, cotreatment with AMH halts theca progenitor differentiation and reduces a

287 aternal and paternal prenatal exposures with AMH levels in adolescent (mean age, 15.4 years) female o