ライフサイエンスコーパス: AMP-activated kinase

1 e kinase domains of AKT and was dependent on AMP-activated kinase.

2 crease in the active, phosphorylated form of AMP-activated kinase.

3 ates nonhistone proteins, including Snf1, an AMP-activated kinase.

4 polarization was also partially dependent on AMP-activated kinase.

5 AMP/ATP ratio that is sufficient to activate AMP-activated kinase.

6 3 significantly inhibited viniferin-mediated AMP-activated kinase activation and diminished the neuro

7 CD8 T cells lacking TRAF6 display defective AMP-activated kinase activation and mitochondrial fatty

8 We found that myostatin represses AMP-activated kinase activation in the heart via transfo

9 n VHL(+) cells was likely due to the reduced AMP-activated kinase activity in these cells.

10 ma membrane GLUT1 levels, possibly involving AMP-activated kinase activity.

11 Treatment with the AMP-activated kinase agonist, AICAR, increases V(max) fo

12 kinase alpha, as compound C, an inhibitor of AMP-activated kinase alpha, abrogated endorepellin-media

13 Endorepellin functioned upstream of AMP-activated kinase alpha, as compound C, an inhibitor

14 e oxygen species (ROS) and the activation of AMP-activated kinase alpha1 (AMPK-alpha1).

15 e and in mice deficient in both apoE and the AMP-activated kinase alpha1 subunit (AMPK-alpha1) (Apoe(

16 The AMP-activated kinase AMPK was investigated as a potentia

17 n of cAMP-dependent protein kinase (PKA) and AMP activated kinase (AMPK) was increased in the brain,

18 d PGC1alpha and low adenosine monophosphate (AMP)-activated kinase (AMPK) activity.

19 Adenosine monophosphate-activated protein (AMP)-activated kinase (AMPK) is a highly conserved kinas

20 originating from mitochondria that sustains AMP-activated kinase (AMPK) activation and the metabolic

21 reas increasing the cellular energy level by AMP-activated kinase (AMPK) activation does the opposite

22 nilotinib up-regulated the phosphryaltion of AMP-activated kinase (AMPK) and protein phosphatase PP2A

23 -deficient mice also exhibit enhanced muscle AMP-activated kinase (AMPK) and reduced liver stearoyl-C

24 The metabolic sensor AMP-activated kinase (AMPK) binds to and phosphorylates

25 tide 3-kinase-dependent activation of the 5'-AMP-activated kinase (AMPK) by peroxynitrite (ONOO-) and

26 AK1/NUAK2) and related to the PAR-1 and SNF1/AMP-Activated kinase (AMPK) families.

27 Salt-inducible kinase 2 (SIK2) is the only AMP-activated kinase (AMPK) family member known to inter

28 AMP-activated kinase (AMPK) has been implicated in regul

29 mines the role of protein kinase C (PKC) and AMP-activated kinase (AMPK) in acetaminophen (APAP) hepa

30 Our results show a rapid activation of AMP-activated kinase (AMPK) in macrophages upon exposure

31 Activation of AMP-activated kinase (AMPK) in skeletal muscle increases

32 demonstrated that a master metabolic sensor, AMP-activated kinase (AMPK) induced phosphorylation at t

33 We recently found that the metabolic sensor AMP-activated kinase (AMPK) inhibits the epithelial Na+

34 AMP-activated kinase (AMPK) is a fuel-sensing enzyme pre

35 AMP-activated kinase (AMPK) is a key player in energy se

36 AMP-activated kinase (AMPK) is a ubiquitous metabolic se

37 AMP-activated kinase (AMPK) is an evolutionarily conserv

38 The yeast Snf1/AMP-activated kinase (AMPK) maintains energy homeostasis

39 overexpression of a constitutively active 5'-AMP-activated kinase (AMPK) mutant or a kinase-inactive

40 iated with increased inflammation, decreased AMP-activated kinase (AMPK) phosphorylation, and altered

41 test whether the ubiquitous metabolic sensor AMP-activated kinase (AMPK) regulates ENaC, we examined

42 The AMP-activated kinase (AMPK) senses the energy status of

43 through the reactive oxygen species-mediated AMP-activated kinase (AMPK) signaling pathway.

44 es, with both models showing reduced retinal AMP-activated kinase (AMPK) signaling, elevated acetyl C

45 ch, stimulates production of ROS to activate AMP-activated kinase (AMPK) to increase glucose uptake.

46 In addition, the AMP-activated kinase (AMPK) was shown to be activated.

47 Yet the contribution of AMP-activated kinase (AMPK), a central energy sensor pro

48 AMP-activated kinase (AMPK), a metabolic sensor, was act

49 yme thought to be activated during CR is the AMP-activated kinase (AMPK), a sensor of cellular energy

50 ction of leptin, concomitant with inhibiting AMP-activated kinase (AMPK), activates acetyl-CoA carbox

51 Here, we report that the AMP-activated kinase (AMPK), an enzyme involved in respo

52 We demonstrated in vitro that AC6 inhibits AMP-activated kinase (AMPK), an important modulator of c

53 that Abeta42 oligomers trigger activation of AMP-activated kinase (AMPK), and its activation is incre

54 ucose on LCFA metabolism, assess the role of AMP-activated Kinase (AMPK), and to establish if changes

55 t to Akt, ONOO(-) significantly activated 5'-AMP-activated kinase (AMPK), as evidenced by its increas

56 lin-dependent protein kinase beta, activates AMP-activated kinase (AMPK), leading to increased glucos

57 d the AMP/ATP ratio, subsequently activating AMP-activated kinase (AMPK), leading to increased stress

58 Here we show that TPr stimulation activates AMP-activated kinase (AMPK), which in turn limits TPr-in

59 lowers serum glucose levels by activating 5'-AMP-activated kinase (AMPK), which maintains energy home

60 ins cellular energy resources and stimulates AMP-activated kinase (AMPK).

61 via activation of the cellular energy sensor AMP-activated kinase (AMPK).

62 to determine if free fatty acid inhibits the AMP-activated kinase (AMPK).

63 tes activate the intracellular energy sensor AMP-activated kinase (AMPK).

64 ectron transport chain) or the activation of AMP-activated kinase (AMPK).

65 Viniferin activates AMP-activated kinase and enhances mitochondrial biogenes

66 DAF-18/PTEN, AMP-activated kinase and fatty acid biosynthesis are als

67 Snf1 is the ortholog of mammalian AMP-activated kinase and is responsible for activation o

68 AMP-activated kinase and mammalian target of rapamycin c

69 67 expression by inducing phosphorylation of AMP-activated kinase and subsequent mTOR proproliferativ

70 rapamycin activated a protein kinase Calpha, AMP-activated kinase, and CREB-dependent vasculoprotecti

71 or calcium/calmodulin protein kinase kinase, AMP-activated kinase, and RhoA/ROCK.

72 rks--those centered on Ras/protein kinase A, AMP-activated kinase, and target of rapamycin complex I,

73 This regulation involved a novel AMP-activated kinase-dependent Sirt2 phosphorylation at

74 of an adenovirus encoding dominant-negative AMP-activated kinase diminished the improvement in limb

75 ATP hydrolysis, is associated with elevated AMP-activated kinase function, and, if triggered by this

76 Mutations of the AMP-activated kinase gamma 2 subunit (AMPKgamma2), N488I

77 active oxygen species-mediated activation of AMP-activated kinase in Huh7.5 cells during HCV (JFH-1)-

78 controlled by fuel gauging protein kinases: AMP-activated kinase in mammals, Sucrose Non-Fermenting1

79 Inhibition of AMP-activated kinase in vivo rescued cardiac hypertrophy

80 involves phosphorylation of nutrient-sensing AMP-activated kinase, inhibition of rapamycin-sensitive

81 and other mitochondrial inhibitors activates AMP-activated kinase leading to the downregulation to bo

82 In this study, we identified MARK4, an AMP-activated kinase-related kinase, as a negative regul

83 in response to ischemic stress by promoting AMP-activated kinase signaling.

84 pletion, Mig1 is phosphorylated by the yeast AMP-activated kinase Snf1 and exported into the cytoplas

85 ng pathways, including Ras/protein kinase A, AMP-activated kinase, the high-osmolarity response mitog

86 of intracellular protein kinases, PKA, Snf1p/AMP-activated kinase, TOR, Gcn2p, and the cyclin-depende

87 mechanism for how metformin activates AMPK (AMP-activated kinase) was investigated in isolated skele

88 Vps34 is also inhibited by activation of the AMP-activated kinase, which inhibits mTOR/S6K1 in glucos