ライフサイエンスコーパス: ANA

1 ANA positivity was associated with the presence of the H

2 ANA presidents were more likely to be employed at ranked

3 ANA prevalence increased with age (P=0.01), and ANAs wer

4 ANA prevalence was modestly higher in African Americans

5 ANA were detected de novo in six and three subjects with

6 ANA-12-treated Tg mice developed more gut aSyn aggregati

7 ANA-3 strains lacking arcA and etrA showed minor to mode

8 ANAs and non-ANAs did not differ in Vkappa family or Jka

9 ANAs were assessed by indirect immunofluorescence.

10 The 2012 ANA Annual Meeting's President's Symposium highlighted d

11 were strongest for high-titer (>/= 1:1,280) ANA: hair, OR = 11.41 (95% CI: 1.60, 81.23); blood, OR =

12 At pH < or = 6.5 ANA induced (45)Ca(2+) uptake either in primary cultures

13 rotein revealed that, at low pH (< or =6.5), ANA could induce an elevation of intracellular free Ca(2

14 s of autoreactivity between anti-nuclear Ab (ANA)-resistant CD45E613R.B6 and ANA-permissive CD45E613R

15 vated serum levels of BAFF, antinuclear Abs (ANA) and immune complexes.

16 e to chromatin resulting in antinuclear Abs (ANA) production in the lupus-prone NZM2410 mouse.

17 lthough the Ig H chains of anti-nuclear Abs (ANA) have been described to possess certain shared molec

18 elop high titers of IgG2a/c antinuclear Abs (ANAs) with specificity for dsDNA, ssDNA, and histones.

19 SLAM family genes, produce antinuclear Abs (ANAs).

20 s revealed the presence of anti-nuclear Abs (ANAs) in the plasma of 92% of the Tsk2/+ mice.

21 nucleic acid (FANA) and arabinonucleic acid (ANA) paired to RNA are substrates of RNase H.

22 chemical modification Altriol Nucleic Acid (ANA) within small interfering RNA (siRNA) duplexes that

23 Altritol-modified nucleic acids (ANAs) support RNA-like A-form structures when included i

24 four XNA chemistries, arabino nucleic acids (ANAs), 2'-fluoroarabino nucleic acids (FANAs), hexitol n

25 ifferent chemistries (arabino nucleic acids, ANA; 2'-fluoroarabino nucleic acids, FANA; hexitol nucle

26 cells rather than lack of selection against ANA(+) plasma cells.

27 (AHAs) or alcohol non-heightened aggressors (ANAs) during resident-intruder confrontations after self

28 Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheu

29 Although ANA residues were detrimental at the 5' end of the antis

30 thermore, disease transition is higher among ANA+ African Americans compared with ANA+ European Ameri

31 f a particular Vkappa1 family sequence among ANAs, we proceeded to clone a novel New Zealand Black Vk

32 and N-nitrosoanabasine (NAB) from anabasine (ANA).

33 nteract with the endocannabinoid anandamide (ANA) and certain inflammatory metabolites of arachidonic

34 Anastrozole (ANA) alone delivers significant disease-free survival be

35 ace area involvement (ssDNA ab, P = .01; and ANA, P = .005), and higher skin scores (ANA, P = .004).

36 The DeltacymA strains of CN-32 and ANA-3 negatively affected the reduction of Fe(III) and M

37 enate in DeltacymA strains of both CN-32 and ANA-3.

38 rved differences in life span between AA and ANA lines, prompting a utility of this animal model in a

39 var3 were markedly different between AA and ANA rats, 52% and 100%, respectively.

40 owship) in the combined and separate AAN and ANA networks.

41 n contrast, during their presidency, AAN and ANA presidents worked at a diffuse set of institutions w

42 ofessional ties of presidents of the AAN and ANA since 1948.

43 , abnormal nailfold capillaries, and ANA and ANA subsets, as well, were not related to survival.

44 y tests for antinuclear antibodies (ANA) and ANA subsets were obtained at initial presentation.

45 We found that, compared with both ANA- and ANA+ healthy individuals, patients with SLE of both race

46 tored removal of developing autoreactive and ANA-expressing B cells.

47 CID patients contained more autoreactive and ANA-expressing clones, indicative of defective central a

48 -nuclear Ab (ANA)-resistant CD45E613R.B6 and ANA-permissive CD45E613R.BALB/c mice.

49 The elevated BAFF and ANA titers were also detected in human patients with pri

50 In men, abnormal nailfold capillaries, and ANA and ANA subsets, as well, were not related to surviv

51 increased ANA-specific Ab-forming cells and ANA titers.

52 nduced IL10 expression in Jurkat T cells and ANA-1 macrophages, which further suggests that the immun

53 ociations between chemical concentration and ANA positivity were observed, but only the association i

54 depressor and sympatho-inhibitory effect and ANA-12 produced the opposite response.

55 mic resolution, we demonstrate that FANA and ANA display subtle conformational differences.

56 ng the conformational boundaries of FANA and ANA residues in crystal structures of A- and B-form DNA

57 ent with this, the conformations of FANA and ANA were found to be intermediate between the A- and B-f

58 m), GIS (Gismondine, 0.45 nm x 0.31 nm), and ANA (Analcime, 0.42 nm x 0.16 nm) zeolites.

59 samples were collected from all subjects and ANA levels were measured by immunofluorescence analysis.

60 prevalence increased with age (P=0.01), and ANAs were more prevalent among females than males (17.8%

61 The prevalence of ACPAs and ANAs was higher in RA cases compared to controls (each P

62 In these experiments, groups of AHAs and ANAs self-administered 1.0 g/kg alcohol (6% w/v) or wate

63 s-sectional associations between mercury and ANAs (indirect immunofluorescence; cutoff >/= 1:80).

64 tor antagonist (the TrkB receptor antagonist ANA-12) reversed the diminished cocaine self-administrat

65 Co-treatment with the TrkB antagonist ANA-12 blocked HDACi rescue of visual function and assoc

66 laboratory tests for antinuclear antibodies (ANA) and ANA subsets were obtained at initial presentati

67 develop spontaneous antinuclear antibodies (ANA) and fatal glomerulonephritis when on the C57BL/6 ba

68 Antinuclear antibodies (ANA) are important in diagnosis and follow-up of patient

69 n to the presence of antinuclear antibodies (ANA), a widely used biomarker of autoimmunity, in a repr

70 oantibodies are true antinuclear antibodies (ANA), and 50% of the ANAs are also reactive with a diver

71 e count, presence of antinuclear antibodies (ANA), presence of human leukocyte antigen (HLA-)B27, age

72 d whether they carry antinuclear antibodies (ANA).

73 rmed the presence of antinuclear antibodies (ANAs) and other autoantibodies in morphea but found they

74 IgG antinuclear antibodies (ANAs) are a feature of several autoimmune diseases.

75 Although antinuclear antibodies (ANAs) are detected in many autoimmune diseases, up to 20

76 questions concerning antinuclear antibodies (ANAs) in lupus involve their pathogenic potential and th

77 d elevated levels of antinuclear antibodies (ANAs) in their serum and showed evidence of escape of pr

78 by high-avidity IgG antinuclear antibodies (ANAs) that are almost certainly products of T cell-depen

79 ase characterized by antinuclear antibodies (ANAs) that form immune complexes that mediate pathogenes

80 Presence of antinuclear antibodies (ANAs) was also a risk factor for developing 1 or more oc

81 The presence of antinuclear antibodies (ANAs) was determined using indirect immunofluorescence w

82 antibodies (ACPAs), antinuclear antibodies (ANAs), anti-tissue transglutaminase antibodies (AGTAs),

83 esence or absence of antinuclear antibodies (ANAs), the ANA staining patterns, and the presence or ab

84 ads to production of antinuclear antibodies (ANAs).

85 lerance and secreted antinuclear antibodies (ANAs).

86 oduction, including anti-nuclear antibodies (ANAs), frequently occur in ADA-SCID patients after treat

87 mosome 4 was linked to antinuclear antibody (ANA) and anti-double stranded DNA (dsDNA) antibody (Ab)

88 mercury biomarkers and antinuclear antibody (ANA) positivity and titer strength.

89 female preponderance, antinuclear antibody (ANA) positivity, and certain human leukocyte antigen typ

90 bead-based assays for antinuclear antibody (ANA) testing is a new clinical option.

91 ositive patients were anti-nuclear antibody (ANA) positive.

92 one of the classical anti-nuclear antibody (ANA) staining patterns.

93 ex (SLEDAI), serology (antinuclear antibody [ANA] and anti-double-stranded (ds) DNA), complement C3 a

94 (anti-LC1), antimitochondrial, antinuclear (ANA), and antiactin antibodies (AAA) were determined at

95 NCWS or CD develop autoimmune disorders, are ANA positive, and showed DQ2/DQ8 haplotypes compared wit

96 uring disease, as many patients with SLE are ANA negative at screening despite previously testing pos

97 trial results suggest that patients who are ANA negative might not respond to certain agents, screen

98 can Americans and European Americans who are ANA-negative (ANA-) healthy, ANA+ healthy, or have SLE u

99 une diseases, up to 20% of healthy women are ANA-positive (ANA+) and most will never develop clinical

100 ropic nanofluidic-filter (nanofilter) array (ANA) is a unique molecular-sieving structure for separat

101 e anisotropically patterned nanosieve array (ANA) structures.

102 ) and the American Neurological Association (ANA).

103 Circulating antinuclear autoantibodies (ANAs) typically found in autoimmune conditions, have als

104 iated with serum antinuclear autoantibodies (ANAs), T cell hyperactivity, and elevated CD4/CD8 ratios

105 Autoimmune ANA/ENA reference sera react preferentially with DS affi

106 NA positive, to explore associations between ANA and concentrations of dioxins, dibenzofurans, polych

107 We found that, compared with both ANA- and ANA+ healthy individuals, patients with SLE of

108 Austrobaileyales together form the so-called ANA-grade of angiosperms, which are extant representativ

109 e presence of abnormal nailfold capillaries, ANA, and anti-Scl-70 antibodies were related to an incre

110 nyl phenyl benzo (b)thiophene-2-carboxamide (ANA-12) into the dorsal medial NTS (dmNTS) of male Sprag

111 s and severe proteinuria without circulating ANA, anti-dsDNA, and antinucleosome Ab.

112 e eluates from these kidneys did not contain ANA, anti-dsDNA, and antinucleosome Ab, indicative of th

113 addressing the sequence strategy containing ANA in comparison with 5 years of TAM in a low- to inter

114 In contrast, ANA+ healthy African Americans exhibited elevated expres

115 compared to their nonpreferring counterpart ANA line.

116 the longer dication ANA-TFA(2+) and dianion ANA(2-) have closed-shell ground state, which can be exp

117 let diradicaloids, while the longer dication ANA-TFA(2+) and dianion ANA(2-) have closed-shell ground

118 genes, notably, Vkappa ai4 among anti-dsDNA ANAs, Vkappa23-45 among anti-ssDNA ANAs, and Vkappa21-12

119 An assay panel combining anti-dsDNA, ANA, anti-MCV, EC4d, and BC4d is sensitive and specific

120 manipulation of TLR9 gene dosage eliminates ANA in CD45E613R.BALB/c mice, but confoundingly permits

121 his method has the promise to greatly expand ANA testing in clinical settings for initial patient ass

122 xy-2'-fluoro-beta-D-arabinonucleic acid (2'F-ANA) sugar modification not only meet these criteria, bu

123 kemia cells with fully phosphorothioated 2'F-ANA-DNA chimeras (PS-2'FANA-DNA) and compared their gene

124 Therefore, our data demonstrate that PS-2'F-ANA-DNA chimeras are efficient gene silencing molecules,

125 mRNA and protein expression, but the PS-2'F-ANA-DNA were able to accomplish this at 20% of the dose

126 bia, Yale, and University College London for ANA presidents.

127 ctive study, serum samples were positive for ANA in 28% of subjects with NCWS, 7.5% of subjects with

128 ive study, serum samples tested positive for ANA in 46% of subjects with NCWS (median titer, 1:80), 2

129 t of splenic mononuclear cells isolated from ANA-positive Sle1ab mice with anti-IL-6 Ab or AG490, an

130 r characteristics that distinguish AHAs from ANAs, we tested additional mice for their aggression fol

131 Trk-B receptor inhibitor ANA-12, or FTY720 + ANA-12 from 1 to 4 months of age.

132 tal clusters within voids throughout the GIS-ANA transformation.

133 Vanilloids displaced [(3)H]ANA in VR1-expressing cells, suggesting competition for

134 ive antibodies including potentially harmful ANAs.

135 more than 32 million persons in the US have ANAs, and that the prevalence is higher among females, o

136 igher plasma levels of IL-6 than did healthy ANA+ European Americans.

137 that is absent in their SLE or even healthy ANA- counterparts, or among African American cohorts.

138 ) autoimmunity-associated B cells in healthy ANA+ European Americans that is absent in their SLE or e

139 ericans who are ANA-negative (ANA-) healthy, ANA+ healthy, or have SLE using single cell mass cytomet

140 of IgG plasma cells and protects against IgG ANAs.

141 In ANA-1 murine macrophages, LPS-mediated NO synthesis decr

142 In ANA-positive individuals, cellular staining patterns wer

143 In ANA-positive individuals, nuclear patterns were seen in

144 event transition to clinical autoimmunity in ANA+ healthy individuals.

145 icals of concern and should track changes in ANA and other autoantibodies over time.

146 investigations of predictors and changes in ANA prevalence over time.

147 Transcription of arcA, etrA, and crp in ANA-3 was similar in cells grown on arsenate and cells g

148 Deletion of cymA in ANA-3 also eliminated growth on and reduction of arsenat

149 There was no difference in ANA prevalence among morphea subtypes.

150 at this novel immune signature identified in ANA+ healthy European Americans may protect them from T-

151 The current increase in ANA requests is driven by broadening the use of ANA from

152 cya) proteins affect arsenate respiration in ANA-3.

153 s of Cys-30 and Cys-32 with Ser) resulted in ANA-3 strains that exhibited anaerobic growth deficienci

154 rate that the two As(V) reductase systems in ANA-3 respond to different amounts and types of inorgani

155 ior alcohol intake to escalate aggression in ANAs.

156 es associated with systemic lupus, including ANA formation and T cell hyperactivity.

157 mice were strongly associated with increased ANA-specific Ab-forming cells and ANA titers.

158 on in thymic epithelial cells did not induce ANAs, and that lack of H2-O expression in bone marrow-de

159 ehicle, FTY720, the Trk-B receptor inhibitor ANA-12, or FTY720 + ANA-12 from 1 to 4 months of age.

160 nt with neurotrophin receptor TrkB inhibitor ANA-12 and MEK inhibitor PD98059 attenuates the neurotro

161 ver, the non-competitive BDNF/TrkB inhibitor ANA-12 reduced E2-induced 4T1BR5 BM to levels similar to

162 zation of metal clusters containing GIS into ANA, which retained these metal clusters within voids th

163 ain agents, screening strategies now involve ANA and anti-DNA antibody testing to identify patients w

164 s investigated in the murine macrophage line ANA-1.

165 lonal antibodies rescued from the same mice, ANAs exhibited increased utilization of VH5/7183 genes a

166 databases, one consisting of 264 monoclonal ANAs and the other consisting of 145 non-ANAs, drawn fro

167 t support the clinical testing of monoclonal ANAs as a cancer therapy, if confirmed by further experi

168 Multiple ANA modifications within the sense strand were also well

169 and European Americans who are ANA-negative (ANA-) healthy, ANA+ healthy, or have SLE using single ce

170 nal ANAs and the other consisting of 145 non-ANAs, drawn from previously published work.

171 g anti-ssDNA ANAs, and Vkappa21-12 among non-ANAs.

172 ANAs and non-ANAs did not differ in Vkappa family or Jkappa gene usag

173 eferring AA rats compared with nonpreferring ANA rats.

174 ovel technique to detect naturally occurring ANA(+) B cells and plasma cells.

175 percent of females were ANA positive; 96% of ANA positives had a nuclear speckled staining pattern.

176 These actions of ANA were similar to the effects determined previously fo

177 y, and the designed structural anisotropy of ANA causes different-sized or charged biomolecules to fo

178 No significant associations of ANA with education, family income, alcohol use, smoking

179 redominant role of SHM in the development of ANA and underscore the importance of self-tolerance chec

180 With the exception of ANA, the autoantibody profile does not markedly vary in

181 However, the generation of ANA in itself is insufficient to account for the severit

182 bserved a major checkpoint for generation of ANA(+) IgG(+) plasma cells in both nonautoimmune mice an

183 C tolerance checkpoint and the generation of ANA-specific Ab-forming cells.

184 perillyl alcohol, suppressed the increase of ANA.

185 ed both hepatic fibrosis and serum levels of ANA and immune complexes.

186 Furthermore, bilateral microinjection of ANA-12 into the dmNTS greatly diminished baroreflex sens

187 and after bilateral dmNTS microinjections of ANA-12.

188 -encoding genes) in the DeltaarsR2 mutant of ANA-3 were increased in cells grown under anaerobic cond

189 erestingly, we observed increased numbers of ANA(+) IgG(+) plasma cells despite normal tolerance chec

190 Young age of onset, presence of ANA, and elevated ESR appeared to be predictive factors

191 e consistent with known toxicity profiles of ANA and TAM treatment.

192 Sequencing of ANA after identical 2-year treatment with TAM in both ar

193 marate was absent in the DeltacymA strain of ANA-3.

194 The synthesis of ANA requires higher crystallization temperatures (~415 K

195 ffinity of FANA considerably exceeds that of ANA.

196 se progression, despite equivalent titers of ANA.

197 In vivo treatment of ANA-positive B6.Sle1ab mice with the ras pathway inhibit

198 This was particularly true of ANA modifications at or near the 3' end of the sense or

199 requests is driven by broadening the use of ANA from a test for lupus to a test for diverse autoimmu

200 egy of 2 years of TAM followed by 3 years of ANA led to small outcome and toxicity benefits.

201 TAM or 2 years of TAM followed by 3 years of ANA.

202 ntal data favoring the antitumor activity of ANAs might support the clinical testing of monoclonal AN

203 Interestingly, the L chains of ANAs exhibited differential usage of certain complementa

204 ) tolerance checkpoint in the development of ANAs in these mice is not defined.

205 The frequencies of ANAs detected by a bead-based assay are lower than those

206 The frequencies of ANAs in the sera from African American, Hispanic, and Eu

207 en carried out to elucidate the functions of ANAs in cancer patients.

208 egions appears to be a prominent hallmark of ANAs.

209 From the PheWAS, the presence of ANAs was significantly associated with a diagnosis of Sj

210 Concordance for the presence of ANAs was significantly higher in MZ twins compared with

211 The prevalence of ANAs, AHAs, and ssDNA abs in patients with morphea was 3

212 Prevalence of ANAs, AHAs, ssDNA abs in patients with morphea vs matche

213 ld-type mice demonstrated that production of ANAs requires participation of CD4(+) T cells from H2-O(

214 The pathogenic role of ANAs in autoimmunity is well studied; however, little re

215 therapies has provided a new perspective on ANA expression during disease, as many patients with SLE

216 his model allowed us to demonstrate that one ANA clone was generated by SHM after a V(H) gene replace

217 ACA was the only ANA that demonstrated a definite bimodal distribution of

218 um was negative for antinuclear antibody (or ANA), cytoplasmic antineutrophil cvtoplasmic antibody (o

219 ad no effect on aggression in either AHAs or ANAs.

220 eristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subje

221 d significantly higher levels than the other ANA staining patterns in both RA and healthy population

222 ssociated nucleosome proteins, whereas other ANAs bind protein components of complexes of RNA and RNA

223 NA opposite RNA is preferred by RNase H over ANA, and the RNA affinity of FANA considerably exceeds t

224 E613R.BALB/c mice, but confoundingly permits ANA in CD45E613R.B6 mice.

225 5% of cage-mated CAST/ei mice had a positive ANA and none of the C3H/HeJ age-matched controls were po

226 proportion of Tsk2/+ animals with a positive ANA increased slightly with age.

227 up to 20% of healthy women are ANA-positive (ANA+) and most will never develop clinical symptoms.

228 xpected trifluoroacetic substituted product (ANA-TFA) was isolated.

229 is enriched for cells expressing prototypic ANA heavy chains in these mice in a non-autoimmune backg

230 enriched with B cells expressing prototypic ANA heavy chains.

231 stent biotypes (as determined with the RapID ANA II system); however, strains were misidentified, and

232 gnificantly enhanced disease despite reduced ANA titers.

233 epatic B lymphocytes and resulted in reduced ANA and immune complex titers.

234 Remarkably, ANAs were less common in overweight and obese individual

235 RIIB(-/-) ANA, by converting them to antinucleolar antibodies.

236 and significant improvement in SLEDAI score, ANA, anti-ds DNA, complement, and carbon monoxide diffus

237 and ANA, P = .005), and higher skin scores (ANA, P = .004).

238 elicited increased CD4/CD8 ratios and serum ANAs, 2 cardinal Sle3-associated phenotypes.

239 e parent duplex were synthesized with single ANA residues at each position on the strand, and the res

240 the framework types FAU, LTA, EMT, GIS, SOD, ANA, CAN, and JBW.

241 Some ANAs bind DNA or associated nucleosome proteins, whereas

242 Fe: 0.05; Fe tot: 32.1 mM) by Shewanella sp. ANA-3 (10(8) cells/mL) in the presence of different conc

243 phosphate deaminase AgaS from Shewanella sp. ANA-3 were validated in vitro using individual enzymatic

244 As a conclusion, ACA displays a specific ANA staining pattern with a bimodal distribution, and AC

245 nti-dsDNA ANAs, Vkappa23-45 among anti-ssDNA ANAs, and Vkappa21-12 among non-ANAs.

246 Values are comparable to a standard ANA test but require a total processing time of ~20min.

247 In this study using LPS-stimulated ANA-1 murine macrophages, we demonstrate that expression

248 n this study using a model of LPS-stimulated ANA-1 murine macrophages, we demonstrate that short rang

249 reduction pathways in Shewanella sp. strain ANA-3 are induced by arsenite and under anaerobic condit

250 on and activity of the Shewanella sp. strain ANA-3 arsenate respiratory reductase (ARR), the key enzy

251 ular respiration using Shewanella sp. strain ANA-3 as a model organism.

252 tion) in the bacterium Shewanella sp. strain ANA-3 specifically confers respiratory As(V) reductase a

253 In Shewanella sp. strain ANA-3, the arsenate respiration genes (arrAB) are induce

254 In Shewanella sp. strain ANA-3, utilization of arsenate as a terminal electron ac

255 arr and ars operons in Shewanella sp. strain ANA-3.

256 spiratory reduction in Shewanella sp. strain ANA-3.

257 stems are expressed in Shewanella sp. strain ANA-3.

258 bitor of STAT3 signaling pathway, suppressed ANA production in short-term culture, indicating that th

259 stant to letrozole (T+LET R), anastrozole (T+ANA R), and exemestane (T+EXE R), as well as long-term e

260 nt lines showed that LTEDaro, T+LET R, and T+ANA R cells contained a constitutively active estrogen r

261 onventional gel-based separation techniques, ANA offers the potential for faster separation, higher t

262 oxa)quinodimethanes with nine (ABA) and ten (ANA) consecutively fused six-membered rings.

263 < or = 6.5 are consistent with the idea that ANA and other eicosanoids act as endogenous ligands of V

264 Here we report that ANA-modified siRNAs targeting the MDR1 gene can exhibit

265 Mutation reversion analyses revealed that ANA arose predominantly from nonautoreactive B cells tha

266 Evidence suggests that ANA responses can decrease over time because of the natu

267 Our results demonstrate that ANAs and AHAs are more prevalent among patients with mor

268 The ANA consists of a two-dimensional periodic nanofilter ar

269 The ANA is physically robust and can be reused repeatedly.

270 The ANA prevalence in the US population of individuals ages

271 The ANA structures, composed of periodically patterned deep

272 bsence of antinuclear antibodies (ANAs), the ANA staining patterns, and the presence or absence of an

273 t 5'-exonuclease degradation afforded by the ANA modification.

274 the C57BL/6 genome that are required for the ANA phenotype, further indicating the epistatic properti

275 volunteers, we compared distributions of the ANA levels.

276 lementarity-determining region (CDR3) of the ANA originate from V(D)J recombination or somatic hyperm

277 ingly, the duration of action of some of the ANA-modified siRNAs was substantially greater than that

278 Using microfluidic channels surrounding the ANA, the fractionated biomolecule streams are collected

279 Together with the ANA data of 9,575 healthy volunteers, we compared distri

280 equence and chemical composition without the ANA modification.

281 antinuclear antibodies (ANA), and 50% of the ANAs are also reactive with a diverse group of antigens

282 Most intriguingly, the CDR3 regions of the ANAs exhibited alternating arginine/lysine peaks at H96,

283 We demonstrate that sensitivity to ANA is modulated by strength of TLR9 signal, because str

284 n the prefrontal cortex (PFC) as compared to ANAs while the two phenotypes expressed similar levels o

285 electrochemical method for quantifying total ANA for use as a point-of-care diagnostic aid.

286 cribe the fabrication of planar and vertical ANA chips and how to perform continuous-flow bioseparati

287 ination Survey (1999-2004), of whom 14% were ANA positive, to explore associations between ANA and co

288 Sixteen percent of females were ANA positive; 96% of ANA positives had a nuclear speckle

289 ts that the loss of activity associated with ANA modification of the 5'-antisense strand may be due t

290 alysis revealed that SLE was associated with ANA positivity (>/=20 units), anti-MCV negativity (</=70

291 ut not urinary, mercury were associated with ANA positivity (sample sizes 452, 1,352, and 804, respec

292 population are not strongly associated with ANA.

293 uced estimates of chemical associations with ANA in males, nulliparous females, and parous females; t

294 in regions of ethanol-naive AA compared with ANA rats.

295 r among ANA+ African Americans compared with ANA+ European Americans.

296 Duplexes with ANA modifications at appropriate positions in both stran

297 An Oligonucleotide with ANA at the 5' end was more stable in the presence of 5'-

298 The siRNA with ANA at position 7 in the seed region was active in a mou

299 end of the antisense strand, the siRNAs with ANA at position 6 or 7 in the seed region had activity c

300 of SLE in which all somatic mutations within ANA V regions, including those in CDR3, could be unequiv