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1 -deleted beta-catenin poorly colocalize with APC protein.
2 clusters and the absence of linear arrays of APC protein.
3 acids (aa) each in the central region of the APC protein.
4 tations in the microtubule-binding domain of APC protein.
5  expression of an N-terminal fragment of the APC protein.
6 pc in the mouse that yields complete loss of Apc protein.
7 epeats in the mutation cluster region of the APC protein.
8 ntestinal tumors that show loss of wild-type Apc protein.
9 ry for optimal nuclear import of full-length APC protein.
10 e the nuclear localization signals (NLSs) in APC protein.
11 th an Apc mutation that yields no detectable APC protein.
12  functionally distinct from the conventional APC protein.
13 ength APC, but not with mutant SW480 or HT29 APC proteins.
14 nvolve the cytoskeletal or adhesive roles of APC proteins.
15 eric coiled coil with mutant and full-length APC proteins.
16  cadherin or the adenomatous polyposis coli (APC) protein.
17 n, axin, and the Adenomatous Polyposis Coli (APC) protein.
18  multiple clones expressing different mutant APC proteins(1-4).
19 in also binds to adenomatous polyposis coli (APC) protein, a cytosolic protein that is the product of
20 n that binds the adenomatous polyposis coli (APC) protein, a tumour suppressor.
21 phase cells, the adenomatous polyposis coli (APC) protein accumulates on a small subset of microtubul
22                           Loss of functional APC protein activates the Wnt signal transduction pathwa
23  associated with adenomatous polyposis coli (APC) protein, an oncosuppressor, is implicated in the re
24 increased stability of beta-catenin bound to APC protein and E-cadherin, compared with full-length be
25 ates the dynamics of beta-catenin binding to APC protein and E-cadherin.
26                                              APC protein and GSK-3beta bind beta-catenin, retain it i
27 ity to bind to E-cadherin, alpha-catenin, or APC protein and to serve as a substrate for tyrosine kin
28 anges in beta-catenin binding to cadherin or APC protein, and the ensuing effects on cell morphology
29 P interacts with adenomatous polyposis coli (APC) protein, and is stabilized in both APC-mutated huma
30  Apc (Apc(+/+)) or with heterozygous loss of Apc protein (Apc(1638N)).
31 cally normal enterocytes bearing a truncated Apc protein (Apc(Min/+)) migrated more slowly in vivo th
32 fied carboxyl-terminal basic domain of human APC protein (APC-basic) bound directly to and bundled ac
33 onal fragment of adenomatous polyposis coli (APC) protein (APC-25) complexes with beta-cat, reduces b
34                   During normal development, APC proteins are essential negative regulators of Wnt si
35  activation by beta-catenin and suggest that APC proteins are required for the regulation of Wnt tran
36                   These results suggest that APC proteins are required not only for the activity of t
37                                The truncated APC proteins are, in general, stable and almost certainl
38 cells (expressing wild-type beta-catenin and APC proteins) are more sensitive to apoptosis induced by
39                                  A truncated APC protein associated with familial and sporadic colore
40 ta show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and tha
41 umulation of the adenomatous polyposis coli (APC) protein at the plus ends of leading-edge microtubul
42              The adenomatous polyposis coli (APC) protein, axin, and glycogen synthase kinase 3beta f
43                                          The APC protein binds to the cellular adhesion molecule beta
44 functional redundancies existing between the Apc proteins both in normal homeostasis and in tumorigen
45 cleavage of beta-catenin, gamma-catenin, and APC protein, but not alpha-catenin or E-cadherin.
46 ctions have been assigned to the multidomain APC protein, but the cellular effects of APC expression
47        Many functions have been proposed for APC proteins, but these have often rested on dominant-ne
48 teracts with the adenomatous polyposis coli (Apc) protein, but the functional significance of this in
49      Conversely, knocking down of endogenous APC protein by small interfering RNA (siRNA) blocked VPA
50           Cells were exposed for 1 minute to APC, protein C zymogen, or mutant Ser360Ala-APC, and [Ca
51 ed markedly increased expression of insulin, aPC/protein C, endothelial protein C receptor, and matri
52 tion of NH2-terminal deleted beta-catenin in APC protein clusters and the absence of linear arrays of
53 ta-catenin distribution between cadherin and APC protein complexes and the functions of these complex
54  including nucleoli, whereas the cytoplasmic APC protein concentrated at the leading edge of migratin
55                                              APC protein-containing membranes are actively involved i
56 ession status of adenomatous polyposis coli (APC) protein determines the relative sensitivity of colo
57                            Redistribution of APC protein did not depend on continual nuclear export.
58 match repair and adenomatous polyposis coli (APC) proteins, diet, inflammatory processes, and gut mic
59 We also tested the hypothesis that truncated APC proteins found in tumors are dominant negative.
60                                      Loss of APC protein function results in increased intracellular
61              The adenomatous polyposis coli (APC) protein functions as a negative regulator of the Wn
62 on of the full-length, approximately 320-kDa APC protein, further establishing that the two intrinsic
63           Together, these data indicate that APC protein has a role in directed cell migration.
64 he widely used Min mouse in which the mutant Apc protein has zero 20AARs.
65 nofluorescence microscopy placed full-length APC protein in both the nucleus and the cytoplasm.
66 l deletions also colocalize prominently with APC protein in clusters at the tips of plasma membrane p
67 l fractionation to determine the location of APC protein in epithelial cells.
68  intestinal architecture and the presence of APC protein in intestinal epithelial cells.
69  treatment rather than a general role of the APC protein in the mitotic spindle checkpoint.
70                                              APC proteins in both vertebrates and Drosophila contain
71 ried out the first assessment of the role of APC proteins in brain development, simultaneously inacti
72 des new insights into functions of truncated APC proteins in cancer.
73 ryos as a model, we investigated the role of APC proteins in CIN.
74 thers subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total
75 1 bound and sequestered wild-type and mutant APC proteins in extracts of human colon cancer cell line
76 ing in this process in C. elegans similar to APC proteins in other systems.
77 ole of wild-type adenomatous polyposis coli (APC) protein in native epithelia is poorly understood.
78 cipitates of full-length, but not truncated, APC protein include a mitosis-specific kinase activity i
79 pathways consistent with the function of the APC protein, including apoptosis, cell adhesion, cell mo
80 ation and indicate that dynamic beta-catenin-APC protein interactions are critical for regulating cel
81 e biochemical activities associated with the APC protein is down-regulation of transcriptional activa
82 on of beta-catenin binding to E-cadherin and APC protein is important in controlling epithelial cell
83                                     Although APC protein is located in both the cytoplasm and the nuc
84                                              APC protein is located in both the cytoplasm and the nuc
85 d beta-catenin associated with the wild-type APC protein is recruited to the SCF(beta-TrCP) complex,
86          The analysis of the normal roles of APC proteins is complicated by the presence of two APC f
87      Loss of the adenomatous polyposis coli (APC) protein is a common initiating event in colon cance
88                  Adenomatous polyposis coli (APC) protein is a large tumor suppressor that is truncat
89              The adenomatous polyposis coli (APC) protein is an important tumour suppressor in the co
90              The adenomatous polyposis coli (APC) protein is implicated in the majority of hereditary
91              The adenomatous polyposis coli (APC) protein is inactivated in most colorectal tumours.
92             The adenomatous polpyposis coli (APC) protein is mutated in most colorectal tumours.
93 S-containing transcript encoded an alternate APC protein isoform, we generated and affinity-purified
94 onventional APC, at least one of the four BS-APC protein isoforms also interacts with beta-catenin.
95                            In the intestine, APC protein levels increase at the crypt/villus boundary
96                                 We show that APC protein localizes mainly to clusters of puncta near
97               The carboxyl-terminal third of APC protein mediates direct interactions with microtubul
98 cleavage of beta-catenin, gamma-catenin, and APC protein might contribute to paclitaxel-induced apopt
99        We have previously suggested that the APC protein might modulate the frequency of mutations, s
100 are present in biliary tract cancers and the APC protein modulates levels of beta-catenin, we evaluat
101 the two intrinsic APC NESs are necessary for APC protein nuclear export.
102  both beta-cat and Axin, we hypothesize that APC proteins play an additional role in destructosome as
103 g cell migration is exerted by the truncated APC protein present in the Min/+ mouse.
104 modification for the APC TSG, because mutant APC proteins probably retain some function and the two h
105 ause loss of the C-terminal functions of the APC protein - probably involved in microtubule binding,
106 shifts resulting in nonfunctional, truncated APC protein products.
107             This subcellular distribution of APC protein requires microtubules, but not actin filamen
108                           Loss of functional APC protein results in the accumulation of beta-catenin.
109 s, simultaneous reduction in both Drosophila Apc proteins results in the global nuclear accumulation
110 ticoagulant response to activated protein C (APC):protein S in modified prothrombin time assays, the
111 hat the activities of the chimera and of the APC.protein S complex are equivalent because the active
112 ght of the fluorescein in the membrane-bound APC.protein S complex would be 84 A above the surface.
113 ioning it close to the 84 A observed for the APC.protein S complex.
114 ls correlated with anticoagulant response to APC/protein S (r = 0.47, P = 0.035), but not with activa
115         In normal plasma, added HDL enhanced APC/protein S anticoagulant activity in modified prothro
116 3)Cer) can enhance anticoagulant activity of APC/protein S by mechanisms that are distinctly differen
117 V for the inactivation of factor VIII by the APC/protein S complex.
118              The addition of human FV to the APC/protein S inactivation mixture increases by approxim
119 dase treatment reduced plasma sensitivity to APC:protein S in parallel with GlcCer reduction.
120 ified proteins, inactivation of factor Va by APC:protein S was enhanced by GlcCer alone and by GlcCer
121  plasma in the presence, but not absence, of APC:protein S, which suggests that GlcCer or Gb3Cer can
122 s that APC alleles with 5' mutations produce APC protein that down-regulates beta-catenin, inhibits b
123 the first Axin-binding SAMP repeat, yielding Apc proteins that are predicted to be deficient in desta
124 ion of intestinal stem cells that retain the APC protein; these effects are reversed by TGFB inhibito
125  The deltaN89beta-catenin accumulated on the APC protein to a level 10-fold over that of wild-type be
126 transport of the adenomatous polyposis coli (APC) protein to cortical sites.
127 dscape for aptamers binding allophycocyanin (APC) protein via a novel Closed Loop Aptameric Directed
128                                  The nuclear APC protein was concentrated in discrete subnuclear regi
129                       In addition, wild-type Apc protein was detected by immunohistochemistry in all
130                               When wild-type APC protein was expressed using an inducible expression
131 onation, which demonstrated that full-length APC protein was located in both the membrane/cytoskeleta
132                                  Full length Apc protein was not detected in the tumor cells from Min
133  parental cysts, adenomatous polyposis coli (APC) protein was localized in linear arrays and in punct
134                                       Mutant APC proteins were purified and characterized for their i
135 n activity when compared with tumors lacking Apc protein, which could lead to context-dependent inhib
136 petition for the adenomatous polyposis coli (APC) protein, which in other systems has been shown to p
137                            Colocalization of APC protein with rRNA confirmed a nucleolar localization
138  of these novel open reading frames predicts APC proteins with different amino-terminal domains and t
139 plicing of APC leads to alternative forms of APC proteins with potentially unique functions in growth
140 e interaction of adenomatous polyposis coli (Apc) protein with the plus ends of microtubules.

 
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