ライフサイエンスコーパス: Ascaris

1 serine protease inhibitors from the nematode Ascaris.

2 ased attention as a transmission pathway for Ascaris.

3 uclear RNA genes and the SL RNA homologue in Ascaris.

4 more open and accessible than is the case in Ascaris.

5 8)-like and gastrin-like immunoreactivity in Ascaris.

6 n observed in C. elegans but are not seen in Ascaris.

7 n different species of CCK-like molecules in Ascaris.

8 todes, and treatment failure is emerging for Ascaris.

9 pathways in the divergent parasitic nematode Ascaris.

10 ted with the piRNA pathway have been lost in Ascaris.

11 In Hb Ascaris, a hydrogen bonding network that includes the E7

12 The oxygen-avid, homooctameric hemoglobin of Ascaris (AH) has an unusual structure.

13 Ascaris ALG-4 and its associated 26G-RNAs target and lik

14 Sensitization to Ascaris and D. pteronyssinus was independently associate

15 th those recently described for the nematode Ascaris and mammalian hemoglobins, and more generally su

16 Sensitization to the cross-reactive Ascaris and mite tropomyosins partially underlies this f

17 eaks occur within the eliminated DNA in both Ascaris and Parascaris, ensuring chromosomal breakage an

18 chromosome break sites are conserved between Ascaris and Parascaris, whereas only 10% are conserved i

19 ar immune response to adult and larval-stage Ascaris antigens in young adults with moderate infection

20 me, as well as to investigate the ability of ascaris antigens to elicit a reaction in a humanized rat

21 Th1 and Th2 cytokines in response to control ascaris antigens were observed over the same period.

22 IgE responses to Ascaris are associated with asthma symptoms in a populat

23 nths or nematodes (hookworms, whipworms, and Ascaris) are roundworms that infect more than 1 billion

24 By using embryos of the parasitic nematode Ascaris as a model, we developed methods to introduce an

25 Ascaris beta-tubulin isotype A clusters with helminth be

26 The extent of natural cross-transmission of Ascaris between pig and human hosts in different geograp

27 antitative trait loci influence variation in Ascaris burden in humans.

28 Observed Ascaris counts (mean = -0.01 log(10) ova per wet gram of

29 Even in the absence of a piRNA pathway, Ascaris CSR-1 may still function to "license" as well as

30 Previous work on the parasitic nematode Ascaris demonstrated that programmed DNA elimination enc

31 e equilibrium conformational distribution of Ascaris dioxygen Hb.

32 We provide an ultrastructural analysis of Ascaris DNA elimination and show that eliminated DNA is

33 Furthermore, as determined by RT-PCR, Ascaris does not express the transcript of the neuronal

34 In addition, we modeled the viability of Ascaris eggs as a function of uncharged carboxylic acid

35 Then, we inactivated Ascaris eggs through exposure to these carboxylic acids.

36 ic acids at these concentrations inactivated Ascaris eggs when the pH was below the pKa for the acids

37 We propose interactions between Ascaris eIF4E and the SL impact eIF4G and contribute to

38 Additional interactions occur between Ascaris eIF4E and the SL on binding the m(2,2,7)G-SL.

39 Using an Ascaris embryo cell-free translation system, we found th

40 ss both DNA and RNA during several stages of Ascaris embryogenesis.

41 n will facilitate experimental strategies in Ascaris embryos complementing other biochemical tools av

42 been used to study parasite transmission in Ascaris-endemic and -nonendemic regions of the world.

43 A comparison of the two classes of Ascaris endo-siRNAs, 22G-RNAs and 26G-RNAs, to those in

44 The Ascaris enzyme contains 30 additional residues at its am

45 and/or commercial kits are available (e.g., Ascaris EVs), thus making it a valuable tool for the rap

46 At a genome-wide level, Ascaris exposure was associated with 23 differentially m

47 Ascaris exposure was associated with substantially lower

48 We investigated the associations of Ascaris exposure with lung function, asthma, and DNA met

49 itization is (1) common, (2) associated with Ascaris exposure, and (3) distinguished by a low percent

50 iated with rural living, antibody markers of Ascaris exposure, and total IgE, but not active infectio

51 erum levels of total IgE and specific IgE to Ascaris extract, Asc s 1 (ABA-1), Asc l 3 (tropomyosin)

52 the human specific T. trichiura species and Ascaris genus.

53 -C) to obtain fully assembled chromosomes of Ascaris germline and somatic genomes, enabling a complet

54 Prevalent enteric pathogens include Ascaris, Giardia, enterotoxigenic Escherichia coli, Shig

55 Here we show that Ascaris haemoglobin enzymatically consumes oxygen in a r

56 We propose that Ascaris haemoglobin functions as a 'deoxygenase', using

57 The structural and functional adaptations of Ascaris haemoglobin suggest that the molecular evolution

58 The results explain why Hb Ascaris has one of the highest oxygen affinities known (

59 Ascaris has ten Argonautes with five worm-specific Argon

60 uilibration within the distal heme pocket of Ascaris Hb and that the distribution of distal heme pock

61 e pocket conformers for the CO derivative of Ascaris Hb in the sol-gel is highly dependent on the his

62 rogen bonding interactions, and suggest that Ascaris Hb is uniquely designed for dioxygen capture.

63 of conformers in the dioxygen derivative of Ascaris Hb, by utilizing sol-gel encapsulation.

64 2) and distal residues in the oxy complex of Ascaris hemoglobin has been shown to result in a rigid s

65 high CO off rate relative to that of O(2) in Ascaris hemoglobin is attributed to a rapid equilibrium

66 A second Fe-CO stretching mode in Ascaris hemoglobin is observed at 515 cm(-1).

67 In contrast, the CO off rate in Ascaris hemoglobin is very similar to that in sperm whal

68 worms, infection intensity, types of worms (ascaris, hookworm, or trichuris), risk of bias, cluster

69 Serum Ascaris IgG antibodies were measured in 671 adults aged

70 provide an overview of the parasite nematode Ascaris, including the history of its role in biological

71 Ascaris-infected pigs had increased levels of liver mRNA

72 Foodborne Ascaris infection (12.3 million cases, 95% UI 8.29-22.0

73 ariants in a rural Chinese population, where Ascaris infection is prevalent, and an urban UK populati

74 We did not observe differences in Ascaris infection prevalence between the control group a

75 Compared to the control group, Ascaris infection prevalence was lower in the water trea

76 M-induced) allergic inflammation followed by Ascaris infection to demonstrate that allergic sensitiza

77 of H. pylori seropositivity, as was current Ascaris infection, in keeping with recent evidence from

78 tion drives a response that mimics a primary Ascaris infection, such that CD4+ Th2-mediated eosinophi

79 ar, significant effects on susceptibility to Ascaris infection.

80 However, human Ascaris infections in Europe were of pig origin, and the

81 e chain reaction confirmed the reductions in Ascaris infections measured by microscopy in the WSH and

82 dominated for many years in the treatment of Ascaris infections, but persistent use of BZs has alread

83 ribute to sustainable control strategies for Ascaris infections, particularly in similar settings wit

84 Ascaris infections, with a worldwide prevalence above 10

85 Ascaris is a large roundworm parasite that infects human

86 The appearance of anthelmintic resistance in Ascaris is a risk for the target of eliminating ascarias

87 prevalent, and an urban UK population where Ascaris is largely unknown but asthma and allergy are pr

88 resulting in the reversal of the HDM-induced Ascaris larval killing.

89 s, some of which are likely an adaptation to Ascaris' life cycle and parasitism.

90 atodes Ascaris suum, which infects pigs, and Ascaris lumbicoides, which infects humans.

91 matodes Trichuris trichiura (a whipworm) and Ascaris lumbricoides (a roundworm), respectively.

92 red beta-tubulin isotypes were identified in Ascaris lumbricoides and A. suum genomes.

93 The association between Ascaris lumbricoides and hookworm infestation and the ri

94 hiura, without compromising efficacy against Ascaris lumbricoides and hookworm.

95 accine CVD 103-HgR in children infected with Ascaris lumbricoides and investigated the effect of albe

96 Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection,

97 Secondary outcomes were Ascaris lumbricoides and Trichuris trichiura prevalence,

98 , and Entamoeba histolytica), and helminths (Ascaris lumbricoides and Trichuris trichiura), as well a

99 The ability of Ascaris lumbricoides antigen to elicit IgE-dependent rea

100 (OR 0.57) but greater parasite burdens with Ascaris lumbricoides at 5 years were associated with inc

101 an immunodeficiency virus type 1 (HIV-1) and Ascaris lumbricoides co-infection has led to significant

102 ces of beta-carotene, extra dietary fat, and Ascaris lumbricoides infection on serum retinol concentr

103 To define the cytokine response to Ascaris lumbricoides infection, the cellular immune resp

104 Ascaris lumbricoides infections was the most predominant

105 There was, however, evidence that Ascaris lumbricoides infections were associated with an

106 The roundworm Ascaris lumbricoides infects 0.8 billion people worldwid

107 The parasitic nematode Ascaris lumbricoides infects one billion people worldwid

108 finished flooring was associated with lower Ascaris lumbricoides prevalence (Bangladesh aPR 0.33, 95

109 Control and elimination of the parasite Ascaris lumbricoides relies on mass drug administration

110 itors found in the nonhematophagous nematode Ascaris lumbricoides var. suum.

111 In species-specific analysis, Ascaris lumbricoides was associated with significantly i

112 Ascaris lumbricoides was the most prominent species (13.

113 Infection with roundworm (Ascaris lumbricoides) is associated with earlier first b

114 susceptibility to infection with roundworm (Ascaris lumbricoides).

115 Infections with intestinal worms, such as Ascaris lumbricoides, affect hundreds of millions of peo

116 Infection with malaria, Trichuris trichiura, Ascaris lumbricoides, and hookworms were all associated

117 ination in the parasitic nematode of humans, Ascaris lumbricoides, and the parasitic nematode of dogs

118 minth infections in humans are attributed to Ascaris lumbricoides, and there are concerns over the an

119 Soil-transmitted helminths (hookworm, Ascaris lumbricoides, and Trichuris trichiura) are the m

120 nce predictions ranged from 5.0 to 23.8% for Ascaris lumbricoides, from 2.0 to 14.5% for hookworms, a

121 nfection with the soil-transmitted helminths Ascaris lumbricoides, hookworm (Ancylostoma duodenale an

122 Infections with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura)

123 Ascaris lumbricoides, Necator americanus, Trichuris tric

124 (>/=0.70 kU/L), whereas negative results for Ascaris lumbricoides, T gondii, herpes simplex virus, an

125 influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted i

126 ansmitted helminth infections (ie, hookworm, Ascaris lumbricoides, Trichuris trichiura) with the Kato

127 ions of improved WASH on infection with STH (Ascaris lumbricoides, Trichuris trichiura, hookworm [Anc

128 effects on parasite infections by measuring Ascaris lumbricoides, Trichuris trichiura, hookworm, and

129 a coli, Iodamoeba butschlii, Endolimax nana, Ascaris lumbricoides, Trichuris trichiura, Strongyloides

130 omic factors. The only STHs detected was for Ascaris lumbricoides, which was detected in 16% (12/74)

131 the live oral cholera vaccine CVD 103-HgR in Ascaris lumbricoides-infected subjects randomized in a d

132 ors during early development of the nematode Ascaris lumbricoides.

133 ajor zygotic gene activation in the nematode Ascaris lumbricoides.

134 of scaling up a STH MDA programme targeting Ascaris lumbricoides.

135 Third, the Tas retroviral envelope (Ascaris lumricoides) may have been obtained from Herpesv

136 Furthermore, Ascaris maintained for 5 days contained a significant am

137 Unlike the mammalian enzyme, the Ascaris malic enzyme is not regulated by ATP, and no ATP

138 The Ascaris motility machinery can be studied conveniently i

139 As in Ascaris, mutagenesis of the bulge nucleotide in stem-loo

140 Extending the study to the Ascaris mutants allows for examination of the effect of

141 all of the antibodies recognize epitopes, in Ascaris neurons, that include some or all of the C-termi

142 ot eggs from Fasciolopsis buski, Enterobius, Ascaris or Clonorchis sinensis.

143 whether infection with the common roundworm Ascaris or its bystander immunological effects influence

144 nd total IgE, but not active infections with Ascaris or Trichuris species.

145 Adult Ascaris organisms were obtained from humans and pigs in

146 0) per wet gram, sd = 1.1 log(10)), the high Ascaris ova counts in fecal sludges (prevalence = 88%; m

147 microscopy to enumerate presumptively viable Ascaris ova in feces, fecal sludges, and soils from comp

148 ting can result in a steady-state density of Ascaris ova in soils capable of sustaining transmission,

149 nd the extended persistence and viability of Ascaris ova in soils.

150 Comparisons of Ascaris, Parascaris, and Baylisascaris ascarid chromosom

151 Fractionation of Ascaris peptide extracts by high performance liquid chro

152 n conducting an analysis of variation within Ascaris populations from pig and human hosts across the

153 have any nematodes (prevalence ratio, 0.19), ascaris (prevalence ratio, 0.06), hookworm (prevalence r

154 ld explain why the soil-transmitted helminth Ascaris remains endemic despite nearly universal coverag

155 anaphylaxis, and inhibits airway tryptase in Ascaris-sensitized cynomolgus monkeys with favorable pha

156 also exhibited oral efficacy in a naturally Ascaris-sensitized sheep asthma model showing significan

157 nd logistic regressions were used to analyze Ascaris seropositivity as associated with lung function

158 Ascaris seropositivity was associated with lower FEV(1)

159 ts that chromosome fusions occurred, forming Ascaris sex chromosomes that become independent chromoso

160 g transmission, given the high prevalence of Ascaris shedding by children (prevalence = 25%; mean = 3

161 All new Ascaris somatic chromosome ends are recapped by de novo

162 s: the whipworm Trichuris sp., the roundworm Ascaris sp., the flatworm Dicrocoelium sp. and the fish

163 Ascaris species are soil-transmitted helminths that infe

164 Levels of total IgE, Ascaris-specific IgE, and alpha-gal IgE were measured in

165 Ascaris sperm cells lack actin and associated motors, an

166 The dynamics of the Ascaris sperm cytoskeleton can be studied in a cell-free

167 tein-based motility apparatus assembled from Ascaris sperm extracts.

168 Although Ascaris sperm locomotion closely resembles that seen in

169 Although Ascaris sperm motility closely resembles that seen in ma

170 ialization of the cell motility machinery of Ascaris sperm provides a powerful system in which to pro

171 In Ascaris sperm, protrusion and retraction are powered by

172 e developed an in vitro motility system from Ascaris sperm, unique amoeboid cells that use filament a

173 is consistent with its essential role in the Ascaris spliced leader RNA, whereas in Leptomonas mutati

174 Anti-Ascaris spp.

175 IgG4 and Ascaris spp.

176 describe the prevalence of Toxocara spp. and Ascaris spp. seropositivity and associations with allerg

177 as the morphine-like tissue localization in Ascaris, suggests that the endogenous morphine is intend

178 Mice were inoculated with Ascaris suum (A. suum) eggs concurrent with ragweed (RW)

179 emodeling after chronic antigen challenge in Ascaris suum (AA)-sensitized cats.

180 rotected mice recovering from infection with Ascaris suum against subsequent infection with the phylo

181 embryo development in the parasitic nematode Ascaris suum and compared them with known small RNAs of

182 were also found in two parasitic nematodes, Ascaris suum and Oesophagostomum dentatum.

183 f the DNA eliminating pig parasitic nematode Ascaris suum and the horse parasite Parascaris univalens

184 two such hemoglobins, one from the nematode Ascaris suum and the other from the sulfide-fixing clam

185 4.5%, respectively, 4 h after challenge with Ascaris suum antigen (Ag).

186 ore and serially after airway challenge with Ascaris suum antigen alone, or after pretreatment with a

187 before and 24 h after aerosol challenge with Ascaris suum antigen in seven sheep hypersensitive to th

188 r as long as 2 h after airway challenge with Ascaris suum antigen, without and after pretreatment wit

189 ergic sheep undergoing airway challenge with Ascaris suum antigen.

190 ly after, and up to 2 h after challenge with Ascaris suum antigen.

191 to six sheep with airway hypersensitivity to Ascaris suum antigen.

192 acute responses or dual responses to inhaled Ascaris suum antigen.

193 e, it is shown that the CCA-adding enzyme of Ascaris suum carries such a specific adaptation in form

194 The NAD-malic enzyme from Ascaris suum catalyzes the divalent metal ion-dependent

195 The parasitic worm Ascaris suum contains the opiate alkaloid morphine as de

196 onance (NMR) data indicate that the nematode Ascaris suum eIF4E binds the two different caps in a sim

197 -avid hemoglobin from the parasitic nematode Ascaris suum exhibits one of the slowest known O(2) off

198 ties of pseudocoelomic body fluid from adult Ascaris suum gastrointestinal helminths (ABF) and its de

199 AD-malic enzyme from the parasitic roundworm Ascaris suum has been studied using a steady-state kinet

200 he AF8 and AF2 neuropeptides of the nematode Ascaris suum have been identified, cloned, and sequenced

201 Pharmacological experiments on Ascaris suum have demonstrated the presence of three (N-

202 ecular studies in Caenorhabditis elegans and Ascaris suum have identified key steps and factors invol

203 er distribution in the distal heme pocket of Ascaris suum hemoglobin (Hb) studied by resonance Raman

204 n Fe-CO stretching mode in the CO complex of Ascaris suum hemoglobin as compared to vertebrate hemogl

205 during infection with the helminth parasite Ascaris suum in pigs.

206 In an Ascaris suum infection model in pigs, it was found that,

207 hat protection from allergic inflammation by Ascaris suum infection was characterized by a global inc

208 es infects 0.8 billion people worldwide, and Ascaris suum infects innumerable pigs across the globe.

209 Using PCR techniques, we detected, in Ascaris suum intestine, message for: Asu-trp-2, Asu-gon-

210 ing edge protrusion in the amoeboid sperm of Ascaris suum is driven by the localized assembly of the

211 fected mice were more resistant to migrating Ascaris suum larvae in the lungs.

212 The major sperm protein (MSP) of Ascaris suum mediates amoeboid motility by forming an ex

213 The major sperm protein (MSP) of Ascaris suum mediates amoeboid motility by forming an ex

214 The structure of the Ascaris suum mitochondrial NAD-malic enzyme in binary co

215 ectrophysiological and anatomical studies of Ascaris suum motor neurons demonstrated a strong correla

216 ructures of dimers and helical assemblies of Ascaris suum MSP has identified five conserved interacti

217 In vivo and in vitro studies of Ascaris suum MSP have demonstrated that motility occurs

218 d mutagenesis was used to change K199 in the Ascaris suum NAD-malic enzyme to A and R and Y126 to F.

219 meters of several active site mutants of the Ascaris suum NAD-malic enzyme was investigated to determ

220 carcinoma cell culture, raw bovine milk, and Ascaris suum nematode excretions), recovering size and s

221 al antibody, AF1-003, highly specific to the Ascaris suum neuropeptide AF1 (KNEFIRFamide), was genera

222 Diminution in the nematode Ascaris suum occurs during early embryonic cleavages and

223 Pigs infected with Ascaris suum or controls were given 100 microg (low-dose

224 no significant difference in inactivation of Ascaris suum ova in digesters operated at different soli

225 ed the fate of embryonated and unembryonated Ascaris suum ova in six laboratory-scale mesophilic (35

226 been used to study the kinetic mechanism of Ascaris suum phosphofructokinase (PFK) at pH 8.0 for the

227 The nematode Ascaris suum primarily infects pigs, but also causes dis

228 erm protein (MSP)-based amoeboid motility of Ascaris suum sperm requires coordinated lamellipodial pr

229 extracts from spermatozoa from the nematode Ascaris suum suggest that retraction forces are generate

230 racted development of the parasitic nematode Ascaris suum to provide a comprehensive time course of m

231 lecular weight SPIs originally isolated from Ascaris suum where they are believed to protect the para

232 The NAD-malic enzyme from Ascaris suum will utilize L-aspartate, (2S,3R)-tartrate,

233 as 4 and 24 h after inhalation challenge by Ascaris suum) abolished both late-phase bronchoconstrict

234 The hemoglobin from Ascaris suum, a parasitic nematode, has a spontaneous di

235 ptides in the nervous system of the nematode Ascaris suum, AMRNALVRFamide (AF21), NGAPQPFVRFamide (AF

236 y important parasites, Toxoplasma gondii and Ascaris suum, and gene expression in 11 different tissue

237 ester (L-NAME) before aerosol challenge with Ascaris suum, and the effect on antigen-induced airway r

238 e of the mitochondrial NAD-malic enzyme from Ascaris suum, in a quaternary complex with NADH, tartron

239 Early development of the parasitic nematode, Ascaris suum, occurs inside a highly resistant eggshell,

240 hes in the genome of the parasitic nematode, Ascaris suum, revealed a chimeric protein that is simila

241 oduction of branched acids in the roundworm, Ascaris suum, that demonstrates selectivity for forming

242 two closely related parasites, the nematodes Ascaris suum, which infects pigs, and Ascaris lumbicoide

243 r macrophages, and airway-derived cells from Ascaris suum-allergic cynomolgus monkeys did not produce

244 the nervous system of the parasitic nematode Ascaris suum.

245 in the nematodes Caenorhabditis elegans and Ascaris suum.

246 l acid residues of the NAD-malic enzyme from Ascaris suum.

247 mplex (PDC) of the adult parasitic nematode, Ascaris suum.

248 otonin-like immunoreactivity in the nematode Ascaris suum.

249 mintic properties against the swine nematode Ascaris suum.

250 in vitro in cell-free extracts of sperm from Ascaris suum: inside-out vesicles derived from the plasm

251 ode small RNAs as well as features unique to Ascaris that illustrate significant flexibility in the u

252 However, in the nematode Ascaris the zygotic genome is never silent, and the mate

253 os from the human and pig parasitic nematode Ascaris to characterize the DSBs.

254 supporting further investigation of zoonotic Ascaris transmission in the United States.

255 dilutions of specimens containing Entamoeba, Ascaris, Trichuris, and hookworm.

256 tion may allow for sustained transmission of Ascaris under these conditions.

257 Ascaris WAGO small RNAs demonstrate target plasticity ch

258 similarity, suggesting that the intestine of Ascaris will also be sensitive to DEC.

259 Ascaris worm burden as assessed by egg counts was measur

260 the transmission dynamics and speciation of Ascaris worms from humans and pigs that are of importanc

261 We sequenced 54 whole-genomes from Ascaris worms obtained from individuals in a longitudina