ライフサイエンスコーパス: B-cell antigen receptor

1 a lower threshold for activation through the B cell antigen receptor.

2 these cells in response to cross-linking the B cell antigen receptor.

3 22 modulates signal transduction through the B cell antigen receptor.

4 ues from the cancer microenvironment and the B cell antigen receptor.

5 tiple tyrosines after the aggregation of the B cell antigen receptor.

6 on is suppressed upon activation through the B cell antigen receptor.

7 s in the signaling pathways activated by the B cell antigen-receptor.

8 or capable of modulating signals through the B-cell antigen receptor.

9 egatively regulates B-cell activation by the B-cell antigen receptor.

10 signal transduction machinery coupled to the B-cell antigen receptor.

11 n B lymphocytes following aggregation of the B-cell antigen receptor.

12 til now was thought to be mediated mainly by B cell antigen receptors.

13 TAM)-coupled receptors, including the T- and B-cell antigen receptors.

14 ion pathway is similar to that of the T- and B-cell antigen receptors.

15 Thus, CD19 functions as a B cell antigen receptor accessory molecule that modifies

16 B-cell antigen receptor accumulates at the synapse, segr

17 , FcgammaRIIB, provides a signal that aborts B cell antigen receptor activation, blocking extracellul

18 eates distinct signaling effectors following B cell antigen receptor activation.

19 Ligation of the B cell antigen receptor also induced tyrosine phosphoryl

20 phoblastoid cells lack signaling through the B cell antigen receptor and concluded that the fault in

21 transmembrane signals generated through the B cell antigen receptor and other surface molecules regu

22 eficiency altered calcium response evoked by B cell antigen receptors and impaired CD40-evoked prolif

23 re lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repa

24 Constitutive signal transduction by B cell antigen-receptors and/or their surrogates appears

25 Plasma cells no longer express a B-cell antigen receptor and are hence deprived of signal

26 Soluble antigen binds to the B-cell antigen receptor and is internalized for subseque

27 is present in the cytoplasmic tail of T- and B-cell antigen receptors and mediates signaling during l

28 hat show enriched expression of autoreactive B-cell antigen receptors and that produce several types

29 gement of immunoreceptors such as T-cell and B-cell antigen receptors and the Fc receptors on mast ce

30 cell malignancies depend on signals from the B-cell antigen receptor, and Bruton tyrosine kinase (BTK

31 thus blocking production of both T cell and B cell antigen receptors; (b) syngeneic group in which t

32 Nfkb1(SSAA) mutation decreased B cell antigen receptor (BCR) activation of NF-kappaB in

33 ERK activity and CLL proliferation required B cell antigen receptor (BCR) activation, as inhibition

34 ergoes a rapid tyrosine phosphorylation upon B cell antigen receptor (BCR) activation.

35 oduce substantial amounts of IL-10 following B cell antigen receptor (BCR) activation.

36 controlled by signals generated through the B cell antigen receptor (BCR) and are associated with ch

37 itional and mature B cells requires both the B cell antigen receptor (BCR) and BLyS receptor 3 (BR3),

38 B cell antigen receptor (BCR) and CD40 signaling are rew

39 the relationship between the affinity of the B cell antigen receptor (BCR) and the immune response to

40 ive B cells via sequential engagement of the B cell antigen receptor (BCR) and Toll-like receptor (TL

41 splenic mouse B cells stimulated through the B cell antigen receptor (BCR) and/or CD38, a BCR corecep

42 Signals propagated through the B cell antigen receptor (BCR) are vital for the developm

43 ng pathways induced by the engagement of the B cell antigen receptor (BCR) as a negative regulator.

44 B cell antigen receptor (BCR) association with lipid raf

45 l-known mediator of inhibitory signals after B cell antigen receptor (BCR) coaggregation with the low

46 arry on their surface multiple copies of the B cell antigen receptor (BCR) comprising the membrane-bo

47 B cell antigen receptor (BCR) cross-linking activates bo

48 B cell antigen receptor (BCR) cross-linking activates th

49 SHIP is rapidly tyrosine phosphorylated upon B cell antigen receptor (BCR) cross-linking and forms a

50 cipitated with anti-Shc antibodies following B cell antigen receptor (BCR) cross-linking or interleuk

51 Signal transduction by the ligated B cell antigen receptor (BCR) depends on the preorganiza

52 Recognition of antigen by the B cell antigen receptor (BCR) determines the subsequent

53 Cross-linking B cell antigen receptor (BCR) elicits early signal trans

54 The signal transduction events supporting B cell antigen receptor (BCR) endocytosis are not well u

55 B cell antigen receptor (BCR) engagement led to the prog

56 ivation of Akt by multiple stimuli including B cell antigen receptor (BCR) engagement requires phosph

57 of premalignant splenic B cells by means of B cell antigen receptor (BCR) engagement resulted in sig

58 cellular calcium mobilization in response to B cell antigen receptor (BCR) engagement.

59 Btk and BAP-135 exist in a complex before B cell antigen receptor (BCR) engagement; in response to

60 The B cell antigen receptor (BCR) functions to initiate sign

61 for MBC survival, but a requirement for the B cell antigen receptor (BCR) has not been tested.

62 Ligation of the B cell antigen receptor (BCR) induces a cascade of signa

63 Binding of antigen to the B cell antigen receptor (BCR) initiates a multitude of e

64 Antigen binding to the B cell antigen receptor (BCR) initiates an array of sign

65 Ligation of the B cell antigen receptor (BCR) initiates humoral immunity

66 The binding of antigen to the B cell antigen receptor (BCR) initiates two major cellul

67 Affinity maturation of the B cell antigen receptor (BCR) is a conserved and crucial

68 The B cell antigen receptor (BCR) is a large complex that co

69 Signaling through the B cell antigen receptor (BCR) is amplified and prolonged

70 The B cell antigen receptor (BCR) is composed of a membrane-

71 The B cell antigen receptor (BCR) is coupled to the mobiliza

72 Signal transduction through the B cell antigen receptor (BCR) is determined by a balance

73 In this disease, the B cell antigen receptor (BCR) is intimately linked to di

74 this study, we demonstrate that ligation of B cell antigen receptor (BCR) leads to activation of Akt

75 Cross-linking of the B cell antigen receptor (BCR) leads to the activation of

76 f cytosolic Ca(2+) following ligation of the B cell antigen receptor (BCR) led to the assumption that

77 B cell antigen receptor (BCR) ligation leads to receptor

78 Bam32 is tyrosine-phosphorylated upon B cell antigen receptor (BCR) ligation or pervanadate st

79 d stimulation, antigen aggregation occurs in B cell antigen receptor (BCR) microclusters containing i

80 ow that ligation of either beta1 integrin or B cell antigen receptor (BCR) on human tonsillar B cells

81 Cross-linking of the B cell antigen receptor (BCR) on immature WEHI 231 B cel

82 murine strains, sequential engagement of the B cell antigen receptor (BCR) on the cell surface and to

83 Crosslinking of the B cell antigen receptor (BCR) or the mast cell Fcepsilon

84 Signals transduced by the B cell antigen receptor (BCR) play a central role in reg

85 The B cell antigen receptor (BCR) plays a central role in th

86 The establishment of a diverse B cell antigen receptor (BCR) repertoire by V(D)J recomb

87 In B cells, stimulation of the B cell antigen receptor (BCR) results in the production

88 How different classes of the B cell antigen receptor (BCR) sense viral antigens used

89 The B cell antigen receptor (BCR) serves both to initiate si

90 s the BLNK (B cell linker) linker protein in B cell antigen receptor (BCR) signal transduction and B

91 B cell activation is regulated by B cell antigen receptor (BCR) signaling and antigen inte

92 or on the surface of B cells that attenuates B cell antigen receptor (BCR) signaling and, therefore,

93 T cell antigen receptor (TCR) and B cell antigen receptor (BCR) signaling are initiated an

94 Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essent

95 ine phosphatase CD45 plays a crucial role in B cell antigen receptor (BCR) signaling by activating Sr

96 Notch2 and B cell antigen receptor (BCR) signaling determine whethe

97 s Cbl-b functions as a negative regulator of B cell antigen receptor (BCR) signaling during the norma

98 The strength of B cell antigen receptor (BCR) signaling in response to a

99 1 complex functions to significantly enhance B cell antigen receptor (BCR) signaling in response to c

100 anism of Lin28b action nor the importance of B cell antigen receptor (BCR) signaling in this process

101 B cell antigen receptor (BCR) signaling is critical for

102 ronic exposure to self-antigens desensitizes B cell antigen receptor (BCR) signaling on anergic B cel

103 D40 delivers costimulatory signals alongside B cell antigen receptor (BCR) signaling to regulate affi

104 , the Fc gammaRIIB1 is a potent inhibitor of B cell antigen receptor (BCR) signaling when coligated t

105 ted in the regulation of genes important for B cell antigen receptor (BCR) signaling.

106 were generated to analyze the role of Lyn in B cell antigen receptor (BCR) signaling.

107 ubpopulation of lymphoma cells with impaired B cell antigen receptor (BCR) signaling.

108 B cell antigen receptor (BCR) signals induce Syk activat

109 To explore the role of B cell antigen receptor (BCR) specificity in driving B1

110 In addition, B cell antigen receptor (BCR) stereotypes as defined by

111 rogression, and proliferation in response to B cell antigen receptor (BCR) stimulation.

112 s tyrosine phosphorylated and activated upon B cell antigen receptor (BCR) stimulation.

113 ablished that BTK transmits signals from the B cell antigen receptor (BCR) to transcription factor NF

114 atibility complex class II molecules and the B cell antigen receptor (BCR) transduce similar signals

115 Binding of antigen to the B cell antigen receptor (BCR) triggers both BCR signalin

116 Binding of antigen to the B cell antigen receptor (BCR) triggers signaling that ul

117 studies of the structure and function of the B cell antigen receptor (BCR) used by these leukemic cel

118 Nck bound directly to the B cell antigen receptor (BCR) via the non-immunoreceptor

119 Ligation of the B cell antigen receptor (BCR) with antigen induces lipid

120 s such as the T cell antigen receptor (TCR), B cell antigen receptor (BCR), and Fc receptors uses the

121 e kinase is essential for signaling from the B cell antigen receptor (BCR), and thus for antibody res

122 IRF8 dampened signaling via the B cell antigen receptor (BCR), facilitated antigen-speci

123 cell development requires expression of the B cell antigen receptor (BCR), it remains unclear whethe

124 Within the B cell antigen receptor (BCR), the cytoplasmic tails of

125 sphotyrosine phosphatase that down-regulates B cell antigen receptor (BCR)- and CD19-generated signal

126 ing ligand (APRIL), which are related, block B cell antigen receptor (BCR)-induced apoptosis upstream

127 e Bam32(-/-) cells exhibited lower levels of B cell antigen receptor (BCR)-induced calcium mobilizati

128 Over the past several decades, B cell antigen receptor (BCR)-induced signaling pathways

129 reportedly mediated in part by inhibition of B cell antigen receptor (BCR)-mediated p21ras activation

130 nctions as a Ca2+ release channel during the B cell antigen receptor (BCR)-stimulated Ca2+ signaling

131 gnaling by multiple receptors, including the B cell antigen receptor (BCR).

132 blished in mature B cells stimulated via the B cell antigen receptor (BCR).

133 l transducer of signals originating from the B cell antigen receptor (BCR).

134 ponses are signaled by receptors such as the B cell antigen receptor (BCR).

135 ose effects are switched by signals from the B cell antigen receptor (BCR).

136 zygote for CD19, a crucial coreceptor of the B cell antigen receptor (BCR).

137 ling from BAFFR, a receptor for BAFF and the B cell antigen receptor (BCR).

138 (Dok-3) attenuates signals transduced by the B cell antigen receptor (BCR).

139 ies by selection of somatically hypermutated B cell antigen receptors (BCR) on immune complexes (ICs)

140 periments suggest that Ikaros and Aiolos set B cell antigen-receptor (BCR)- and TCR-mediated signalin

141 s respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through

142 enes encoding the variable (V) region of the B-cell antigen receptor (BCR) are assembled from V, D (d

143 Signals through the B-cell antigen receptor (BCR) are important for the surv

144 se human tonsillar B cells ligated via their B-cell antigen receptor (BCR) but not proliferation via

145 crobial molecules, enhance signalling by the B-cell antigen receptor (BCR) by activating the actin-se

146 Mature B cells coexpress both IgM and IgD B-cell antigen receptor (BCR) classes, which are organiz

147 CD22 can interact with both the B-cell antigen receptor (BCR) complex and signalling mol

148 Similar to resting mature B cells, where the B-cell antigen receptor (BCR) controls cellular survival

149 Finally, B-cell antigen receptor (BCR) cross-linking was less sen

150 CD19 is rapidly phosphorylated upon B-cell antigen receptor (BCR) cross-linking, leading to

151 nt of extracellular calcium influx following B-cell antigen receptor (BCR) cross-linking.

152 ease glucose uptake and glycolysis following B-cell antigen receptor (BCR) crosslinking.

153 B-cell antigen receptor (BCR) expression is a key featur

154 Cross-linking of the B-cell antigen receptor (BCR) induces tyrosine phosphory

155 Engagement of the B-cell antigen receptor (BCR) initiated by the Src kinas

156 The B-cell antigen receptor (BCR) internalizes bound antigen

157 Antigenic stimulation through the B-cell antigen receptor (BCR) is considered to promote t

158 an early event in signal transduction by the B-cell antigen receptor (BCR) is its translocation to sp

159 Binding of antigen to B-cell antigen receptor (BCR) leads to antigen internali

160 Following B-cell antigen receptor (BCR) ligation, the cytoplasmic

161 T-independent type II immune responses, and B-cell antigen receptor (BCR) proliferative responses.

162 Kinases downstream of B-cell antigen receptor (BCR) represent attractive targe

163 osis with CD40 stimulation, independent of a B-cell antigen receptor (BCR) rescue signal.

164 ed kinase (Erk) activation mediated by tonic B-cell antigen receptor (BCR) signaling and that this si

165 e cooperation between MYC overexpression and B-cell antigen receptor (BCR) signaling for the initiati

166 aracterizing the immature B-cell response to B-cell antigen receptor (BCR) signaling in vitro and in

167 In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical for

168 Activation of the B-cell antigen receptor (BCR) signaling pathway contribu

169 regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR) signaling through modulati

170 ways to gene activation and are activated by B-cell antigen receptor (BCR) signaling, we examined whe

171 In immature B lymphocytes, B-cell antigen receptor (BCR) signalling stimulates immu

172 ls are selected for an intermediate level of B-cell antigen receptor (BCR) signalling strength: atten

173 Small-molecule drugs that target the B-cell antigen receptor (BCR) signalosome show clinical

174 B-cell antigen receptor (BCR) signals are crucial for in

175 des a transcription factor (EGR1) that links B-cell antigen receptor (BCR) signals to downstream acti

176 CD21 and CD35) on B cells cooperate with the B-cell antigen receptor (BCR) to efficiently recognize a

177 Studies of model B-cell antigen receptor (BCR) transgenic systems have hi

178 raction of a B cell expressing self-specific B-cell antigen receptor (BCR) with an auto-antigen resul

179 in-positive B cells (Ramos), ligation of the B-cell antigen receptor (BCR) with anti-IgM antibodies c

180 proteins, pro-apoptotic family members, the B-cell antigen receptor (BCR), and histone deacetylase.

181 Remarkably, when antigen is bound to the B-cell antigen receptor (BCR), processing can trigger a

182 the nature of negative responses through the B-cell antigen receptor (BCR), we have screened an expre

183 ed into cytoplasmic signaling events through B-cell antigen receptor (BCR)-based signalosomes at the

184 al experiments have invoked a model in which B-cell antigen receptor (BCR)-Fc receptor for immunoglob

185 The influence of ligand:receptor affinity on B-cell antigen receptor (BCR)-induced apoptosis in the I

186 Concomitant FcRH1 ligation enhances B-cell antigen receptor (BCR)-induced Ca(2+) mobilizatio

187 PKCbeta is indispensable for B-cell antigen receptor (BCR)-induced NF-kappaB activati

188 B-cell antigen receptor (BCR)-mediated signaling plays a

189 tion compromises the activity of the pivotal B-cell antigen receptor (BCR)-proximal effector spleen t

190 KD3, which are both rapidly activated by the B-cell antigen receptor (BCR).

191 les in initiating signal transduction by the B-cell antigen receptor (BCR).

192 responses following stimulation through the B-cell antigen receptor (BCR).

193 rmine the role of TRAF3 in signaling via the B-cell antigen receptor (BCR).

194 signaling pathways, some emanating from the B-cell antigen receptor (BCR).

195 y mutated IgV genes, with strikingly similar B cell antigen receptors (BCRs) arising from the use of

196 Surface expression of B cell antigen receptors (BCRs) containing Ig and Igalph

197 Studies of B cell antigen receptors (BCRs) expressed by leukemic ly

198 s diversified B cell pools and high-affinity B cell antigen receptors (BCRs) for pathogen clearance.

199 y chain (IgH) and light chain (IgL) of their B cell antigen receptors (BCRs).

200 rvival and transcription of IgG2a-containing B cell antigen receptors (BCRs).

201 ursors of these antibodies act as functional B-cell antigen receptors (BCRs) that initiate subsequent

202 ate an extraordinarily diverse repertoire of B-cell antigen receptors (BCRs).

203 ell survival relies on signals transduced by B-cell antigen receptors (BCRs).

204 Gnathostomes use T- and B-cell antigen receptors belonging to the immunoglobulin

205 reus (SpA), a virulence factor with targeted B cell antigen receptor-binding properties, we found tha

206 for optimal cell surface expression of mIgE B-cell antigen receptors but not for intracellular IgE e

207 of immature B cells after engagement of the B cell antigen receptor by suppressing the expression of

208 ivated B cells diversify variable regions of B cell antigen receptors by somatic hypermutation in ger

209 in a dose-dependent fashion, also reduced a B-cell antigen receptor calcium signal, indicating this

210 In some cells, ligating the B cell antigen receptor can protect the cell from apopto

211 r Bob-1) is regulated synergistically by the B-cell antigen receptor, CD40L and interleukin signaling

212 s of D mu chain with other components of the B cell antigen receptor complex and suggest possible mec

213 The B cell antigen receptor complex contains heterodimers of

214 intensity to that induced by the endogenous B cell antigen receptor complex.

215 al for Ig-mediated B-cell activation via the B-cell antigen receptor complex (BCR) on human and murin

216 y signals derived from the surface expressed B cell antigen receptor controls B cell development, sur

217 ions affecting Toll-like receptor signaling, B-cell antigen receptor coreceptors (eg, CD19), or enzym

218 Proliferative response to B cell antigen receptor cross-linking in vitro was chose

219 The same two sites were phosphorylated upon B cell antigen receptor cross-linking.

220 m Staphylococcus aureus (SpA) interacts with B cell antigen receptors encoded by variable region heav

221 ntibodies requires additional stimulation by B cell antigen receptor engagement and IL-15.

222 CD22 phosphorylation is an early event of B cell antigen receptor engagement and results in the re

223 ted the phosphorylation of Akt downstream of B cell antigen receptor engagement in SHIP1-null DT40 B

224 individuals, indicating strong selection of B cell antigen receptors even in the absence of microbio

225 Co-ligation of wild-type PECAM-1 with the B-cell antigen receptor expressed on chicken DT40 B cell

226 or zeta, CD3epsilon, CD3delta, and CD3gamma, B cell antigen receptor Igalpha and Igbeta, and Fc recep

227 between CD38 and components of the IgM class B cell antigen receptor (IgM-BCR) and its coreceptor com

228 n response to activation signals through the B cell antigen receptor in the presence of CD40 engageme

229 in intact cells following aggregation of the B-cell antigen receptor in a reaction that was inhibited

230 ntial deficit in both lipopolysaccharide and B cell antigen receptor-induced proliferation and signal

231 the marginal zone B cell population, optimal B cell antigen receptor-induced proliferation, and B cel

232 e biochemical pathways involved in directing B cell antigen receptor-induced signals to processes lea

233 In normal B cells, antigen receptor-induced NF-kappaB activation r

234 signaling event following activation of the B cell antigen receptor is phosphorylation of the CD79a

235 Here, we generated humanized B cell antigen receptor knock-in mouse models to test wh

236 We demonstrate that signaling by B cell antigen receptors leads to distinct and mutually

237 Aggregation of the B-cell antigen receptor leads to the activation of the 7

238 B cell antigen receptor ligation resulted in enhanced ty

239 ive regulation of calcium mobilization after B cell antigen receptor ligation, CD22 phosphorylation,

240 provided evidence that signaling through the B cell antigen receptor may play a role in the clinicall

241 d tonsillar B cells with anti-CD95 abolished B cell antigen receptor-mediated calcium mobilization.

242 ll lymphoma line, Daudi, less susceptible to B cell antigen receptor-mediated cell death, responded t

243 pha phosphorylation correlates with impaired B cell antigen receptor-mediated induction of the pro-su

244 for both T and B cell development and T and B cell antigen receptor-mediated signal transduction.

245 BTK plays a nonredundant and pivotal role in B cell antigen receptor-mediated STAT5A activation in B

246 sphorylation of RAFTK following integrin- or B cell antigen receptor-mediated stimulation was decreas

247 In B cells, antigen receptor-mediated death can be rescued

248 B-cell antigen receptor mediates the gathering of antige

249 the clonal structure, with higher-centrality B cell antigen receptors more likely to be detected acro

250 immunoglobulin G internalized as antigens by B cell antigen receptors or transfected Fc receptors.

251 eceptors, a consequence of coligation of the B-cell antigen receptor or Fc(epsilon)RI, respectively,

252 In addition, we present the B Cell Antigen Receptor Pathway, an STKE Connections Map

253 r-292 or -492 demonstrate hyperactive T- and B-cell antigen receptor phenotypes.

254 These results indicate that the mIgE B-cell antigen receptor plays a critical role in establi

255 requires expression of the precursor to the B cell antigen receptor (pre-BCR) and escape from signal

256 Signals through the pre-B cell antigen receptor (pre-BCR) and interleukin 7 rece

257 7 receptor (IL-7R) and the precursor to the B cell antigen receptor (pre-BCR) in B lymphopoiesis has

258 In B lymphopoiesis, activation of the pre-B cell antigen receptor (pre-BCR) is associated with bot

259 signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in

260 through the pre-B stage triggered by the pre-B-cell antigen receptor (pre-BCR).

261 ymerase delta (Poldelta) complex, and T- and B-cell antigen receptor repertoire analysis.

262 tracing using single-cell RNA sequencing and B cell antigen receptor sequencing in spleen and bone ma

263 Single-cell T cell and B cell antigen receptor-sequencing data analysis can pot

264 ormed the analysis of single-cell T cell and B cell antigen receptor-sequencing data.

265 to regulate Src kinases required for T- and B-cell antigen receptor signal transduction.

266 rowth factor signaling in endothelium and in B cell antigen receptor signaling in B lymphocytes.

267 show that CD19 plays a key accessory role in B cell antigen receptor signaling independent of CR2 col

268 onstrate that Btk is a limiting component of B cell antigen receptor signaling pathways and suggest t

269 CD22, a negative regulator of B cell antigen receptor signaling, binds glycoconjugates

270 s and B cells with mutations that exaggerate B cell antigen receptor signaling.

271 evelopmental or differentiation state of the B cell, antigen receptor signaling can promote either ap

272 LV-treated B cells exhibited enhanced B-cell antigen receptor signaling and an in vivo selecti

273 The negative regulation of T- or B-cell antigen receptor signaling by CD5 was proposed ba

274 ells, and the crucial requirement for strong B-cell antigen receptor signaling in the maturation of B

275 ses (PTKs), the Src- and Syk-PTKs, in T- and B-cell antigen receptor signaling.

276 required for pre-B cell clonal expansion and B-cell antigen receptor signaling.

277 the absence of Syk, a kinase that transduces B cell antigen receptor signals required for positive se

278 CD79a and CD79b function as transducers of B cell antigen receptor signals via a cytoplasmic sequen

279 AF2 participates in synergy between CD40 and B cell antigen receptor signals, and in CD40-mediated, T

280 e-phosphorylated following beta1 integrin or B cell antigen receptor stimulation in human B cells.

281 uclear receptors that are rapidly induced by B cell antigen receptor stimulation.

282 Crosslinking of the B cell antigen receptor surface immunoglobulin induces t

283 tyrosine in response to cross-linking of the B cell antigen receptor, thereby generating phosphotyros

284 re B cells, can be rescued by creating a new B cell antigen receptor through nested secondary immunog

285 y which miRNAs regulate signal downstream of B cell antigen receptor to prevent aberrant activation a

286 s functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host de

287 n, and involving synergistic stimulation via B-cell antigen receptors, toll-like receptor 7 (TLR7), a

288 ditional role for mTORC1 was revealed when a B-cell antigen receptor transgene was found to circumven

289 Previous work using B cell antigen receptor transgenic animals suggested tha

290 Ligation of the B cell antigen-receptor triggers an intricate maze of in

291 Herein, we report that ablation of B cell antigen receptor ubiquitination in vivo uncouples

292 s known to provide a confined space in which B-cell antigen receptors undergo selection.

293 Activation of the B cell antigen receptor up-regulated Btk protein level 1

294 In B cells, engagement of the B cell antigen receptor was required for presentation of

295 f ITAM-containing cytoplasmic regions of the B-cell antigen receptor was expressed in immortalized mu

296 ated by coligation of the coreceptor and the B cell antigen receptor, which dramatically increases fo

297 ocalization and interaction of the IgM-class B cell antigen receptor with the coreceptor CD19.

298 trategies to generate a repertoire of T- and B-cell antigen receptors with sufficient diversity to re