ライフサイエンスコーパス: BMSC

1 BMSC CM contained a heat-labile factor that increased BM

2 BMSC co-transplantation doubles the number of functional

3 BMSC micropellet cultures supplemented with KGN alone co

4 BMSCs from six of the eight centers were tested for thei

5 BMSCs inoculated alone induced osteoblast suppression, a

6 BMSCs isolated from femur and tibia of Sprague-Dawley ra

7 BMSCs may reduce pathogen burden by inhibiting growth th

8 BMSCs secreted TGF-beta1 into the cerebrospinal fluid, a

9 BMSCs that migrated from the injection site survived at

10 antly lower levels in cultures of Bag-1(+/-) BMSCs supplemented with BMP-2, while genes with roles in

11 vel genetically engineered Tet-Off-SDF-1beta BMSCs, which over-express SDF-1beta under tight doxycycl

12 mir which can mimic the effects of pri-miR-9-BMSCs and protect injured pancreas.

13 microRNA-9 (miR-9) modified BMSCs (pri-miR-9-BMSCs) can significantly reduce the pancreatic edema, in

14 Coinoculation of myeloma cells and a BMSC line, isolated from myeloma-permissive mice, into o

15 m both micro- and nanoscale surface-adherent BMSCs increased the osteoclast number (P < 0.01).

16 Difference in surface topography altered BMSC phenotype and influenced BMM osteoclastogenesis.

17 of the efficacy and specificity of AMSC and BMSC tropism towards glioma.

18 y, our results show novel roles of BMSCs and BMSC-derived Dkk1 in the pathogenesis of multiple myelom

19 roles in bone-immune cell communication and BMSC immune suppressive functions.

20 rase reporter expression in mono-culture and BMSC co-culture.

21 ively interferes with CLL cell migration and BMSC-mediated drug resistance, and establishes a rationa

22 th the monocytes/macrophages population, and BMSC-induced monocyte CXCL1.

23 liferation rate of both commercial AMSCs and BMSCs as compared to primary culture AMSCs, suggesting p

24 Predifferentiated ASCs and BMSCs were treated with ET1 for 2 cell passages and then

25 We analyzed subpopulations of ASCs and BMSCs with or without ETAR and/or ETBR, and we found tha

26 osteoblastogenesis of MC3T3-E1 cultures and BMSCs induced towards the bone lineage by multi-layered

27 d demonstrates the requirement for NOTCH and BMSCs in fracture repair, irrespective of fracture stabi

28 outer shell to eliminate iron overload, and BMSCs implantation with high-molecular-weight keratin hy

29 the quantity formed was highly variable and BMSCs from only three centers supported hematopoiesis.

30 colony-stimulating factor (M-CSF) as well as BMSC CM from each of the 4 surfaces.

31 ly on the surface, but increased the average BMSC adhesion densities under indirect contact.

32 s amplifies multiorgan complications because BMSCs promote vascular repair.

33 ritical role mediating the crosstalk between BMSCs and T(reg) in the bone marrow microenvironment.

34 ence with the CXCL12 gradient established by BMSCs.

35 osis factor alpha and M-CSF was increased by BMSCs cultured on both micro- and nanoscale titanium top

36 ch can translate into protection mediated by BMSCs.

37 We found that GDF15 is produced by BMSCs after direct contact with plasma cells and enhance

38 at long-lasting antihyperalgesia produced by BMSCs required their chemotactic factors such as CCL4 an

39 d a preconditioned group with PVE and CD133+ BMSC cotreatment (PVE+SC group, n = 11) and a group pret

40 CD133 bone marrow-derived stem cell (CD133+ BMSC) application before extended right hepatectomy.

41 lysis suggest that PVE, together with CD133+ BMSC pretreatment, could positively impact overall outco

42 shown that portal venous infusion of CD133+ BMSCs substantially increases hepatic proliferation, whe

43 istinct osteogenically-committed CD271+CD56+ BMSC subset and implicates it in subchondral bone sclero

44 demonstrated that bone marrow stromal cell (BMSC) and CB-BF pellet cultures make cartilage in vitro

45 f bone marrow mesenchymal stem/stromal cell (BMSC) chondrogenesis.

46 alizing nodules in bone marrow stromal cell (BMSC) cultures.

47 To identify human bone marrow stromal cell (BMSC) subsets with enhanced ability to engraft/contribut

48 c potential of human bone marrow stem cells (BMSC) with stem cells derived from human dental pulp (DP

49 dies suggest that bone marrow stromal cells (BMSC) can promote myeloma growth and survival and osteol

50 ells with patient bone marrow stromal cells (BMSC) showed similar beta1 integrin-specific enhancement

51 which stimulates bone marrow stromal cells (BMSC) to AML blast transfer of mitochondria through AML-

52 or together with bone marrow stromal cells (BMSC).

53 rrow-derived mesenchymal stem/stromal cells (BMSC).

54 iation of bone mesenchymal progenitor cells (BMSCs).

55 bone, while bone marrow stromal/stem cells (BMSCs) and other skeletal progenitors may also contribut

56 bone marrow-derived mesenchymal stem cells (BMSCs) are not known.

57 Bone marrow mesenchymal stem cells (BMSCs) exhibit an age-dependent reduction in osteogenesi

58 Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential of repairing SAP, but the deta

59 bone marrow-derived mesenchymal stem cells (BMSCs) increases the production of T(reg) cells via a me

60 on of murine bone marrow-derived stem cells (BMSCs) into functional DCs in the presence of the cytoki

61 ntiation of cultured bone marrow stem cells (BMSCs) into the adipocyte lineage was suppressed by 17-b

62 d senescence of bone mesenchymal stem cells (BMSCs) isolated from a TDO patient, providing a molecula

63 of local bone marrow mesenchymal stem cells (BMSCs) on osteoarthritis (OA) of the temporomandibular j

64 Bone mesenchymal stem cells (BMSCs) on the 3D nanofiber assemblies with smaller pore

65 bone marrow-derived mesenchymal stem cells (BMSCs) showed great potential in controlling T1DM.

66 ation of bone marrow mesenchymal stem cells (BMSCs) to osteoblasts and chondrocytes was reduced, and

67 ance and bone marrow mesenchymal stem cells (BMSCs) transplantation following intracerebral hemorrhag

68 bone marrow derived mesenchymal stem cells (BMSCs) using the in vitro direct culture method, greater

69 s study, rat bone marrow stromal stem cells (BMSCs) were tracked after IV administration to rats with

70 bone marrow-derived mesenchymal stem cells (BMSCs), remains challenging.

71 c potency to bone marrow-derived stem cells (BMSCs).

72 d we now find that bone marrow stroma cells (BMSCs) are severely and permanently damaged by the pre-c

73 of primary mouse bone marrow stromal cells (BMSCs) and 3T3-L1 pre-adipocytes via interaction with Pp

74 iminished in both bone marrow stromal cells (BMSCs) and calvarial cells of mutant mice.

75 BM stromal cells (BMSCs) are key players in the microenvironmental support

76 Bone marrow stromal cells (BMSCs) are versatile mesenchymal cell populations underp

77 cancer cells and bone marrow stromal cells (BMSCs) as a model to investigate the role of stromal con

78 om PCa cells into bone marrow stromal cells (BMSCs) as a novel mechanism through which primary tumor-

79 fant ALL cells on bone marrow stromal cells (BMSCs) at clinically achievable concentrations causes ro

80 ic programming of bone marrow stromal cells (BMSCs) could influence the function of progenitor osteob

81 e metabolomics of bone marrow stromal cells (BMSCs) derived from hyperglycaemic (type 2 diabetes mell

82 enic potential of bone marrow stromal cells (BMSCs) differs between MB versus long bones (LB).

83 neath a confluent layer of BM stromal cells (BMSCs) due to interference with the CXCL12 gradient esta

84 imary FBLP-1 null bone marrow stromal cells (BMSCs) exhibited significantly reduced extracellular mat

85 .t.) injection of bone marrow stromal cells (BMSCs) following lumbar puncture alleviates early- and l

86 When bone marrow stromal cells (BMSCs) from WT and Col6alpha2-KO mice were treated with

87 rrow-derived mesenchymal stem/stromal cells (BMSCs) hold great potential for cell-based therapy, yet

88 -1(+) multipotent bone marrow stromal cells (BMSCs) in mice, as well as on well-characterized, clinic

89 antly secreted by bone marrow stromal cells (BMSCs) in MM.

90 implant-adherent bone marrow stromal cells (BMSCs) in osteoclastogenesis is influenced by surface to

91 ifferentiation of bone marrow stromal cells (BMSCs) of Bag-1(+/-) (heterozygous) female mice was decr

92 Bone marrow-derived stromal cells (BMSCs) protect against acute lung injury (ALI).

93 odel in which the bone marrow stromal cells (BMSCs) remained unresponsive to OB differentiation signa

94 ne marrow-derived multipotent stromal cells (BMSCs) that contribute to wound healing, particularly in

95 transfer from the bone marrow stromal cells (BMSCs) to HSCs through a reactive oxygen species (ROS)-d

96 ne marrow derived mesenchymal stromal cells (BMSCs) were used to CBTs for ConA-induced ALF and Fah-de

97 ulations of mouse bone marrow stromal cells (BMSCs), a common problem being contamination with hemato

98 temic infusion of bone marrow stromal cells (BMSCs), a major type of multipotent stromal cells, produ

99 n the presence of bone marrow stromal cells (BMSCs), can induce ectopic bone formation in vivo.

100 including bone marrow-derived stromal cells (BMSCs), display tissue-specific responses, there is a ne

101 h can derive from bone marrow stromal cells (BMSCs), takes a role in modulating osteoblast and osteoc

102 ssion of Vcam1 in bone marrow stromal cells (BMSCs), ultimately leading to a systemic immunodeficienc

103 nic commitment of bone marrow stromal cells (BMSCs).

104 iency using human bone marrow stromal cells (BMSCs).

105 co-cultured with bone marrow stromal cells (BMSCs).

106 o transfect human bone marrow stromal cells (BMSCs).

107 Human bone marrow stromal cells (BMSCs, also known as bone marrow-derived mesenchymal ste

108 tipotent, bone marrow-derived stromal cells (BMSCs, also known as mesenchymal stem cells [MSCs]), are

109 Once in the circulation, BMSCs also produced rapid alterations in host blood cell

110 ial and primary culture AMSCs and commercial BMSCs demonstrated no statistically significant differen

111 typically-distinct, osteogenically-committed BMSC subset in human OA trabecular bone.

112 BMSC-supported osteoclastogenesis, confluent BMSCs were cultured with parathyroid hormone (PTH), 1,25

113 In contrast, BMSC induced hormone-independent growth of breast cancer

114 ression in freshly isolated BMSCs or control BMSCs cultured in parallel but in nondifferentiating med

115 Therefore, quiescent Cxcl12-creER(+) BMSCs transform into osteoblast precursor cells in a man

116 necrosis factor alpha, and M-CSF in cultured BMSCs at different time points were measured by real-tim

117 ransplantation of primary, but not cultured, BMSCs quantitatively reconstitutes stroma function in vi

118 lular pool, we transplanted clonally derived BMSCs into fetal sheep.

119 ed and functionally insufficient in diabetic BMSCs (dBMSCs).

120 rast, triglyceride content in differentiated BMSCs or 3T3-L1 cells was suppressed as a result of memb

121 versely, deficiency of XBP1 in healthy donor BMSCs displayed a range of effects on BMSCs that were op

122 the intrinsic properties of OB/BMSCs (i.e., BMSC-extracellular matrix adhesion and migration, cell g

123 gnificantly protected genetically engineered BMSCs from H2O2-induced cell death through increasing au

124 vator of NF-kappaB ligand (RANKL), enhancing BMSC support of MM cell growth and osteoclast formation

125 SDF-1 in the therapeutic effect of exogenous BMSCs was examined by both in vitro and in vivo studies.

126 We also show that GILZ-expressing BMSCs present antigen in a way that favors T(reg) cells.

127 pathway is a critical maintenance factor for BMSCs during skeletal development, although the precise

128 Two to four BMSC lots from each center were compared using global ge

129 Among the twenty-four BMSC lots from the eight centers intra-center transcript

130 Although mitochondrial transfer from BMSC to nonmalignant CD34(+) cells occurs in response to

131 Moreover, mitochondria transfer from BMSCs into HSCs, in the response to bacterial infection,

132 ich allows the mitochondria to transfer from BMSCs into HSCs.

133 OA cartilage and the rescuing effect of GFP-BMSC injections were impaired by the inhibitors of C-X-C

134 green fluorescent protein-labeled BMSCs (GFP-BMSCs) were weekly injected into the TMJ region for 4, 8

135 The reparative effects of exogenous GFP-BMSCs were investigated by morphological observation and

136 The implanted GFP-BMSCs differentiated into type II collagen-positive cell

137 The differentiation of GFP-BMSCs in the cartilage was examined by double immunofluo

138 on synergistically in the recruitment of GFP-BMSCs towards degraded cartilage in mice OA of the TMJ.

139 The migration of GFP-BMSCs towards OA cartilage and the rescuing effect of GF

140 apability of attracting the migration of GFP-BMSCs.

141 hat, at 7 d post-transplant, the EphB2(high) BMSCs engrafted in the ISC region at levels of 2.1 +/- 0

142 In the host, BMSCs may attenuate pro-inflammatory cytokine and chemok

143 s to have weak chondrogenic potency in human BMSC cultures relative to TGF-beta1, does not obstruct h

144 XBP1s overexpression in healthy human BMSCs enhanced gene and/or protein expression of VCAM-1,

145 racterized, clinical-grade multipotent human BMSCs.

146 en with either mouse BMSCs (mBMSCs) or human BMSCs (hBMSCs).

147 e (GFP group) - were incorporated with human BMSCs into a solution of photocrosslinkable gelatin, whi

148 ationship between apoptosis and autophagy in BMSC homeostasis is complex and not well understood.

149 Such exquisite balance in BMSC function appears intrinsically linked to Toll-like

150 reducing live KMT2A-AFF1 infant ALL cells in BMSC co-cultures.

151 abetes and hyperglycemia-induced deficits in BMSC regulation, and strategies to reverse them, offers

152 cells toward bendamustine and fludarabine in BMSC cocultures.

153 cell death and reduced clonogenic growth in BMSC-adherent myeloma cell lines, aldehyde dehydrogenase

154 ount of blood vessels in DPSC-MG, but not in BMSC-MG.

155 1-CXCR2 signaling plays an important role in BMSC-produced antihyperalgesia.

156 hermore, increased expression of miR-146a in BMSCs correlated with inhibition of PGE synthase-2 and i

157 Overexpression of Cdo1 in BMSCs inversely suppressed the osteogenesis.

158 adipocyte precursor population decreased in BMSCs harvested from the KO animals.

159 Dkk1 was highly expressed in BMSCs and in myeloma-permissive bone marrow.

160 Knockdown of Dkk1 expression in BMSCs decreased their ability to promote myeloma and the

161 in the TCA cycle, is increased by 24-fold in BMSCs from T2D mice.

162 Strikingly, siRNA knockdown of Gfi1 in BMSCs from MM patients significantly restored expression

163 ious findings that overexpression of GILZ in BMSCs antagonizes TNF-alpha-elicited inflammatory respon

164 microRNA-188 (miR-188) is markedly higher in BMSCs from aged compared with young mice and humans.

165 o metabolites are substantially regulated in BMSCs from T2D mice, with the tricarboxylic acid (TCA) c

166 mine that Phc2-dependent Vcam1 repression in BMSCs is mediated by the epigenetic regulation of H3K27m

167 etermined that removal of NOTCH signaling in BMSCs and subsequent depletion of this population result

168 maintenance and differentiation switches in BMSCs.

169 In contrast, few injected BMSCs traveled to the brain and almost none endured ther

170 regulation caused migration of i.t.-injected BMSCs to DRGs through the CXCL12 receptor CXCR4, which w

171 presented a transcriptionally 'intermediate' BMSC population.

172 y PCa exosome-mediated transfer of PKM2 into BMSCs and subsequent up-regulation of CXCL12.

173 with miR-146a expression in freshly isolated BMSCs or control BMSCs cultured in parallel but in nondi

174 have shown previously that freshly isolated BMSCs when induced to express neuronal stem cell markers

175 tiation capabilities of the locally isolated BMSCs.

176 ity of radiolabeled or fluorescently labeled BMSCs traveled to and remained in peripheral organs (lun

177 Exogenous green fluorescent protein-labeled BMSCs (GFP-BMSCs) were weekly injected into the TMJ regi

178 To explore MB versus LB BMSC-supported osteoclastogenesis, confluent BMSCs were

179 1,25D3- or PTH+1,25D3-treated LB BMSCs expressed significantly higher RANKL and lower ost

180 f2 by Keap1, altered metabolism, and limited BMSC multipotency.

181 ls of 2.1 +/- 0.2%, while control EphB2(low) BMSCs engrafted at 0.3 +/- 0.1% (P<0.01).

182 ls (hMSC) may be harvested from bone marrow (BMSC) and adipose (AMSC) tissue.

183 of the stem cells derived from bone marrow (BMSC), dental pulp (DPSC) and dental apical papilla (SCA

184 MM-BMSC cell-cell contact was not required for MM cells to

185 strate here that microRNA-9 (miR-9) modified BMSCs (pri-miR-9-BMSCs) can significantly reduce the pan

186 Furthermore, more BMSCs survived in the core-shell hydrogel group in vivo

187 ysaccharide (LPS) and then with either mouse BMSCs (mBMSCs) or human BMSCs (hBMSCs).

188 potential reason for the low yield of mouse BMSCs is the flushing of the marrow used to remove singl

189 m cells (ASCs) and bone marrow-derived MSCs (BMSCs).

190 reover, the expression of FAP by multipotent BMSCs may point toward the cellular origins of tumor str

191 ccordingly, both mouse and human multipotent BMSCs were recognized by FAP-reactive T cells.

192 Nonetheless, BMSC treatment produced dramatic changes in the number a

193 reduction (a TBD-associated gene) in normal BMSCs by small interfering TERC-RNA (siTERC-RNA) recapit

194 bone or support hematopoiesis, unlike normal BMSCs.

195 However, in the CLF model, not BMSCs but adult HCs transplantation lessened liver injur

196 Notably, BMSC-specific inhibition of miR-188 by intra-bone marrow

197 Notably, BMSCs appear to function as a critical fulcrum, providin

198 ation, was markedly increased in FBLP-1 null BMSCs.

199 rentiation) and the communication between OB/BMSCs and BMMs (i.e., RANKL expression) that controls os

200 dulating both the intrinsic properties of OB/BMSCs (i.e., BMSC-extracellular matrix adhesion and migr

201 tures, suggesting that KGN does not obstruct BMSC hypertrophy.

202 hat the pericyte differentiation capacity of BMSC was greater with high expression of alpha-SMA and N

203 Molecular and functional characterization of BMSC-induced hormone independence and HT resistance in a

204 ombinant factors reproducing the dynamics of BMSC-generated secretion can mediate a highly effective

205 In addition, the effects of BMSC treatment on blood cell composition, brain glia and

206 The presence of BMSC-derived mitochondria in the epithelia was evident o

207 To determine the role of BMSC mitochondria in this protection, we airway-instille

208 rutinib reverses the cyto-protective role of BMSC on FLT3-ITD AML survival.

209 Herein, we tested the role of BMSC-derived Wnt5a/Ror2 signaling in regulating osteocla

210 tch between osteogenesis and adipogenesis of BMSCs and may represent a potential therapeutic target f

211 on observed after systemic administration of BMSCs to MCAO rats is likely due to the cellular changes

212 Through comparison of BMSCs from wild-type and diabetic mice, with a known red

213 an in vitro system, and the contributions of BMSCs to myeloma pathogenesis in an intact, immune compe

214 vated during osteoblastic differentiation of BMSCs in vitro.

215 The differentiation of BMSCs was also improved, and the expression of Wnt/beta-

216 do1 suppresses osteogenic differentiation of BMSCs, through a potential mechanism which involves in W

217 P-2-stimulated osteogenic differentiation of BMSCs.

218 BMP-2-directed osteogenic differentiation of BMSCs.

219 idomide abrogated this stimulatory effect of BMSCs and significantly decreased the percentage of SP c

220 not IL-10, reversed the analgesic effect of BMSCs.

221 une regulation without actual engraftment of BMSCs.

222 show that miR-9 is a key paracrine factor of BMSCs attenuating SAP targeting the NF-kappaB1/p50 gene

223 n vivo transplantation (defining features of BMSCs).

224 ver, studies have shown that the majority of BMSCs are trapped in the lungs immediately after intrave

225 e role for NOTCH and the requisite nature of BMSCs following fracture is unknown.

226 ing adipogenesis of ASCs and osteogenesis of BMSCs was attenuated by blocking endothelin receptor typ

227 The nonadherent population of BMSCs harvested from the long bone diaphysis of KO anima

228 The osteogenic potential of BMSCs treated with these polyplexes was validated by det

229 ed investigation of hepatogenic potential of BMSCs v/s DMSCs (DPSC, SCAP & DFSC) along-with secretome

230 control of the immunoregulatory potential of BMSCs.

231 ture, which may adversely affect recovery of BMSCs physically associated with the abluminal surface o

232 ta-estradiol (E2) enhanced responsiveness of BMSCs of wild-type and Bag-1(+/-) mice to BMP-2, and pro

233 ollectively, our results show novel roles of BMSCs and BMSC-derived Dkk1 in the pathogenesis of multi

234 The delayed senescence of BMSCs leads to increased bone formation by compensating

235 and culturing an expandable subpopulation of BMSCs with enhanced intestinal homing and contribution t

236 ficantly impaired the growth and survival of BMSCs in vitro and decreased the number of osteoblast (O

237 that SDF-1beta can mediate cell survival of BMSCs in vitro through increasing autophagy.

238 /ETBR(+) subpopulations of ASCs and those of BMSCs pretreated with ET1 were prone to turning into adi

239 In the capacity of therapeutic use of BMSCs other than structural repair and replacement, more

240 Additional transplants based on BMSC EphB2 expression demonstrated that, at 7 d post-tra

241 We found that SDF-1beta had no effect on BMSC proliferation; however, SDF-1beta significantly pro

242 ufacturing methods used and their effects on BMSC characteristics and function.

243 donor BMSCs displayed a range of effects on BMSCs that were opposite to those cells with overexpress

244 XCL12 receptor CXCR4, which was expressed on BMSCs.

245 The results showed that only BMSCs remitted liver damage and rescued ALF in ConA-trea

246 Here, we evaluated whether NOTCH and/or BMSCs are required for fracture repair by performing non

247 giva (GMSCs), which has many advantages over BMSCs, can delay or prevent progress of T1DM.

248 Knock-down of XBP1 in MM patient BMSCs greatly compromised their increased VCAM-1 protein

249 hat quiescent Cxcl12-creER(+) perisinusoidal BMSCs differentiate into cortical bone osteoblasts solel

250 SSCs) within the BM stromal cell population (BMSCs, also known as BM-derived mesenchymal stem cells),

251 t the secretory signatures of CD133-positive BMSCs are uniquely defined by distinct biological contex

252 ated ASCs and osteogenesis of ET1-pretreated BMSCs were increased compared to those of control cells.

253 2 levels in MC-4 before OBs or naive primary BMSCs, and Gfi1 induction was blocked by anti-TNF-alpha

254 In this process, BMSCs inhibited ConA-induced inflammatory response by de

255 J subchondral BMSCs enhanced by UAC promoted BMSCs to increase Cxcl12 and Rankl expression, in which

256 Purified BMSC populations devoid of hematopoietic contamination a

257 rm that Ade mediates the osteogenesis of rat BMSCs through the STAT3 signaling pathway and restrains

258 coated Mg, the nHA and mHA coated Mg reduced BMSC adhesion densities directly on the surface, but inc

259 m cells from different craniofacial regions, BMSCs appear more suitable for engineering of mature vas

260 We found that PKM2 up-regulates BMSC CXCL12 production in a HIF-1alpha-dependent fashion

261 isoform, plays a critical role in regulating BMSC survival under oxidative stress through increasing

262 These restored BMSCs can resume their role in regenerative tissue repai

263 CD73)(+) ENG(-) (CD105)(-) LY6A(+) (SCA1)(+) BMSC subpopulation.

264 gene expression being exquisitely sensitive BMSC paracrine signals.

265 Microarray profiles of control and siTERC-BMSCs showed decreased hematopoietic factors at the mess

266 findings are consistent with defects in SSCs/BMSCs contributing to BM failure in TBD.

267 that Wnt5a/Ror2 signaling in TMJ subchondral BMSCs enhanced by UAC promoted BMSCs to increase Cxcl12

268 Moreover, i.t. BMSCs reduced CCI-induced spontaneous pain and axonal in

269 support a paracrine mechanism by which i.t. BMSCs target CXCL12-producing DRGs to elicit neuroprotec

270 TERC-RNA (siTERC-RNA) recapitulated the TBD-BMSC phenotype by reducing proliferation and secondary c

271 TBD-BMSCs exhibited reduced clonogenicity, spontaneous diffe

272 Upon in vivo transplantation into mice, TBD-BMSCs failed to form bone or support hematopoiesis, unli

273 (DPSC-MG) induced more vessel formation than BMSC-MG.

274 ng an aptamer delivery system, we found that BMSC-specific overexpression of miR-188 in mice reduced

275 These results demonstrated that BMSCs and adult HCs are the optimal sources of CBTs for

276 We found that BMSCs from both MM-bearing mice and MM patients had incr

277 Furthermore, we investigate that BMSCs deliver miR-9 to the injured pancreas or periphera

278 s the first evidence, to our knowledge, that BMSCs protect against ALI by restituting alveolar bioene

279 Emerging preclinical studies suggest that BMSCs may protect against infectious challenge either by

280 n-stream target of TNFalpha, suggesting that BMSCs from Col6alpha2-KO mice are highly sensitive to TN

281 Reducing Ror2 expression in the BMSC cell line by siRNA or blocking the downstream signa

282 strated a suppression of the capacity of the BMSC cell line to promote Wnt5a-dependent migration (inc

283 he TGF-beta1-only cultures, depending on the BMSC donor.

284 ulated into the core hydrogel to support the BMSC growth and differentiation.

285 study, we found that XBP1s is induced in the BMSCs of the MM microenvironment.

286 These BMSCs showed an increased CXCL12 protein expression leve

287 ced chondrogenic differentiation compared to BMSCs cultured on the assemblies with larger pore size.

288 n PDGF-B higher gene expressions compared to BMSCs.

289 o Furthermore, upon in vivo transplantation, BMSC pellets remodelled into miniature bone/marrow organ

290 Transplanted BMSCs often fail to engraft within the bone marrow (BM),

291 le for the impaired survival of transplanted BMSCs.

292 hesion and migration compared with wild type BMSCs.

293 that XBP1s is a pathogenic factor underlying BMSC support of MM cell growth and osteoclast formation

294 But there exists much difficulty in using BMSCs as a clinical therapy.

295 rences in manufacturing resulted in variable BMSC characteristics including their ability to form bon

296 C4-2B cell populations when co-cultured with BMSC, resulting in a significant disconnect between biol

297 in patient-derived organoids cocultured with BMSCs.

298 Cocultures of ZR75-1 and LNCaP with BMSCs exhibited paracrine IL6-induced HT resistance via

299 duces ectopic bone formation with or without BMSCs.

300 ion of prominent differentiation genes in WT BMSCs.