ライフサイエンスコーパス: BaP

1 ene (PHE), pyrene (PYR), and benzo[a]pyrene (BaP).

2 (r = 0.64, 0.72, and 0.74, for PHE, PYR, and BaP).

3 ene (PHE), pyrene (PYR), and benzo[a]pyrene (BaP).

4 d products, and biomass-associated products (BAP).

5 (r = 0.70, 0.68, and 0.70 for PHE, PYR, and BaP).

6 lung cells and zebrafish to benzo[a]pyrene (BAP).

7 eterocyclic amines (HCA) and benzo(a)pyrene (BaP).

8 e toxin, and the biofilm-associated protein (Bap).

9 udy explores polygenic scores related to the BAP.

10 to 4%) and decreases (3%) for particle-bound BaP.

11 ic etiology of ASD-related phenotypes in the BAP.

12 IDASE2, in the early root growth response to BAP.

13 y to these transplacental ovarian effects of BaP.

14 were reached within only 2 h of exposure to BaP.

15 absolutely required for detoxication of oral BaP.

16 rasting shoot and root proteome responses to BAP.

17 unosuppression approximately 30 days on oral BaP.

18 as a function of long-term oral exposure to BaP.

19 e transposon disrupts the coding sequence of bap.

20 h from BMHA and 95.9% with induced growth on BAP.

21 ML cell lines in the presence and absence of BaP.

22 CD1)] to AML and eBL cell lines treated with BaP.

23 characteristic of the syndrome [6-9] and the BAP [10, 11], we examined whether neural sensitivity to

24 The mixture of NNK plus BaP (2 micromol each) was administered by gavage as eigh

25 ties including the broader autism phenotype (BAP) [2, 3].

26 ounds (8.3-, 4.3-, and 8.7-fold increase for BaP, 3-MC, and urethane, respectively).

27 ly induced lung tumors following exposure to BaP, 3-methylcholanthrene (3-MC), and urethane.

28 omatography (HPLC)-fluorescence detection of BaP-7,8,9,10-tetraols released from human DNA upon acid

29 cid hydroperoxides to support epoxidation of BaP-7,8-diol at a much higher rate than with cumene hydr

30 The cytotoxicity of BaP-7,8-diol significantly increased in mammalian cells

31 1A2, and CYP3A4, were also able to epoxidize BaP-7,8-diol using various fatty acid hydroperoxides, al

32 olizes benzo[a]pyrene-trans-7,8-dihydrodiol (BaP-7,8-diol) into the highly mutagenic and carcinogenic

33 orting in vivo CYP2S1-catalyzed oxidation of BaP-7,8-diol, and that fatty acid hydroperoxides and CYP

34 yet been described for the bioactivation of BaP-7,8-diol.

35 romatic hydrocarbons such as benzo[a]pyrene (BaP), a common constituent of tobacco smoke.

36 h a peptide derived from the BCR-ABL fusion (BAp), a key driver mutation, generated a small populatio

37 Benzo[a]pyrene (BaP), a key polycyclic aromatic hydrocarbon (PAH) often

38 Benzo[a]pyrene (BaP), a major carcinogen in cigarette smoke, is detected

39 tive organotypic cultures to benzo[a]pyrene (BaP), a major carcinogen in cigarette smoke, resulted in

40 Intakes of benzo(a)pyrene (BaP), a marker of PAHs, and 2-amino-1-methyl-6-phenyl-im

41 Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is one of

42 Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon, is the major ca

43 We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation

44 t of DNA adducts specific to benzo[a]pyrene (BaP), a representative PAH, in maternal and cord blood.

45 Our results show that BaP accumulates in the lipid bodies of Chlorella sp. and

46 ity, metabolism of BaP, and formation of DNA-BaP adducts.

47 Whereas BaP alone shifted differentiation away from the choliner

48 In cells treated with BaP alone, the transition from cell division to neurodif

49 With the BaP amino tribenzoate, the 6-chloronucleoside provided s

50 no tribenzoate as compared to the bay-region BaP amino tribenzoate.

51 ded A-type K+ currents led to an increase of bAP amplitude and an increase of concurrent Ca2+ influx.

52 liminated the distance-dependent decrease in bAP amplitude and its associated Ca(2+) signal.

53 dritic A-type K(+) current and increased the bAP amplitude in distal dendrites.

54 was generated and was not due to a change in bAP amplitude or shape.

55 Voltage imaging in the branches showed that bAP amplitude was initially constant and then steadily d

56 1 PCs) is responsible for the attenuation of bAP amplitude with distance from the soma.

57 Benzo[a]pyrene (BaP), an archetypical polycyclic aromatic hydrocarbon, i

58 ha,9 beta-trisbenzoyloxy-7,8,9,10-tetrahydro BaP and (+/-)-1 beta-amino-2 alpha,3 alpha,4 beta-trisbe

59 rmine the shared genetic overlap between the BAP and ASD.

60 to the dA adducts, the C-N reactions of both BaP and BcPh amino tribenzoates with the 2-bromo-2'-deox

61 The dual roles of BAP and BON genes in repressing defense responses mediat

62 All abnormal BAP and CTX concentrations fell within the elevated ( ge

63 Age- and sex-specific BAP and CTX concentrations of at least the 97th percenti

64 rmined the mutagenic response to mixtures of BaP and PhIP at concentrations relevant to human exposur

65 Mixtures of BaP and PhIP produced dose responses different from thos

66 mechanisms related to the cooking compounds BaP and PhIP.

67 is Forster resonance energy transfer between BaP and photosystems of Chlorella sp., indicating the cl

68 BaP and TCDD enhanced osteoclast formation in bone marro

69 e show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inte

70 Chemical carcinogens such as benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

71 iated with action potential backpropagation (bAP) and a supralinear increase in dendritic Ca(2+).

72 drogen peroxide (H2O2), 6-benzylaminopurine (BAP) and calcium chloride (CaCl2) could induce tolerance

73 city to the aromatic CK 6-benzylaminopurine (BAP) and that fast posttranscriptional and/or posttransl

74 id hormone (PTH), bone alkaline phosphatase (BAP), and C-telopeptide (CTX) in youth infected with hum

75 Outcomes included change in TRP, PTH, BAP, and CTX from baseline to week 12 by TDF/noTDF; and

76 sorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts.

77 higher molecular weight PAHs (BaA, BkF, BbF, BaP, and IcdP), most of which did not undergo significan

78 gest that the critical anticancer actions of BaP are decreases in SCD1 levels and monounsaturated fat

79 c hydrocarbons (PAH) such as benzo[a]pyrene (BaP) are ubiquitous environmental pollutants found in to

80 We have described Bap as the surface structure involved in adherence of A.

81 om contaminated sites, using benzo[a]pyrene (BaP) as an example.

82 stral basolateral (BLA) and basal posterior (BAP)- as they provide a major source of glutamatergic in

83 DMPC-NP-SLBs and DMPC-SUVs, with and without BaP, as their sole carbon source.

84 The spatial profile of the bAP-associated Ca(2+) influx was biphasic, with an initi

85 d) received a single gavage dose of 50 mg/kg BaP at either noon or midnight, and mammary tissues were

86 In TC neurons, bAP attenuation strength varies according to firing mode

87 We suggest that modulations in the bAP baseline-to-peak amplitude by local EPSPs act as a m

88 the quercetin metabolites at 10muM inhibited BaP+BC-induced cell death.

89 a similar order, these compounds suppressed BaP+BC-induced cytochrome P450 (CYP)1A1/1A2 expression b

90 reactive oxygen species formation induced by BaP+BC; however, Q3G had the best effect on decreasing t

91 nd isorhamnetin also significantly decreased BaP+/-BC-induced DNA damage by 64%, 60% and 24%, respect

92 BAP but not BLA increased unconditioned port-entries, wh

93 death due to absent metabolic activation of BaP by CYP1B1 in immune cells.

94 nd mechanisms of chemical transformations of BaP by ozone in indoor and outdoor environments are stil

95 Our results indicate that, although BaP can act directly as a developmental neurotoxicant, i

96 BaP carcinogenicity is believed to occur mainly through

97 a photooxidation reaction of benzo(a)pyrene (BaP) carried out in controlled conditions using a 6 W UV

98 ts show that prenatal exposure of females to BaP causes premature ovarian failure and ovarian tumorig

99 Prenatal exposure to BaP causes premature reproductive senescence in mice, an

100 uct, oleate, rescued AML and e-BL cells from BaP cell killing and decreased levels of BaP-induced rea

101 We also identified that the BAP chromatin-remodeling complex probably functions coop

102 f urine plated onto blood (blood agar plate [BAP]), colistin-nalidixic acid (CNA), and MacConkey agar

103 mplex associates either with Osa to form the BAP complex or with Bap170 and Bap180 to form the PBAP c

104 We conclude that the BAP complex regulates expression of genes involved in me

105 Silencing additional two genes of the BAP complex was shown to have the same phenotype, confir

106 chromatin remodeling Osa-containing Brahma (BAP) complex.

107 moky coal was associated with higher outdoor BaP concentrations [GM ratio (GMR) = 2.79] and lower out

108 o which (3)H-benzo(a)pyrene ((3)H-BaP; total BaP concentrations of 1, 10, and 100 ppm) was added in a

109 tions, the baseline-to-peak amplitude of the bAP could be either increased, decreased or unaltered at

110 This "oral BaP Cyp1" mouse paradigm represents a powerful teaching

111 Thus, for oral BaP, CYP1A1 is more important in detoxication than in me

112 g agents in transforming PAHs to NPAHs, with BaP-d12 being the most readily nitrated.

113 terogeneous reactions of benzo[a]pyrene-d12 (BaP-d12), benzo[k]fluoranthene-d12 (BkF-d12), benzo[ghi]

114 Reaction of BaP-d12, BkF-d12, and BghiP-d12 with NO2 and NO3/N2O5 re

115 Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced t

116 ST occurred in the presence of bulky BaP DE DNA adducts attached to the end of the viral DNA

117 Position-specific effects of these BaP DE DNA adducts were found for inhibition of integras

118 reoselective synthesis of the cis adducts of BaP DE-2 with 2'-deoxyguanosine as well as the first syn

119 pha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP DE-2) by 2'-deoxyadenosine and 2'-deoxyguanosine is

120 particle changes alone accounting for 15% of BaP decline under 2050 emissions.

121 BaP decreased SCD1 protein levels in each cell line (0.4

122 iction of developmental potential by the Erm-BAP-dependent mechanism functionally distinguishes inter

123 , these data led us to conclude that the Erm-BAP-dependent mechanism stably restricts the development

124 uire either boosting or the reduction of the bAP, depending on the initial size of both signals.

125 iver CYP1A1, is critically important in oral BaP detoxication.

126 pe, the addition of dexamethasone along with BaP did the opposite.

127 ckout mice treated by oral administration of BaP die at 28 to 32 days with immunosuppression, whereas

128 individuals with autism and parents with the BAP differed from controls on measures of social cogniti

129 acid and EGF were required to promote hiPSCs-BAP differentiation at a level similar to adult-BAP diff

130 differentiation at a level similar to adult-BAP differentiation.

131 onary cytosol to catalyze conjugation of the BaP diol epoxide was significantly reduced.

132 ced cyclobutane pyrimidine dimers (CPDs) and BaP diol epoxide-deoxyguanosine (BPDE-dG), which are rem

133 n mammalian cells overexpressing CYP2S1, and BaP-diol-t-epoxide formation in these cells also increas

134 a]pyrene-r-7,t-8-dihydrodiol-t-9,10-epoxide (BaP-diol-t-epoxide), using cumene hydroperoxide in lieu

135 this, a significant increase in the level of BaP DNA adducts was measured in the lungs of null animal

136 Number and brightness analysis suggests that BaP does not aggregate inside Chlorella sp. (average bri

137 related to the pragmatic language and rigid BAP domains.

138 Similarly, we observed significant BaP dose x Gclm genotype interactions on ovarian follicl

139 deleted in hepatocytes can ingest large oral BaP doses (125 mg/kg/d) without apparent toxicity.

140 -type mice remain healthy for 1 year on high BaP doses (125 mg/kg/day).

141 Ten-fold lower oral BaP doses result in adenocarcinoma of the proximal small

142 to low, noncytotoxic doses (0.1 and 1 nM) of BaP elicited increased promoter hypermethylation and red

143 Additionally, the PEF-determined BaP-equivalent concentrations were compared to those det

144 d the PEF-method provided lower estimates of BaP-equivalents than the BDM.

145 the PEF-method provided higher estimates of BaP-equivalents than the BDM.

146 Experimental measurements show that a BAP evoked by current injection at the soma causes calci

147 After DA depletion, bAP-evoked Ca(2+) transients were enhanced in distal den

148 Local application of DA depressed dendritic bAP-evoked Ca(2+) transients, whereas application of ACh

149 ffect lipid metabolism, we hypothesized that BaP exerts anticancer effects by disrupting lipogenesis.

150 BaP exposure also increased HPV16 and HPV18 viral titers

151 d ovarian tumorigenesis after transplacental BaP exposure compared with Gclm(+/+) females.

152 ion: the same oral, but not intraperitoneal, BaP exposure leads to dramatic differences in target-org

153 more ovarian tumors in response to prenatal BaP exposure than Gclm(+/+) females.

154 The lifetime of BaP fluorescence was measured to be 14 ns in N,N-dimethy

155 in thin films exhibited fast initial loss of BaP followed by a slower decay at long exposure times.

156 BaP forms covalent DNA adducts after metabolic activatio

157 -rich layer at the surface shields the inner BaP from ozone.

158 Relative oral bioavailability (RBA) of the BaP from soil was estimated by comparing the area under

159 n be simulated if there is slow diffusion of BaP from the film interior to the surface, resolving lon

160 cous surface crust that hinders diffusion of BaP from the film interior to the surface.

161 Thus, the BAP genes function as general negative regulators of PCD

162 stoves (> 50% of stoves) had higher outdoor BaP (GMR = 1.49) compared to areas with fewer ventilated

163 BaP has been shown to accumulate in phytoplankton and zo

164 and medroxyprogesterone acetate (designated BaP) has potent in vivo anticancer activity in acute mye

165 bezafibrate and medroxyprogesterone acetate (BaP) has shown anti-leukaemic activity in vitro and in v

166 , referred to as the broad autism phenotype (BAP), have been documented repeatedly in unaffected rela

167 d survival did not correlate with numbers of BAp:I-A(b)-specific T cells, but rather with increased e

168 835/2011 were exceeded for BaP in 12%, and for total 4 PAHs in 28%, with a greater

169 ead to a better understanding of the role of Bap in biofilm formation on medical surfaces and in colo

170 studied the localization and aggregation of BaP in Chlorella sp., a microalga that is one of the pri

171 ASD-PGS associations emerged with BAP in mothers only, highlighting the potential for a fe

172 might reflect efficient detoxication of oral BaP in proximal small intestine such that significant am

173 when added to saturated BaP solutions, sorb BaP in ratios of up to 10/1 to 5/1 lipid/BaP, over a 2-w

174 d dams were treated with 0, 2, or 10 mg/kg/d BaP in sesame oil by gavage from gestational days 7 to 1

175 thickness and volume, suggesting a role for Bap in supporting the development of the mature biofilm

176 acterize the location and the aggregation of BaP in the cell.

177 T-MS), kinetics studies of the ozonolysis of BaP in thin films exhibited fast initial loss of BaP fol

178 e staphylococcal biofilm-associated protein (Bap) in a bloodstream isolate of Acinetobacter baumannii

179 yridyl)-1-butanone (NNK) and benzo[a]pyrene (BaP) in A/J mice.

180 In Chlorella grown in sediments spiked with BaP, in 12 h the BaP uptake could be visualized using fl

181 Interestingly, BLA and BAP inactivation produced dissociable effects.

182 ning viral titer that high concentrations of BaP increase HPV31b titers within the context of organot

183 rements of hormone metabolites, showing that BAP increases ABA levels in the shoot and 1-aminocyclopr

184 rmore, this study shows that the presence of Bap increases the bacterial cell surface hydrophobicity.

185 benzo[k]fluoranthene (BkP), benzo[a]pyrene (BaP), indeno[123-cd]pyrene (IP) and benzo[ghi]perylene (

186 tte smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on lung epithelial cells in

187 s including smoking compound benzo[a]pyrene (BaP) induced E6/E7 and IL-6 expression.

188 Nicotine had no effect on BaP-induced changes in cell number or growth, but it syn

189 expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene e

190 BaP-induced Cyp1a1 and Cyp1b1 mRNA levels were higher 4

191 we identified the role of proteins mediating BAP-induced ethylene production, METHIONINE SYNTHASE1 an

192 ates that quercetin metabolites decrease the BaP-induced harmful effect of beta-carotene in A549 cell

193 tigate the effects of these compounds on the BaP-induced harmful effects of BC.

194 r deficiency in AhR significantly suppresses BaP-induced lung cancer.

195 ature proteins are increased during NNK plus BaP-induced lung carcinogenesis, and I3C inhibits this e

196 rom BaP cell killing and decreased levels of BaP-induced reactive oxygen species, whereas supplementa

197 P inhibition of cell growth and enhanced the BaP-induced shift in phenotype toward a higher proportio

198 I3C reduced NNK plus BaP-induced tumor multiplicity by 78% in experiment 1 an

199 al and electrophysiological model to measure BAP-induced voltage and calcium signals in spines after

200 Chlorpyrifos coexposure augmented BaP inhibition of cell growth and enhanced the BaP-induc

201 The concentration of BkP, BaP, IP and BghiP in smoked, grilled and boiled meat sam

202 0.5, 1.0, 1.5mug/kg, respectively, for BkP, BaP, IP and BghiP.

203 formation by A. baumannii and suggests that Bap is involved in intercellular adhesion within the mat

204 Since BaP is known to deregulate multiple pathways of cellular

205 Also, BaP is miscible with organic oils such as squalane, lino

206 However, Bap is not involved in internalization of the bacterium

207 on microscopy analyses of biofilms show that Bap is required for three-dimensional tower structure an

208 ycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) is a major component of cigarette smoke condensate

209 Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (

210 The backpropagating action potential (BAP) is hypothesised to provide distance-dependent infor

211 the A. baumannii biofilm-associated protein (Bap) is necessary for mature biofilm formation on medica

212 Benzo(a)pyrene (BaP) is present at less than 1%, and therefore is not a

213 that the step sizes of both M10(Full)LZ and BAP-M10(1-979)HMM are widely distributed on single actin

214 sin-X without artificial dimerization motif (BAP-M10(1-979)HMM).

215 The BAP may help inform the etiology of ASD by allowing the

216 Studies of this broad autism phenotype (BAP) may provide a potentially important complementary a

217 Elucidation of the BaP mechanism of action is required in order to understa

218 puts, and is nearly invariant to the rate of bAP-mediated "cross-talk" from other dendrites over a 10

219 zed in the presence of BaP were dependent on BaP-mediated alteration in CDK1 kinase activity for main

220 portance of Erk1/2 pathway activation to the BaP-mediated increase in viral titer was determined by E

221 Here, we report that BaP-mediated upregulation of virus synthesis is correlat

222 ies indicate time-of-day exposure influences BaP metabolism in mouse mammary glands and describe an i

223 in vitro model for investigating changes in BaP metabolism resulting from cross-talk between the mol

224 on receptor-induced P450 gene expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp

225 pact of circadian rhythms on benzo-a-pyrene (BaP) metabolism in the mouse mammary gland and develop a

226 ment, as evident by the measurable levels of BaP metabolites in virtually all human urine samples exa

227 BaP-metabolizing CYP1B1 in the PSI and CYP3A59 in the PG

228 Overall, BaP modulation of the HPV life cycle could potentially e

229 rall geometric mean (GM) of outdoor PM(2.5), BaP, NAP, and NO(2) were 45.3 ug/m(3), 9.7 ng/m(3), 707.

230 such that significant amounts of the inducer BaP no longer reach the liver.

231 By contrast, neither benzo(a)pyrene (BaP) nor fine particulate matter with aerodynamic diamet

232 Dexamethasone enhanced the effect of BaP on cell numbers and altered the impact on neurotrans

233 We explored the effects of benzo[a]pyrene (BaP) on neurodifferentiation in PC12 cells, in combinati

234 ls (metabolically competent) were exposed to BaP or PhIP individually or in mixtures.

235 The osteoclastogenesis triggered by BaP or RANK-L was reduced in Ahr(-/-) cells, consistent

236 ase from a backpropagating action potential (bAP) or subthreshold depolarization was reduced if it wa

237 modeling demonstrates that the slow decay of BaP over long times can be simulated if there is slow di

238 orb BaP in ratios of up to 10/1 to 5/1 lipid/BaP, over a 2-week period at 33 degrees C.

239 ically, thermodynamic modeling predicts that BaP phase separates from secondary organic aerosol mater

240 We demonstrate that BAP predominantly regulates proteins involved in carbohy

241 s and the ABA response, whereas in the root, BAP rapidly and strongly up-regulates the majority of pr

242 The extent to which BaP RBA was diminished in soil versus food varied among

243 of cervical cells to high concentrations of BaP resulted in a 10-fold increase in HPV type 31 (HPV31

244 whereas treatment with low concentrations of BaP resulted in an increased number of HPV genome copies

245 condary organic aerosol material so that the BaP-rich layer at the surface shields the inner BaP from

246 On BAP, sensitivity was 96.0% with induced growth.

247 Low molecular mass BAP sequences are less likely to be broken down by diges

248 oxyguanosine (dG) adducts of benzo[a]pyrene (BaP) series 1 (syn) and benzo[c]phenanthrene (BcPh) seri

249 nd calcium signals, the spatial influence of bAP signaling in TC and TRN neurons is more restricted,

250 colloidal stability, when added to saturated BaP solutions, sorb BaP in ratios of up to 10/1 to 5/1 l

251 -SLBs and DMPC-SUVs, indicating preferential BaP sorption into the hydrophobic lipids.

252 Bap-specific monoclonal antibody (MAb) 6E3 was generated

253 in bone marrow cell cultures and gavage with BaP stimulated bone resorption and osteoclastogenesis in

254 AP) and the known carcinogen benzo(a)pyrene (BaP), sulfur dioxide (SO(2)), and nitrogen dioxide (NO(2

255 growth, but it synergistically enhanced the BaP suppression of differentiation into both dopaminergi

256 BaP targeting of CDK1 occurred independently of HPV stat

257 ategories: bone augmentation procedures (11% BAP), teeth extractions (26% EXT), surgical implant plac

258 [2,3-b]indole (AalphaC), and benzo[a]pyrene (BaP); the cooked-meat carcinogens MeIQx, AalphaC, and 2-

259 This BAP-TM allows noninvasive real-time imaging of any cell

260 Tumors expressing the BAP-TM have high sensitivity for magnetic resonance and

261 ivation of L1 is dependent on the ability of BaP to cause DNA damage because it is absent in HeLa cel

262 followed by incubation with benzo[a]pyrene (BaP), to investigate the effects of these compounds on t

263 fuel oil-to which (3)H-benzo(a)pyrene ((3)H-BaP; total BaP concentrations of 1, 10, and 100 ppm) was

264 etermine the role of miRNAs as regulators of BAP toxicity and identify the predicted functional conse

265 or several miRNAs as potential regulators of BAP toxicity in human lung cells associated with cell mi

266 ternal ASD-PGSs were explored in relation to BAP traits and their child's ASD symptomatology.

267 Our results confirm that BAP treated hESC (ESCd) lack a mesoderm signature and ar

268 l A, a specific inhibitor of CDK1 kinase, to BaP-treated cultures, resulted in the production of noni

269 Oral BaP-treated Cyp1a1/1a2/1b1(-/-) mice showed the same "re

270 s of the same genotype, Gclm(-/-) prenatally BaP-treated females had significantly greater decrements

271 ments in offspring production than Gclm(+/+) BaP-treated females.

272 y (LC-MS)-based detection of BPDE-N(2)-dG in BaP-treated rodents, and indirectly through high-perform

273 hifts in urinary metabolite patterns in oral BaP-treated triple-knockout and wild-type mice were also

274 Finally, BaP treatment activated p90RSK and its downstream target

275 Here, we show that BaP treatment activates the Ras-Raf-Mek1/2-Erk1/2 signal

276 Furthermore, we found that BAP treatment affects endogenous hormonal homeostasis, a

277 occurred independently of HPV status, since BaP treatment also increased CDK1 activity in tissues de

278 BaP treatment decreased fatty acid and phospholipid bios

279 Specifically, BaP treatment increased accumulation of hyperphosphoryla

280 important role in mediating the response to BaP treatment that ultimately leads to increased viral t

281 A and fibroblast growth factor-2 signaling (BAP treatment).

282 Benzo[a]pyrene (BaP) treatment induced oxidative stress, mitochondrial r

283 In the shoot, BAP up-regulates the abundance of proteins involved in a

284 bF (up to 0.39 ng/g), BkF (up to 0.90 ng/g), BaP (up to 0.29 ng/g) and Bghip (up to 0.43 ng/g) were d

285 wn in sediments spiked with BaP, in 12 h the BaP uptake could be visualized using fluorescence micros

286 of soil organic matter, does not affect the BaP uptake rate by DMPC-NP-SLBs and DMPC-SUVs, indicatin

287 d electron microscopy (EM) structures of the BAP variant of ClpB that binds the protease ClpP, clearl

288 d to the bacterial biotin acceptor peptides (BAP) varies among different mammalian cell types and can

289 limit of detection (LOD) of 5.2 x 10(-11) M BaP was achieved, and highly accurate, that is, a repeat

290 backpropagating dendritic action potential (bAP) was not critical in this process.

291 After several days of oral BaP, we found surprisingly low CYP1A1 levels in liver, c

292 studied prototype of PAHs is benzo[a]pyrene (BaP), well known to be toxic, mutagenic, and carcinogeni

293 PV31b virions synthesized in the presence of BaP were dependent on BaP-mediated alteration in CDK1 ki

294 reticulum (ER)-associated co-chaperone SIL1/BAP were identified to be the major cause of MSS.

295 HCAs and BaP were significantly associated with increased risk of

296 Bronchial allergen provocations (BAP) were repeated at weeks 1, 2, 4, and 8.

297 zo[b]fluoranthene (BbF), and benzo[a]pyrene (BaP), were detected in 96% of the samples at individual

298 ferase induction relative to benzo[a]pyrene (BaP), which is used as a positive reference PAH congener

299 d from growth on BMHA and blood agar plates (BAP), with and without cefoxitin disk induction.

300 xyguanosine and a diol epoxide metabolite of BaP, with subsequent mutation of critical growth control