ライフサイエンスコーパス: Breg cell

1 ween plasmacytoid dendritic cells (pDCs) and Breg cells.

2 T cell-dependent inflammatory response into Breg cells.

3 mablast differentiation but failed to induce Breg cells.

4 plasmablasts, and IL-10(+) and/or IL-1RA(+) Breg cells.

5 onditions reduces the number and function of Breg cells.

6 e the functional properties and phenotype of Breg cells?

7 ll subsets shows that GA-dependent increased Breg cell activities are specifically supported by the B

8 p35 may be utilized for in vivo expansion of Breg cells and autologous Breg cell immunotherapy.

9 induces both human and mouse IL-10-producing Breg cells and increases their survival with a concomita

10 B cells into IL-10-producing CD24(+)CD38(hi) Breg cells and plasmablasts, via the release of IFN-alph

11 Here we show that IL-35 induces Breg cells and promotes their conversion to a Breg subse

12 the regulatory properties of a new brand of Breg cells and provided mechanistic insights into potent

13 used to induce autologous Breg and IL-35(+) Breg cells and treat autoimmune and inflammatory disease

14 t SLAMF5 is a negative moderator of IL-10(+) Breg cells, and may serve as a therapeutic target in MS

15 Taken together, Breg cells appear to be involved in mediating allergen t

16 This work describes how Breg cells are critical in humoral homoeostasis and may

17 CD19(+)CD73(-)CD25(+)CD71(+)TIM-1(+)CD154(+) Breg cells are enriched in the peripheral blood of human

18 Regulatory B (Breg) cells are characterized by their immunosuppressive

19 Regulatory B (Breg) cells are immunosuppressive cells that support imm

20 Can a Breg cell arise at every stage in B cell development?

21 We highlight these Breg cells as a new important factor in the modulation o

22 and desensitized groups, B cell activation-, Breg cells-, BCR-signaling-, and differentiation-related

23 cells, they also raise other questions about Breg cell biology and phenotype.

24 ons to discuss the advances in understanding Breg cell biology, with a particular emphasis on their o

25 in vivo existence of allergen-specific human Breg cells comes from direct detection of their increase

26 Human Breg cells control TFH cell maturation, expand follicula

27 CD24(+)CD38(hi) Breg cells conversely restrained IFN-alpha production by

28 The majority of Breg cells described in mouse and man have been identifi

29 asmablast differentiation, and regulatory B (Breg) cell development during allergen-specific immunoth

30 Regulatory B cells (Breg cells) differentiate in response to inflammation an

31 sed mice and both cytokines directly promote Breg cell differentiation and IL-10 production.

32 Is inflammation the primary requisite for Breg cell differentiation?

33 ignaling (IL-12Rbeta2 KO mice) produced less Breg cells endogenously or after treatment with IL-35 an

34 G subtypes and Ab avidity; and regulatory B (Breg) cell frequency and function.

35 Several types of murine and human Breg cells have been described, such as mouse CD5(+)CD1d

36 this review, we discuss immunobiology of i35-Breg cell, i35-Breg therapies for autoimmune diseases an

37 vivo expansion of Breg cells and autologous Breg cell immunotherapy.

38 ovel observations demonstrate a role for the Breg cell in germinal center reactions and suggest that

39 could be a useful therapy for recovering the Breg cells in autoimmune situations in which their activ

40 t microbiota promotes the differentiation of Breg cells in the spleen as well as in the mesenteric ly

41 ts have shown the ability to induce Treg and Breg cells in vivo which may have potential importance f

42 e control of the activities of regulatory B (Breg) cells in immune disorders is an emerging therapeut

43 induced by both the gut flora and arthritis, Breg cells increase in number and restrain excessive inf

44 Adoptive transfer of Breg cells induced by recombinant IL-35 suppressed EAU w

45 opose that alteration in pDC-CD24(+)CD38(hi) Breg cell interaction contributes to the pathogenesis of

46 Both altered pDC-CD24(+)CD38(hi) Breg cell interactions and STAT1-STAT3 activation were n

47 However, Breg cell mediated immune suppression, independent of IL

48 Human regulatory B (Breg) cells modulate cellular responses, but their contr

49 Breg cells modulated IL-21 receptor expressions on TFH c

50 ve pDC-mediated expansion of CD24(+)CD38(hi) Breg cell numbers in SLE was associated with altered STA

51 Breg cells obtained by Toll-like receptor 9 and CD40 act

52 We sought to assess the role of Breg cells on TFH cell development and function.

53 Allergen-specific regulatory T and Breg cells orchestrate a general immunoregulatory activi

54 Here we show that Breg cells play a critical role in regulating humoral im

55 nt inflammatory environments induce distinct Breg cell populations.

56 autoimmune disease, and increased numbers of Breg cells prevent host defense to infection and promote

57 ystem to determine its direct effects on the Breg cell properties of human B cells.

58 s mediating the induction and development of Breg cells remain unclear.

59 controlling the generation of regulatory B (Breg) cells remain ill-defined.

60 generation of regulatory T and regulatory B (Breg) cell responses; regulation of IgE and IgG4; decrea

61 IL-10(+) and dual-positive IL-10(+)IL-1RA(+) Breg cells significantly correlated with improved clinic

62 on their ontogeny; we propose that multiple Breg cell subsets can be induced in response to inflamma

63 ssion of TIM1 or TIM4 on these Breg or other Breg cell subsets.

64 transforming growth factor beta (TGF-beta), Breg cells suppress immunopathology by prohibiting the e

65 terleukin-10 (IL-10)-producing regulatory B (Breg) cells suppress autoimmune disease, and increased n

66 Peripheral blood CD19(+)CD25(+) Breg cells suppressed T cell proliferation compared with

67 quality control measures to deliver a viable Breg-cell therapy product for administration to a transp

68 opulation selection and quality control of a Breg-cell therapy product.

69 induced the conversion of human B cells into Breg cells, these findings suggest that IL-35 may be use

70 flammatory signals in the differentiation of Breg cells, they also raise other questions about Breg c

71 Human Breg cell types include CD27(+)CD24(high) B10 cells, CD2

72 smablasts and IL-10- and/or IL-1RA-producing Breg cells was greater among responders compared with no

73 Recently, inducible IL-10-secreting Breg cells were also demonstrated to contribute to aller

74 Breg cells were included in these cultures, and their ef

75 IL-1 receptor antagonist (IL-1RA)-producing Breg cells were investigated and correlated to clinical