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1 ve to CC chemokines, which is unique to CX(3)C chemokines.
2 are a rich source of eosinophil-selective C-C chemokines.
3 decrease in the production of a number of C-C chemokines.
4 anced expression of a profile of C-C and C-X-C chemokines.
5 on the discrete target cell selectivity of C-C chemokines.
6 dus-2 also had unusual characteristics for C-C chemokines.
7 t broadly recognizes human and murine CC and C chemokines.
8 kine genes, including TNFalpha, IL6, and C-X-C chemokine 10 (CXCL10) Exosomes engineered with elevate
9 tively, elevated serum concentrations of C-X-C chemokine 10 (CXCL10), a potent chemoattractant for an
10 ternative macrophage activation-associated C-C chemokine (AMAC) 1, or dendritic cell-derived C-C chem
13 helial cells (PMC) to release C-X-C and/or C-C chemokines and express adhesion molecules that initiat
15 h increased expression of genes encoding C-X-C chemokines and inflammatory cytokines when compared wi
16 ells from normal and HIV-1+ donors produce C-C chemokines and other unidentified factors that can inh
17 The data suggest that a dual mechanism of C-C chemokines and specific Abs may engage and down-modula
18 owed distinct differences in expression of C-C chemokines and their receptors between children with H
19 tory protein-1alpha (MIP-1alpha) and other C-C chemokines, and that addition of anti-CD28 gives very
23 We observed that Stx1 induces multiple C-X-C chemokines at the mRNA level, including interleukin-8
24 is overproduction of eosinophil-promoting C-C chemokines by sinus epithelium, perhaps driven in part
25 Previous studies have suggested that the C-C chemokine C10 is involved in the chronic stages of hos
28 hage inflammatory protein [MIP]-1alpha), C-X-C chemokines (cytokine induced neutrophil chemoattractan
31 racterized by elevated IgE, Th2 cytokines, C-C chemokines, eosinophilic inflammation, and persistent
34 man colonic epithelial cells produce the C-X-C chemokine epithelial neutrophil-activating peptide-78
36 hat Th1 and Th2 cytokines may regulate the C-C chemokine expression in PMCs and thus play a biologica
37 , we examined the effect of MIP-1 gamma, a C-C chemokine family member, on receptor activator of NF-k
38 possibility that the sole member of the CX(3)C chemokine family, fractalkine (fkn), induces angiogene
39 site regulation of MCP-1, a member of the C-C chemokine family, in a rat model of volume-overload co
40 Fractalkine, the first member of the CX(3)C chemokine family, induces leukocyte chemotaxis through
43 chemokine lymphotactin, and the murine CX(3)C chemokine fractalkine with high affinity (K(d) = 1.6 t
44 2 cells may induce selective production of C-C chemokines from epithelium and indicate that glucocort
45 mine lung tissue for expression of CXC and C-C chemokine genes and bronchoalveolar lavage (BAL) fluid
48 MDM, we found that the production of the C-X-C chemokine growth-regulated oncogene alpha (GRO-alpha)
50 inophil activation; however, mRNA for this C-C chemokine has been shown to be constitutively expresse
52 lammation with increases in Th2 cytokines, C-C chemokines, IgE production, and mucous cell metaplasia
53 challenge with increases in Th2 cytokines, C-C chemokines, IgE production, and mucous cell metaplasia
54 mononuclear cells (CBMC) to secrete these C-C chemokines in comparison to adult blood mononuclear ce
55 ease mRNA and protein levels of multiple C-X-C chemokines in IECs, with increased mRNA stability at l
57 usly shown that Stxs can induce multiple C-X-C chemokines in intestinal epithelial cells in vitro, in
60 D4-specific chemoattractant, and RANTES, a C-C chemokine, in response to GD-specific IgG (GD-IgG).
66 of the monocyte chemotactic and activating C-C chemokine JE/monocyte chemotactic protein-1 has been p
67 ion at 90 minutes; the generation of the C-X-C chemokine KC (2.86 +/- 0.30 ng/mL at 5 hours); sinusoi
68 this study, we assessed the role of the C-X-C chemokine KC in lung antibacterial host defense using
69 factor alpha and interleukin (IL-12) and C-X-C chemokines KC and macrophage inflammatory protein 2 th
70 ytokines with myelogenic potential such as C-C chemokine ligand (CCL)2, interleukin (IL)-6, and VEGF-
71 a, tumor necrosis factor-alpha, IL-6, or C-X-C chemokine ligand 1 in blood or brain, but systemic IL-
72 Crystal structures of M3 in complex with C chemokine ligand 1/lymphotactin and CC chemokine ligan
73 iral therapy (ART) initiation, levels of C-X-C chemokine ligand 10 (CXCL10), lipopolysaccharide-bindi
74 racterize the homologues of human eotaxin (C-C chemokine ligand 11) and CCR3 from other species, such
75 at anti-VEGFR2 therapy up-regulates both C-X-C chemokine ligand 12 (CXCL12) and C-X-C chemokine recep
77 4, telomerase reverse transcriptase, and C-X-C chemokine ligand 12 compared with NS-deficient mammary
79 identify the T-cell activation regulators C-C chemokine ligand 19 and C-C chemokine receptor 7 as po
80 obesity activates hepatocyte expression of C-C chemokine ligand 2 (CCL2/MCP-1) leading to hepatic rec
82 s, presumably via a mechanism of decreased C-C chemokine ligand 2 levels in the cerebrospinal fluid.
83 e the role of the C-C chemokine receptor 6/C-C chemokine ligand 20 (CCR6/CCL20) chemokine axis in med
84 Several N-terminally engineered analogs of C-C chemokine ligand 5 (CCL5), a natural ligand of CCR5, a
86 n in many inflammatory chemokines, such as C-C chemokine ligand 5, CXC ligand 9 (CXCL9), and CXCL10.
87 F-deficient mice had reduced expression of C-C chemokine ligand 5, CXCL9, and CXCL10 at early time po
88 )Flk1(+) circulating angiogenic cells in a C-C chemokine ligand 5/C-C chemokine receptor 5-dependent
90 ze IL-21(+)CXCL13(+) (IL-21-positive and C-X-C chemokine ligand type 13-positive) Tfh-like cells.
91 ALD, and increased circulating chemokines, C-C chemokine ligand types 2 (CCL2), and C-C chemokine lig
92 , C-C chemokine ligand types 2 (CCL2), and C-C chemokine ligand types 5 (CCL5) in patients with alcoh
94 uman CXC chemokine interleukin-8, the murine C chemokine lymphotactin, and the murine CX(3)C chemokin
95 t not TGF-beta2 or TGF-beta3, and elevated C-C chemokines macrophage chemoattractant protein-1, macro
97 macrophage inflammatory protein-2 and the C-C chemokines macrophage inflammatory protein-1alpha and
98 ity by induction of the cysteine-cysteine (C-C) chemokine macrophage inflammatory protein 1beta (MIP-
99 on with a decrease in lung levels of the C-X-C chemokine, macrophage inflammatory protein-2 and the C
100 cells may be critical effector cells, and C-C chemokines may play important roles in the initiation
103 the receptor for the IFN-gamma-inducible C-X-C chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11.
110 age inflammatory protein-2, as well as the C-C chemokines murine monocyte chemoattractant protein-1 a
112 CHEMR1 may be a receptor for unidentified C-C chemokine or a low-affinity receptor for MIP-1alpha.
113 emonstrating that mesothelial cell-derived C-C chemokines play a biologically important role in the r
121 deltaT cells are recruited to the liver by C-C chemokine receptor (CCR) 2, CCR5, and nucleotide-bindi
125 major histocompatibility complex class II, C-C chemokine receptor (CCR) type 1, CCR2, CX3C chemokine
126 chemokine (C-C motif) ligand (CCL)2, CCL4, C-C chemokine receptor (CCR)1, and CCR5, which are involve
127 revealed that HCC-1 specifically activated C-C chemokine receptor (CCR)1, but not closely related rec
128 -) T cells were activated CD69(+)CD45RA(-) C-C chemokine receptor (CCR)7(-) effector memory and perfo
129 s been shown to increase the production of C-C chemokine receptor (CCR5)-binding chemokines under cer
131 zyme cyclooxygenase-2, the IL-8 receptor C-X-C chemokine receptor (CXCR) 1, and the intracellular kin
133 The chemokine CXCL16 and its receptor, C-X-C chemokine receptor (CXCR6), affect tumor progression t
136 ME-treated mice expressed higher levels of C-C chemokine receptor 2 (CCR2) and CCR3 mRNA and containe
140 c steatosis in obese mice deficient in the C-C chemokine receptor 2 (CCR2) that regulates myeloid cel
142 enerate mice with a targeted disruption of C-C chemokine receptor 2 (CCR2), the receptor for MCP-1.
143 e inflammation, it remains unclear whether C-C chemokine receptor 2 (CCR2)- and Ly6C-expressing infla
144 C chemokine receptor 5 (CCR5)-Delta 32 and C-C chemokine receptor 2 (CCR2)-64I (relative hazard = 0.4
148 hat the monocyte chemoattractant protein-1/C-C chemokine receptor 2 axis plays a critical role in the
149 gh) monocytes express heightened levels of C-C chemokine receptor 2 on their surface, avidly infiltra
150 Monocyte chemoattractant protein-1 and C-C chemokine receptor 2 were increased in the tissues fro
151 monocyte chemoattractant protein (MCP)-1, C-C chemokine receptor 2(CCR2), interleukin (IL)-1beta, an
152 distinct subsets of tissue-resident CCR2- (C-C chemokine receptor 2) and CCR2+ macrophages orchestrat
160 The G protein-coupled receptor (GPCR) C-X-C chemokine receptor 3 (CXCR3) is a potential drug targe
161 dition to IL-17A, the chemokine receptor C-X-C chemokine receptor 3 (CXCR3) is also important to enab
162 and abolished their differentiation into C-X-C chemokine receptor 3 (CXCR3)(lo)CD43(lo) effector-like
164 e found that HIV-1 coat proteins that used C-C chemokine receptor 3 or C-X-C chemokine receptor 4 as
165 ig), which like HuIP-10 is an agonist of C-X-C chemokine receptor 3, does not inhibit KSHV-GPCR signa
168 of the chemokine (C-X-C motif) ligand 12/C-X-C chemokine receptor 4 (CXCR4) and VEGF/VEGFR1 pathways
170 h C-X-C chemokine ligand 12 (CXCL12) and C-X-C chemokine receptor 4 (CXCR4) in orthotopic murine CRC
172 The G protein-coupled protein receptor C-X-C chemokine receptor 4 (CXCR4) is an attractive target f
173 tors C-C chemokine receptor 7 (CCR7) and C-X-C chemokine receptor 4 (CXCR4) on melanoma cells undergo
175 Aggressive human melanomas express, C-X-C chemokine receptor 4 (CXCR4), the receptor for the che
176 ns that used C-C chemokine receptor 3 or C-X-C chemokine receptor 4 as coreceptors inhibited prolifer
177 he stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 axis, in the development of those
178 ifications of the chemokine RANTES bind to C-C chemokine receptor 5 (CCR5) and block human immunodefi
179 We have shown that mice that express the C-C chemokine receptor 5 (CCR5) have enhanced local tumor
180 s study, we demonstrate a crucial role for C-C chemokine receptor 5 (CCR5) in the accelerated recruit
183 used a B16-F10 melanoma model to show that C-C chemokine receptor 5 (CCR5) knockout (CCR5(-/-)) mice
184 we evaluated whether the disruption of the C-C chemokine receptor 5 (CCR5) locus in pigtailed macaque
185 o CD4 followed by engagement of either the C-C chemokine receptor 5 (CCR5) or C-X-C chemokine recepto
189 of breast milk CD4(+) T cells expressed the C chemokine receptor 5 (CCR5), whereas 26%-73% of cells
190 -67% of the vaginal CD4(+) T cells expressed C chemokine receptor 5 (CCR5), whereas 84%-99% coexpress
191 of a protective genotype, consisted of: 1) C-C chemokine receptor 5 (CCR5)-Delta 32 and C-C chemokine
194 iral load and could be traced to a single, C-C chemokine receptor 5-tropic founder virus with shorter
195 al autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic
197 s study was to investigate the role of the C-C chemokine receptor 6/C-C chemokine ligand 20 (CCR6/CCL
198 We hypothesized that chemokine receptors C-C chemokine receptor 7 (CCR7) and C-X-C chemokine recept
199 ells carry out immune functions, using the C-C chemokine receptor 7 (CCR7) and its cognate ligands, C
200 ates CXCR5 but not Bcl6, and downregulates C-C chemokine receptor 7 (CCR7) expression in T cells in v
202 ) adipose tissue immune cells that express C-C chemokine receptor 7 (CCR7) in mice and humans, and th
204 ion regulators C-C chemokine ligand 19 and C-C chemokine receptor 7 as potential mediators of immune
205 up-regulation of SDF-1, and its receptor C-X-C chemokine receptor 7, was documented on podocytes and
208 -X-C chemokine receptor type 4 (CXCR4) and C-C chemokine receptor type 1 (CCR1), which are the recept
209 requency of MO, T cells, and expression of C-C chemokine receptor type 2 (Ccr2) and C-C chemokine rec
214 ic burned patients with a special focus on C-C chemokine receptor type 2 (CCR2) expressions on classi
217 whether CCX140-B, a selective inhibitor of C-C chemokine receptor type 2 (CCR2), could further reduce
218 tants of C-C motif chemokine 7 (CCL7) with C-C chemokine receptor type 2 (CCR2), monosulfated CCR2, a
221 ting factor 1 receptor blockade diminished C-C chemokine receptor type 2 [CCR2(neg) (Ly6C(lo))] monoc
222 macrophage-1 receptor, Sialil-Lewis X, and C-C chemokine receptor type 2 expression in monocytes.
223 especially within the hemoglobin delta and C-C chemokine receptor type 2 genes, respectively, causing
225 ngolimod (FTY720)-sensitive manner and use C-C chemokine receptor type 2 to accumulate in inflamed sk
226 encing of the monocyte-recruiting receptor C-C chemokine receptor type 2 with short-interfering RNA d
227 , the heart is largely populated by CCR2- (C-C chemokine receptor type 2) macrophages of embryonic de
228 IL-13 receptor alpha1 and donor eosinophil C-C chemokine receptor type 3 (CCR3) and interleukin 1 rec
229 or this activation, and the combination of C-C chemokine receptor type 4 (CCR4) chemokine receptors a
230 two G protein-coupled receptors (GPCRs) C-X-C chemokine receptor type 4 (CXCR4) and atypical chemoki
231 tions were impaired by the inhibitors of C-X-C chemokine receptor type 4 (CXCR4) and C-C chemokine re
232 al features, including overexpression of C-X-C chemokine receptor type 4 (CXCR4) and upregulation of
233 f a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AMD310
234 eviously demonstrated that antagonism of C-X-C chemokine receptor type 4 (CXCR4) by plerixafor (AMD31
236 aro et al demonstrate high expression of C-X-C chemokine receptor type 4 (CXCR4) mutation in Waldenst
239 ly, a pepducin selectively targeting the C-X-C chemokine receptor type 4 (CXCR4) was found to be an a
240 ed by altered expression of the cytokine C-X-C chemokine receptor type 4 (Cxcr4), an established regu
242 up-regulation of c-Kit, IL-3Ralpha, and C-X-C chemokine receptor type 4 from either human ECs or emb
243 ing a hybrid beta(2)-adrenergic receptor-C-X-C chemokine receptor type 4 structure as a template, we
244 s was correlated with the number of dermal C-C chemokine receptor type 4(+) T helper type 2 cells, IL
245 rophil aging, were antagonized by CXCR4 (C-X-C chemokine receptor type 4) and regulated the outer top
246 ce in collagen and elastin staining, and C-X-C chemokine receptor type 4, nuclear factor kappa beta,
247 chrome c, stromal cell-derived factor-1, C-X-C chemokine receptor type 4, vascular endothelial growth
249 nhibitor T20 (Fuzeon, enfuvirtide) and the C-C chemokine receptor type 5 (CCR5) blocker maraviroc (Se
250 f C-C chemokine receptor type 2 (Ccr2) and C-C chemokine receptor type 5 (Ccr5) in the livers of pati
252 studies demonstrated that ORM1 can bind to C-C chemokine receptor type 5 (CCR5) on muscle cells and d
254 cantly higher prechallenge levels of CD4(+)C-C chemokine receptor type 5 (CCR5)(+)HLA-DR(+) T cells i
255 ortance of the G-protein-coupled receptor, C-C chemokine receptor type 5 (CCR5), in human disease sin
257 get T-cell population is enriched with a C-X-C chemokine receptor type 5 (CXCR5)(+)CD4(+) TFH precurs
259 ms targeting the human hemoglobin beta and C-C chemokine receptor type 5 genes have substantial off-t
260 emokine (C-C motif) ligand 5 that binds to C-C chemokine receptor type 5 on BCCs and BCCs secrete cyt
262 SIV)-specific CD8 T cells express CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor requir
264 motif) ligand 16 (CXCL16) that binds to C-X-C chemokine receptor type 6 (CXCR6) on MSCs and MSCs sec
265 ion and expression of the migration marker C-C chemokine receptor type 7 (CCR7) in PGN-stimulated cel
266 e-homing molecules CD62 ligand (CD62L) and C-C chemokine receptor type 7 (CCR7), which are expressed
267 receptor 3 (ACKR3), previously known as C-X-C chemokine receptor type 7 (CXCR7), has emerged as a ke
268 ling (CD14dimCD16(+)) monocytes, and their C-C chemokine receptor type-2 (CCR2) expression were quant
272 Ccl-2; also known as MCP-1) or its cognate C-C chemokine receptor-2 (Ccr-2) develop cardinal features
273 n immunodeficiency virus (HIV) and human C-X-C chemokine receptor-4 (CXCR4) facilitates migration of
274 antly, expression of the protumorigenic, C-X-C chemokine receptor-4 (CXCR4), was reduced in DEN-induc
277 ) joint, we investigated the expression of C-C chemokine receptors (CCR) 1-6 and C-X-C receptor 3 (CX
279 filtrate by modulating the expression of C-X-C chemokine receptors 2 and 4 on peripheral blood neutro
280 n experiments using cells transfected with C-C chemokine receptors, 125I-MCP-2 bound to human embryon
281 interferon-gamma, [IFN-gamma], and IL-12), C-C chemokines (regulated upon activation, normal T cell e
283 -gamma-inducible protein 10 (HuIP-10), a C-X-C chemokine, specifically inhibits signaling of KSHV-GPC
284 eceptor has been shown to respond to the C-X-C chemokine stromal-derived factor (SDF-1) and has recen
285 Lymphotactin, the unique member of the "C" chemokine subclass, is a highly basic protein that bi
288 aracterization of a novel murine and human C-C chemokine termed Exodus-2 for its similarity to Exodus
289 4) is an abundant platelet alpha-granule C-X-C chemokine that has weak chemotactic potency but strong
290 C-C chemokine (HCC)-1 is a recently cloned C-C chemokine that is structurally similar to macrophage i
291 moattractant protein-1 is one of the major C-C chemokines that has been implicated in liver injury.
293 ral basis for pleiotropic signaling of the C-C chemokine type 5 (CCR5) G protein-coupled receptor (GP
294 ion of proinflammatory cytokines C-C and C-X-C chemokines was seen in the rats exhibiting necroinflam
295 ograft RNA expression of several C-X-C and C-C chemokines was tested during rejection of full thickne
296 e in eotaxin, a potent eosinophil-specific C-C chemokine, was also observed during fibroblast-mast ce
298 experiments provide direct evidence that C-X-C chemokines, when expressed in sufficient quantity in t
299 nflammatory protein 1alpha (MIP-1alpha), a C-C chemokine with monocyte chemoattractant capability, in
300 ic protein-4 (MCP-4) is a newly identified C-C chemokine with potent eosinophil chemoattractant prope