ライフサイエンスコーパス: C-X-C chemokine

1 enhanced expression of a profile of C-C and C-X-C chemokines.

2 ion in response to these two closely related C-X-C chemokines.

3 cytokine genes, including TNFalpha, IL6, and C-X-C chemokine 10 (CXCL10) Exosomes engineered with ele

4 ntuitively, elevated serum concentrations of C-X-C chemokine 10 (CXCL10), a potent chemoattractant fo

5 with increased expression of genes encoding C-X-C chemokines and inflammatory cytokines when compare

6 C-X-C chemokines are potent chemoattractants that are be

7 HT-29 cells induced mRNA for several C-C and C-X-C chemokines as well as IFNs and GM-CSF.

8 We observed that Stx1 induces multiple C-X-C chemokines at the mRNA level, including interleuki

9 y with the rapid but transient expression of C-X-C chemokines by epithelial cells infected with invas

10 NA complexes to ablate the gene encoding the C-X-C chemokine co-receptor type 4 in primary human CD4(

11 crophage inflammatory protein [MIP]-1alpha), C-X-C chemokines (cytokine induced neutrophil chemoattra

12 t human colonic epithelial cells produce the C-X-C chemokine epithelial neutrophil-activating peptide

13 phil chemoattractant (CINC), a member of the C-X-C chemokine family, in intact rats.

14 ucible protein-10 (IP-10) is a member of the C-X-C chemokine family.

15 s to determine the effect of Stx1 on various C-X-C chemokine genes in IECs.

16 in MDM, we found that the production of the C-X-C chemokine growth-regulated oncogene alpha (GRO-alp

17 However, the human C-X-C chemokines growth-regulated oncogene (GROalpha) an

18 The data suggest that C-X-C chemokines have important pathogenic potential in

19 increase mRNA and protein levels of multiple C-X-C chemokines in IECs, with increased mRNA stability

20 eviously shown that Stxs can induce multiple C-X-C chemokines in intestinal epithelial cells in vitro

21 This study examined the role of C-X-C chemokines in PMN infiltration into P. aeruginosa-

22 Recent studies suggest a role for C-X-C chemokines in the pathogenesis of neutrophilic hep

23 e MIG (monokine induced by IFNgamma) gene, a C-X-C chemokine, in mouse macrophages.

24 and monocyte chemotactic protein-3, and the C-X-C chemokine interferon-inducible protein-10.

25 The expression and secretion of the C-X-C chemokines interleukin-8 (IL-8) and GROalpha were

26 Production of the C-X-C chemokines interleukin-8 (IL-8) and growth-regulat

27 Interleukin-8 (IL-8), a C-X-C chemokine, is induced by TNF-alpha and initiates i

28 ivation at 90 minutes; the generation of the C-X-C chemokine KC (2.86 +/- 0.30 ng/mL at 5 hours); sin

29 In this study, we assessed the role of the C-X-C chemokine KC in lung antibacterial host defense us

30 sis factor alpha and interleukin (IL-12) and C-X-C chemokines KC and macrophage inflammatory protein

31 1beta, tumor necrosis factor-alpha, IL-6, or C-X-C chemokine ligand 1 in blood or brain, but systemic

32 troviral therapy (ART) initiation, levels of C-X-C chemokine ligand 10 (CXCL10), lipopolysaccharide-b

33 d that anti-VEGFR2 therapy up-regulates both C-X-C chemokine ligand 12 (CXCL12) and C-X-C chemokine r

34 Binding of its ligand, C-X-C chemokine ligand 12 (CXCL12), results in receptor

35 Oct4, telomerase reverse transcriptase, and C-X-C chemokine ligand 12 compared with NS-deficient mam

36 ng C-C motif chemokine ligand (CCL)5, CCL20, C-X-C chemokine ligand 8, IL-6, and IFN-beta.

37 larize IL-21(+)CXCL13(+) (IL-21-positive and C-X-C chemokine ligand type 13-positive) Tfh-like cells.

38 The role the C-X-C chemokines macrophage inflammatory protein (MIP)-2

39 iation with a decrease in lung levels of the C-X-C chemokine, macrophage inflammatory protein-2 and t

40 hage functions, has been shown to induce the C-X-C chemokines Mig and IP-10.

41 is the receptor for the IFN-gamma-inducible C-X-C chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL

42 mokine ligand 12 (CXCL12) has two receptors: C-X-C chemokine motif receptor 4 (CXCR4) and atypical ch

43 Interestingly, the C-X-C chemokine murine macrophage inflammatory protein-2

44 The C-X-C chemokines of the IL-8 family possess potent chemo

45 describe cellular and tissue targets of rat C-X-C chemokine peptides.

46 rvum-infected epithelial cells suggests that C-X-C chemokines produced by those cells contribute to t

47 The kinetics of C-X-C chemokine production by C. parvum-infected epithel

48 ll-derived chemokine, MIP-2, and LPS-induced C-X-C chemokine production in the lungs.

49 vation; and TNF-alpha, IL-6, and LPS-induced C-X-C chemokine production in the lungs.

50 c enzyme cyclooxygenase-2, the IL-8 receptor C-X-C chemokine receptor (CXCR) 1, and the intracellular

51 its leukocytes after binding to its receptor C-X-C chemokine receptor (CXCR) 3.

52 The chemokine CXCL16 and its receptor, C-X-C chemokine receptor (CXCR6), affect tumor progressi

53 igated the role of the chemotactic receptors C-X-C chemokine receptor 3 (CXCR3) and C-C chemokine rec

54 The G protein-coupled receptor (GPCR) C-X-C chemokine receptor 3 (CXCR3) is a potential drug t

55 n addition to IL-17A, the chemokine receptor C-X-C chemokine receptor 3 (CXCR3) is also important to

56 ion and abolished their differentiation into C-X-C chemokine receptor 3 (CXCR3)(lo)CD43(lo) effector-

57 Lymphocytes expressing C-X-C chemokine receptor 3 CD8 significantly correlated

58 (HuMig), which like HuIP-10 is an agonist of C-X-C chemokine receptor 3, does not inhibit KSHV-GPCR s

59 ole of the chemokine (C-X-C motif) ligand 12/C-X-C chemokine receptor 4 (CXCR4) and VEGF/VEGFR1 pathw

60 ither the C-C chemokine receptor 5 (CCR5) or C-X-C chemokine receptor 4 (CXCR4) coreceptor.

61 both C-X-C chemokine ligand 12 (CXCL12) and C-X-C chemokine receptor 4 (CXCR4) in orthotopic murine

62 C-X-C chemokine receptor 4 (CXCR4) is a transmembrane ch

63 The G protein-coupled protein receptor C-X-C chemokine receptor 4 (CXCR4) is an attractive targ

64 eceptors C-C chemokine receptor 7 (CCR7) and C-X-C chemokine receptor 4 (CXCR4) on melanoma cells und

65 Internalization of C-X-C chemokine receptor 4 (CXCR4), but not CXCR5, was a

66 Aggressive human melanomas express, C-X-C chemokine receptor 4 (CXCR4), the receptor for the

67 ng properties for cells that overexpress the C-X-C chemokine receptor 4 (CXCR4).

68 oteins that used C-C chemokine receptor 3 or C-X-C chemokine receptor 4 as coreceptors inhibited prol

69 th the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 axis, in the development of t

70 n response to IFN-gamma, thus downregulating C-X-C chemokine receptor 4 expression critical for neutr

71 The atypical C-X-C chemokine receptor 7 (CXCR7) has been implicated i

72 the up-regulation of SDF-1, and its receptor C-X-C chemokine receptor 7, was documented on podocytes

73 uction in the skin, and that blockage of the C-X-C chemokine receptor type 1 and 2 inhibits flare-up

74 The two G protein-coupled receptors (GPCRs) C-X-C chemokine receptor type 4 (CXCR4) and atypical che

75 njections were impaired by the inhibitors of C-X-C chemokine receptor type 4 (CXCR4) and C-C chemokin

76 ogical features, including overexpression of C-X-C chemokine receptor type 4 (CXCR4) and upregulation

77 ht of a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AM

78 e previously demonstrated that antagonism of C-X-C chemokine receptor type 4 (CXCR4) by plerixafor (A

79 Moreover, Plg regulated C-X-C chemokine receptor type 4 (CXCR4) expression in st

80 Overexpression of the G protein-coupled C-X-C chemokine receptor type 4 (CXCR4) has been previou

81 Roccaro et al demonstrate high expression of C-X-C chemokine receptor type 4 (CXCR4) mutation in Wald

82 The C-X-C chemokine receptor type 4 (CXCR4) plays a crucial

83 ence was associated with very high levels of C-X-C chemokine receptor type 4 (CXCR4) production.

84 cently, a pepducin selectively targeting the C-X-C chemokine receptor type 4 (CXCR4) was found to be

85 caused by altered expression of the cytokine C-X-C chemokine receptor type 4 (Cxcr4), an established

86 eloid-derived suppressor cells and decreases C-X-C chemokine receptor type 4 (CXCR4)-expressing myelo

87 The C-X-C chemokine receptor type 4 (CXCR4)/stromal cell der

88 via up-regulation of c-Kit, IL-3Ralpha, and C-X-C chemokine receptor type 4 from either human ECs or

89 y using a hybrid beta(2)-adrenergic receptor-C-X-C chemokine receptor type 4 structure as a template,

90 neutrophil aging, were antagonized by CXCR4 (C-X-C chemokine receptor type 4) and regulated the outer

91 erence in collagen and elastin staining, and C-X-C chemokine receptor type 4, nuclear factor kappa be

92 The C-X-C chemokine receptor type 4, or CXCR4, is a chemokin

93 cytochrome c, stromal cell-derived factor-1, C-X-C chemokine receptor type 4, vascular endothelial gr

94 tly, innovative radiopharmaceuticals such as C-X-C chemokine receptor type 4-targeted small molecules

95 macrophage colony-stimulating factor and the C-X-C chemokine receptor type 4.

96 Recently, a subset of CD8 T cells expressing C-X-C chemokine receptor type 5 (CXCR5) and exhibiting f

97 uction of the TFH program, as exemplified by C-X-C chemokine receptor type 5 (CXCR5) upregulation.

98 target T-cell population is enriched with a C-X-C chemokine receptor type 5 (CXCR5)(+)CD4(+) TFH pre

99 us (SIV)-specific CD8 T cells express CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor re

100 oexpressing markers of T(FH) differentiation C-X-C chemokine receptor type 5, inducible costimulator,

101 -X-C motif) ligand 16 (CXCL16) that binds to C-X-C chemokine receptor type 6 (CXCR6) on MSCs and MSCs

102 Here, we show that forced expression of C-X-C chemokine receptor type 6 (whose ligand is highly

103 nged animal survival only when co-expressing C-X-C chemokine receptor type 6.

104 kine receptor 3 (ACKR3), previously known as C-X-C chemokine receptor type 7 (CXCR7), has emerged as

105 rleukin)-17 and the chemokine receptor CXCR (C-X-C chemokine receptor)-6.

106 human immunodeficiency virus (HIV) and human C-X-C chemokine receptor-4 (CXCR4) facilitates migration

107 portantly, expression of the protumorigenic, C-X-C chemokine receptor-4 (CXCR4), was reduced in DEN-i

108 l infiltrate by modulating the expression of C-X-C chemokine receptors 2 and 4 on peripheral blood ne

109 e of the C-C chemokine receptors, unlike the C-X-C chemokine receptors, discriminate against Galpha16

110 C-X-C chemokine secretion in C. parvum-infected epitheli

111 IFN)-gamma-inducible protein 10 (HuIP-10), a C-X-C chemokine, specifically inhibits signaling of KSHV

112 ne receptor has been shown to respond to the C-X-C chemokine stromal-derived factor (SDF-1) and has r

113 y be determined by selective upregulation of C-X-C chemokine synthesis.

114 (PF4) is an abundant platelet alpha-granule C-X-C chemokine that has weak chemotactic potency but st

115 ng peptide-2 (NAP-2) are two closely related C-X-C chemokines that differ in their abilities to induc

116 ression of proinflammatory cytokines C-C and C-X-C chemokines was seen in the rats exhibiting necroin

117 ese experiments provide direct evidence that C-X-C chemokines, when expressed in sufficient quantity