ライフサイエンスコーパス: C-tail

1 phobic C-terminal transmembrane helices (or 'C-tails').

2 of Smo carboxyl-terminal intracellular tail (C-tail).

3 uires a signal (TLS1) in its cytosolic tail (C-tail).

4 ntegrin targeted STAT1 through its signaling C tail.

5 nsisting of 8 residues (RHKVRFEG) in the PC1 C tail.

6 stabilized by the centrally positioned MTF1 C-tail.

7 is required for efficient export of the Cox2 C-tail.

8 ore-lining helix and proximal portion of the C-tail.

9 d by PKA/CK1-mediated phosphorylation of Smo C-tail.

10 promotes dimerization/oligomerization of Smo C-tail.

11 extension of the kinase domain known as the C-tail.

12 volving both the intracellular loops and the C-tail.

13 btype being regulated by determinants in its C-tail.

14 th Costal2 (Cos2) and Fused (Fu) through its C-tail.

15 EGF-like1, CUB3, EGF-like2, CUB4, CUB5, and C-tail.

16 ation of a second signal (TLS2) in the Kex2p C-tail.

17 erived from the vasopressin receptor-2 (V2R) C-tail.

18 harge' the inhibitory potential of the DCLK1 C-tail.

19 n (AR) and a C-terminal extension termed the C-tail.

20 ubdomain, substrate-binding site, and kinase C-tail.

21 e GRK4alpha, including Ser-485 in the kinase C-tail.

22 of Pacsin 2 via a coiled-coil domain in its C-tail.

23 Gga2p VHS domain binds a site in the Vps10p C-tail.

24 ical, segments (TMSs) and cytoplasmic N- and C-tails.

25 ks of E. coli TatC involving both its N- and C-tails.

26 le substitutions of tyrosine residues in the C-tail affected neither phenotype.

27 Moreover, the C-tail alone is sufficient to mediate ssDNA binding.

28 Surprisingly, removal of the C-tail alone or mutation of highly conserved residues wi

29 tyrosine-containing endocytic motifs of the C-tail also impaired internalization.

30 The CXCR4 C-terminal domain (C-tail) also has a binding site for the actin-binding pr

31 ns of HHV-8 ORF74 was carried out to provide C-tail-altered proteins for functional analyses.

32 The APH proximal C-tail, although still accessible to Cys-directed reagen

33 We present evidence that U24 is a C-tail-anchored protein that is dependent for its functi

34 gested a direct interaction between the PTEN C-tail and a segment in the N-terminal region of the cat

35 tion with hydrophobic elements in arrestin's C-tail and alpha-helix I as well as its active state by

36 the involvement of receptor residues in the C-tail and beta-arrestin binding using site-directed mut

37 nase A (PKA)-mediated phosphorylation of Smo C-tail and depends on cell surface localization of both

38 this autoinhibition by interacting with the C-tail and engaging it in complex formation.

39 ing us to map important contact sites in the C-tail and in the ICL2 and ICL3 of the receptor.

40 decision is dictated specifically by the MOR C-tail and occurs irrespectively of the presence or abse

41 several tyrosine-containing sequences in the C-tail and seventh transmembrane domain.

42 arkable similarities in the functions of the C-tail and sigma3.2 finger of the bacterial factor sugge

43 (VHS) domains both bind a site in the Kex2p C-tail and that the Gga2p VHS domain binds a site in the

44 ng an intramolecular interaction between its C-tail and the C2 domain.

45 een the kinked hydrophobic fragment in hKOPR C-tail and the curved hydrophobic surface in GEC1 around

46 I-C modifications consist in the loss of the C-tail and the fusion with ectopic sequences.

47 y labeled arrestin with one nitroxide in the C-tail and the other in the N-domain.

48 recognized association between the cytosolic C-tail and the TM 4,5-loop was demonstrated using GST pu

49 s of the delta- and mu-opioid receptors, the C-tail and third intracellular domain of the delta-opioi

50 'reads' the message in the receptor phospho-C-tails and distinct phospho-interaction patterns are re

51 Fusions between the identified transmembrane C-tails and the exclusively Tat-dependent reporter prote

52 erminals in the caudate (Cd), especially the Cd tail and the adjacent ventral posterior Pu.

53 uirement for the first 62 amino acids of the C-tail, and the binding of calmodulin to this region did

54 o dissociate from each other and bind to the C-tail, and the DEP domain also binds to the third loop,

55 C tails are as abundant as G tails and are generated by

56 ere structural elements of the kinase domain C-tail are aligned to form novel interactions to the nuc

57 all of the serine/threonine residues in the C-tail are converted to alanine or to aspartate/glutamat

58 Therefore, Val477 and other residues in the C-tail are expected to play a role in the activation of

59 PVI transmembrane arginine and intracellular C-tail are necessary for coupling to Fc Rgamma and for s

60 ating that regulatory sequences on the GluR2 C-tail are required for the accumulation of synaptic AMP

61 Truncation of the C-tail at residues 324, 342, and 354 reduced internaliza

62 tion by phosphorylating Smo C-terminal tail (C-tail) at Ser741/Thr742, which is facilitated by PKA an

63 DPDPE moved the receptor C-tail away from the Gbetagamma dimer, resulting in beta

64 onist stimulation based on the source of its C-tail; beta 1AR with a beta 2AR C-tail underwent down-r

65 pendent phosphorylation site in the receptor C-tail, both showed that PKC isozymes facilitate approxi

66 evidence that distal carboxyl-terminal tail (C-tail), but not proximal, phosphorylation of the chemok

67 uggests that Cox18 not only translocates the C-tail, but also must deliver it in a distinct state com

68 GST-hKOR C-tail, but not GST, bound HA-NHERF-1/EBP50 transfected

69 to an agonist, but replacement of the GHSR1a C-tail by the tail of the vasopressin 2 receptor greatly

70 Aa and chimeric motors containing the Kif5Aa C-tail can rescue deficits.

71 16 protomers via its carboxy tail, but such C-tail clustering only occurred in stimulated membranes.

72 membrane domain directed octamers as well as C-tail clusters require Tha4's transmembrane glutamate r

73 ding reduction of FGF14(V160A) to the Nav1.6 C-tail compared with FGF14(K74A/I76A) Altogether these s

74 In contrast, overexpression of a PC1 C-tail construct increased intracellular calcium and sel

75 The PAR2 cytoplasmic tail (C-tail) contains multiple sites of phosphorylation and m

76 The GST fusion of the M3R C-tail could not bind to wild-type Gbeta(5)-RGS7 but cou

77 ferred from BPV1 E1 to HPV11 E1, that of the C-tail could not.

78 ds, and the orientation of their hydrophobic C-tails could be responsible for the resistance of rats

79 dentified role of a pair of cysteines in the C-tail (Cys-2610 and Cys-2613), a pair of highly conserv

80 PKC phosphorylation sites within the CysLT1R C-tail (CysLT1RS(313-316)A) reduced receptor internaliza

81 is basally palmitoylated at highly conserved C-tail cysteines.

82 to the 14-3-3 interaction motif in the hKOPR C-tail decreased interaction of coatomer protein I (COPI

83 The C-tail-deleted and phosphorylation-deficient receptors w

84 Analysis of various C-tail deletion mutants revealed that a region between r

85 wever, both variants, wild-type vGPCR, and a C-tail deletion version of the receptor were equally abl

86 phorylation-deficient, and cytoplasmic tail (C-tail) deletion mutants of both receptors were expresse

87 While studying C-terminal (C-tail) deletion mutants of Mtf1 and TFB2M, we stumbled

88 d pair, serine 861 and 864, is the principal C-tail determinant that mediates LGR5 constitutive inter

89 ation, but the chimeric beta2AR with beta1AR C-tail did not.

90 that both transmembrane domain directed- and C-tail directed oligomerization occur in the translocase

91 is in a partially open conformation with the C-tail disordered.

92 mbrane-adjacent CRAC4 and the long cytosolic C tail domain with several other CRAC motifs, which are

93 Cbv1 proteins is mediated by their cytosolic C tail domain, where we identified seven cholesterol rec

94 of the lamin A/C gene, and one in the lamin C tail domain.

95 does promote some translocation of the Cox2 C-tail domain across the inner membrane and causes incre

96 The Cox2 C-tail domain is exported post-translationally by the hi

97 Our data suggest that the C-tail domain is recognized posttranslationally by a spe

98 tion of a complex comprised of Fabp5 and the C-tail domain of Canx dictates the permeability of the m

99 protein-protein contact with the cytoplasmic C-tail domain of Canx.

100 T and mGluR1 seven-transmembrane domain plus C-tail domain retained good response to [Ca(2+)](o) whet

101 lacking proteins required for export of the C-tail domain, Cox18 and Mss2.

102 truncation of the last 40 residues from the C-tail domain, indicating that sequence and/or structura

103 ne-based motif localized within the receptor C-tail domain.

104 or sites of phosphorylation occur within the C-tail domain.

105 ed for post-translational export of the Cox2 C-tail domain.

106 ndently of beta-arrestins and the receptor's C-tail domain.

107 motif localized within the C-terminal tail (C-tail) domain.

108 N domain can be modulated by the acidic and C-tail domains.

109 ndicate that combined deletion of the AR and C-tail drastically reduces DNA replication, by 85%, and

110 vailable TFB2M structures disclosed that the C-tail engages in intramolecular interactions with the D

111 Association of NHERF-1/EBP50 with hKOR C-tail enhanced oligomerization of NHERF-1/EBP50.

112 e rhodopsin C terminus with Arg29 controls a C-tail exchange mechanism in which the C tail of arresti

113 dered region (IDR) at the carboxyl-terminus (C-tail) executes its functions.

114 gnificantly, the amphipathic helix (APH) and C-tail exhibited substantial changes in accessibility wh

115 flating NT loop and growing RNA:DNA with the C-tail explain abortive synthesis and transition into el

116 igated the distinct mechanisms of N-tail and C-tail export by analysis of epitope-tagged Cox2 variant

117 C-tail export was blocked by truncation of the last 40 r

118 of cytochrome oxidase activity because Cox2p C-tail export was not blocked in mitochondria lacking Co

119 mportant roles in leader peptide processing, C-tail export, and stabilization of Cox2.

120 KlCox2p that appears to be due to a block of C-tail export.

121 ted for antinociceptive activity (55 degrees C tail flick) in mice.

122 d a partial agonist effect in the 55 degrees C tail-flick assay and a full agonist effect in the acet

123 e formalin test, and the thermal (49 degrees C) tail-flick and increasing-temperature (3 degrees C/mi

124 A warm-water (50 degrees C) tail-flick assay revealed a significant decrease in m

125 t, in addition to interacting with the CXCR4 C-tail, FLNA interacted with a region in the receptor th

126 e minimum necessary requirement of the GluA1 C-tail for LTP in mouse CA1 hippocampal pyramidal neuron

127 model, we found no requirement of the GluA1 C-tail for LTP.

128 ion of chimeric proteins in which the AR and C-tail from HPV11 E1 were replaced by those of BPV1 indi

129 Surprisingly, removal of the C-tail from intact-Ac45 caused cellular phenotypes also

130 , GST-GEC1 interacted directly with the hKOR C-tail, full-length hKOR, and tubulin.

131 g selective interactions with the alpha1D-AR C-tail fusion protein.

132 M1 (GAT) and glutathione S-transferase-Kex2p C-tail fusions show that Gga2p binds directly to the Kex

133 Proteolysis of the C-tail generated a trypsin-resistant core that was a mix

134 e, and the protein kinase A, G, and C kinase C-tail greatly impaired receptor phosphorylation.

135 has no affinity for DNA but deletion of the C-tail greatly increases Mtf1's DNA binding affinity.

136 llular loop PKA site Ser262 and the putative C-tail GRK sites Ser355, Ser356 of the human beta2AR ove

137 h beta 2AR C-tail > beta 2AR with a beta 1AR C-tail > beta 1AR.

138 rder being beta 2AR > beta 1AR with beta 2AR C-tail > beta 2AR with a beta 1AR C-tail > beta 1AR.

139 The C-tails had a corresponding effect on agonist-stimulated

140 hibits an inter-domain twist and a displaced C-tail, hallmarks of active arrestin.

141 ) is inactive, whereas membrane-tethered Smo C-tail has constitutive albeit low levels of Hh signalin

142 in vivo and suggest that the function of the C-tail has evolved in a PV type-specific manner.

143 titrations revealed that Mtf1 with an intact C-tail has no affinity for DNA but deletion of the C-tai

144 tional rearrangements of the alpha1C subunit C-tail have been implicated in Ca2+ signal transduction.

145 hese data argue that both the alpha1C N- and C-tails have important but different roles in the voltag

146 of serine and threonine residues in the PAR2 C-tail hinder constitutive internalization through a non

147 nsfection of 293 cells with EGFR lacking the C-tail, i.e. Y974DeltaEGFR or Y992DeltaEGFR, led to EGF-

148 olecular recognition features present in the C-tail IDR enhance PTEN's protein-protein interactions t

149 ctions emanate from and are nucleated by the C-tail IDR, which form pliable network-hubs.

150 iple IDP-IDP interactions facilitated by its C-tail IDR.

151 Deletion of the last four amino acids of the C-tail (IIGV) eliminated these export signals and preven

152 amino acid region of the DHHC5 intracellular C-tail immediately after the fourth transmembrane domain

153 mum possible effect, %MPE) in the 52 degrees C tail-immersion test after a 72-h infusion from implant

154 e375, Phe377, Phe380, and Arg382) anchor the C tail in a position that blocks binding of the receptor

155 ngle-transmembrane (TM) topology placing the C tail in the ER lumen, and to bind vIL-6 via these sequ

156 Mss2p plays a role in recognizing the Cox2p C tail in the matrix and promoting its export.

157 Here we investigated the role of the C tail in Tie2 activation, signaling, and function both

158 , Gprk2 forms a dimer/oligomer and binds Smo C-tail in a kinase activity-independent manner to stabil

159 e catalytic core may have coevolved with the C-tail in AGC kinases.

160 xtensive literature on the role of the GluA1 C-tail in AMPAR trafficking, there is no effect of overe

161 ific, differential regulatory effects of the C-tail in gyrases from different organisms.

162 To examine the role of the EGFR C-tail in signal transducer and activator of transcripti

163 t transient anchoring of the alpha1C subunit C-tail in the plasma membrane inhibits Ca2+-dependent an

164 Viral-mediated delivery of the GluA2 C-tail in vivo blocked these synaptic changes, indicatin

165 G(i) and the other involving events at Smo's C-tail independent of G(i).

166 entire 11-transmembrane spanning region plus C-tail induced NFAT-green fluorescent protein nuclear tr

167 rease in channel conductance; thus, the TARP C-tail influences ion permeation.

168 The hKOPR C-tail interacted with 14-3-3zeta in rat brain extracts

169 ow that glutathione S-transferase (GST)-hKOR C-tail interacted with purified NHERF-1/EBP50, whereas G

170 However, none of the mutations in the C-tail interfered with this interaction or altered the a

171 ded for catalytic activity suggests that the C-tail is a cis-acting regulatory module that can also s

172 The C-tail is a hallmark of AGC functional divergence inasmu

173 ere that, in contrast to E. coli gyrase, the C-tail is a very moderate negative regulator of Bacillus

174 Ser(780) in the Kex2p C-tail is crucial for binding: an Ala substitution block

175 A large-scale movement of the C-tail is demonstrated by direct distance measurements u

176 le on the background of 3A mutant, where the C-tail is detached from the body of the molecule by trip

177 e observations, along with the fact that the C-tail is needed for catalytic activity suggests that th

178 ction of the AR is transferable, that of the C-tail is not.

179 Here, we show that MEF2B C-tail is physiologically phosphorylated at specific res

180 tro, AMPA receptor trafficking via the GluA2 C-tail is required for the delayed increase in postsynap

181 ynaptic incorporation of this isolated GluR1 C-tail is sufficient to permit spine enlargement even wh

182 found that Smo lacking its C-terminal tail (C-tail) is inactive, whereas membrane-tethered Smo C-tai

183 how that the presence of a cytoplasmic tail (c-tail) is indispensible, and identified two domains in

184 Rs revealed a highly conserved region in the C tail, just distal to the seventh transmembrane domain.

185 r of gelsolin was open when we truncated the C-tail latch from this protein.

186 g the length of the intrinsically disordered C-tail linker modifies the interfilament spacing.

187 We report here characterization of a C-tail loss-of-function mutant, CF327A, and a related su

188 mine block, whereas complete deletion of the C-tail markedly enhanced the TARP-induced increase in ch

189 polar FtsZ protofilaments through their the C-tails may facilitate the coherent treadmilling dynamic

190 We have reported that a histone C tail modification, ubiquitylation of H2B, is required

191 It is interesting that PAR2 C-tail mutants lost the capacity to stably associate wit

192 ion, utilizing intracellular second loop and C-tail mutants of GHSR1a.

193 The inability of internalized PAR2 C-tail mutants to stably associate with arrestins also r

194 nel conductance, we examined various gamma-2 C-tail mutants.

195 ols a C-tail exchange mechanism in which the C tail of arrestin is released and exposes several charg

196 interactions in the polar core and along the C tail of arrestin.

197 6 weeks, group B) or short (+12 weeks, group C) tail of Peg-IFN-alpha/RBV treatment, and RGT with 12

198 ract strongly with the cytoplasmic carboxyl (C)-tail of hIKCa1 in a yeast two-hybrid system.

199 region of AKT2 and the catalytic domain and C-tail of AKT1 prevented strain activation of GSK-3beta,

200 region of AKT1 and the catalytic domain and C-tail of AKT2 did not.

201 ealed that clathrin binding increases as the C-tail of arrestin2 is shortened while site-directed mut

202 into the intracellular loops (ICLs) and the C-tail of AT1R.

203 Thus, the palmitoylated C-tail of CCR5 is the major determinant of its raft asso

204 that its activity is required to export the C-tail of Cox2p bearing a short C-terminal epitope tag.

205 When the C-tail of CXCR4 was exchanged for that of CCR5, the resu

206 a beta-turn confirmation in the cytoplasmic C-tail of each transporter.

207 c density (PSD) and binds to the cytoplasmic C-tail of GluN2B.

208 Residues in the C-tail of GRK2, although not ordered in the crystal stru

209 The C-tail of hSKCa3, a human neuronal small conductance cha

210 The data thus indicate that the C-tail of Mgm101, likely displayed on the ring surface,

211 location in the path of the nascent RNA, the C-tail of Mtf1 serves as a sensor of the RNA-DNA hybrid

212 he structure reported by Bunting et al., the C-tail of Pol IV contacts a hydrophobic cleft on the cla

213 pe Kex2p and a fusion protein containing the C-tail of Ste13p, and also caused missorting of carboxyp

214 e with TFB2M, although autoinhibition by the C-tail of TFB2M was not as complete as in Mtf1.

215 nance, we identified a tribasic motif in the C-tail of the 5-HT(1A)R on which Yif1B binds directly wi

216 endent on type I PSD-95/DLG/ZO1 (PDZ) in the C-tail of the beta1-AR and on protein kinase A (PKA) act

217 orm (38-117) of GEC1 that interacts with the C-tail of the human kappa opioid receptor (hKOR) by yeas

218 GEC1-(38-117) did not interact with the C-tail of the mu or delta opioid receptors.

219 NHERF1 interacts with the C-tail of the P2Y(12)R and unlike many other GPCRs, NHER

220 city, it is the physical interactions of the C-tail of the receptor that mediate the long-term stabil

221 d intracellular loop but instead require the C-tail of the receptor.

222 eous mutation of two dileucine motifs in the C-tail of TXA2Rbeta did not affect agonist-promoted inte

223 ion of alpha-helix I, beta-strand I, and the C-tail of visual arrestin-1, facilitating its transition

224 R chimera with type I PDZ sequences from the C-tails of aquaporin-2 or GluR1 recycled in a SAP97- and

225 verexpression of arrestin-3, identifying the C-tails of both receptors as necessary in arrestin-3 int

226 se data indicate that phosphorylation of the C-tails of CXCR1 and CXCR2 are required for arrestin tra

227 h purified NHERF-1/EBP50, whereas GST or GST-C-tails of micro or delta opioid receptors did not.

228 We found that the C-tails of the two polypeptide chains of the rat Abeta(1

229 The C-terminal tail (C-tail) of AGC kinase domains is a highly conserved feat

230 opsin, and the flexible C-terminal sequence (C-tail) of arrestin becomes dynamically disordered in bo

231 a recombinant cytosolic C-terminal fragment (C-tail) of GluR1 is driven to the postsynaptic density a

232 ntified a crucial role of carboxyl-terminus (C-tail) of Neuroligin 2 (NL2), a cell adhesion molecule

233 LTP requires the cytoplasmic carboxyl tail (C-tail) of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-is

234 of the non-conserved acidic C-terminal tail (C-tail) of the CTDs has been reported.

235 binds to the intracellular C-terminal tail (C-tail) of the receptor for parathyroid hormone and para

236 Kex2p chimera containing the cytosolic tail (C-tail) of the vacuolar protein sorting receptor, Vps10p

237 ucine sorting motifs in the cytosolic tails (C-tails) of intracellular receptors.

238 ng, there is no effect of overexpressing the C-tail on basal transmission.

239 onstrated that PC1 constructs containing the C-tail only or the entire 11-transmembrane spanning regi

240 Deletion of the C-tail or mutation of both C-tail tyrosine residues of F

241 proteins that interact with the polycystin-1 C-tail (P1CT), this segment was used as bait in a yeast

242 niformly into the membrane interface and the C-tails pack closer together in a mesh-like network.

243 LTP, synaptic scaling is blocked by a GluR2 C-tail peptide but not by a GluR1 C-tail peptide.

244 Attempts at using a purified C-tail peptide to rescue the activity loss of the trunca

245 by a GluR2 C-tail peptide but not by a GluR1 C-tail peptide.

246 These findings demonstrate that the Tie2 C tail performs a novel negative regulatory role in Tie2

247 Systematic evaluation of the PTEN C-tail phospho-cluster showed autoinhibition, and confor

248 R1 internalization via recognition of distal C-tail phosphorylation sites rather than the canonical t

249 main and kinase domain, which is relieved by C-tail phosphorylation, but the precise molecular mechan

250 uorescence approaches, we show that the Mtf1 C-tail promotes RNA growth during initiation by stabiliz

251 teraction motif (354)RQSTS(358) in the hKOPR C-tail reduced interaction of the hKOPR with 14-3-3zeta

252 The C-tail reduces the degree of DNA bending by the CTDs but

253 Removal of the acidic region and the C-tail region convert the chimera from a strong activato

254 tubule binding region, and 392IVYK395 in the C-tail region of the protein.

255 n a finding that suggested that the flexible C-tail region of these factors autoregulates their DNA b

256 usly thought, but also recruits its flanking C-tail region to the kinase core, thereby concertedly po

257 e whether residues in the TARP intracellular C-tail regulate polyamine block and channel conductance,

258 lomavirus 1 (BPV1) E1 showed that the AR and C-tail regulate the oligomerization of the protein into

259 herefore offer clues to how the EGF receptor C-tail regulates STAT activity.

260 Thus, the PAR2 C-tail regulates the stability of arrestin interaction a

261 , FGF14 binds directly to the Nav1.6 channel C-tail, regulating channel gating and expression, proper

262 f the receptor in the complex as well as the C-tail release upon receptor binding.

263 ytic domain of Pm, and the functions of this C-tail remain elusive.

264 notypes also found for cleaved-Ac45, whereas C-tail removal from cleaved-Ac45 still allowed its trans

265 interaction between these channels via their C-tails renders them capable of coordinating their gatin

266 contrast to the absolute requirement for the C-tail reported for BPV1 E1 in vitro and confirmed here

267 ues 314-322) in the context of a full-length C-tail resulted in severe reduction in surface expressio

268 ons out of 20, all within or adjacent to the C-tail, resulted in significant deficiencies in the abil

269 A fully ordered kinase C-tail reveals interactions linking the C-tail with impo

270 Antibodies against the Kex2p and Vps10p C-tails selectively block transport of Kex2p and the Kex

271 membrane, and the need for accessibility of C-tail sequences argue that the TGN-PVC transport reacti

272 cessary for some GPCRs, we found that distal C-tail sites might not be sufficient to specify recruitm

273 re conserved residues that interact with the C-tail strikingly diverge from the canonical residues ob

274 ther MAPK members by virtue of a unique long C-tail, suggesting specific mechanisms of regulation.

275 icking aspartic acid residue at T1736 in the C-tail suggests that phosphorylation of this residue reg

276 that GEC1 had stronger association with KOPR-C-tail than GABARAP.

277 spensible, and identified two domains in the c-tail that are necessary for NLGN function at inhibitor

278 sphorylation of serine residues within CXCR4 C-tail that are required for binding and ubiquitination

279 vealed multiple tyrosine residues within the C-tail that can act as the docking sites for both Stat1

280 cation across the inner membrane of the COX2 C-tail that contains the apo-CuA site.

281 an acidic region (AR) and a C-terminal tail (C-tail) that have been shown to regulate the oligomeriza

282 ns and three regions of the C-terminal tail (C-tail): the N-lobe tether (NLT), the active-site tether

283 is interaction or altered the ability of the C-tail to assemble into dimers.

284 PAR2 C-tail truncation mutants displayed normal agonist-induc

285 cription (STAT) activation, a series of EGFR C-tail truncations were constructed.

286 lysosomes via AP-3 interaction with a second C-tail tyrosine motif proximal to the transmembrane doma

287 Deletion of the C-tail or mutation of both C-tail tyrosine residues of FGFR1 to phenylalanine aboli

288 control adaptor protein recognition of PAR1 C-tail tyrosine-based motifs are not known.

289 urce of its C-tail; beta 1AR with a beta 2AR C-tail underwent down-regulation, and beta 2AR with a be

290 switched, the chimeric beta1AR with beta2AR C-tail underwent ubiquitination and down-regulation, but

291 own-regulation, and beta 2AR with a beta 1AR C-tail underwent up-regulation.

292 urate termination by RNA polymerase III on a C-tailed VA1 template.

293 The C-tail was required for endoplasmic reticulum export and

294 t in which all serines and threonines in the C-tail were converted to alanines and designated it PAR2

295 ed by a 231-residue-long COOH-terminal tail (C-tail), which contains multiple tyrosine residues.

296 Pulldown assay of GST-KOPR-C-tail with HA-GEC1 or HA-GABARAP revealed that GEC1 had

297 nase C-tail reveals interactions linking the C-tail with important determinants of kinase activity, i

298 Initially, steric clashes of the Mtf1 C-tail with short RNA-DNA hybrids cause abortive synthes

299 show that Gga2p binds directly to the Kex2p C-tail, with relative affinities Asp(780) > Ser(780) > A

300 ater (38 degrees C, 50 degrees C, 54 degrees C) tail withdrawal assay.