ライフサイエンスコーパス: C-terminal Src kinase

1 as a positive regulator of dCsk (Drosophila C-terminal Src kinase).

2 in a manner dependent on SHPs and Leukocyte C-terminal Src kinase.

3 n was basally associated with c-Src and Csk (C-terminal Src kinase), a negative regulator of Src acti

4 Csk (C-terminal Src kinase), a protein tyrosine kinase, consi

5 ns in Src phosphorylation and recruitment of C-terminal Src kinase, a negative regulator of Src, when

6 e-phosphorylated PAG serves as an anchor for C-terminal SRC kinase, an inhibitor of SRC-family kinase

7 ly kinase negative regulatory proteins, Csk (C-terminal Src kinase), and its transmembrane adaptor, C

8 domain-containing phosphatase-1 (Shp-1) and C-terminal Src kinase, and we use modeling of early TCR

9 Immunolocalization with a C-terminal SRC kinase antibody, which recognizes several

10 d by additional experimentation leaving CSK (C-terminal Src kinase) as the strongest candidate for ib

11 This variant exhibits a 50% decrease in C-terminal Src kinase binding affinity and contributes t

12 nd CD148 and the cytoplasmic tyrosine kinase C-terminal Src kinase Csk.

13 ing the second phosphorylation event include C-terminal Src kinase (Csk) and Bruton's tyrosine kinase

14 one or both of two known inhibitors of Lck, C-terminal Src kinase (Csk) and protein tyrosine phospha

15 ynamically controlled by the tyrosine kinase C-terminal Src kinase (CSK) and the tyrosine phosphatase

16 rotein kinase A (PKA) complex that activates C-terminal Src kinase (CSK) and thereby down-regulates k

17 hown by inhibition through overexpression of C-terminal Src kinase (Csk) and transdominant negative S

18 We identified C-terminal Src kinase (Csk) as a tyrosine kinase respons

19 study, we assessed the cooperative roles of C-terminal Src kinase (Csk) binding protein (Cbp) and Ca

20 C-terminal Src kinase (Csk) binds to tyrosine phosphoryl

21 The C-terminal Src kinase (Csk) contains a catalytic domain

22 C-terminal Src kinase (Csk) contains a catalytic domain

23 C-terminal Src kinase (Csk) encodes a critical negative

24 The C-terminal Src kinase (Csk) family of protein tyrosine k

25 d that the IGF-IR and IR associated with the C-terminal Src kinase (CSK) following ligand stimulation

26 he crystal structure of the kinase domain of C-terminal Src kinase (CSK) has been determined by molec

27 C-terminal Src kinase (Csk) is a multidomain tyrosine ki

28 The C-terminal Src Kinase (Csk) is a potent inhibitor of Src

29 C-terminal Src kinase (Csk) is a PTK that specifically p

30 at cells expressing either LAIR-1 mutants or C-terminal Src kinase (CSK) mutants, and 3) T cells from

31 C-terminal Src kinase (Csk) phosphorylates and down-regu

32 The C-terminal Src kinase (Csk) phosphorylates and down-regu

33 ras, activation of c-Src through deletion of C-terminal Src kinase (CSK) results in the development o

34 C-terminal Src kinase (Csk) specifically phosphorylates

35 Downregulation of Src family kinases by the C-terminal Src kinase (Csk) suppressed Btk* activation a

36 Arg (Arg-318) in the protein-tyrosine kinase C-terminal Src kinase (Csk) was investigated.

37 slocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src

38 C-terminal Src kinase (CSK), a negative regulator of TCR

39 xamates as metal-mediated inhibitors against C-terminal Src kinase (Csk), a protein tyrosine kinase.

40 Here we report that C-terminal Src kinase (Csk), a tyrosine kinase that nega

41 that regulate LCK homeostasis, such as CD45, C-terminal Src kinase (CSK), and c-Cbl, in lipid raft do

42 The Src inhibitor, PP2, the C-terminal Src kinase (Csk), and dominant-negative Pyk2

43 The C-terminal Src kinase (Csk), the primary negative regula

44 LLCPKcl4 with an expression construct of the C-terminal Src kinase (CSK), which inhibits Src family k

45 Platelet SFKs are inhibited by C-terminal Src kinase (Csk), which phosphorylates a cons

46 ctivity is controlled by the upstream kinase C-terminal Src kinase (CSK), whose activity, in turn, is

47 n and are under the principal control of the C-terminal Src Kinase (Csk).

48 on of the SFKs and their negative regulator, C-terminal Src kinase (Csk).

49 us (Tyr 527 in c-Src), which is catalyzed by C-terminal Src Kinase (Csk).

50 hosphorylation of their C-terminal region by C-terminal Src kinase (Csk).

51 pha receptor-associated factor 2 (TRAF2) and C-terminal Src kinase (Csk).

52 he C terminus of the protein tyrosine kinase C-terminal Src kinase (Csk).

53 on of its C-terminal tail by another kinase, C-terminal Src kinase (Csk).

54 T-cell activation is negatively regulated by C-terminal Src kinase (CSK); however, the exact mechanis

55 ecific interaction between the SH3 domain of C-terminal Src kinase (Csk-SH3) and a proline-rich pepti

56 trate that regulation of Src64 by Drosophila C-terminal-Src Kinase (Csk) contributes to the packaging

57 The SH2 domain of the C-terminal Src kinase [Csk] contains a unique disulfide

58 lated and subsequently down-regulated by the C-terminal Src kinase, Csk.

59 The Drosophila C-terminal Src kinase (d-Csk) is a genetic modifier of w

60 Mutations in the Drosophila homolog of C-terminal Src kinase (dcsk) were identified as dominant

61 se inhibitor PP2 and the negative regulatory C-terminal Src kinase in GT1-7 cells but not in HEK293 c

62 the aliphatic residues central to the Ptpn22-C-terminal Src kinase interaction.

63 L:OX40 interaction led to the recruitment of C-terminal src kinase into lipid rafts, causing a prefer

64 Csk (C-terminal Src kinase) is a protein tyrosine kinase that

65 Csk (C-terminal Src kinase) is a protein tyrosine kinase that

66 Csk (C-terminal Src kinase) is a protein tyrosine kinase whic

67 al cell adhesion and migration by activating C-terminal Src kinase, leading to inhibition of pp60Src.

68 Transient expression of plasmids containing C-terminal Src kinase or kinase-deficient dominant-negat

69 ring of an inhibitory protein kinase A (PKA)-C-terminal Src kinase pathway assembled in lipid rafts.

70 Further, DCsk (the Drosophila homolog of the C-terminal Src kinase) phosphorylates and interacts gene

71 Fgr was co-expressed with C-terminal Src kinase to maintain C-terminal tail phosph

72 nhibits TCR-mediated signaling by recruiting C-terminal Src kinase to the membrane and/or receptor co

73 -receptor tyrosine kinases-Abl via pY251 and C-terminal Src kinase via pY239.

74 of SFK activation: release of inhibition by C-terminal Src kinase, weakening of the inhibitory intra

75 culate that the protein-tyrosine kinase Csk (C-terminal Src kinase), which is also activated by Galph