ライフサイエンスコーパス: CAEV

1 eutralizing antibody titers against CAEV-63, CAEV-Co, and CAEV-1g5 compared to titers of SU-W-immuniz

2 oss-reactive neutralizing antibodies against CAEV-Co, a virus isolate closely related to CAEV-63, and

3 ease in neutralizing antibody titers against CAEV-63, CAEV-Co, and CAEV-1g5 compared to titers of SU-

4 irus isolate closely related to CAEV-63, and CAEV-1g5, an isolate geographically distinct from CAEV-6

5 ntibody titers against CAEV-63, CAEV-Co, and CAEV-1g5 compared to titers of SU-W-immunized goats.

6 structural and functional parallels between CAEV gp135 and HIV-1 gp120 that may be more broadly appl

7 Replication-defective CAEV proviral constructs lacking the env, tat, and vif g

8 all ruminant caprine arthritis-encephalitis (CAEV) and visna lentiviruses and the betaretroviruses Ja

9 proviral constructs and plasmids expressing CAEV, MVV, or vesicular stomatitis virus envelope glycop

10 1g5, an isolate geographically distinct from CAEV-63, were determined.

11 Epitope mapping of sera from CAEV-infected goats localized immunodominant linear epit

12 FN-gamma in the context of both a functional CAEV LTR and a heterologous promoter.

13 ith the envelope glycoproteins of MVV K1514, CAEV CO, and lytic and nonlytic North American MVV strai

14 f caprine arthritis-encephalitis lentivirus (CAEV-63).

15 trast, functional receptors for the nonlytic CAEV CO are absent from human cells.

16 ptomatic goats have a dominant population of CAEV SU-reactive T-helper 1 (Th1)-like lymphocytes in PB

17 c MVV receptors and the narrow host range of CAEV.

18 es in the putative virion-proximal region of CAEV gp135 comprising putative beta-strands 4, 5, and 25

19 following in vitro stimulation with purified CAEV gp135 surface protein (SU).

20 tis-encephalitis virus long terminal repeat (CAEV LTR).

21 d-type and modified SU-induced type-specific CAEV-63 neutralizing antibodies and cross-reactive neutr

22 expression of IFN-gamma cDNA promoted by the CAEV LTR was confirmed by the intramuscular (IM) injecti

23 with a putative receptor binding site in the CAEV and visna virus gp135.

24 nstrate that the putative GAS element in the CAEV LTR binds specifically to a cellular factor induced

25 Thus, the GAS sequence in the CAEV LTR is essential for the response to IFN-gamma and

26 the nuclear factor to the GAS element in the CAEV LTR is inhibited by antibody directed against STAT1

27 at least one mechanism for activation of the CAEV LTR by IFN-gamma in monocytes.

28 ssary and sufficient for the response of the CAEV LTR to this cytokine.

29 CAEV-Co, a virus isolate closely related to CAEV-63, and CAEV-1g5, an isolate geographically distinc

30 ted, unlike the Icelandic MVV and similar to CAEV, were limited to cells of ruminant species, regardl

31 wo modified SU (SU-M and SU-T) and wild-type CAEV-63 SU (SU-W) were produced in vaccinia virus and ut

32 us and caprine arthritis-encephalitis virus (CAEV) and human immunodeficiency virus type 1 (HIV-1) gp

33 V) and caprine arthritis-encephalitis virus (CAEV) cause encephalitis, progressive pneumonia, arthrit

34 The caprine arthritis-encephalitis virus (CAEV) long terminal repeat (LTR) is activated by gamma i

35 ivirus caprine arthritis-encephalitis virus (CAEV) were evaluated by semiquantitative reverse transcr