ライフサイエンスコーパス: CARS

1 CARS and SHG/TPF imaging was performed at one wavenumber

2 CARS has previously demonstrated the capability to detec

3 CARS imaging demonstrated disintegration of myelin sheat

4 CARS imaging revealed that in the nuclei of proliferatin

5 CARS microscopy can be used to image the outer regions o

6 CARS microscopy could thus provide quantitative and semi

7 CARS microscopy detected changes in living hTMC morpholo

8 CARS microspectroscopy further indicated lower lipid flu

9 CARS-Cyp is expressed in a variety of tissues and cell t

10 CARSs also catalyze co-translational cysteine polysulfid

11 easured at the peak and dip frequencies of a CARS band.

12 With technical advancements, CARS/TPAF may represent a new avenue for noninvasively i

13 After CARS/TPAF imaging, hTMC were fixed, stained with the flu

14 elated diseases, individuals with bi-allelic CARS variants are unique in presenting with a brittle-ha

15 Each affected person carries bi-allelic CARS variants: one individual is compound heterozygous f

16 reduction and linear discriminant analysis, CARS (AUC = 0.93) and TPEF (AUC = 0.83) showed an excell

17 two novel candidate loci near the FRMD3 and CARS genes.

18 We demonstratedexpression of both FRMD3 and CARS in human kidney.

19 l transferase, and it lies between Nup98 and CARS.

20 he sclera contained regions lacking TPAF and CARS fluorescence of approximately 3 to 15 mum in diamet

21 and coherent anti-Stokes Raman scattering (B-CARS) offers the same inherent chemical contrast as spon

22 We also show that B-CARS imaging can be used to measure spectral signatures

23 We report about a Bessel beam CARS approach for axial profiling of multi-layer structu

24 lectron microscopy, the relationship between CARS signal strength and nanodiamond size is quantified.

25 Here we develop a broadband CARS setup based on a compact, industrial grade ytterbiu

26 ectroscopy technique that achieves broadband CARS measurements at an ultrahigh scan rate of more than

27 e's strength, we use it to perform broadband CARS spectroscopy of the transient mixing dynamics of to

28 iquid hot water pretreated rapeseed straw by CARS and show how the framework can be extended for 3D i

29 s found between lipid volume data yielded by CARS microscopy and total fatty acid content obtained fr

30 The calibrated CARS signal in turn enables the analysis of the number a

31 PAF channel) and thickness of surface cells (CARS channel).

32 Complex CARS susceptibility spectra, which are linear in the che

33 strate the concept of supervised compressive CARS microspectroscopy, enabling artifact-less high-spee

34 me imaging (FLIM) and time gating to correct CARS for the autofluorescence background native to soil

35 We have also correlated CARS with two-photon fluorescence microscopy simultaneou

36 This Clk associating RS-cyclophilin (CARS-Cyp) possesses 39% homology to the NK-TR1 (natural

37 To date, CARS variants have not been implicated in any human dise

38 These observations demonstrate CARS microscopy as a powerful noninvasive imaging tool f

39 stretching vibrational band, we demonstrate CARS imaging and spectroscopy of lipid-rich tissue struc

40 ward-detected CARS (F-CARS) and epi-detected CARS (E-CARS) images are recorded simultaneously.

41 Both forward- and epi-detected CARS are used to probe the parallel axons in the spinal

42 .68 with forward- and 0.63 with epi-detected CARS.

43 Forward-detected CARS (F-CARS) and epi-detected CARS (E-CARS) images are

44 F-CARS and E-CARS images of live and unstained cells reveal details i

45 icles surrounding the nucleus is imaged by E-CARS at the frequency of the C-H stretching Raman band.

46 ected CARS (F-CARS) and epi-detected CARS (E-CARS) images are recorded simultaneously.

47 rger than the excitation wavelength, while E-CARS allows detection of smaller features with a high co

48 essments of tRNA charging indicate that each CARS variant causes a loss-of-function effect.

49 In mouse ears, CARS microscopy revealed dynamic changes in sebaceous gl

50 diation in tissue gives rise to a strong epi-CARS signal that makes in vivo imaging possible.

51 F-CARS and E-CARS images of live and unstained cells revea

52 F-CARS is used for visualizing features comparable to or l

53 Forward-detected CARS (F-CARS) and epi-detected CARS (E-CARS) images are recorded

54 We call this technique FAST CARS (femtosecond adaptive spectroscopic techniques for

55 oherent anti-Stokes Raman scattering (FASTER CARS) using tip-enhanced techniques markedly improves th

56 ong CH-related vibrations have been used for CARS imaging.

57 ral unmixing procedures for single-frequency CARS and propose a mitigative strategy toward these effe

58 The Raman spectra were retrieved from CARS spectra and found to be in excellent agreement with

59 s is made possible by an integration of a FT-CARS system and a rapid-scanning retro-reflective optica

60 Over the past two decades, FT-CARS spectroscopy has undergone substantial evolution, p

61 e basic principles of wide-field detected FT-CARS microscopy and demonstrate how it can be used as a

62 kes Raman scattering (wide-field detected FT-CARS) microscopy capable of acquiring high-contrast labe

63 al principles and diverse applications of FT-CARS spectroscopy and delve into the potential future ad

64 Our rapid-scanning FT-CARS technique holds great promise for studying chemical

65 rm coherent anti-Stokes Raman scattering (FT-CARS) spectroscopy is a powerful spectroscopic method th

66 rm coherent anti-Stokes Raman scattering (FT-CARS) spectroscopy technique that achieves broadband CAR

67 Intrinsic to FT-CARS microscopy, the ability to control the range of tim

68 However, CARS requires a second synchronized laser source and the

69 Here, we propose a deep learning-assisted HS-CARS imaging approach for the investigation of drug fing

70 Cell classification pipelines based on HS-CARS and FLIM features were developed to obtain insights

71 al coherent anti-Stokes Raman scattering (HS-CARS) microscopy and multiphoton-excited fluorescence li

72 al coherent anti-Stokes Raman scattering (HS-CARS) microscopy, a label-free nondestructive chemical i

73 erved elevated lipid intensities with the HS-CARS modality in cells treated with LNPs versus PBS-trea

74 nd SFG imaging was faster, but hyperspectral CARS and SFG imaging has the potential to be applied to

75 es were used and compared: (i) hyperspectral CARS combined with principal component analysis (PCA) an

76 I-CARS was validated in the UCAR cohort (n = 190) with goo

77 R patients with favorable characteristics, I-CARS suggests a 24% probability of successful LVAD expla

78 A weighted score termed I-CARS, effectively stratified patients based on their pro

79 l differentiation and tissue engineering, if CARS/SHG microscopy is to be used as a non-invasive, lab

80 In sum, our efforts implicate CARS variants in human inherited disease, expand the loc

81 f chlorophyll fluorescence and absorption in CARS and SRS microscopy.

82 classified the 1,857 postmenopausal women in CARS as prior/current HRT users if they took HRT before

83 Investigating CARS-dependent persulfide production may thus clarify ab

84 deuterated acyl chains that provide a large CARS signal from the symmetric CD(2) stretch vibration a

85 l-free and truly non-invasive nature of live CARS and SHG imaging and their value and translation pot

86 identified by the lipid-rich plasma membrane CARS signal.

87 sruption of the genes encoding mitochondrial CARSs in mice and human cells shows that CARSs have a cr

88 Multimodal CARS microscopy also permits label-free identification o

89 ssed and unstained liver tissues, multimodal CARS imaging provides a wealth of critical information i

90 its sensitivity and versatility, multimodal CARS microscopy should be a powerful tool for the clinic

91 Analysis of multiple CARS/TPAF images revealed that corneal epithelial and en

92 Analysis of multiplex CARS images can distinguish between molecular components

93 but experimentally simple SGH/TPEF/multiplex CARS multimodal imaging approach for a label-free charac

94 el image analysis approach for multispectral CARS data based on colocalization allows correlating spe

95 Simultaneous narrowband CARS and SFG imaging was faster, but hyperspectral CARS

96 SFG imaging and (ii) simultaneous narrowband CARS and SFG imaging.

97 genes include RRM1, GOK (D11S4896E), Nup98, CARS, hNAP2 (NAP1L4), p57KIP2 (CDKN1C), KVLQT1 (KCNA9),

98 Here, unsupervised multivariate analysis of CARS datasets was used to visualize the subcellular comp

99 Analysis of CARS/TPAF images of hTMC treated with latanoprost reveal

100 imental implementation for the generation of CARS by Bessel beam excitation using only passive optica

101 However, the inherent coherent nature of CARS poses challenges for quantitative chemical imaging

102 isted analysis of liver lipid level based on CARS signal intensity is consistent with triglyceride me

103 DCNNs based on CARS, SHG/TPF, or Raman images have discriminated betwee

104 Unlike other CARS-based (coherent anti-Stokes Raman scattering) spect

105 We validated our CARS imaging strategy in vitro to in vivo with synthetic

106 In addition, label-free and non-perturbative CARS imaging allow rapid screening of mitochondrial toxi

107 riable selection algorithms: PLS, MCUVE-PLS, CARS-PLS, and iSPA-PLS.

108 ce-less interferometric broadband pump/probe CARS to retrieve the vibrational spectral phase.

109 cattering of the intense forward-propagating CARS radiation in tissue gives rise to a strong epi-CARS

110 PTR/CARS spectra measured at a 210-ns delay contain distinct

111 coherent anti-Stokes Raman spectroscopy (PTR/CARS).

112 ratures low enough to freeze lumi, these PTR/CARS results provide the first detailed view of the vibr

113 The formation of lumiRT, monitored via PTR/CARS spectra recorded on the nanosecond time scale, can

114 Intense punctate CARS signals from the retinal pigment epithelial layer w

115 This is challenging because the raw CARS signal results from the coherent interference of re

116 eered to express chimeric antigen receptors (CARS), when activated peripheral blood mononuclear cells

117 (CARS) with the advantages of time-resolved CARS spectroscopy.

118 elated, using childhood autism rating scale (CARS) and Vineland Adaptive scales, magnetic resonance i

119 sed using the childhood autism rating scale (CARS), autism behavior checklist (ABC), and adaptive beh

120 ng simultaneously acquired forward-scattered CARS signals and epi-detected autofluorescence.

121 Coherent anti-Stokes Raman scattering (CARS) and second harmonic generation (SHG) are non-linea

122 ch as coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS) microscopy p

123 ties, coherent anti-Stokes Raman scattering (CARS) and sum-frequency generation (SFG), were successfu

124 ques: coherent anti-Stokes Raman scattering (CARS) and two-photon autofluorescence (TPAF).

125 ques: coherent anti-Stokes Raman scattering (CARS) and two-photon autofluorescence (TPAF).

126 with coherent anti-Stokes Raman scattering (CARS) and two-photon excited fluorescence (TPEF) nonline

127 trong coherent anti-Stokes Raman scattering (CARS) at the sp(3) vibrational resonance of diamond.

128 Coherent Anti-Stokes Raman Scattering (CARS) has found critical applications across various fie

129 o the coherent anti-Stokes Raman scattering (CARS) images of DOPC/DPPC-d62 bilayers.

130 e and coherent anti-Stokes Raman scattering (CARS) imaging of the sciatic nerve, we deciphered the sp

131 lized coherent anti-Stokes Raman scattering (CARS) imaging to examine paclitaxel distribution in vari

132 iplex coherent anti-Stokes Raman scattering (CARS) imaging via supercontinuum excitation to probe mor

133 Coherent anti-Stokes Raman scattering (CARS) is an emerging tool for label-free characterizatio

134 olved coherent anti-Stokes Raman scattering (CARS) is used as a probe for monitoring the vibrational

135 using coherent anti-Stokes Raman scattering (CARS) microscopy and isotopic perfusion experiments.

136 g the coherent anti-Stokes Raman scattering (CARS) microscopy and two-photon excited fluorescence (TP

137 ctral coherent anti-Stokes Raman scattering (CARS) microscopy can be used to provide quantitative vol

138 dband coherent anti-Stokes Raman scattering (CARS) microscopy can be very useful for fast acquisition

139 ctral coherent anti-Stokes Raman scattering (CARS) microscopy compatible with MPEF and SHG for multim

140 gated coherent anti-Stokes Raman scattering (CARS) microscopy for monitoring lipid contents in living

141 modal coherent anti-Stokes Raman scattering (CARS) microscopy for the detection and characterization

142 ally, coherent anti-Stokes Raman scattering (CARS) microscopy images have been acquired and are compa

143 ctral coherent anti-Stokes Raman scattering (CARS) microscopy images of organic materials and biologi

144 oduce coherent anti-Stokes Raman scattering (CARS) microscopy multiplexed with confocal fluorescence

145 Coherent anti-Stokes Raman scattering (CARS) microscopy on the other hand can potentially be ad

146 -free coherent anti-Stokes Raman scattering (CARS) microscopy to mouse oocytes and pre-implantation e

147 Coherent anti-Stokes Raman scattering (CARS) microscopy was used to study effects on myelin she

148 e and coherent anti-Stokes Raman scattering (CARS) microscopy we identified that thirteen zooplankton

149 using Coherent Anti-Stokes Raman Scattering (CARS) microscopy which achieves non-invasive label free

150 nning coherent anti-Stokes Raman scattering (CARS) microscopy with a lateral resolution of 0.25 mum.

151 nning coherent anti-Stokes Raman scattering (CARS) microscopy with fast data acquisition and high sen

152 se of coherent anti-Stokes Raman scattering (CARS) microscopy, a highly sensitive vibrational imaging

153 with coherent anti-Stokes Raman scattering (CARS) microscopy, a label-free vibrational imaging techn

154 ctral coherent anti-Stokes Raman scattering (CARS) microscopy, together with a quantitative image ana

155 using Coherent Anti-Stokes Raman Scattering (CARS) microscopy, which is used to selectively visualize

156 em of coherent anti-Stokes Raman scattering (CARS) microscopy.

157 with coherent anti-Stokes Raman scattering (CARS) microscopy.

158 nning coherent anti-Stokes Raman scattering (CARS) microscopy.

159 ed by coherent anti-Stokes Raman scattering (CARS) microscopy.

160 using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device.

161 ed on coherent anti-Stokes Raman scattering (CARS) microspectroscopy with simplex maximization and en

162 ng is Coherent anti-Stokes Raman scattering (CARS) spectroscopy, using synchronized pump/Stokes laser

163 olved coherent anti-Stokes Raman scattering (CARS) with the advantages of time-resolved CARS spectros

164 ining coherent anti-Stokes Raman scattering (CARS) with video-rate microscopy.

165 (RS), Coherent anti-Stokes Raman scattering (CARS), Second Harmonic Generation (SHG) and Two Photon F

166 PEF), coherent anti-Stokes Raman scattering (CARS), second-harmonic generation (SHG), and sum-frequen

167 ining coherent anti-Stokes Raman scattering (CARS), two-photon excited autofluorescence (TPEF), and s

168 ed on coherent anti-Stokes Raman scattering (CARS).

169 with coherent anti-Stokes Raman scattering (CARS).

170 ion to both coherent anti-Stokes scattering (CARS) and stimulated Raman scattering (SRS) spectroscopi

171 addition, we have demonstrated simultaneous CARS imaging of myelin and two-photon excitation fluores

172 Spectral CARS further shows that LDs postdifferentiation contain

173 of coherent anti-Stokes Raman spectroscopy (CARS) and tip-enhanced Raman spectroscopy (TERS).

174 Coherent Anti-Stokes Raman Spectroscopy (CARS) is performed on single spores (conidia) of the fun

175 and coherent anti-Stokes Raman spectroscopy (CARS) microspectroscopy allowed us to locally identify a

176 Coherent anti-Stokes Raman spectroscopy (CARS) uses vibrational resonances to study nuclear wavep

177 hat coherent anti-Stokes Raman spectroscopy (CARS), a nonlinear spectroscopy of great utility and pot

178 S), coherent anti-Stokes Raman spectroscopy (CARS), stimulated Raman spectroscopy (SRS) and surface e

179 as coherent anti-Stokes Raman spectroscopy (CARS).

180 mplitudes exhibited a factor of 100 stronger CARS signal, as compared with the Raman signal.

181 The Coumadin Aspirin Reinfarction Study (CARS) database contains information on HRT use and menop

182 lice Computed Tomography-The CArS 320 Study [CARS-320]; NCT00967876).

183 nsatory anti-inflammatory response syndrome (CARS).

184 nsatory anti-inflammatory response syndrome (CARS; excessive anti-, but no/low proinflammatory mediat

185 Cysteinyl-tRNA synthetase (CARS) encodes the enzyme that charges tRNA(Cys) with cys

186 ic and mammalian cysteinyl-tRNA synthetases (CARSs).

187 TG-CARS allowed us to identify previously unknown lipid dro

188 tive to soil particles and fungal hyphae (TG-CARS) using time-correlated single-photon counting (TCSP

189 We combined TPEF, TG-CARS, and FLIM to maximize image contrast for live fungi

190 These results demonstrate that CARS microscopy provides a novel non-invasive method of

191 These results demonstrate that CARS/SHG/TPF microscopy has a prospective use as a label

192 This study demonstrates that CARS microscopy is a promising tool for studying the seb

193 We show that CARS imaging can quantify the size, number and spatial d

194 Additionally, we show that CARS microscopy allows imaging of different molecules of

195 Our results show that CARS microscopy can be used effectively for in situ imag

196 We show that CARS microscopy is more sensitive than Oil Red O histolo

197 ial CARSs in mice and human cells shows that CARSs have a crucial role in endogenous CysSSH productio

198 The CARS analysis shows a distinct decrease in protein and i

199 The CARS signal is enhanced by ~11 orders of magnitude relat

200 The CARS technique was successful in imaging cells in the in

201 toplasm, and lipid droplets by analyzing the CARS spectra within the C-H stretching region only.

202 Included in the map are the CARS, NAP2, p57/KIP2, KVLQT1, ASCL2, TH, INS, IGF2, H19,

203 trong association was also identified at the CARS (cysteinyl-tRNA synthetase) locus (OR = 1.36, P = 3

204 od outer segments could be identified by the CARS signal from their lipid-rich plasma membranes.

205 chemical composition, are retrieved from the CARS intensity spectra using the causality of the suscep

206 Importantly, the CARS signals from cellular sheddings from MCAs with LPA

207 alue decomposition on the square root of the CARS intensity, providing an automatic determination of

208 found that through the non-linearity of the CARS process in combination with the folded illumination

209 hly sensitive, camera-based detection of the CARS signal allows for fast and direct hyperspectral wid

210 Generation of the CARS signal is optimized for water imaging with broadban

211 d on the relative change in intensity of the CARS-signal at two distinct wavenumbers, which have been

212 und between participants' performance on the CARS and the number of weekly trials.

213 The imaging contrast based on the CARS signal from the H2O stretching vibration shows a cl

214 osis in NIH 3T3 cells is monitored using the CARS signal from aliphatic C-H stretching vibration.

215 With the CARS signal from CH2 vibration, we have measured the ord

216 from human amelanotic melanomas subjected to CARS imaging exhibited strong pheomelanotic signals.

217 concentration from the difference of the two CARS intensities measured at the peak and dip frequencie

218 artilage in three-dimensional cultures using CARS and SHG microscopy and demonstrate the live-imaging

219 nsaturated fatty acids can be detected using CARS hyperspectral imaging.

220 of cartilage were preliminarily imaged using CARS, SHG and TPF.

221 enic mouse adrenal cortical (Y-1) cells with CARS microscopy in real time without perturbations to th

222 ack collagen autofluorescence coincided with CARS signal, indicating the presence of stromal fibrobla

223 spectroscopic analysis was corroborated with CARS/TPEF multimodal imaging to visualize the distributi

224 orks (DCNNs) were trained independently with CARS, SHG/TPF, and Raman images, taking into account bot

225 taneous imaging of LDs and mitochondria with CARS and two-photon fluorescence microscopy clearly show

226 ing method as a classifier, was trained with CARS spectra using immunofluorescence images as a refere