ライフサイエンスコーパス: CART

1 CART (cocaine and amphetamine regulated transcript) is a

2 CART 55-102 detection on Western blot was unchanged by h

3 CART analysis generated a simple and practical algorithm

4 CART analysis generated an algorithm based on the combin

5 CART analysis showed 5/18 non-HLA antibodies distinguish

6 CART analysis suggested that resting mean pulmonary arte

7 CART elements are commonly overrepresented in diverse se

8 CART highlighted ocular symptoms as the most relevant va

9 CART identifed an AUC >=435 mg*hr/L for TCS.

10 CART induced a long-lasting (>6 h) hypothermia: a 1.5 de

11 CART is widely distributed in the brain of mammals, amph

12 CART transcript abundance was measured in total hypothal

13 CART treatment of APP/PS1 mice also reduced reactive oxy

14 CART's classification as a catabolic neuropeptide is bas

15 CART-BCMA cells were manufactured and expanded in all su

16 CART-BCMA infusions with or without lymphodepleting chem

17 CART-immunoreactive fibers in IN showed a significant re

18 CART-immunoreactive fibers were found in the subpallium,

19 CART.BiTE cells secreted EGFR-specific BiTEs that redire

20 CARTs are structurally unique and operate through an unp

21 ) Cyclophosphamide (Cy) 1.5 g/m2 + 1-5 x 107 CART-BCMA cells; and 3) Cy 1.5 g/m2 + 1-5 x 108 CART-BCM

22 ects were treated in 3 cohorts: 1) 1-5 x 108 CART-BCMA cells alone; 2) Cyclophosphamide (Cy) 1.5 g/m2

23 T-BCMA cells; and 3) Cy 1.5 g/m2 + 1-5 x 108 CART-BCMA cells.

24 CART-19 may be more effective than 5 x 10(7) CART-19 at inducing CR without excessive toxicity.

25 A CART analysis using multiple screening parameters-C/D, H

26 MIBG scintigraphy) and the 30-to-15 ratio (a CART), remained positively associated with MFR (P <= 0.0

27 In addition, CART induced phosphorylation of CREB, IRS, PKB, FoxO1, p

28 In addition, CART is a regulator of neuronal survival.

29 Additionally, CART peptide was higher in the nucleus accumbens (NAc) o

30 over expression of CREB in the NAc affected CART peptide levels, Herpes simplex virus-1 vectors over

31 Attainment of a CR after CART-19 infusion, regardless of cell dose, is associated

32 equent life-threatening adverse events after CART infusion are cytokine release syndrome and CAR-rela

33 the distribution of immunoreactivity against CART peptides (CARTp-ir) in the brains of two bird speci

34 NPY, AGRP, CART, and pomc1a somata showed distribution patterns sim

35 l risk ratios were approximately 0.5 for all CART-derived AUC/MIC exposure thresholds, indicating tha

36 We further showed that alphaCAR19-CART cells could be used as an "antidote" to deplete CAR

37 Although CART is widely distributed in the brain of a range of ve

38 ve cells of pIII at PND 4 and that Ucn 1 and CART are strongly but not completely co-localized in pII

39 cterize the ontogenetic profile of Ucn 1 and CART during postnatal development in C57BL/6J (B6) mice.

40 d immunohistochemical staining for Ucn 1 and CART showed that Ucn 1-immunoreactivity (ir) was absent

41 Brn-3b and positive for both calretinin and CART retina markers.

42 for immunohistochemical analysis of CART and CART+tryptophan hydroxylase (TPH), CART+estrogen recepto

43 As new treatment indications and CART constructs enter the clinic, the number of patients

44 ble analysis, stepwise regression, LASSO and CART.

45 r to that of saliva, as determined by LR and CART.

46 petite control hormones, PYY, alpha-MSH, and CART, are hampered.

47 eta and PR were detected in CART neurons and CART fibers appeared to innervate TPH-positive serotonin

48 First, NPY and CART are coexpressed in the same neurons within the DMH,

49 imals were immunostained with cFos, NPY, and CART antisera.

50 xpression of the anorexigenic genes POMC and CART was up-regulated by 1, 2, 5 and 1, 2, respectively,

51 suppression of anorexigenic systems POMC and CART.

52 st a potential role for NPY, AGRP, POMC, and CART in regulating energetic status in A. burtoni female

53 Responses and CART-BCMA expansion were associated with CD4:CD8 T cell

54 After 45 min, subjects were sacrificed and CART peptide expression was examined using immunohistoch

55 nued Health) atherothrombosis risk score and CART (Classification and Regression Tree) analysis.

56 Effects of CCK on Y2R and CART expression were reduced by CART small interfering R

57 osting, and full interaction models, such as CART, have been investigated largely in isolation.

58 y similar pattern of Abeta plaque-associated CART immunoreactivity was observed in the cortex of AD c

59 st (exendin-9-39) in control rats attenuated CART hypothermia and hypophagia, indicating that GLP-1R

60 and cyclophosphamide, frequently used before CART administration, downregulated IDO expression in lym

61 n trees represented by hybrid models between CART and boosted stumps that can outperform either of th

62 y indicate shared genetic regulation between CART expression and other neurobiological processes refe

63 shared expression of target antigens between CARTs and T-ALL blasts leads to CART fratricide.

64 In birds, CART inhibits food intake, whereas neuropeptide Y (NPY),

65 In both CART and MDR analyses, reflux was also the strongest ind

66 failure (HF), or renal insufficiency, and by CART analysis were those with >=2 vascular beds affected

67 eatine kinase-MB (CK-MB), and TnI and BNP by CART.

68 NPY-immunoreactive neurons were contacted by CART-immunoreactive fibers and 96 +/- 2.8% NPY-immunorea

69 ceiving early or delayed therapy, defined by CART timepoint.

70 K on Y2R and CART expression were reduced by CART small interfering RNA or brefeldin A.

71 his study and 38 were infused with anti-CD19 CART cells (CART-19).

72 s, antagonizing this enzyme may benefit CD19-CART therapy.

73 and improved the antitumor activity of CD19-CART in vivo.

74 investigate the effects of tumor IDO on CD19-CART therapy, we used a xenograft lymphoma model express

75 CD19-CARTs inhibited IDO-negative tumor growth but had no eff

76 Because tumor IDO inhibits CD19-CARTs, antagonizing this enzyme may benefit CD19-CART th

77 Inhibition of CD19-CARTs was not mitigated by the incorporation of costimul

78 CD1a-CARTs are fratricide resistant, persist long term in viv

79 ic and safe use of fratricide-resistant CD1a-CARTs for relapsed/refractory coT-ALL.

80 ons, and leptin suppresses the increased CeA CART expression of leptin-deficient animals.

81 d 38 were infused with anti-CD19 CART cells (CART-19).

82 , such as chimeric antigen receptor T cells (CART) and blinatumomab, have drastically changed the out

83 CAR (chimeric antigen receptor) T cells (CARTs) are genetically engineered T cells that express C

84 vironment suppresses CAR-expressing T cells (CARTs) through the activity of indoleamine 2,3-dioxygena

85 of chimeric antigen receptor (CAR) T cells (CARTs) to T-ALL remains challenging because the shared e

86 Unlike EGFR-specific CAR-T cells, CART.BiTE cells did not result in toxicity against human

87 single-expressing CART or pooled combination CART.

88 Conspicuous CART-immunoreactive cells were observed in the bed nucle

89 In contrast, CART 1 and 3 have a much more restricted distribution, p

90 In contrast, CART was expressed in climbing fiber bands in all four t

91 comparable to the corresponding conventional CART-19, but with lower cytokine levels, thereby offerin

92 status (incidental vs contributing), current CART, plasma HIV RNA, reading ability, and CD4 cell nadi

93 Both E- and E+P-administration decreased CART gene expression on the microarray and with qRT-PCR.

94 In summary, E decreased CART mRNA, but this effect did not translate to the prot

95 taining CD3zeta and 4-1BB signaling domains (CART-BCMA), in subjects with relapsed/refractory MM.

96 CREB mutant (HSV-mCREB) did not alter either CART mRNA or peptide levels.

97 tive anti-CD123 messenger RNA-electroporated CART (RNA-CART123); (2) T-cell ablation with alemtuzumab

98 iquely, the epiphysis also appears to employ CART as a neurotransmitter.

99 ls also caused a 50% reduction of endogenous CART protein.

100 l support for the hypothesis that endogenous CART peptides in the NAc inhibit the actions of cocaine

101 CART peptides in the NAc and that endogenous CART peptides influence body weight and cocaine-induced

102 Exogenous CART treatment in APP/PS1 mice prevented depolarization

103 s study, we examined the effect of exogenous CART 55-102 on beta cell viability and dissected its sig

104 ized and the protective effects of exogenous CART treatment were examined.

105 Treatment of APP/PS1 mice with exogenous CART ameliorated memory deficits; this effect was associ

106 gainst B-ALL compared with single-expressing CART or pooled combination CART.

107 e widespread neuronal expression pattern for CART 2 and 4 suggests a prominent role for the peptide i

108 tides in vivo in the NAc supports a role for CART peptides in psychostimulant-induced reward and rein

109 omplex, interactive network whereby the four CART gene products may have nonredundant functions in en

110 we have mapped the distribution of the four CART mRNAs in the central nervous system of the adult ze

111 Further, CART has been implicated in the transition to puberty.

112 h-old APP/PS1 mice had significantly greater CART immunoreactivity in the hippocampus and cortex.

113 Hindbrain CART application reduced food intake and body weight and

114 othermic and hypophagic effects of hindbrain CART, whereas CART-induced hyperglycemia was not altered

115 However, CART.BiTE cells eliminated heterogenous tumors in mouse

116 tamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the pr

117 cence, which showed that Ucn 1 was absent in CART-positive cells of pIII at PND 4 and that Ucn 1 and

118 N, but also starvation induced a decrease in CART-expressing neurons in this region.

119 vation resulted in a significant decrease in CART-positive cells in the nucleus recessus lateralis (N

120 ERbeta and PR were detected in CART neurons and CART fibers appeared to innervate TPH-p

121 t on CART mRNA, but it caused an increase in CART immunostaining.

122 The trends in CART ontogeny suggest that it may be involved in the est

123 Forskolin, which was known to increase CART mRNA levels in GH3 cells, was utilized to show that

124 that over expression of CREB would increase CART peptide levels.

125 However, P administration increased CART-immunopositive area in comparison to the OVX contro

126 on showed that HSV-CREB injections increased CART mRNA and peptide levels.

127 expression of CREB in the rat NAc increased CART mRNA and peptide levels, but it is not known if thi

128 s and that the social environment influences CART expression in the prairie vole in a region- and sti

129 ablishes zebrafish as a model to investigate CART function in physiology and development.

130 kappa.CART expansion peaked 1-2 weeks after infusion, and cell

131 kappa.CART infusion is feasible and safe and can lead to compl

132 5 mg/kg cyclophosphamide 4 days before kappa.CART infusion (0.2 x 108 to 2 x 108 kappa.CARTs/m2).

133 pa.CART infusion (0.2 x 108 to 2 x 108 kappa.CARTs/m2).

134 tically modified to express kappa.CAR (kappa.CARTs).

135 e remission after 2 and 3 infusions of kappa.CARTs, and 1 had a partial response.

136 No toxicities attributable to kappa.CARTs were observed.

137 For comparison, KNN, CART, SIMCA, PLS-DA and PCA-LDA were also used.

138 em for Cardiac Catheterization Laboratories (CART-CL) program.

139 The entopeduncular nucleus is a major CART-containing group in the adult teleost forebrain tha

140 We found that in mice CART was expressed in climbing fiber bands that generall

141 strogen (E) and progesterone (P) on midbrain CART mRNA and peptide expression and 3) to determine whe

142 ression and 3) to determine whether midbrain CART neurons contain steroid receptors.

143 In these mostly CART-treated persons, mtDNA haplogroup B was associated

144 These results highlight mRNA-CART therapy as a viable approach to induce systemic ant

145 The mRNA-CART system is a highly effective delivery platform for

146 urthermore, a survival model by multivariate CART analysis that was based on number of adverse factor

147 We also identify a neuropeptide, CART (cocaine- and amphetamine-regulated transcript), th

148 nly occasionally expressed OX or CRH but not CART.

149 ptinemia increases the activity of these NPY/CART neurons.

150 In additional experiments, we observed CART expression in loose clusters of spinocerebellar mos

151 e thresholds, indicating that achievement of CART-derived AUC/MIC exposure thresholds was associated

152 up); (b) for immunohistochemical analysis of CART and CART+tryptophan hydroxylase (TPH), CART+estroge

153 Stereological analysis of CART immunostaining at five levels of the Edinger-Westph

154 CCK in stimulating expression of Y2R and of CART itself in these neurons in vivo and in vitro, but n

155 ct of E or E+P administration on the area of CART immunostaining.

156 ate whether (1) caudal brainstem delivery of CART produces energetic, cardiovascular, and glycemic ef

157 systemically after intracranial delivery of CART.BiTE cells.

158 re was a decrease in the staining density of CART peptide in the NAc of the shRNA injected rats.

159 udy were 1) to determine the distribution of CART immunoreactive neurons in the monkey midbrain, 2) t

160 We studied the distribution of CART-immunoreactivity in the brain of zebra finch, Taeni

161 ients with advanced CLL, a 5 x 10(8) dose of CART-19 may be more effective than 5 x 10(7) CART-19 at

162 low (5 x 10(7)) or high (5 x 10(8)) dose of CART-19, and 24 were evaluable for response assessment.

163 Enrichment of CART 2 and 4 in the preoptic and tuberal areas emphasize

164 there abundant and overlapping expression of CART 2, 3, and 4 in the EN, but also starvation induced

165 6 h) restraint stress upon the expression of CART mRNA in the hippocampus and the amygdala and the ef

166 Data reveal a novel function of CART in temperature regulation and open possibilities fo

167 d tuberal areas emphasizes the importance of CART in neuroendocrine functions.

168 to starvation underscores the importance of CART neuropeptide in energy processing.

169 finding that CREB can regulate the levels of CART mRNA and peptides in vivo in the NAc supports a rol

170 of drug resistance is a major limitation of CART.

171 d to NLRP6- and caspase 11-dependent loss of CART(+) neurons and impaired glucose regulation.

172 The cellular resolution mapping of CART mRNA and the response of CART-expressing nuclei to

173 ors (GLP-1Rs) contribute to the mediation of CART-induced effects.

174 The pattern of CART expression in zebrafish suggests conserved evolutio

175 There is a distinct population of CART neurons located in the vicinity of the Edinger-West

176 amine natural variation in the regulation of CART transcript abundance (CARTta) in the hypothalamus.

177 Release of CART peptide (CARTp) from cultured vagal afferent neuron

178 ion mapping of CART mRNA and the response of CART-expressing nuclei to starvation underscores the imp

179 ude that, although the overall topography of CART-expressing afferents is restricted within a conserv

180 ether our data point to the potential use of CART in therapeutic interventions targeted at enhancing

181 -2-, IL-7-, and IL-15-dependent expansion of CARTs; diminished their proliferation, cytotoxicity, and

182 rs, median CD4 nadir 178 cells/mm(3), 72% on CART, and 46% with HAND.

183 dministration alone had a variable effect on CART mRNA, but it caused an increase in CART immunostain

184 FP profiles in the NG expressed CGRP (5%) or CART (4%).

185 ylase (TPH), CART+estrogen receptors (ER) or CART+progesterone receptors (n=5/group) and (c) for West

186 type had a significant effect on AGRP, POMC, CART, and NPY-Y1R, with an exercise and genotype interac

187 ur findings indicate that the GLP-1R on POMC/CART-expressing ARC neurons likely mediates liraglutide-

188 revealed that GLP-1 directly stimulates POMC/CART neurons and indirectly inhibits neurotransmission i

189 sy fibers in the mouse AZ/PZ, whereas in rat CART immunoreactive mossy fibers terminated predominantl

190 ript (CART) peptide depletion in adult rats, CART shRNAs or scrambled control shRNAs were administere

191 Four monkeys received CART (consisting of the nonpenetrating agents PMPA and R

192 regions of brain from monkeys that received CART as compared with four SIV-infected, untreated contr

193 hoid compartments from animals that received CART.

194 lays an important role in patients receiving CARTs, as up to half of patients might need an admission

195 These data show that shRNA can reduce CART peptides in the NAc and that endogenous CART peptid

196 Adrenalectomy reduced CART expression in the dentate gyrus but not the amygdal

197 e, suggesting that the energy status sensing CART circuits is active early in development.

198 mRNA/Ser-CART transfection efficiencies of >95% are achieved in v

199 nates and cationic oligo(serine esters), Ser-CARTs are readily prepared (one flask) by a mild ring-op

200 r or intravenous (iv) injections of mRNA/Ser-CARTs into living mice result in in vivo expression of a

201 charge-altering releasable transporters (Ser-CARTs).

202 othalamus, and pituitary, conspicuously show CART innervations, suggesting functions analogous to tho

203 The actions of CCK in stimulating CART and Y2R expression in vagal afferent neurons and in

204 In this study, CART localization in APP/PS1 mice was characterized and

205 In summary, CART treatment reduced multiple neuropathological measur

206 In individuals with reflux symptoms, CART analysis indicated that strongest interaction was a

207 ices, cardiovascular autonomic reflex tests (CARTs), and cardiac (123)I-metaiodobenzylguanidine (MIBG

208 regionally and time specific manner and that CART is regulated by corticosteroid actions in the hippo

209 Thus, we demonstrate that CART 55-102 protects beta cells against glucotoxicity an

210 Our data establish that CART expression is regulated by stress in a regionally a

211 ocaine-mediated reward, we hypothesized that CART could be a target gene for CREB in the NAc and that

212 Current hypotheses postulate that CART peptides there oppose the rewarding actions of coca

213 ion and chromatin condensation revealed that CART 55-102 reduced glucotoxicity-induced apoptosis in b

214 We show that CART increased proliferation in INS-1 (832/13) cells, an

215 These findings suggest that CART in the NAc is differentially responsive to the sex

216 Together, the data suggest that CART neurons in the midbrain have a unique steroid respo

217 The CART algorithm selected the most likely variables distin

218 The CART model successfully predicted the 3-month-ahead redu

219 The CART-immunoreactive system in the zebrafish central nerv

220 absolute value) in patients who achieved the CART-derived day 1 and 2 thresholds for AUC/MIC by broth

221 th >=1 high-risk feature identified from the CART analysis, rivaroxaban and aspirin prevented 33 seri

222 leotide containing the CRE sequence from the CART gene proximal promoter.

223 s found to bind to the CRE sequence from the CART promoter.

224 redicting a dementia diagnosis; however, the CART analysis did reveal important TICV subgroups, inclu

225 r, and number of teeth identified AMI in the CART decision trees.

226 P-CREB bound directly to the CRE site in the CART promoter, using chromatin immunoprecipitation (ChIP

227 analysis was conducted by repetition of the CART analysis in 58 cases and 58 controls, each matched

228 ttributed to the increased expression of the CART gene by direct interaction of P-CREB with the CART

229 -CREB antibodies showed an enrichment of the CART promoter fragment containing the CRE region over Ig

230 Intratumoral injection of the CART-mRNA complexes resulted in mRNA expression at the s

231 was due to a direct action of P-CREB on the CART gene promoter.

232 Therefore, we hypothesized that the CART system may play a role in the regulation of social

233 of P-CREB protein and P-CREB binding to the CART promoter CRE-containing region.

234 ene by direct interaction of P-CREB with the CART promoter CRE site, rather than by some indirect act

235 short-term combined antiretroviral therapy (CART) on brain virus burden in rhesus monkeys using the

236 tion and combination antiretroviral therapy (CART), and with neurodegenerative diseases.

237 ntiviral agents used in combination therapy (CART) of human immunodeficiency virus type 1 (HIV-1) inf

238 These CART(+) neurons send axons to the prevertebral ganglia a

239 Thus CART is not involved in glucose mobilization.

240 this method can produce models equivalent to CART or gradient boosted stumps at the extremes by varyi

241 gens between CARTs and T-ALL blasts leads to CART fratricide.

242 CART and CART+tryptophan hydroxylase (TPH), CART+estrogen receptors (ER) or CART+progesterone recept

243 Clinical Assessment Reporting and Tracking (CART) program representing all 76 VA cardiac catheteriza

244 linical Assessment, Reporting, and Tracking (CART) Program to analyze patients who underwent coronary

245 Clinical Assessment Reporting and Tracking (CART) Program.

246 linical Assessment, Reporting, and Tracking (CART) program.

247 linical Assessment, Reporting, and Tracking (CART) program.

248 caine- and amphetamine-regulated transcript (CART) expression can be used to partition sensory-motor

249 caine- and amphetamine-regulated transcript (CART) gene is regulated by cocaine and other drugs of ab

250 caine- and amphetamine-regulated transcript (CART) has emerged as a potent anorectic agent.

251 caine- and amphetamine-regulated transcript (CART) has recently been reported to attenuate Abeta-indu

252 caine- and amphetamine-regulated transcript (CART) is an islet peptide that promotes glucose-stimulat

253 caine- and amphetamine-regulated transcript (CART) mRNA and peptide expression have been found betwee

254 caine- and amphetamine-regulated transcript (CART) neurons by LepRb neurons, and leptin suppresses th

255 caine- and amphetamine-regulated transcript (CART) neuropeptide has been implicated in the neural reg

256 ocaine and amphetamine regulated transcript (CART) peptide depletion in adult rats, CART shRNAs or sc

257 caine- and amphetamine-regulated transcript (CART) peptidergic system is involved in processing diver

258 ocaine and Amphetamine-Regulated Transcript (CART) peptides are implicated in a wide range of behavio

259 caine- and amphetamine-regulated transcript (CART) peptides are widely distributed throughout the neu

260 caine- and amphetamine-regulated transcript (CART) peptides, have been shown to decrease cocaine rewa

261 caine- and amphetamine-regulated transcript (CART), but the significance of this is unknown.

262 caine- and amphetamine-regulated transcript (CART), orexin, brain-derived neurotropic factor (BDNF),

263 caine- and amphetamine-regulated transcript (CART), which co-localizes with Ucn 1 in the perioculomot

264 caine- and amphetamine-regulated transcript (CART)-expressing neurons in the PVH and AVPV.

265 caine- and amphetamine-regulated transcript (CART).

266 ss cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked e

267 cocaine- and amphetamine-related transcript (CART), galanin, gastrin-releasing peptide (GRP), neurope

268 cocaine- and amphetamine-related transcript (CART), oxytocin (OX), corticotrophin releasing hormone (

269 ocaine and amphetamine-regulated transcript, CART; pro-opiomelanocortin, pomc1a) neurons in the brain

270 zed charge-altering releasable transporters (CART) for local intratumoral delivery of mRNA coding for

271 ls: charge-altering releasable transporters (CARTs) for mRNA delivery into cells.

272 sing the classification and regression tree (CART) algorithm can provide improved predictive understa

273 ion, and classification and regression tree (CART) analyses were performed for diagnostic and prognos

274 rametric Classification and Regression Tree (CART) analyses were performed to model group heterogenei

275 Classification and regression tree (CART) analysis and logistic regression analyses were per

276 Classification and Regression Tree (CART) analysis selected a panel of four markers that mos

277 Classification and regression tree (CART) analysis was performed to determine the AUC associ

278 A classification and regression tree (CART) analysis was used to assess combinations of variab

279 Classification and regression tree (CART) analysis was used to determine the delay in approp

280 Classification and regression tree (CART) analysis was used to develop a multivariate algori

281 Classification and Regression Tree (CART) analysis was used to identify day 1 and 2 exposure

282 us), and classification and regression tree (CART) analysis.

283 ss using classification and regression tree (CART) analysis.

284 n (MDR), classification and regression tree (CART), and traditional logistic regression (LR) models.

285 SSO) and classification and regression tree (CART).

286 on, and classification and regression trees (CART) analyses were used for statistical analysis.

287 sis and classification and regression trees (CART) analysis were used for statistical analysis.

288 ly used Classification and Regression Trees (CART) have played a major role in health sciences, due t

289 ased on classification and regression trees (CART).

290 ession, classification and regression trees (CARTs), and least absolute shrinkage and selection opera

291 alectomy and corticosteroid replacement upon CART expression in these regions of the adult rat brain.

292 Using CART analysis, we stratified 2 subgroups of patients wit

293 ical Assessment, Reporting, and Tracking (VA CART) program.

294 rved in intact rats to hindbrain ventricular CART, suggesting that forebrain processing is required f

295 As in other vertebrates, CART in the brain of T. guttata may perform several func

296 icrobially responsive subset of viscerofugal CART(+) neurons, enriched in the ileum and colon, modula

297 ypophagic effects of hindbrain CART, whereas CART-induced hyperglycemia was not altered by GLP-1R blo

298 noreactivity (ir) was absent at PND 1, while CART-ir was already apparent in pIIIu at birth, a findin

299 jected fourth intracerebroventricularly with CART (0.1, 1.0, and 2.0 microg).

300 thalamic slices of fasted birds treated with CART-peptide showed a significant reduction (P < 0.001)