ライフサイエンスコーパス: CDH

1 CDH (predominantly left-sided, LCDH) was created in Spra

2 CDH fetuses treated with sildenafil, either with or with

3 CDH infants had a 3-fold increased risk of RIH compared

4 CDH is typically diagnosed with antenatal ultrasonograph

5 CDH lungs display an increased expression of 2 microRNAs

6 CDH might thus be viewed as an evolutionary atavism.

7 CDH patients had a significantly higher RIH hazard compa

8 CDH remains a significant cause of neonatal mortality.

9 CDH strongly correlated with likelihood of restoration o

10 CDH was assessed by evaporative stimuli using a visual a

11 CDH was assessed by thermal and evaporative stimuli.

12 CDH was created on gestational day (GD)23 (n=54).

13 RIH incidences were 10.0% (CDH), 2.1% (NR), and 6.2% (SI).

14 In total, 21 107 infants (201 CDH, 389 NR, and 20 517 SI) were included.

15 map chromosomal anomalies in a cohort of 26 CDH+ patients.

16 The controlled installation of N-CH(3,) -CDH(2,) -CD(2)H, -CD(3), and -(13)CH(3) groups into phar

17 We performed exome sequencing in 39 CDH trios and compared the frequency of de novo variants

18 > 1.6 kg) were randomized to either open (5 CDH, 5 EA/TEF) or thoracoscopic (5 CDH, 5 EA/TEF) repair

19 r open (5 CDH, 5 EA/TEF) or thoracoscopic (5 CDH, 5 EA/TEF) repair.

20 s, we did not find COUP-TFII mutations in 73 CDH samples.

21 tify deleterious GATA4 sequence changes in a CDH cohort.

22 ndings in fetuses exposed to Nitrofen with a CDH with those in Nitrofen-exposed fetuses without a CDH

23 mouse model and one adult human male with a CDH-associated PLS3 variant were observed to have increa

24 those in Nitrofen-exposed fetuses without a CDH, and control fetuses whose mothers received olive oi

25 defective diaphragm vascular development and CDH and that heparan sulfate facilitates angiogenic SLIT

26 in vascular development in the diaphragm and CDH.

27 well as subsequent diaphragm hypoplasia and CDH.

28 red prenatal therapy for lung hypoplasia and CDH.

29 r clinical studies on tracheal occlusion and CDH.

30 miR-200b in the nitrofen rat model of PH and CDH and evaluate its use as an in vivo prenatal therapy.

31 In PH and CDH defects of ANG-1/TIE-2/BMPR-related signalling are n

32 dization in the nitrofen rat model of PH and CDH.

33 Both CDH-sham and CDH-TO fetuses treated with placebo had an increased med

34 Anterior CDH is also seen in Gata4(+/-) mice and has been describ

35 7 or Gata4 is sufficient to produce anterior CDH in mice and that haploinsufficiency of SOX7 and GATA

36 ncreasing the electron transfer rate between CDH and the electrode, and (c) facilitating the creation

37 onally mediate the electron transfer between CDH and the electrode.

38 ble to mediate the electron transfer between CDH and the electrode.

39 Both CDH-sham and CDH-TO fetuses treated with placebo had an

40 Although GATA4-deficient mice have both CDH and cardiac defects, no humans with cardiac defects

41 rmined for methyl-1,4-benzoquinone with both CDH and CBQR, whereas the rate of iron reduction by CDH

42 CBQR, whereas the rate of iron reduction by CDH was five times higher than by CBQR, and its activati

43 recent advances in neonatal intensive care, CDH still has a high mortality and morbidity.

44 iaphragm and that FREM1 deficiency can cause CDH in both humans and mice.

45 s advantage is strongly influenced by center CDH volume and ECLS experience.

46 DH (AfGDH) and a Phanerochaete chrisosporium CDH (PcCDH)-derived heme b-binding cytochrome domain to

47 variants play a significant role in complex CDH cases.

48 As sporadic complex CDH likely has a significant impact on reproductive fitn

49 on, we estimate that 15% of sporadic complex CDH patients are attributable to de novo LGD or deleteri

50 dinucleotide (FAD), a cytochrome domain (CYT(CDH)) containing heme b, and a linker region connecting

51 rect electron transfer (DET) between the CYT(CDH) and the electrode.

52 vel application of cellobiose dehydrogenase (CDH) as sensing element for a Bioelectronic Tongue (BioE

53 ascus thermophilus cellobiose dehydrogenase (CDH) based bioanode and Myrothecium verrucaria bilirubin

54 tion of lactose by cellobiose dehydrogenase (CDH) from the basidiomycete Phanerochaete chrysosporium,

55 Cellobiose dehydrogenase (CDH) is a monomeric extracellular flavocytochrome compos

56 Cellobiose dehydrogenase (CDH) is a promising enzyme for the construction of biofu

57 ains of the enzyme cellobiose dehydrogenase (CDH) isolated from the fungi Neurospora crassa, Corynasc

58 ar flavocytochrome cellobiose dehydrogenase (CDH) participates in lignocellulose degradation.

59 in cofactor within cellobiose dehydrogenase (CDH) was found to be responsible for the reduction of al

60 ubstrates and with cellobiose dehydrogenase (CDH), a known natural supplier of electrons.

61 Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown.

62 osed of a catalytic dehydrogenase domain (DH(CDH)) containing flavin adenine dinucleotide (FAD), a cy

63 "missed" case of congenital hip dislocation (CDH) can be a disaster for the patient and the outcome m

64 ith anatomically less severe left liver-down CDH had significantly increased need for ECMO if repaire

65 Of these, 99% of left liver-down CDH survived, 91% of right CDH survived, and 76% of left

66 versely, no radical was detected with either CDH or CBQR upon the addition of methyl-1,4-benzoquinone

67 Of 5855 ECLS-eligible CDH patients, 1701 (29.1%) received ECLS.

68 hort study was performed using ECLS-eligible CDH Study Group registry patients born between 2007 and

69 nodiamonds, which was tested in experimental CDH in vivo.

70 SVH incidences were 0.6%, 0.3%, and 1.5% for CDH, NR, and SI, respectively.

71 tering strategy identified 27 candidates for CDH.

72 tudy establishes the first genetic model for CDH and identifies a previously unsuspected role for Sli

73 In the rabbit model for CDH, the combination of maternal sildenafil and TO has a

74 respectively) among infants prophylaxed for CDH, standard indications (SIs) and those without increa

75 Recently a minimally deleted region for CDH has been identified on chromosome 15q26.1-26.2 by CG

76 entification and prioritization strategy for CDH, an approach that can be extended to other diseases

77 s to indicate root coverage as treatment for CDH.

78 Three new genes CDH-J, PCDH-J and FAT-J were found.

79 neonates participated in the study; four had CDH, and one had primary pulmonary hypertension.

80 o GATA4 mutations have been reported to have CDH.

81 imerism; 4 had complete donor hematopoiesis (CDH).

82 isk of both congenital diaphragmatic hernia (CDH) and cardiac defects.

83 re isolated congenital diaphragmatic hernia (CDH) and changes in tracheal and amniotic fluid of fetus

84 Congenital diaphragmatic hernia (CDH) and esophageal atresia with tracheoesophageal fistu

85 nfants with congenital diaphragmatic hernia (CDH) are at an increased risk of respiratory morbidity f

86 iniscent of congenital diaphragmatic hernia (CDH) cases in humans.

87 ciated with congenital diaphragmatic hernia (CDH) continue to suffer significant morbidity and mortal

88 etuses with congenital diaphragmatic hernia (CDH) induced by maternal ingestion of 2,4-dichlorophenyl

89 Congenital diaphragmatic hernia (CDH) is a common (1 in 3,000 live births) major congenit

90 Congenital diaphragmatic hernia (CDH) is a common and severe birth defect.

91 Congenital diaphragmatic hernia (CDH) is a common birth defect that results in a high deg

92 Congenital diaphragmatic hernia (CDH) is a common birth malformation with a heterogeneous

93 Congenital diaphragmatic hernia (CDH) is a common life-threatening birth defect.

94 OF REVIEW: Congenital diaphragmatic hernia (CDH) is a rare developmental defect resulting in variabl

95 Congenital diaphragmatic hernia (CDH) is a relatively common birth defect associated with

96 Congenital diaphragmatic hernia (CDH) is a serious birth defect that accounts for 8% of a

97 Congenital diaphragmatic hernia (CDH) is a severe birth defect.

98 Congenital diaphragmatic hernia (CDH) is a significant cause of pediatric mortality in hu

99 Rationale: Congenital diaphragmatic hernia (CDH) is an anomaly with a high morbidity and mortality.

100 Congenital diaphragmatic hernia (CDH) is an often fatal birth defect that is commonly ass

101 Congenital diaphragmatic hernia (CDH) is one of the most common and lethal congenital ano

102 Congenital diaphragmatic hernia (CDH) remains a significant cause of neonatal morbidity a

103 treatments, congenital diaphragmatic hernia (CDH) remains associated with variable survival and signi

104 Congenital diaphragmatic hernia (CDH), a life-threatening anomaly, is a major cause of pe

105 tients with congenital diaphragmatic hernia (CDH), those with agenesis of the diaphragm.

106 inatally in congenital diaphragmatic hernia (CDH), where the typical pulmonary vascular changes are p

107 nfants with congenital diaphragmatic hernia (CDH).

108 lopment and congenital diaphragmatic hernia (CDH).

109 s including congenital diaphragmatic hernia (CDH).

110 tients with congenital diaphragmatic hernia (CDH); however, data to support its ongoing use in this p

111 on-isolated congenital diaphragmatic hernia (CDH+) is a severe birth defect that is often caused by d

112 clusion for congenital diaphragmatic hernia (CDH, n=13), and resection of sacrococcygeal teratoma (SC

113 vantage was found to occur primarily at high CDH volume centers that offer frequent ECLS for the high

114 ort due to cervical dentin hypersensitivity (CDH) and esthetic dissatisfaction.

115 Cervical dentin hypersensitivity (CDH) is characterized by tooth pain arising from root ex

116 can cause cervical dentin hypersensitivity (CDH), which is characterized by tooth pain.

117 Human fetal hypoplastic CDH lungs have a specific miR-200/miR-10a signature.

118 poplastic lungs as well as human hypoplastic CDH lungs.

119 f chromosomal regions recurrently altered in CDH, a description of the retinoid hypothesis of CDH, an

120 A decrease in CDH was observed after periodontal surgery for root cove

121 ng of the mechanisms of pulmonary defects in CDH has the potential for creating targeted therapies, p

122 ontaining Robo genes have been documented in CDH.

123 ventricular dysfunction occurs frequently in CDH and is an independent determinant of severity and cl

124 We show that late lung hypoplasia in CDH is associated with (compensatory) upregulation of mi

125 TGF-beta2 expression was lower in CDH lungs.

126 These findings demonstrate that the lungs in CDH are deficiently vascularized at the alveolar surface

127 tension determine mortality and morbidity in CDH babies.

128 miR-200b overexpression in CDH lungs results in decreased TGF-beta/SMAD signaling.

129 insic, herniation-independent cause of PH in CDH.

130 Prospective studies on RSV prophylaxis in CDH infants are limited.

131 Statistically significant reduction in CDH (P <0.001), significant reduction in impact of oral

132 howed statistically significant reduction in CDH and esthetic dissatisfaction with no intergroup sign

133 R-200b is associated with better survival in CDH babies.

134 gions of recurrent copy number variations in CDH, expression profiles of the developing diaphragm, pr

135 r is primarily defective in nitrofen-induced CDH-associated lung hypoplasia.

136 methylation dynamics of 4 TSGs (p15(INK4B), CDH-1, DAPK-1, and SOCS-1) were studied in sequential bo

137 recessive FREM1 mutations can cause isolated CDH in humans.

138 FETO improves survival in isolated CDH with severe pulmonary hypoplasia compared with the s

139 , and 23 of 25 inborn patients with isolated CDH survived (92%).

140 into fetal surgery, whereas those with ITM, CDH, and SCT all exhibited secondary cardiovascular sequ

141 interaction networks expanded from the known CDH-causing genes, and prioritized genes with ultrarare

142 he total capillary surface area for the left CDH and control lungs were 0.7 +/- 0.3 m2 and 2.8 +/- 1.

143 the total alveolar surface area of the left CDH and control lungs were 1.8 +/- 0.8 m2 and 6.1 +/- 1.

144 The reactor was prepared by cross-linking CDH onto aminopropyl-silanised controlled pore glass (CP

145 own, and, despite the identification of many CDH-associated genes, the etiology of CDH is incompletel

146 1, a membrane-type matrix metalloproteinase, CDH-3, a Fat-like protocadherin, and hemicentin, a fibul

147 d characterisation and optimisation of a new CDH/AuNP-based bioanode were performed and the following

148 m patients with CDH and preterm and term non-CDH control subjects were derived and analyzed by bulk R

149 and highly disruptive variants, in 11.3% of CDH patients.

150 ffect of divalent cations on the activity of CDH was also present for graphite/PEI/MtCDH electrodes b

151 lyethyleneimine (PEI) prior to adsorption of CDH from Myriococcum thermophilum (MtCDH).

152 ns, familial aggregation, and association of CDH with chromosomal abnormalities.

153 Although the exact etiology of most cases of CDH remains unknown, there is a growing body of evidence

154 ges were identified by aCGH in our cohort of CDH+ patients.

155 s concluded that the bioanode, consisting of CDH, produced hydrogen peroxide at toxic concentrations.

156 nd that lung mesenchyme-specific deletion of CDH-implicated genes encoding pre-B cell leukemia transc

157 for the role of FREM1 in the development of CDH comes from an N-ethyl-N-nitrosourea -derived mouse s

158 A4 may each contribute to the development of CDH in individuals with 8p23.1 deletions.

159 likely to play a role in the development of CDH in patients with 15q26 deletions, we did not find CO

160 oding gene-contributes to the development of CDH, we generated mice with a deletion of the second exo

161 previously implicated in the development of CDH.

162 ute, along with GATA4, to the development of CDH.

163 oles of specific genes in the development of CDH.

164 play an important role in the development of CDH.

165 y be helpful for supporting the diagnosis of CDH in unclear cases and thus avoiding unnecessary appar

166 The discovery of CDH loci using standard genetic approaches has been hind

167 guously showed that the cytochrome domain of CDH interacts with the copper site of the LPMO and that

168 FAD) cofactor of the dehydrogenase domain of CDH.

169 f many CDH-associated genes, the etiology of CDH is incompletely understood.

170 as described >350 years ago, the etiology of CDH is poorly understood.

171 g of the heterogeneous molecular etiology of CDH.

172 tients provide evidence for the existence of CDH-related genes on chromosomes 2q37, 6p22-25 and 14q,

173 n reaction in tracheal and amniotic fluid of CDH patients undergoing FETO.

174 Bochdalek-type CDH, the most common form of CDH.

175 is a likely contributor to the formation of CDH in individuals with 15q deletions, and it may also b

176 elopment, a discussion of syndromic forms of CDH, a detailed review of chromosomal regions recurrentl

177 s been reported to be by the reduced heme of CDH.

178 a description of the retinoid hypothesis of CDH, and evidence of the roles of specific genes in the

179 b improves PH and decreases the incidence of CDH.

180 therapy decreases the observed incidence of CDH.

181 We sought to determine if the lungs of CDH lambs have: (1) a reduction in total capillary surfa

182 have used the nitrofen-induced rat model of CDH, which demonstrates immature lungs by biochemical, m

183 nd improves gas exchange in animal models of CDH, but the effects in humans are still under investiga

184 The exon-intron organization of CDH-J was experimentally verified by PCR with specifical

185 dence for novel genes in the pathogenesis of CDH associated with other anomalies and suggest that de

186 the role of genetics in the pathogenesis of CDH has been established, only a small number of disease

187 e believe are related to the pathogenesis of CDH.

188 ylation on the electrochemical properties of CDH from Phanerochaete chrysosporium (PcCDH) and Ceripor

189 of dimensions, perceived after reduction of CDH and esthetic dissatisfaction of patients with GRs tr

190 Infants who underwent repair of CDH from 2000 to 2008 at Pediatric Health Information Sy

191 led trial shows that thoracoscopic repair of CDH is associated with prolonged and severe intraoperati

192 Compared to the Late group, Early repair of CDH on ECMO was associated with a lower mortality rate,

193 d conventional ventilation for the repair of CDH, calling into question the safety of this practice.

194 s in PPF-derived fibroblasts are a source of CDH.

195 tron transfer ability is inferior to that of CDH.

196 Successful treatment of CDH is dependent on the integration of human genomic and

197 contributor to some other Bochdalek-type of CDH.

198 Average yearly hospital volume of CDH repair varied from 1.4 to 17.5 cases per year.

199 io of mortality by yearly hospital volume of CDH repair, after adjustment for salient patient and hos

200 that hospitals which perform high volumes of CDH repair achieve lower in-hospital mortality.

201 tion with a coronally advanced flap (CAF) on CDH, esthetics, and oral health-related quality of life

202 te the effect of surgical defect coverage on CDH and quality of life in patients with GR.

203 studies on the impact of heparin and DTIs on CDH outcomes are warranted.

204 ents with pretreatment methylation of p15 or CDH-1 promoters reversed methylation during the first cy

205 nerated from whole exome sequencing of other CDH cohorts or multiplex kindreds and provide ideal cand

206 n markers as well as the expression of other CDH-associated genes.

207 e with diaphragm defects are enriched in our CDH cohort compared with 120 size-matched random gene se

208 SOX7 sequence changes were identified in our CDH cohort.

209 Approximately 3% of our CDH cohort who are heterozygous with ultra-rare predicte

210 ite recent advances, including nitric oxide, CDH remains an unsolved problem with a mortality rate of

211 d with an isolated left-sided posterolateral CDH covered by a membranous sac who had no features sugg

212 inhibition of RA receptor signaling promotes CDH pathogenesis through a complex gene network.

213 lso has a approximately 980 residue protein (CDH-11 and CG11059) with two cadherin domains and whose

214 del of fetal lung compression recapitulating CDH features was developed and used to determine the eff

215 Surgical defect coverage may reduce CDH and improve patient quality of life, by keratinized

216 root coverage procedures predictably reduce CDH.

217 inated the flavin radical present in reduced CDH, as detected by low temperature ESR spectroscopy, wh

218 urgical root coverage techniques at reducing CDH in cases of gingival recession.

219 f left liver-down CDH survived, 91% of right CDH survived, and 76% of left liver-up CDH survived.

220 (p < 0.05), respectively, and for the right CDH and control lungs 0.9 +/- 0.3 m2 and 3.8 +/- 1.5 m2

221 (p < 0.01), respectively, and for the right CDH and control lungs 2.5 m2 +/- 0.1 and 11.2 +/- 1.9 m2

222 es including increased survival in high-risk CDH patients.

223 All studies selected isolated severe CDH fetuses with a lung-to-head ratio 1.0 or less and li

224 that patients with anatomically less severe CDH benefit from delayed surgery whereas patients with a

225 ereas patients with anatomically more severe CDH may benefit from a more aggressive surgical approach

226 ight ratio was significantly reduced in sham-CDH fetuses either (1.2 +/- 0.3% vs 2.3 +/- 0.3% in cont

227 Thirty-seven patients-27 with left-sided CDH and 10 with right-sided CDH-had umbilical venous cat

228 Sixty-eight neonates-54 with left-sided CDH and 14 with right-sided CDH-had a nasogastric tube.

229 The tubes in 21 patients with left-sided CDH had a normal anatomic course at radiography.

230 The catheters in 12 patients with left-sided CDH had apex leftward convexity.

231 ic tubes in the 14 patients with right-sided CDH had leftward deviation.

232 catheter in eight patients with right-sided CDH had rightward shift; all eight patients had liver he

233 with left-sided CDH and 14 with right-sided CDH-had a nasogastric tube.

234 with left-sided CDH and 10 with right-sided CDH-had umbilical venous catheters.

235 wed no correlation with air blast-stimulated CDH (P = 0.256) or cold stimulus (P = 0.563).

236 the lethally immature lungs of the full-term CDH rats can be improved by biochemical, morphometric, p

237 nerates 1-hexene isotopomers having terminal CDH groups, with an isotope effect of 3.1(1) and 4.1(1),

238 incidences across all groups, implying that CDH infants may benefit from palivizumab during the RSV

239 The CDH progresses through continuous growth of the liver in

240 that patients respond differently across the CDH anatomic severity spectrum and lay the foundation fo

241 al prediction suggested that the heme in the CDH may exist in proximity to the FAD of AfGDH if the he

242 icenter, prospectively collected data in the CDH Study Group (CDHSG) registry, abstracted between 201

243 model of a variant identified in one of the CDH-affected families, c.1497G>C (p.Trp499Cys), shows pa

244 -aim retrospective cohort study based on the CDH Study Group registry for the period of 2007-2017.

245 osomes 2q37, 6p22-25 and 14q, and refine the CDH minimal deleted region on 15q26 to an interval that

246 ental pathways that likely contribute to the CDH phenotype.

247 f these patients, the stomach was within the CDH.

248 that defects in this event may contribute to CDH.

249 important and underrecognized contributor to CDH pathophysiology and determinant of disease severity.

250 TO) to reverse severe lung hypoplasia due to CDH.

251 12.5 when experimental perturbations lead to CDH phenotypes, and E16.5 when the diaphragm is fully fo

252 ically weaker and more compliant, leading to CDH.

253 criptional co-regulator, have been linked to CDH and pulmonary hypoplasia in humans and mice.

254 ic surgery outcomes and variables related to CDH in patients >/=18 years of age were included.

255 it3 developed a central (septum transversum) CDH.

256 mutants of COUP-TFII exhibit Bochdalek-type CDH, the most common form of CDH.

257 fl) embryos developed typical Bochdalek-type CDH.

258 Wild type CDH is only the second example of a b-type heme with Met

259 Although the aetiology remains unknown, CDH has a polygenic origin in approximately one-third of

260 reas patients with more severe left liver-up CDH survived at a higher rate when repair was performed

261 right CDH survived, and 76% of left liver-up CDH survived.

262 When CDH is antenatally diagnosed, early referral to a tertia

263 nafil had no effect on this parameter, while CDH fetuses undergoing TO had a lung-to-body-weight rati

264 uration of hypoplastic lungs associated with CDH.

265 pain dimension had positive correlation with CDH (P <0.05).

266 total of 3367 newborn infants diagnosed with CDH and entered into the registry were reviewed.

267 pregnancies (n = 5) or carrying fetuses with CDH (n = 5).

268 o decreased in lung tissue from fetuses with CDH compared with the other groups.

269 eased expression of SP-A in rat fetuses with CDH secondary to Nitrofen exposure.

270 R imaging was calculated in 172 fetuses with CDH.

271 s of this protein in lungs from fetuses with CDH.

272 ome sequencing study on 275 individuals with CDH.

273 be found in up to 30.9% of individuals with CDH.

274 nifestation of CLD in surviving infants with CDH is associated with the prenatally determined observe

275 a prospectively on all liveborn infants with CDH over a 10-year period.

276 n a change in the management of infants with CDH with less frequent use of ECMO and a greater use of

277 r dysfunction and outcome among infants with CDH.Methods: Multicenter, prospectively collected data i

278 substrate binding precludes interaction with CDH.

279 ted radiographs obtained in 71 neonates with CDH to determine whether nasogastric tubes, umbilical ve

280 everal predictable patterns in neonates with CDH.

281 for low- and intermediate-risk neonates with CDH.

282 l care, more severely affected newborns with CDH are now surviving.

283 pread use in the management of newborns with CDH, ECLS has not been consistently associated with impr

284 Of 3367 patients with CDH (1366 [40.6%] females; median estimated gestational

285 re manifest in all four of the patients with CDH after the airway and lung were filled with radiopaqu

286 are almost invariably seen in patients with CDH and frequently in animal models of this condition.

287 the spectrum of iNO use among patients with CDH and its association with pulmonary hypertension (pHT

288 Basal stem cells (BSCs) from patients with CDH and preterm and term non-CDH control subjects were d

289 pected FLV ratio of 5%, 99% of patients with CDH developed CLD, compared with less than 5% of fetuses

290 tandard ventilatory support of patients with CDH has led to significantly improved survival rates.

291 publication of 60 consecutive patients with CDH in 1999 showed that survival was significantly impro

292 ta from 70 centers, iNO use in patients with CDH may be associated with increased mortality.

293 A total of 1,569 patients with CDH were seen between January 1995 and December 2004 in

294 elevant copy number changes in patients with CDH+.

295 ively reviewed 268 consecutive patients with CDH, combining 208 new patients with the 60 previously r

296 For patients with CDH, thoracoscopy was associated with a significant incr

297 ecific treatment protocols for patients with CDH.

298 abnormalities in lungs of fetal rabbits with CDH, it only partially improves airway morphometry.

299 the pulmonary immaturity of fetal sheep with CDH by physiologic, biochemical, and histologic criteria

300 with cyanide, a mimic of O2 (-) Studies with CDH and its isolated heme b cytochrome domain unambiguou