ライフサイエンスコーパス: CDP-diacylglycerol

1 s a diacylated substrate and does not cleave CDP-diacylglycerol.

2 the affinity of the enzyme for its substrate CDP-diacylglycerol.

3 ynthesis of CL from phosphatidylglycerol and CDP-diacylglycerol.

4 CDP-diacylglycerol, a phospholipid pathway intermediate

5 Cardiolipin (A0.5 = 1.9 mol %), CDP-diacylglycerol (A0.5 = 2.6 mol %), and phosphatidyli

6 , indicating that the capacity to synthesize CDP-diacylglycerol affects gene expression.

7 s the formation of phosphatidylinositol from CDP-diacylglycerol and inositol.

8 lcholine is synthesized by the complementary CDP-diacylglycerol and Kennedy pathways.

9 e synthesis of CL from two lipid substrates, CDP-diacylglycerol and phosphatidylglycerol.

10 phosphatidylserine (PS) is synthesized from CDP-diacylglycerol and serine, a route that is different

11 ynthase catalyzes the synthesis of PG-P from CDP-diacylglycerol and sn-glycerol 3-phosphate and funct

12 membrane phospholipids and was inhibited by CDP-diacylglycerol and sphingoid bases.

13 hosphatidylglycerol, phosphatidylserine, and CDP-diacylglycerol) and inhibited by zwitterionic (phosp

14 Cardiolipin, CDP-diacylglycerol, and phosphatidylinositol were mixed

15 The activation constants for cardiolipin, CDP-diacylglycerol, and phosphatidylinositol were within

16 While both phosphatidic acid and CDP-diacylglycerol appeared to be activators, the most s

17 transferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction,

18 Unlike eukaryotic Cls (that use PG and CDP-diacylglycerol as substrates) or ClsA, the combined

19 ces cerevisiae starts with the conversion of CDP-diacylglycerol (CDP-DAG) and serine to phosphatidyls

20 ytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDP-diacylglycerol; CDP-DG) is an important intermediate

21 a method that localizes membrane-bound [(3)H]CDP-diacylglycerol (DAG) produced from the precursor [(3

22 id biosynthesis, including reduced levels of CDP-diacylglycerol (DAG) synthase activity.

23 sequences of a number of enzymes involved in CDP-diacylglycerol-dependent phosphatidyltransfer identi

24 hase (CDS), which catalyzes the formation of CDP-diacylglycerol from phosphatidic acid, is a key regu

25 hase (CDS), which catalyzes the formation of CDP-diacylglycerol from phosphatidic acid, is a key regu

26 e for the conversion of phosphatidic acid to CDP-diacylglycerol in phospholipid biosynthesis.

27 Radiolabeled CDP-diacylglycerol is unavailable commercially.

28 he CHO1-encoded phosphatidylserine synthase (CDP-diacylglycerol:l-serine O-phosphatidyltransferase, E

29 Enzyme activation by cardiolipin (n=2.8), CDP-diacylglycerol (n=2.1), and phosphatidylinositol (n=

30 e purified Cho1 has a K(m) for its substrate CDP-diacylglycerol of 72.20 muM with a V(max) of 0.079 n

31 portional increase in the cellular levels of CDP-diacylglycerol or phosphatidylinositol.

32 he CHO1-encoded phosphatidylserine synthase (CDP-diacylglycerol pathway enzyme) and loss of the zinc-

33 idylcholine is balanced by the repression of CDP-diacylglycerol pathway enzymes and the induction of

34 in a decrease in the activity levels of the CDP-diacylglycerol pathway enzymes phosphatidylserine sy

35 elated with increased activity levels of the CDP-diacylglycerol pathway enzymes phosphatidylserine sy

36 the synthesis of major phospholipids via the CDP-diacylglycerol pathway.

37 tion of phosphatidylcholine synthesis by the CDP-diacylglycerol pathway.

38 thanolamine, and phosphatidylcholine via the CDP-diacylglycerol pathway.

39 The enzyme CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidy

40 A photoreceptor-specific form of the enzyme CDP-diacylglycerol synthase (CDS), which catalyzes the f

41 A photoreceptor-specific form of the enzyme CDP-diacylglycerol synthase (CDS), which catalyzes the f

42 aled reduced expression of the gene encoding CDP-diacylglycerol synthase 1 (Cds1), an enzyme that cat

43 s a genetic dependency in the context of low CDP-diacylglycerol synthase 1 gene (CDS1) expression.

44 ial cells in vitro, we show ECs deficient in CDP-diacylglycerol synthase 2 are uniquely sensitive to

45 gene pairs, we identified and validated the CDP-diacylglycerol synthase 2 gene (CDS2) as a genetic d

46 C59-encoded dolichol kinase and CDS1-encoded CDP-diacylglycerol synthase enzymes.

47 nsduction genes as a model system, two human CDP-diacylglycerol synthase genes (CDS1 and CDS2) were c

48 ling, rdgB (retinal degeneration B) and cds (CDP-diacylglycerol synthase).

49 y also caused increases in the activities of CDP-diacylglycerol synthase, phosphatidylserine decarbox

50 and 37% amino acid sequence identities with CDP-diacylglycerol synthases reported from Escherichia c

51 In contrast, CDP-diacylglycerol synthases that provide PIS with its s

52 s report, we demonstrate the central role of CDP-diacylglycerol synthetase (CDS) in the regulation of

53 Human CDP-diacylglycerol synthetase (cds1) and phosphatidylino

54 s, a cDNA predicted to encode a second human CDP-diacylglycerol synthetase (cds2) was also uncovered

55 e including DKs, phytol kinases, and several CDP-diacylglycerol synthetases has been identified, and

56 cterium salmoninarum, with and without bound CDP-diacylglycerol to 3.6 and 2.5 A resolution, respecti