ライフサイエンスコーパス: CDV

1 CDV (Km = 2.10 +/- 0.18 mM and Vmax = 1.10 +/- 0.05 micr

2 CDV induces devastating outbreaks in wild and endangered

3 CDV is typically associated with domestic dogs, but litt

4 CDV is vaccine-preventable, and control strategies could

5 CDV treatment resulted in complete resolution of clinica

6 CDV was associated with improved clinical status, viral

7 CDV was discontinued after 7 weeks secondary to transien

8 CDV-specific real-time RT-PCR was performed to screen th

9 Group 2 was administered 1% CDV twice a day for 3 days plus 1% Pred Forte four times

10 The metabolism of [3H]CDV in mock- and cytomegalovirus-infected cells was exam

11 ) was affected by SFA (29.7 %), TP (22.4 %), CDV (19.5 %), PV (10.9 %), CV (10.5 %), MUFA/PUFA ratio

12 ided into two topical treatment groups: 0.5% CDV and PBS control.

13 Topical 0.5% CDV treatment demonstrated significant antiviral inhibit

14 city of the wild-type CDV isolate 5804Han89 (CDV(5804)), the small- and large-plaque-forming variants

15 A CDV unable to recognize the signaling lymphocytic activa

16 d not alter the replication of the three Ad5 CDV variants on the rabbit eye.

17 Comparison with the ferret-adapted CDV(5804P) and the prototypic wild-type CDV(R252) showed

18 asis, than is intraperitoneally administered CDV.

19 patients with classical KS were administered CDV (5 mg/kg/dose) weekly for 2 weeks and then every oth

20 iant panda was previously vaccinated against CDV.

21 bivalent rabies virus-based vaccine against CDV induces protective immune responses against both pat

22 The coding regions of the H proteins of all CDV strains and MV(Edm) were introduced into the CDV and

23 ncomitant treatment with both Pred Forte and CDV significantly reversed the antiviral inhibitory acti

24 ntracellular levels of CDV monophosphate and CDV diphosphate increased approximately 20- and 8-fold,

25 DV vaccine strain Onderstepoort (CDV(OS) and CDV(OL), respectively), and the MV vaccine strain Edmons

26 by IFIT1, the translations of PIV3, SeV, and CDV mRNAs were not.

27 han did ferrets immunized with an attenuated CDV vaccine (0.46 +/- 0.59; n = 7) or the recombinant ve

28 ight loss, and both the NYVAC and attenuated CDV vaccines protected against the development of some c

29 profile and high stability, live-attenuated CDV vaccines can retain residual virulence in highly sus

30 accines are inactivated, the live-attenuated CDV vaccines retain residual virulence for highly suscep

31 subsets when compared to the non-attenuated CDV.

32 This rationally attenuated CDV strain can be used for experimental morbillivirus in

33 Critically, therefore, because CDV circulates among multiple wildlife sources, dog vacc

34 Striking similarities between CDV infection of ferrets and human immunodeficiency viru

35 Cadicivirus (CDV) is unique amongst picornaviruses in having a dicist

36 We have tested candidate CDV vaccines incorporating the fusion (F) and hemaggluti

37 e kinase (EC 2.7.4.6) were found to catalyze CDV diphosphate synthesis from CDV monophosphate, wherea

38 eurovirulent Snyder Hill (SH) strain of CDV (CDV(SH)) and show that this virus rapidly circumvents th

39 Cidofovir (CDV) given by parenteral injection has been shown to pro

40 Cidofovir (CDV), a broad spectrum anti-DNA viral agent, has previou

41 Group 1 was administered 1% cidofovir (CDV) twice a day for 3 days plus comfort tears four time

42 conducted to test the activity of cidofovir (CDV), a drug with in vitro activity against Kaposi sarco

43 ve ether lipid ester analogues of cidofovir (CDV)--hexadecyloxypropyl-CDV (HDP-CDV) and octadecyloxye

44 he acyclic nucleoside phosphonate cidofovir (CDV) and its closely related analogue (S)-9-(3-hydroxy-2

45 the antiviral resistance of three cidofovir (CDV)-resistant variants of adenovirus type 5 (Ad5) and t

46 We used cidofovir (CDV), a nucleotide-analogue KSHV DNA polymerase inhibito

47 We report our experience with cidofovir (CDV) for treatment of ADV infection in 57 HSCT patients,

48 Cidofovir [CDV; (S)-1-(3-hydroxy-2-phosphonomethoxyethyl)cytosine]

49 ovide valuable information about circulating CDV strains, which may foster effective vaccination stra

50 phylogenetic patterns of locally circulating CDV strains.

51 main results are (i) in some circumstances, CDV may not distinguish well between a selected locus an

52 HDP-cyclic CDV, under simulated physiologic conditions, slowly conv

53 of a single intravitreal dose of HDP-cyclic-CDV to prevent viral retinitis for up to 68 days in a ra

54 s study, approximately 35% of the HDP-cyclic-CDV was converted to HDP-CDV.

55 HDP-cyclic-CDV was suspended in phosphate-buffered saline (PBS) at

56 fovir (cCDV) analogs 1-O-hexa-decyloxypropyl-CDV (HDP-CDV) and 1-O-hexadecyloxypropyl-cCDV (HDP-cCDV)

57 A V-defective CDV multiplied with reduced efficiency in lymphocytes an

58 d digestive symptoms elicited by V-defective CDV, but it was dispensable for the invasion of the lymp

59 showed that levels of cidofovir diphosphate (CDV-DP), the active antiviral compound, were >100 times

60 transition from positive to negative during CDV therapy.

61 determined for each virus by comparing each CDV-treated virus group to its respective PBS control, a

62 imal amino acids are necessary for efficient CDV F(1a/b) cleavage.

63 Using biologically equivalent CDV reduced inconsistencies to 10% (P<0.001).

64 For CDV, the proficiency of syncytium formation varies among

65 genomic surveillance and risk assessment for CDV in low resource regions.

66 ns of respiratory disease were evaluated for CDV antigen using a direct fluorescent antibody test (FA

67 ic lesions, immunohistochemical labeling for CDV antigen, and detection of CDV RNA by reverse transcr

68 20) from Chattogram city tested positive for CDV.

69 VNT-negative and -positive sera specific for CDV and PDV.

70 residues 110-114) to mediate specificity for CDV F-Lederle.

71 ween variables in shaping exposure risk from CDV and feline parvovirus.

72 d to catalyze CDV diphosphate synthesis from CDV monophosphate, whereas phosphoglycerate kinase (EC 2

73 t and causes immunosuppression, we generated CDV either unable to recognize one of the receptors or i

74 a real-time RT-PCR assay and a pan-genotype CDV-specific amplicon-based Nanopore sequencing technolo

75 HDP-CDV and HDP-cCDV were taken up rapidly by MRC-5 human lu

76 HDP-CDV seems to circumvent poor cellular uptake by rapid as

77 DV) analogs 1-O-hexa-decyloxypropyl-CDV (HDP-CDV) and 1-O-hexadecyloxypropyl-cCDV (HDP-cCDV), show >1

78 cidofovir (CDV)--hexadecyloxypropyl-CDV (HDP-CDV) and octadecyloxyethyl-CVD (ODE-CDV)--in severe comb

79 In contrast to CDV, HDP-CDV is orally bioavailable and has been reported to be o

80 rally administered treatment with either HDP-CDV or ODE-CDV is 4-8-fold more active, on a molar basis

81 DV, cCDV, and their alkoxyalkanol esters HDP-CDV and HDP-cCDV.

82 ew Zealand Red rabbits and (14)C labeled HDP-CDV.

83 were present 48 hours after the maximum HDP-CDV concentration.

84 Intravitreal pharmacokinetics of HDP-CDV in the retina, choroid, and vitreous followed a two-

85 for the increased antiviral activity of HDP-CDV in vitro, we studied the cellular uptake and anaboli

86 The safety and pharmacokinetics of HDP-CDV intravitreal injections were studied using New Zeala

87 toxicity after intravitreal injection of HDP-CDV up to 28 mug/eye.

88 e (PBS) at 37 degrees C and formation of HDP-CDV was monitored by high-performance liquid chromatogra

89 These data suggest that HDP-CDV and ODE-CDV should be further evaluated as potential

90 ysiologic conditions, slowly converts to HDP-CDV, another potent anti-CMV prodrug that may be taken u

91 When cells were exposed to HDP-CDV, the intracellular half-life of CDV-DP was 10 days v

92 % of the HDP-cyclic-CDV was converted to HDP-CDV.

93 l compound, were >100 times greater with HDP-CDV than levels observed with CDV.

94 ontribute to protection against heterologous CDV strains.IMPORTANCE Rabies virus and canine distemper

95 ogues of cidofovir (CDV)--hexadecyloxypropyl-CDV (HDP-CDV) and octadecyloxyethyl-CVD (ODE-CDV)--in se

96 DV by PCR, culture or tissue histopathology, CDV was given intravenously at 5 mg/kg weekly for 2 cons

97 Severe outcomes of consecutive IAV/CDV infections are mitigated by oral antivirals even whe

98 RNAseq identifies CDV-induced overexpression of trefoil factor (TFF) pepti

99 us and a neighboring neutral locus, but (ii) CDV seldom indicates "selection" in neutral haplotypes w

100 ras and mutagenesis reveals four residues in CDV F-ODP (positions 164, 219, 233, and 317) required fo

101 ropensity for host-switching has resulted in CDV emergence in new species, including endangered wildl

102 ake and anabolic metabolism of (14)C-labeled CDV, cCDV, and their alkoxyalkanol esters HDP-CDV and HD

103 ent glycoproteins were protected from lethal CDV challenge, whereas all animals that received recombi

104 combinant viruses were protected from lethal CDV challenge.

105 ore important than dogs, both in maintaining CDV and as sources of infection for tigers.

106 trol eyes in the Ad5/NZ rabbit ocular model, CDV alone demonstrated a significant antiviral inhibitor

107 Negative CDV FAT results equated to 80% chances of recovery after

108 are located in two nearby clusters in a new CDV H structural model.

109 These data suggest that HDP-CDV and ODE-CDV should be further evaluated as potential antiviral a

110 CDV (HDP-CDV) and octadecyloxyethyl-CVD (ODE-CDV)--in severe combined immunodeficient mice in which e

111 istered treatment with either HDP-CDV or ODE-CDV is 4-8-fold more active, on a molar basis, than is i

112 xcellent model for evaluating the ability of CDV vaccines to protect against symptomatic infection.

113 However, the acquisition of CDV resistance did not alter the replication of the thre

114 eversed the antiviral inhibitory activity of CDV: increased mean Ad5 eye titer, increased Ad5-positiv

115 Characterization of CDV F chimeras and mutagenesis reveals four residues in

116 and animals immunized with a combination of CDV attachment protein- and fusion protein-expressing re

117 This study demonstrates the complexity of CDV dynamics in natural ecosystems and the value of long

118 ause the pathogenesis and clinical course of CDV infection of ferrets is quite similar to that of oth

119 analyzing a long-term serological dataset of CDV in lions and domestic dogs from Tanzania's Serengeti

120 d evaluation of orally active derivatives of CDV.

121 l labeling for CDV antigen, and detection of CDV RNA by reverse transcription-PCR.

122 To gain insights into the determinants of CDV pathogenesis, we isolated a strain highly virulent f

123 In all of the dogs, a diagnosis of CDV infection was established by the presence of compati

124 state-space model, we show that dynamics of CDV have changed considerably over the past three decade

125 We found that the frequency of CDV outbreaks generates fluctuating selection that resul

126 The intracellular levels of CDV monophosphate and CDV diphosphate increased approxim

127 d to HDP-CDV, the intracellular half-life of CDV-DP was 10 days versus 2.7 days reported when cells a

128 sphate, the putative antiviral metabolite of CDV.

129 he infusions to reduce the nephrotoxicity of CDV.

130 Initially, peaks of CDV infection in dogs preceded those in lions, suggestin

131 urces, the most efficient phosphorylation of CDV monophosphate is catalyzed by pyruvate kinase.

132 was relatively unaffected by the presence of CDV, while known late capsid and tegument structural gen

133 (vIRF-1), was unaffected by the presence of CDV, while that of others, such as K4.1 (vMIP-III), K11.

134 North America that vary in the prevalence of CDV and the allele that makes coats black, longitudinal

135 orally active ether lipid-ester prodrugs of CDV and of (S)-HPMPA that have slight differences in the

136 a RABV expressing the attachment protein of CDV vaccine strain Onderstepoort succumbed to infection

137 y is needed to further determine the role of CDV in the treatment of ADV after HSCT.

138 ning the full-length antigenomic sequence of CDV(OS).

139 Genomic sequencing of CDV isolated from one of the infected pandas (giant pand

140 cells, presumably due to the stimulation of CDV uptake and higher activities of phosphorylating enzy

141 the neurovirulent Snyder Hill (SH) strain of CDV (CDV(SH)) and show that this virus rapidly circumven

142 in vivo spread of a neurovirulent strain of CDV provides a novel model system to study the mechanism

143 se genetics systems for wild-type strains of CDV and the use of the resulting recombinant (r) viruses

144 e distemper virus 2 and two other strains of CDV not previously detected in the continental United St

145 died the mechanism of enzymatic synthesis of CDV diphosphate, the putative antiviral metabolite of CD

146 used for preparative enzymatic synthesis of CDV monophosphate.

147 d developed the erythematous rash typical of CDV.

148 man lung fibroblasts in vitro, but uptake of CDV and cCDV was much slower.

149 etail the reliability of inferences based on CDV, using simulation and analytical methods.

150 s the first study to provide genomic data on CDV in Bangladesh and the first demonstration of a mobil

151 nts of the CDV vaccine strain Onderstepoort (CDV(OS) and CDV(OL), respectively), and the MV vaccine s

152 73 was unaffected by the presence of TPA or CDV, suggesting that it was constitutively expressed.

153 Using viral outcome parameters, CDV resistance was determined for each virus by comparin

154 icated in the emergence of highly pathogenic CDV and host switching.

155 An enzymatic activity phosphorylating CDV to its monophosphate derivative was purified from hu

156 iratory syncytial virus (RSV) four weeks pre-CDV causes fatal hemorrhagic pneumonia with lung onslaug

157 s, which concurrently display the protective CDV and RABV glycoprotein antigens.

158 on in a liver transplant recipient receiving CDV infusions.

159 To identify these cells, a recombinant CDV expressing green fluorescent protein was produced by

160 ion activity in the context of a recombinant CDV.

161 thogenesis to the non-attenuated recombinant CDV in a ferret model.

162 We rescued a SLAM-blind recombinant CDV with six mutations that did not infect ferret periph

163 A receptor tropism-intact recombinant CDV with low lethality reveals an 8-day advantage of ant

164 The use of recombinant CDV(SH) (rCDV(SH)) expressing enhanced green fluorescent

165 The robust CDV markers identified in this study will also facilitat

166 Five of six CDV infected giant pandas died.

167 ld be an adequate screening test for suspect CDV or PDV cases and would also be useful for epidemiolo

168 ons about the clinical outcomes of suspected CDV cases, with 2-h turnaround times, by using the CDV F

169 nnecessary euthanasia of dogs with suspected CDV.

170 upramolecular organization of the tetrameric CDV H-protein ectodomain.

171 We present our study showing that CDV FAT results were predictive of clinical recovery (pr

172 We conclude that, although the CDV method does not appear to precisely locate selected

173 pathogenicity between the Ad5 parent and the CDV-resistant variants.

174 x of recombinant rabies viruses carrying the CDV fusion and attachment glycoproteins were protected f

175 To further characterize the CDV strains detected in the four cases, complete gene se

176 virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVA

177 total of 4,508 bases were sequenced for the CDV strains detected from each of the four cases.

178 On the other hand, the CDV IRES forms a 40S/eIF3/IRES ternary complex, with mul

179 strains and MV(Edm) were introduced into the CDV and MV genetic backgrounds, and recombinant viruses

180 Irrespective of the CDV antigens used, all animals developed protective tite

181 he Pre peptide modulates the function of the CDV F protein.

182 Application of the CDV FAT to these samples avoids unnecessary euthanasia o

183 tivated rabies viruses that carry one of the CDV glycoproteins on their surface.

184 eversal, the introduction of sections of the CDV H stalk into MV H shows a five-residue fragment (res

185 In summary, the structure of the CDV H-protein ectodomain provides new insights into the

186 the inherent asymmetric architecture of the CDV H-tetramer being shaped by the neck, which folds int

187 Thus, this spatial organization of the CDV H-tetramer would allow for concomitant protein inter

188 ll- and large-plaque-forming variants of the CDV vaccine strain Onderstepoort (CDV(OS) and CDV(OL), r

189 recombinant rabies viruses carrying only the CDV attachment protein according to the same immunizatio

190 Previous studies showed that the CDV and cyclic cidofovir (cCDV) analogs 1-O-hexa-decylox

191 ses, with 2-h turnaround times, by using the CDV FAT.

192 compared to 55% chances of recovery when the CDV FAT results were positive.

193 ombining the five-residue H chimera with the CDV F-ODP quadruple mutant partially restores activity,

194 Thus, antemortem examination with the CDV FAT on external epithelia of recently vaccinated, si

195 e inoculated topically in both eyes with the CDV-resistant variants R1, R2, and R3, and the Ad5 paren

196 d but useful finding was the ability of this CDV- and PDV-specific cELISA to also detect antibodies a

197 All three CDV vaccines elicited neutralizing titers of at least 1:

198 Importantly, the three CDV strains detected were demonstrated to be genetically

199 ar shedding), but had no effect on the three CDV-resistant variants.

200 Thus, CDV initially infects lymphocytes and massively replicat

201 Thus, CDV takes advantage of mucosal surfaces for host invasio

202 In contrast to CDV, HDP-CDV is orally bioavailable and has been reporte

203 that lions were more likely to be exposed to CDV at a young age but only in low rainfall years.

204 2.7 days reported when cells are exposed to CDV.

205 V F highlights the MV residues homologous to CDV F residues 233 and 317 as determinants for physical

206 es; however, one strain showed similarity to CDV strains detected in a panda from China.

207 nstrate that giant pandas are susceptible to CDV and suggest that surveillance and vaccination among

208 ood viral cultures became negative after two CDV doses.

209 However, wild-type CDV infection is almost always lethal, while MeV infecti

210 e differential fusogenicity of the wild-type CDV isolate 5804Han89 (CDV(5804)), the small- and large-

211 pted CDV(5804P) and the prototypic wild-type CDV(R252) showed that hematogenous infection of the chor

212 nsistent diagnoses when the approved uniform CDV was used.

213 V), acid value (AV), conjugated diene value (CDV), carbonyl value (CV), saturated fatty acids (SFA) e

214 The constrained disequilibrium values (CDV) method approaches this problem by examining differe

215 red a virus from a cDNA copy of the virulent CDV strain's consensus sequence by using a modified reve

216 y vaccinated against canine distemper virus (CDV) and develop respiratory disease.

217 nfect African lions: canine distemper virus (CDV) and feline parvovirus.

218 Canine distemper virus (CDV) and measles virus (MV) cause severe illnesses in th

219 g antibodies against canine distemper virus (CDV) and phocine distemper virus (PDV) in sera from dogs

220 Both canine distemper virus (CDV) and rabies virus (RABV) cause lethal disease in wil

221 dai virus (SeV), and canine distemper virus (CDV) are resistant.

222 ncluding measles and canine distemper virus (CDV) are well known, but the host cells supporting infec

223 NCE Rabies virus and canine distemper virus (CDV) cause high mortality rates and death in many carniv

224 reading frame of the canine distemper virus (CDV) F protein is more complex, with a short hydrophobic

225 y based on a pair of canine distemper virus (CDV) F proteins (strains Onderstepoort (ODP) and Lederle

226 ll entry, we mutated canine distemper virus (CDV) H and identified residues necessary for efficient c

227 rrets with wild-type canine distemper virus (CDV) has been used for this purpose, but in most cases,

228 Canine distemper virus (CDV) has recently emerged as an extinction threat for th

229 eport an outbreak of canine distemper virus (CDV) infection among endangered giant pandas (Ailuropoda

230 Canine distemper virus (CDV) infection of ferrets causes an acute systemic disea

231 Canine distemper virus (CDV) infection of ferrets is clinically and immunologica

232 s, disease caused by canine distemper virus (CDV) infection was suspected based on clinical signs.

233 Canine distemper virus (CDV) infects a wide range of animals, including ferrets,

234 Canine distemper virus (CDV) infects many carnivores, including ferrets and dogs

235 Canine distemper virus (CDV) is a highly contagious virus that affects domestic

236 Canine distemper virus (CDV) is an animal morbillivirus with a worldwide circula

237 Canine distemper virus (CDV) is an enveloped RNA morbillivirus that triggers res

238 cells expressing the canine distemper virus (CDV) or mumps virus F protein.

239 a relationship with canine distemper virus (CDV) outbreaks.

240 ions of ferrets with canine distemper virus (CDV) recapitulate many hallmarks of measles: rash, high

241 The propensity of canine distemper virus (CDV) to spread to the central nervous system is one of t

242 lly, others, such as canine distemper virus (CDV), are a growing concern.

243 We use a canine distemper virus (CDV)-ferret model as surrogate for measles and employ an

244 l genes (e.g., ORFs 25, 26, 64, and 67) were CDV sensitive.

245 ith cellular membrane phospholipids, whereas CDV uptake proceeds via the slow process of fluid endocy

246 fecting functionality when co-expressed with CDV H.

247 of of principle for the treatment of KS with CDV.

248 eater with HDP-CDV than levels observed with CDV.

249 gilant surveillance and early treatment with CDV can prevent the poor outcomes associated with ADV di