ライフサイエンスコーパス: CER

1 CER also uses systematic reviews, evidence-quality appra

2 CER complements traditional efficacy research by placing

3 CER has become a national priority, with considerable ne

4 CER includes evidence generation and evidence synthesis.

5 CER incorporates many attributes of outcomes research an

6 CER is a simple means of controlling the rotation of die

7 CER is sensitive to several chemical and physical parame

8 CER methods in RA include head-to-head clinical trials,

9 CER plays an important role in intracellular sphingolipi

10 CER studies address the question, "Does it work in pract

11 CER was assessed by using the Three-Factor Eating Invent

12 CER was more sensitive to increased leaf temperature in

13 CER will account for a significant portion of funding al

14 CER-1236 T cells demonstrate target-dependent phagocytic

15 S with an added 20% of either SPM (3.3:1:1), CER (3.3:1:1), or CHL (3.3:1:1).

16 Nine NAEs and 16 CERs were analyzed in plasma samples from 999 members of

17 disordered eating, including 7 (5%; 5 IER, 2 CER) adolescents who experienced the onset or reemergenc

18 l ganglia, BG; cortex, COR), 551 normal (248 CER, 174 BG, 129 COR) and 387 pathological brain SPECTs

19 Q3, 2.1 to 6.4 y; 49% attrition; IER n = 29; CER n = 30; P = 0.8).

20 assessed, Depol 670L (DEP) and Ceremix 2XL (CER) were efficient for the recovery of protein extract

21 bral ischemic disease comprised 291 uni- (66 CER, 116 BG, 109 COR) and 96 bilateral defect patterns (

22 en will most likely go extinct, leading to a CER that is equal (or very close) to zero even if season

23 2 (CK2), attenuating its ability to activate CER synthases.

24 We also show that activated CER-1236 T cells exhibit superior cross-presentation abi

25 outcome measures were comparison of CET and CER on ASOCT, and CED on SI between the eyes with succes

26 Inhibition of CK2 and CER synthase rescues GIMAP5-deficient T cells by prevent

27 DEP and CER-based protein extracts were structurally characteriz

28 rk in practice?" The results of efficacy and CER studies may or may not agree.

29 ically significant elevations in the HPG and CER.

30 Associations between dietary identities and CER in females and males, separately and adjusted for re

31 respectively, compared with (+/+) mice, and CER(max) was 2-fold greater in mdr1a/1b(-/-) compared wi

32 (10 nM) increased production of CER[NS] and CER[NDS] ceramides, confirming an effect of oestrogen on

33 Incorporation of both SPM and CER resulted in the formation of microdomains in POPE/PO

34 ncluding the endocannabinoid anandamide) and CERs, to identify common DNA variants influencing the ci

35 by reducing saturated postprandial TAGs and CERs independently of weight loss and diabetes.

36 Mutations in Arabidopsis CER genes eliminate very long chain lipids from the cuti

37 ontrolled by lysosomal sphingolipids such as CER.

38 ng the conventional weight- and gender-based CER estimation.

39 an analysis of the policy development behind CER and focuses on its potential impact on insurance cov

40 EGS1, suggested a casual association between CERs and a range of haematological phenotypes, through 2

41 Both CER and MTR, affected by the variation in the amount of

42 But CER does offer an important opportunity for progress.

43 But CER has been controversial because of its high profile i

44 SGK1[Ser(P)(422)] and C4-CER coincidently bind PDK1 and permit PDK1 to autophosph

45 the PDK1/SGK1 signaling pathway, such as C4-CER, provide a novel therapeutic strategy for a life-lim

46 /SGK1 signaling pathway with C4-ceramide (C4-CER), a non-toxic small molecule, functionally corrects

47 Importantly, C4-CER-mediated activation of both PDK1 and SGK1 is indepen

48 The mechanism of C4-CER action involves a series of mutual autophosphorylati

49 Physiologically, C4-CER significantly increases maturation and stability of

50 etailed mechanistic studies indicate that C4-CER initially induces autophosphorylation of SGK1 at Ser

51 crog/kg/h) dose of the CCK analog caerulein (CER).

52 dicine as high priorities for cardiovascular CER.

53 vidence development to foster cardiovascular CER, and specific studies to address 8 clinical issues i

54 the N-acyl ethanolamine (NAE) and ceramide (CER) classes have emerged as potential biomarkers of car

55 Specifically, cardiolipin (CL), ceramide (CER), and sphingomyelin (SM) accelerate, phosphatidylcho

56 ophageal dysfunction by evaluating ceramide (CER) levels in the skin of children with EoE.

57 some, which mediates conversion of ceramide (CER) into sphingosine and free fatty acids at acidic pH.

58 ogical accumulation of long-chain ceramides (CERs), thereby regulating longevity.

59 mpared with control, reduced some ceramides (CERs) and lysophosphatidylcholines (LPCs) previously ass

60 igating three anatomical levels (cerebellum, CER; basal ganglia, BG; cortex, COR), 551 normal (248 CE

61 e are demonstrable differences in long-chain CERs in the skin of children with EoE but without AD as

62 zyme aggregates grown in the presence of CL, CER, SM, PS, and CL:PC mixtures exert significantly lowe

63 ough synthesis and dissemination of clinical CER of health interventions (2).

64 quality of life in all prospective clinical CER studies in adult oncology; to identify symptoms rele

65 tly associated with HF risk in both cohorts: CER (ceramide) 16:0 (relative risk [RR] per SD in PREDIM

66 ities of using observational data to conduct CER and incorporate it into policy making within a unive

67 Ultralong-chain fatty acid-containing CERs were particularly reduced in the skin of subjects w

68 GIMAP5 controls CER abundance by interacting with protein kinase CK2 (CK

69 he effects of IER (2 days per week) to daily CER over 12 mo on weight loss and diabetes risk markers

70 creased target ligand, conditionally driving CER-1236 function to augment anti-tumor responses.

71 We show that coupled electrorotation (CER) of microscopic particles using microfabricated elec

72 s is an early version of informatics-enabled CER familiar to oncologists.

73 An updated version of informatics-enabled CER relies on EHR-derived structured data linked with su

74 An increase in skin EOS-CER/NS-CER ratio separates the AD(-)PA(+) group from the

75 ydroxy fatty acid sphingosine ceramides (EOS-CERs) to nonhydroxy fatty acid sphingosine ceramides (NS

76 ydroxy fatty acid sphingosine ceramides (EOS-CERs) to nonhydroxy fatty acid sphingosine ceramides (NS

77 A(+) group had a decreased proportion of EOS-CERs (0.8 [P = .001] vs in the AD(-)PA(+) group).

78 real-time fashion, potentially facilitating CER and personalized medicine.

79 r IER and -0.28 [95% CI, -0.36 to -0.20] for CER) and reduced BMI expressed as a percentage of the 95

80 IER and -9.23 [95% CI, -11.82 to -6.64] for CER).

81 ardiovascular disease is a priority area for CER.

82 tment Act of 2009 allocated $1.1 billion for CER.

83 so help to inform prioritization efforts for CER in other health conditions.

84 ponding values in the healthy donor eyes for CER (90.33, 84.9-96.9; P = .02), and CED (13.5, 11.4-15.

85 The choice of method for CER is driven by the relative weight placed on concerns

86 ty general pediatric surgical procedures for CER on the basis of the following 2 complementary measur

87 the National Cancer Institute's program for CER and personalized medicine.

88 at are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1).

89 eliance on instrumental variable studies for CER.

90 For CERs, rs680379 in the SPTLC3 gene, which encodes a subun

91 is, associated with a range of species (e.g. CER[N(24)S(19)]; P = 4.82 x 10-27).

92 rcent of the women were classified as having CER.

93 d alpha-hydroxy-fatty acids (NFA-CER and HFA-CER, respectively) in solution and in bilayers were inve

94 elaxation of the metastable gel phase of HFA-CER caused profound changes in the 13C spectra, primaril

95 s of polar carbon atoms upon cooling the HFA-CER bilayers below the Tm strongly suggests that the liq

96 differences between groups with low and high CER scores by using analysis of covariance and quartiles

97 differently between women with low and high CER scores.

98 antly lower BMC was found in women with high CER scores and body weights <71 kg than in those with hi

99 body weights <71 kg than in those with high CER scores and weights > or =71 kg.

100 Lower BMC in women with high CER scores may indicate an increased risk of osteoporosi

101 lanned pairs from the 5 lowest and 5 highest CER levels.

102 nalized care using RLHC requires advances in CER and biostatistics methodology and the development of

103 rrelated with temperature-induced changes in CER.

104 etween genetically determined differences in CER levels and CVD or diabetes.

105 des a subunit of the rate-limiting enzyme in CER biosynthesis, associated with a range of species (e.

106 design and implementation of PRO measures in CER were developed via a standardized process including

107 r developing or implementing PRO measures in CER.

108 bjects with EoE had significant decreases in CERs with 22-carbon long-chain sphingosine or 22-carbon

109 ent anatomical input (dataset 'A'; including CER, BG, and COR), while for dataset 'B', only one anato

110 quality of care and slowing cost increases, CER will increasingly be a necessary component of this c

111 The incremental CER of endovascular repair was 9,905 dollars per QALY.

112 In sensitivity analyses, the incremental CER was insensitive to immediate conversion rate and pro

113 The incremental CER was sensitive (ie, more than 75,000 dollars per QALY

114 Together, these studies gave 121 independent CERs in seven categories of surgical interventions.

115 We conclude that heat stress inhibited CER primarily by decreasing the activation state of Rubi

116 rature in a manner consistent with inhibited CER and Rubisco activation.

117 The enriched protease inhibitors CER-based protein extract resulted in higher trypsin inh

118 As a step toward integrating CER devices into microfluidic systems, a simple chip was

119 By itself, CER will not solve the tension that exists between the g

120 001) but not by diet group (IER -4.8 5.0 kg; CER -3.2 5.0; P = 0.2).

121 (VLDL) resulted in a 3-fold increase in LCAT CER, whereas addition of apoA-I resulted in a more modes

122 lack of LCAT enzyme did not explain the low CER in apoA-I(-)(/)(-) apoE(-)(/)(-) mice and indicated

123 e a lower dietary protein intake and a lower CER, indicating lower total body muscle mass.

124 ietary identities were associated with lower CER for both females {beta [95% confidence interval (CI)

125 These results suggest that lysosomal CER-mTOR signaling may play a critical role for the cont

126 This lysosomal-CER-mTOR signaling may be a crucial molecular mechanism

127 Although, the median CER (100.72, 89.9-111.2 vs. 121.6, 109.7-139.8; P = .001

128 The median CER of circumcision ($13.78 per disability-adjusted life

129 Median CERs of caesarean sections ($315.12 per DALY) and orthop

130 Median CERs of cleft lip or palate repair ($47.74 per DALY), ge

131 Methods: The HDL mimetic CER-001 was radiolabeled using (89)Zr to allow for PET/C

132 rly high-yield targets for multidisciplinary CER efforts, while the management of appendicitis and ga

133 ams, and the developing plans for a national CER program.

134 ng normal and alpha-hydroxy-fatty acids (NFA-CER and HFA-CER, respectively) in solution and in bilaye

135 ical shifts were observed in the case of NFA-CER during the transition from the liquid-crystalline ph

136 tinction group), and a third group showed no CER after pseudorandom training.

137 nsible for the biosynthesis of NS-CER and NP-CER.

138 ficant inverse correlation between NS-CER/NP-CER and DEGS2/DEGS1 mRNA ratios (p < 0.01) was observed.

139 a positive correlation between the NS-CER/NP-CER ratio and CCL26, IL-5, and IL-13 mRNA expression (p

140 resulting in selectively increased NS-CER/NP-CER ratios as compared to controls in esophageal brushes

141 in non-hydroxy fatty acid phytoceramides (NP-CER) with 18-carbon sphingoid bases, resulting in select

142 sine ceramide with palmitic acid ([N-16:0 NS-CER], sphingomyelins [16:0-18:0 SM]), and lysophosphatid

143 A significant inverse correlation between NS-CER/NP-CER and DEGS2/DEGS1 mRNA ratios (p < 0.01) was ob

144 An increase in skin EOS-CER/NS-CER ratio separates the AD(-)PA(+) group from the AD(+)P

145 hydroxy fatty acid sphingosine ceramides (NS-CER) (p < 0.01), and a decrease in non-hydroxy fatty aci

146 AD(-)PA(+) subjects had an increased EOS/NS-CER ratio versus that in the group of subjects with NA s

147 bases, resulting in selectively increased NS-CER/NP-CER ratios as compared to controls in esophageal

148 zymes responsible for the biosynthesis of NS-CER and NP-CER.

149 rsely, a positive correlation between the NS-CER/NP-CER ratio and CCL26, IL-5, and IL-13 mRNA express

150 hydroxy fatty acid sphingosine ceramides (NS-CERs) in the skin.

151 hydroxy fatty acid sphingosine ceramides (NS-CERs) in the skin.

152 In contrast, the addition of CER, which has an acyl chain structure similar to SPM bu

153 Adding progressively higher amounts of CER or FC to meibum had a strong impact on the rigidity,

154 lder engagement is an important component of CER.

155 ures that effectively decouple the degree of CER and CR development to investigate the IET effect.

156 The secretory dose of CER slightly increased the activities of both forms of m

157 Secretory doses of CER induced a 4-fold increase of both forms of JNK in pa

158 ate for the need for and potential effect of CER at the patient level and the cumulative fiscal burde

159 lingering concerns that the ultimate goal of CER is to empower the government and private insurers to

160 w the role of RCTs in achieving the goals of CER, with particular emphasis on the role of publicly fu

161 e (EBM); (2) to describe the implications of CER for systematic review methodologies in oncology; and

162 uideline development and the implications of CER in this process.

163 tone-foot shock association independently of CER expression, were found in the medial geniculate, hip

164 Inhibition of CER was not a consequence of stomatal closure, as indica

165 The integration of CER methodology and genomics linked to RLHC should enhan

166 An analysis of the principles and methods of CER was undertaken in light of EBM, systematic reviews,

167 This workshop report provides an overview of CER methods, with an emphasis on practical clinical tria

168 h oestradiol (10 nM) increased production of CER[NS] and CER[NDS] ceramides, confirming an effect of

169 nal studies comprise a growing proportion of CER because of their efficiency, generalizability to cli

170 icit restrictions on access to care based on CER like those found in the United Kingdom are unlikely,

171 ther IER [2-d 500 kcal (2100 kJ); n = 61] or CER [1500 kcal (6000 kJ); n = 60] in this 12-mo noninfer

172 ralised CNN architecture produced an overall CER of 0.09 +/- 0.03.

173 Participants' CER was used to estimate total body muscle mass.

174 t the CD83, SGPP1 and DEGS1 loci, and plasma CER traits (P < 5 x 10-8).

175 Exenatide also reduced some postprandial CERs, PCs, and LPCs previously linked to CMR.

176 scues GIMAP5-deficient T cells by preventing CER overaccumulation and cell deterioration.

177 onfounder." The authors identified published CER studies that used instrumental variable analysis and

178 In many published CER analyses of registry data, investigators assessed co

179 The films made of either pure CER or pure FC were clearly collapsible, and had much hi

180 esulted in a mean classification error rate (CER) of 0.08 +/- 0.03 across all subjects.

181 Cholesterol esterification rate (CER) in apoA-I(-)(/)(-) apoE(-)(/)(-) mouse plasma was <

182 ned either a fitted composite exchange rate (CER) with a relative standard error of <=10% or the MT r

183 ne in the light-saturated CO2-exchange rate (CER).

184 omparing measured creatinine excretion rate (CER) to CER estimated using a 4-variable equation previo

185 heir 24-h urinary creatinine excretion rate (CER).

186 The incremental cost-effectiveness ratio (CER) was calculated for endovascular repair relative to

187 d to compare MRI contrast enhancement ratio (CER) pre-injection and post-injection.

188 tative analysis, contrast enhancement ratio (CER), lesion-to-liver contrast (LLC), and SI ratio on dy

189 We extracted cost-effectiveness ratios (CERs) and appraised economic assessments for their metho

190 bviating the evolution of chloride reaction (CER), i.e., ~490 mV, as competitive to the OER.

191 e engineered a chimeric engulfment receptor (CER)-1236, which combines the extracellular domain of TI

192 poE on low-density lipoprotein (LDL) reduced CER (1% free cholesterol (FC) esterified/h) compared to

193 notype (CEP), thickness (CET), reflectivity (CER), and densitometry (CED).

194 Comparative effectiveness research (CER) aims to provide decision makers with the evidence n

195 between comparative effectiveness research (CER) and evidence-based medicine (EBM); (2) to describe

196 rpose of comparative effectiveness research (CER) as developing evidence-based information for interv

197 ths ago, comparative effectiveness research (CER) began its rapid rise, when the American Recovery an

198 Comparative effectiveness research (CER) has been promoted as a way to improve the translati

199 ation of comparative effectiveness research (CER) in pediatric surgery.

200 aluating comparative effectiveness research (CER) in rheumatoid arthritis (RA).

201 Comparative effectiveness research (CER) is intended to address the expressed needs of patie

202 Comparative effectiveness research (CER) is intended to inform decision making in clinical p

203 ative in comparative effectiveness research (CER) is part of a broad and long-term evolution toward g

204 clinical comparative effectiveness research (CER) of oncology treatments or process interventions is

205 Comparative effectiveness research (CER) seeks to assist consumers, clinicians, purchasers,

206 data for comparative effectiveness research (CER) studies.

207 dies for comparative effectiveness research (CER) that link detailed clinical information to tumor bi

208 defines comparative effectiveness research (CER), considering how it is viewed differently in the Un

209 ethod in comparative effectiveness research (CER).

210 cilitate comparative effectiveness research (CER).

211 of PFASs compared to cation-exchange resins (CERs), nonionic resins (NIRs), and GAC regardless of the

212 Because a conditioned emotional response (CER), as well as the eyeblink CR, is acquired during eye

213 inction of a conditioned emotional response (CER).

214 relation between cognitive eating restraint (CER) and total-body measurements of bone mineral density

215 lternative to continuous energy restriction (CER) for weight loss.

216 tion (IER) or continuous energy restriction (CER), with 3 phases: very low-energy diet (weeks 0-4), i

217 tion (IER) or continuous energy restriction (CER).

218 nvolving calculating the Case Epidemic Risk; CER) based on the mathematical theory of branching proce

219 It also reviews the role CER now plays in the Ontario drug funding process and co

220 ha-hydroxy fatty acid-containing sphingosine CERs (with 18-, 20-, and 22-carbon long-chain sphingosin

221 ach other.Observational data used to support CER include disease registries, administrative claims da

222 The large response to supramaximal CER stimulation may be of importance in the early pathog

223 The CER is then one minus the extinction probability.

224 The CER of FNH in the arterial phase (mean, 94.3%+/-33.2) wa

225 The CER-ZA protein was characterized after expression in yea

226 on, "Can it work in optimal conditions?" The CER paradigm employs a wide range of study designs to un

227 nd influences the development of the CR, the CER acquired in initial training can plausibly account f

228 ER, in myoblast cells and to distinguish the CER from other nonregulatory TAAT-containing sequences.

229 er, given the attention it has garnered, the CER paradigm may be precisely the reminder and push requ

230 Over time, we will see if the CER paradigm lives up to its potential.

231 at week 52, this effect was observed in the CER group only (from 59 of 68 [86.7%] to 30 of 49 [61.2%

232 59 of 68 [86.8%] to 31 of 60 [57.1%] in the CER group) at week 16; however, at week 52, this effect

233 enrolled, 71 in the IER group and 70 in the CER group, and 97 (68.8%) completed the intervention, 43

234 ervention, 43 in the IER group and 54 in the CER group.

235 ment of acute pancreatitis biomarkers in the CER-AP mouse pancreatitis model, underlining the potenti

236 suggest a functional network inhibiting the CER composed of prefrontal cortex, medial thalamus, audi

237 ivity were more successful at inhibiting the CER.

238 ely to a key regulatory element in MyoD, the CER, in myoblast cells and to distinguish the CER from o

239 sentations, resulted in the reduction of the CER (freezing behavior).

240 tine practice is a more central tenet of the CER paradigm.

241 ed the development of the eyeblink CR or the CER, prior to a shift of the US to the alternate eye.

242 This renders the CER uninformative in those scenarios.

243 seful assessments of outbreak risks than the CER, enabling practically relevant risk quantification f

244 development of eyeblink CRs rather than the CER.

245 It will also be important that the CER initiative show some impact on the use of health car

246 Therefore, CER-1236 T cells have the potential to achieve tumor con

247 vidence-based medicine and can be adapted to CER by broadening the types of studies included and exam

248 program, providing an option in addition to CER and offering participants more choice.

249 Randomized controlled trials are central to CER because of the lack of selection bias, with the rece

250 measured creatinine excretion rate (CER) to CER estimated using a 4-variable equation previously dev

251 to confirm noninferiority of IER compared to CER.

252 IER produces comparable weight loss to CER over 12 mo in overweight women with previous GDM.

253 elp to inform groups intending to respond to CER funding opportunities in COPD.

254 Decision models are particularly suited to CER, because they make quantitative estimates of expecte

255 n Patients With Acute Coronary Syndrome [TRA.CER] [Study P04736AM3]; NCT00527943).

256 A second group underwent CER acquisition alone (nonextinction group), and a third

257 Only 4 (6%) instrumental variable CER studies considered potential instrument-outcome conf

258 ndex (BMI) z score at 52 weeks in the IER vs CER group.

259 action of individual cerebellar VT value (VT,CER) as the nondisplaceable VT (VND) (VND = VT,CER/1.17)

260 R) as the nondisplaceable VT (VND) (VND = VT,CER/1.17).

261 and incubation time (p-value <0.015), while CER was found to be affected by the quadratric effect of

262 with body weights <71 kg and classified with CER.

263 activation was more closely correlated with CER than the maximum quantum yield of photochemistry of

264 e time points, supramaximal stimulation with CER caused 4- and 27-fold increases, respectively, of th

265 eatic tissue during in vivo stimulation with CER.

266 bjective was to determine whether women with CER had lower total-body BMD and BMC than did other wome

267 Women with CER were significantly more dissatisfied with their bodi