ライフサイエンスコーパス: CHI3L1

1 ggressive metastatic cancer phenotype (SPP1, CHI3L1).

2 om SAGES (n = 150 for CRP, IL-6; n = 126 for CHI3L1).

3 augment the expression of WAT and pulmonary Chi3l1.

4 lens epithelium, and TM and did not express CHI3L1.

5 ted TMSCs began expressing TM marker protein CHI3L1.

6 red genetically to overexpress or lack mouse CHI3L1.

7 L1, underscoring the biological relevance of CHI3L1.

8 novel avenues for investigating the role of CHI3L1.

9 n-reperfused MI and administered recombinant CHI3L1.

10 nd, to a lesser extent, PLS (AUC: CHIT 0.73; CHI3L1 0.51; CHI3L2 0.82) but did not outperform pNFH.

11 0.80; CHI3L2 0.90), mimics (AUC: CHIT1 0.84; CHI3L1 0.73; CHI3L2 0.88) and, to a lesser extent, PLS (

12 ols (area under the curve (AUC): CHIT1 0.92; CHI3L1 0.80; CHI3L2 0.90), mimics (AUC: CHIT1 0.84; CHI3

13 We determined that Chitinase 3-like-1 (Chi3l1), a conserved prototypic chitinase-like protein,

14 Chi3l1 ablation in the polyoma virus middle T (PyMT) bre

15 Inhibition of CHI3L1 activity would be a novel therapeutic approach fo

16 Importantly, CHI3L1 administered after C. albicans inoculation also h

17 pe (MUM1), lymphoproliferation (SPP1, TCL1A, CHI3L1), aggressive clinical behavior (SPP1, CHI3L1, MUM

18 CHI3L1 also contributed to IFN-y-stimulated macrophage P

19 Chi3l1 also played a critical role in WAT accumulation a

20 ta1 (TGFbeta1) and chitinase-3-like protein (CHI3L1) also known as YKL-40, which were shown to arrest

21 Chitinase 3-like 1 (CHI3L1), also known as breast regression protein 39 (BRP

22 Chitinase-3-like-1 (CHI3L1), also known as YKL-40, is a glycoprotein linked

23 Here, we show that Chi3l1 alters the state of glioma stem cells (GSC) to su

24 erence of small molecules in binding between CHI3L1 and biotinylated small molecules or heparan sulfa

25 CSF CHIT1, CHI3L1 and CHI3L2 were elevated in patients with ALS com

26 urine Chitinase 3-like-3 (Chi3l3/Ym1), human Chi3L1 and Chit1 induce oligodendrogenesis.

27 mans alongside genotype associations between CHI3L1 and diabetes at the population level.

28 Foldchange CHI3L1 and IL-6 were associated with increased postopera

29 proteins and that the CHI3L1 inhibitors anti-CHI3L1 and kasugamycin inhibit epithelial cell infection

30 Finally, similar associations between CHI3L1 and metabolic parameters were observed in humans

31 ecific antibodies that simultaneously target CHI3L1 and PD-1.

32 Immunoassays were used to quantify Chit-1, CHI3L1 and phosphorylated neurofilament heavy chain leve

33 mal human bronchial epithelial cells express CHI3L1 and secrete YKL-40 under base-line culture condit

34 t RLH activation inhibits tumor induction of Chi3l1 and the expression of receptor IL-13Ralpha2 and p

35 The simultaneous targeting of CHI3L1 and the PD-1/PD-L1 axis with individual and, more

36 the fibrosis was due to interactions between CHI3L1 and the receptor CRTH2, which trafficked normally

37 (BRP-39), also known as chitinase 3-like 1 (CHI3L1) and encoded by the Chi3l1 gene, is expressed at

38 Mouse breast regression protein 39 (BRP-39; Chi3l1) and its human homologue YKL-40 are chitinase-lik

39 n receptor (AR), chitinase-3-like protein 1 (CHI3L1), and IFN-stimulated genes (ISG).

40 protein (GFAP), chitinase-3-like protein 1 (CHI3L1), and other protein assays are being developed as

41 Targetable alterations in MBC, including AR, CHI3L1, and ISG, arise following estrogen-deprivation, a

42 cell state transitions after treatment with Chi3l1, and MAZ deficiency rescued the Chi3L-induced inc

43 function and expression of TM markers AQP1, CHI3L1, and TIMP3.

44 sts overexpressing MMP1, MMP3, MMP11, HIF1A, CHI3L1, and TNFAIP6 and increased M1 macrophage polariza

45 on in its encoding gene (chitinase 3-like 1 [CHI3L1]) and are increased in patients with several dise

46 Mean anti-chitinase 3-like 1 (CHI3L1), anti-delta-like ligand (DLL-4), and antisurfact

47 Anti-CHI3L1, anti-DLL-4, and anti-SFTPD IgM autoantibody corr

48 the functional role of CHI3L1 in vivo, anti-CHI3L1 antibody was administered into the dextran sulfat

49 en to determine if interventions that target CHI3L1 are effective inhibitors of SC2 viral variant inf

50 CSF Chit-1 and CHI3L1 are significantly increased in ALS, and CSF Chit-

51 ys exacerbate pulmonary fibrosis and suggest CHI3L1 as a potential biomarker for pulmonary fibrosis p

52 genesis and cognitive function, highlighting CHI3L1 as a promising therapeutic target for AD and rela

53 Here, we demonstrate that CHI3L1 augments epithelial cell infection by pseudovirus

54 Chi3l1 augments macrophage bacterial killing by inhibiti

55 NA (siRNA), corneas treated with recombinant CHI3L1 before C. albicans inoculation had markedly ameli

56 tudies demonstrated that chitinase 3-like-1 (Chi3l1) binds to and signals via IL-13Ralpha2.

57 Chi3l1 bound to CD44 and induced phosphorylation and nuc

58 between the degree of kidney injury and both Chi3l1/Brp-39 expression in the kidney and its levels in

59 We evaluated the regulation of Chi3l1 by an HFD and Th2 inflammation.

60 Chitinase-3-like protein 1 (CHI3L1), C-reactive protein (CRP), and interleukin-6 (IL

61 of CD133+SOX2+ cells and increased the CD44+Chi3l1+ cells.

62 eased release of chitinase 3-like protein 1 (CHI3L1), CHI3L2, complement factor B, matrix metalloprot

63 CSF levels of CHIT1, CHI3L1, CHI3L2, phosphorylated neurofilament heavy chain

64 of HF, whereas higher ADM (adrenomedullin), CHI3L1 (chitinase-3-like protein 1), CTSL1 (cathepsin L1

65 interaction between TMEM219 and IL-13Ralpha2-Chi3l1 complexes.

66 3Ralpha2, a recently identified receptor for Chi3l1, consistent with a key role for Chi3l1 in melanom

67 vivo neutralization experiments showed that CHI3L1 contributes to the facilitation of bacterial inva

68 CHI3L1 contributes to tumor progression by stimulating t

69 CHI3L1 correlated with degree of cognitive dysfunction (

70 een 68 CHI3L1 SNPs, methylation levels at 14 CHI3L1 CpG sites in whole-blood DNA, and circulating YKL

71 determine (1) whether methylation levels at CHI3L1 CpG sites mediate the association of CHI3L1 singl

72 Concentrations of CHI3L1, CRP, IL-18BP, IL-6, sICAM-1, and sTNFR2 were qua

73 Blocking this CHI3L1/CRTH2/beta-catenin cascade restores neurogenesis

74 ulation of inflammatory mediators, including CHI3L1, CXCL13, and CSF1.

75 In contrast, CHI3L1-deficient mice showed reduced ventricular remodel

76 Immunoprofiling of infarcted CHI3L1-deficient mouse hearts revealed a faster decline

77 These data demonstrate that CHI3L1-dependent pathways exacerbate pulmonary fibrosis

78 heral blood autoreactive T cells specific to CHI3L1, DLL-4 and SFTPD, respectively.

79 aled cholangiocyte-predominant expression of CHI3L1, DLL-4, and SFTPD.

80 epithelial apoptosis but exhibit exaggerated CHI3L1-driven fibroproliferation, which together promote

81 Purified CHI3L1 efficiently activated the NF-kappaB signaling pat

82 case (RLH) innate immune response to control Chi3l1 elaboration and pulmonary metastasis.

83 The molecular mechanism involves CHI3L1 engaging the CRTH2 receptor and dampening beta-ca

84 These findings provide direct evidence that CHI3L1 exacerbates ventricular inflammation and remodeli

85 compressive stress) applied for 3 h induces CHI3L1 expression by approximately 4-fold compared with

86 function in neuroinflammation, we found that CHI3L1 expression correlates with cognitive impairment i

87 ted the corneal from C. albicans and induced CHI3L1 expression in C57BL/6 mouse corneas.

88 and RT-PCR analyses significantly increased CHI3L1 expression in non-dysplastic mucosa from patients

89 s mechanical stress-induced up-regulation of CHI3L1 expression in normal human bronchial epithelial c

90 rate that mechanical stress potently induces CHI3L1 expression leading to increased secretion of YKL-

91 ytes adjacent to fibrous septa showed higher CHI3L1 expression than did those in more distal areas.

92 CHI3L1 expression was elevated in human TNBCs and other

93 The highest intrahepatic CHI3L1 expression was observed in cirrhosis due to hepat

94 CHI3L1 expression was significantly higher in livers of

95 of EGFR utilizing EGF-family ligands induces CHI3L1 expression.

96 ity progression in patients with PPMS, being CHI3L1 findings less dependent on the inflammatory compo

97 ed 5 significantly associated proteins: AXL, CHI3L1, GAS6, IL-6RA, and SCGB3A2.

98 CHI3L1 gene expression serves as a robust molecular mark

99 SNPs spanning the CHI3L1 gene were genotyped in 259 Yale Center for Asthma

100 hitinase-like protein YKL-40, encoded by the CHI3L1 gene, is a biomarker and functional effector of c

101 itinase 3-like 1 (CHI3L1) and encoded by the Chi3l1 gene, is expressed at high levels by macrophages

102 ymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) gene or its promoter.

103 The effects of CHI3L1 genetic variation on circulating YKL-40 levels ar

104 Following adjustment for CHI3L1 genotype, significantly greater levels of YKL-40

105 CHI3L1 has been implicated in a variety of diseases incl

106 IL-13Ralpha2 uses to mediate the effects of Chi3l1 has not been defined.

107 Chitinase 3-like 1 (CHI3L1) has been shown to play a role in promoting antib

108 CHI3L1, however, played a detectable but minor role in f

109 factor-related activation-induced cytokine, CHI3L1, IL-16, and matrix metalloproteinase-12 were card

110 ts-expressing genes related to inflammation (CHI3L1, IL6) and extracellular matrix remodeling (ASPN),

111 a and determined the cell types that express CHI3L1 in ALS.

112 haviors, which could be rescued by depleting CHI3L1 in astrocytes.

113 This study sought to elucidate the role of CHI3L1 in augmenting the corneal innate immune response

114 etween asthma and obesity and the role(s) of Chi3l1 in fat accumulation have not been defined.

115 knowledge, we investigated the production of Chi3l1 in melanoma lung metastases.

116 r for Chi3l1, consistent with a key role for Chi3l1 in melanoma spread.

117 tified hepatocytes as the major producers of CHI3L1 in normal liver and in cirrhotic tissue, wherein

118 at the protein level of ECM-related SPP1 and CHI3L1 in PCNSL cells was demonstrated by immunohistoche

119 We confirmed roles for Sema7a and Chi3l1 in pulmonary metastasis of EMT6 breast cancer cel

120 The role of Chi3l1 in regulating cellular plasticity confers a targe

121 Activated astrocytes secrete CHI3L1 in response to AQP4 autoantibodies, and this inhi

122 of this study was to investigate the role of CHI3L1 in the development and progression of AD.

123 direct effect on HSCs and support a role for CHI3L1 in the increased susceptibility of aging livers t

124 We investigated the cellular source of CHI3L1 in the liver and its function using liver tissue

125 n were significantly promoted in response to CHI3L1 in these cells.

126 Finally, targeting Chi3l1 in vivo with a blocking antibody inhibited tumor

127 To examine the functional role of CHI3L1 in vivo, anti-CHI3L1 antibody was administered in

128 tically modified mice to define the roles of Chi3l1 in white adipose tissue (WAT) accumulation and Th

129 ATAC-seq revealed that Chi3l1 increases accessibility of promoters containing a

130 strate that TMEM219 plays a critical role in Chi3l1-induced IL-13Ralpha2 mediated signalling and tiss

131 hese responses and the pathways that control Chi3l1-induced tumor responses are poorly understood.

132 To assess whether increased CHI3L1 influences ventricular remodeling, we subjected m

133 In addition, Chi3l1 inhibited Sirt1 expression, and the deficient vis

134 ective ER degraders when combined with AR or CHI3L1 inhibition, perhaps with the addition of immunoth

135 a, delta, or omicron S proteins and that the CHI3L1 inhibitors anti-CHI3L1 and kasugamycin inhibit ep

136 Overall, this work suggests that Chi3l1 interacts with CD44 on the surface of GSCs to ind

137 e Protein [CRP], Chitinase 3-like protein-1 [CHI3L1], Interleukin 18 Binding Protein [IL-18BP], solub

138 y (Ang-1, Ang-2, sFlt-1), immune activation (CHI3L1, IP-10, IL-1ra, IL-6, IL-8, IL-10, sTNFR-1, sTREM

139 Chi3l1 is a modulator of glioma stem cell states that ca

140 These studies demonstrate that Chi3l1 is a multifaceted immune stimulator of tumor prog

141 CHI3L1 is a susceptibility gene for asthma, bronchial hy

142 Thus, CHI3L1 is a universal, VOC-independent therapeutic targe

143 CHI3L1 is also induced in COPD where it regulates epithe

144 CHI3L1 is an emerging biomarker associated with progress

145 CHI3L1 is an inflammation-associated molecule, and its e

146 NP rs4950928, the intronic SNP rs12141494 in CHI3L1 is associated with asthma severity, lung function

147 CHI3L1 is expressed by a subset of activated astrocytes

148 Chi3l1 is induced by a variety of cancers where it porte

149 Chi3l1 is induced by an HFD and Th2 inflammation, and si

150 This is the first report demonstrating that CHI3L1 is induced during fungal infection, where it acts

151 These data demonstrate that Chi3l1 is induced during infection, where it promotes ba

152 The prototypic chitinase-like protein Chi3l1 is induced in cancers and portends a poor prognos

153 ays using intracellular bacteria showed that CHI3L1 is required for the enhancement of adhesion and i

154 d in exercised mice in vivo, indicating that CHI3L1 is secreted during muscle contraction.

155 Microarray analysis identified that CHI3L1 is up-regulated specifically in inflamed mucosa.

156 The glycoprotein YKL-40 (CHI3L1) is a secreted chitinase family protein that indu

157 Chitinase 3-like 1 (Chi3l1) is a secreted protein that is highly expressed i

158 Chitinase 3-like-1 (Chi3l1) is an evolutionarily conserved moiety that plays

159 Chitinase 3-like-1 (CHI3L1) is induced in many cancers where it inhibits ada

160 Chitinase 3-like 1 (CHI3L1) is induced in many cancers, where it portends a

161 Chitinase-3-like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in

162 We found that chitinase-3 like-1 (CHI3L1) is upregulated after MI and secreted by activate

163 nal AD mouse models, with astrocyte-specific CHI3L1 knockout, alongside 5XFAD mice.

164 Here, we demonstrated that circulating CHI3L1 levels are higher in HPS patients with pulmonary

165 icantly increased in ALS, and CSF Chit-1 and CHI3L1 levels correlate to the rate of disease progressi

166 CHI3L1 levels were elevated in cells under conditions th

167 CSF CHI3L1 levels were increased in ALS and DCs compared wit

168 Increased CHI3L1 levels worsened ventricular remodeling.

169 of LINE1 sites but led to demethylation of a CHI3L1 locus that is hypomethylated in RA FLS.

170 ase (Chit-1) and chitinase-3-like protein 1 (CHI3L1), markers of glial activation, in cerebrospinal f

171 CHI3L1 may be a potential therapeutic target for the tre

172 In summary, CHI3L1 may contribute to the proliferation, migration, a

173 of CD8(+) T cells and suggest that targeting Chi3l1 may promote anti-tumor immunity in various tumor

174 the CaMKK was associated with suppression of CHI3L1-mediated glucose uptake.

175 These findings demonstrate that CHI3L1 mediates the development of AD induced by OVA, af

176 In situ hybridization of CHI3L1 messenger RNA (mRNA) identified hepatocytes as th

177 Chitinase 3-like-1 (CHI3L1) messenger RNA and protein expressions were exami

178 on injury (U-IRI) led to sustained low-level Chi3l1 mRNA expression by renal cells and promoted macro

179 del of renal atrophy showed greater Ccl2 and Chi3l1 mRNA expression in infiltrating macrophages and n

180 CHI3L1), aggressive clinical behavior (SPP1, CHI3L1, MUM1), and aggressive metastatic cancer phenotyp

181 The abundance of CP, CHI3L1, NECTIN2, A2M were strongly positively correlated

182 S. pneumoniae-infected Chi3l1 null mice exhibit exaggerated lung injury, inflam

183 deficient visceral fat and Th2 responses in Chi3l1 null mice were reversed by Sirt1 inhibition.

184 iptase-PCR showed high expression of CITED1, CHI3L1, ODZ1, and SCEL in 6/6 additional PTCs.

185 he numerous additional genes include CITED1, CHI3L1, ODZ1, N33, SFTPB, and SCEL.

186 determine the effect of genetic variation in CHI3L1 on asthma severity and YKL-40 expression in subje

187 In this study, we investigated the role of CHI3L1 on CECs during the development of colitis-associa

188 The biological function of CHI3L1 on CECs is unclear.

189 ed the effect of chitinase-3-like protein 1 (CHI3L1) on glucose metabolism and its underlying mechani

190 Notably, targeting astrocytic CHI3L1 or blocking CRTH2 and its downstream effectors su

191 Individual antibodies against CHI3L1 or PD-1 had discrete antitumor effects and additi

192 Notably, antiserum raised against Chi3l1 or Sema7a phenocopied the reduction produced by g

193 In mouse strains with genetic deletions of Chi3l1 or Sema7a, there was a significant reduction in p

194 osidase (CHIT1), chitinase-3-like protein 1 (CHI3L1 or YKL-40), and soluble triggering receptor expre

195 AnkG, and MUC1 but not TM markers AQP1, MGP, CHI3L1, or TIMP3.

196 s, such as those involving ANO3, RGS9, FUT5, CHI3L1, OR1D4, and LIPG in breast; IGF2 in colon; ETV1 i

197 roles likely contributed to the retention of Chi3l1 over species and evolutionary time.

198 ls (p<0.001) and ALS-mimics (CHIT1, p<0.001; CHI3L1, p=0.017; CHI3L2, p<0.001).

199 ed in ALS compared with PLS (CHIT1, p=0.021; CHI3L1, p=0.417; CHI3L2, p<0.001).

200 RIG-like helicase innate immunity suppressed CHI3L1, PD-L1, and melanoma progression.

201 CHI3L1 plays a pathogenic role in colitis, presumably by

202 Therefore, secretory CHI3L1 plays an important role in inflammation-induced l

203 c chitinase-like protein chitinase 3-like-1 (CHI3L1) plays a protective role in the lung by ameliorat

204 ining was performed to identify and quantify CHI3L1-positive cells in tissue sections from ALS, DCs a

205 Increased numbers of CHI3L1-positive cells were observed in postmortem ALS mo

206 Mechanistically, Chi3l1 promoted neutrophil recruitment and neutrophil ex

207 all asthmatic children were genotyped for a CHI3L1 promoter single nucleotide polymorphism (rs495092

208 ymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) promoter, the gene encoding YKL-40, are associat

209 These findings collectively demonstrate that CHI3L1 promotes liver fibrogenesis through a direct effe

210 In vitro studies showed that recombinant CHI3L1 promotes proliferation and activation of primary

211 ochemical staining showed strong staining of CHI3L1 protein around tumor areas in these mouse models.

212 The expression of CHI3L1 protein clearly was detectable in lamina propria

213 patients revealed a significant elevation of CHI3L1 protein concentration in human serum samples from

214 mation-induced lung cancer mouse models, the CHI3L1 protein concentration was also highly increased i

215 wnstream genes products, chitinase 3-like 1 (CHI3L1) protein, showed increased concentration in both

216 ten candidate genes (ORMDL1, ORMDL2, ORMDL3, CHI3L1, RAD50, IL13, IL4, STAT6, FOXP3, and RUNX3) was a

217 he trafficking and effector functions of two CHI3L1 receptors.

218 Exposure of patient-derived GSCs to Chi3l1 reduced the frequency of CD133+SOX2+ cells and in

219 CD274, CHI3L1, REG1B, ITGAV, PRSS8, ITGA11, GDF15, DEFA1_DEFA1B

220 Here we demonstrate that CHI3L1 regulates the expression of PD-L1, PD-L2, PD-1, L

221 ession in animal models, and that miR-24 and CHI3L1 represent novel plasma biomarkers of AAA disease

222 abundance of GPI, PTPN11, OLR1, ENO1, GAPDH, CHI3L1, RETN, CSF3, LCN2, CXCL1, CXCL8, PGLYRP1, LDHB, I

223 rough which Sem7a and its receptors regulate Chi3l1, revealing a host axis involving IL13Ralpha2 that

224 In this study examining CHI3L1's biological function in neuroinflammation, we fo

225 Here, we investigate CHI3L1's function and its therapeutic potential in AD us

226 This study explored CHI3L1's interactions with various oligosaccharides usin

227 Our data reveal that CHI3L1 secretion by astrocytes impairs neural stem cell

228 A velocity following incubation of GSCs with Chi3l1 showed significant changes in GSC state dynamics

229 CHI3L1 CpG sites mediate the association of CHI3L1 single nucleotide polymorphisms (SNPs) with YKL-4

230 was more severe in the corneas treated with Chi3l1 small interfering RNA (siRNA), corneas treated wi

231 stal structures of potent hit compounds with CHI3L1, small molecule probes 19 and 20 were designed fo

232 ntified significant associations of multiple CHI3L1 SNPs and their haplotypes with plasma YKL-40 leve

233 In our study YKL-40 levels, but not CHI3L1 SNPs or methylation levels, were associated with

234 Associations between 68 CHI3L1 SNPs, methylation levels at 14 CHI3L1 CpG sites i

235 the blood and (2) whether these biomarkers (CHI3L1 SNPs, methylation profiles, and YKL-40 levels) ar

236 Results suggested that CHI3L1 stimulated the phosphorylation of AS160 and p38 M

237 TMEM219 or IL-13Ralpha2 similarly decreased Chi3l1-stimulated epithelial cell HB-EGF production and

238 y have demonstrated that chitinase 3-like-1 (CHI3L1) stimulates ACE2 and Spike (S) priming proteases

239 macrophage phagocytosis are associated with CHI3L1 stimulation of the SHP-1 and SHP-2 phosphatases a

240 arkers of immune (IL-6, IL-8, CXCL-10/IP-10, CHI3L1, sTNFR1, and sTREM-1) and endothelial (sVCAM-1, s

241 enic and inflammation pathways suggests that CHI3L1-targeted therapeutics are promising interventions

242 se exhibited higher levels of CSF Chit-1 and CHI3L1 than patients with slow-progressing disease.

243 A promoter SNP (-131C-->G) in CHI3L1, the chitinase 3-like 1 gene encoding YKL-40, was

244 hese animals have a defect in the ability of CHI3L1 to inhibit epithelial apoptosis but exhibit exagg

245 copied one another as regards the ability of Chi3l1 to inhibit oxidant-induced apoptosis and lung inj

246 The ability of CHI3L1 to simultaneously inhibit innate immune responses

247 a mechanistic explanation for the ability of CHI3L1 to stimulate ICPs and inhibit adaptive immune res

248 first animal study linking overexpression of CHI3L1 to various lung tumor mouse models.

249 in vitro studies reveal chitinase 3-like 1 (Chi3l1) to be a major target and effector under the cont

250 CHI3L1 treatment resulted in the induction of the antimi

251 of AMPK and AKT was observed in response to CHI3L1, underscoring the biological relevance of CHI3L1.

252 However, the mechanism(s) that CHI3L1 uses in metastasis have not been defined.

253 We characterized the mechanisms that Chi3l1 uses to foster tumor progression and the ability

254 However, the mechanisms that Chi3l1 uses to mediate these responses and the pathways

255 CHI3L1 was associated with increased glucose uptake in s

256 associated with truncal adiposity, and serum Chi3l1 was associated with persistent asthma and low lun

257 Expression of the cytokine Chi3l1 was decreased in Stat3(-/-) tumors.

258 As determined by IHC, CHI3L1 was expressed in specific cell types in the crypt

259 Additionally, CHI3L1 was found to influence glucose uptake through the

260 We found that Chi3l1 was induced during pulmonary melanoma metastasis

261 which encodes chitinase-like protein YKL-40/CHI3L1, was identified as the gene with the greatest age

262 SNPs nor methylation levels at CpG sites in CHI3L1 were associated with asthma.

263 Fifteen SNPs in CHI3L1 were associated with FEV1, serum YKL-40 levels, o

264 Finally, serum and sputum Chi3l1 were positively associated with truncal adiposity

265 (MCP-1/CCL2), uromodulin (UMOD), and YKL-40 (CHI3L1) were measured in urine samples collected during

266 Chitinase 3-like 1 (CHI3L1), which encodes chitinase-like protein YKL-40/CHI

267 n of chilectins is pronounced in mammals and CHI3L1 (with a proposed function in immunity) is found i

268 zed human astrocytes stably transfected with CHI3L1/YKL-40 exhibited changes in gene expression simil

269 CHI3L1/YKL-40 is an astrocyte-secreted glycoprotein reco

270 We found that CHI3L1/YKL-40 was significantly associated with both chr

271 Chitinase 3-like-1 (CHI3L1/YKL-40) is a protein secreted from restricted cel

272 ligoglucans and the neurodegeneration marker CHI3L1/YKL40.