ライフサイエンスコーパス: CMV retinitis

1 patients may suggest a rise in incidence of CMV retinitis.

2 immune evasion and/or immunopathogenesis of CMV retinitis.

3 with acquired immunodeficiency syndrome and CMV retinitis.

4 vents occurring in the eyes of patients with CMV retinitis.

5 s use as a therapeutic agent in treatment of CMV retinitis.

6 pecific immune parameters of protection from CMV retinitis.

7 es of patients with AIDS and newly diagnosed CMV retinitis.

8 CMV) detection for AIDS patients at risk for CMV retinitis.

9 s of >/=1+ severity associated with inactive CMV retinitis.

10 ects of CMV infections in AIDS patients with CMV retinitis.

11 ng-acting delivery system for the therapy of CMV retinitis.

12 atients with bilateral, clinically resistant CMV retinitis.

13 delaying progression of previously untreated CMV retinitis.

14 acular degeneration, glaucoma, cataract, and CMV retinitis.

15 ty profile of ISIS 2922 for the treatment of CMV retinitis.

16 develops in patients receiving treatment for CMV retinitis.

17 immunotherapy may have a role in refractory CMV retinitis.

18 urvival of 27.0 years after the diagnosis of CMV retinitis.

19 hree remote graders evaluated each image for CMV retinitis.

20 included in the study, 20 had improvement of CMV retinitis.

21 on of eyes with various clinical features of CMV retinitis.

22 a CD4+ T cell count >100 cells/muL developed CMV retinitis.

23 from digital fundus photographs of eyes with CMV retinitis.

24 (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis.

25 and other modulators to the pathogenesis of CMV retinitis.

26 ere obtained from 165 patients with AIDS and CMV retinitis.

27 on in patients with AIDS is cytomegalovirus (CMV) retinitis.

28 suppress the progression of cytomegalovirus (CMV) retinitis.

29 classification criteria for cytomegalovirus (CMV) retinitis.

30 count, age, sex, and prior cytomegalovirus (CMV) retinitis.

31 us photographs of eyes with cytomegalovirus (CMV) retinitis.

32 Among patients without CMV retinitis, 1 of 75 patients with immune recovery dev

33 In a prospective study of 210 patients with CMV retinitis, 26 were identified as having either a phe

34 Of the 52 patients with CMV retinitis, 55.8% were female.

35 Of 76 eyes with CMV retinitis, 61.8% had zone I disease and 21.6% had le

36 Of the 21 eyes (10.2%) with CMV retinitis, 7 (33%) had visual symptoms.

37 L therapy included persistent or progressive CMV retinitis (71.4% of patients); CMV UL54 or UL97 anti

38 In a prospective study of 108 patients with CMV retinitis, 80.6% of patients were found to have eith

39 Cytomegalovirus (CMV) retinitis, a common complication of the acquired im

40 agnosed each image as CMV retinitis present, CMV retinitis absent, or unknown.

41 queous humor can provide valuable markers of CMV retinitis activity.

42 or patients with bilateral versus unilateral CMV retinitis (adjusted odds ratio [aOR], 2.74; 95% conf

43 The incidence of CMV retinitis after 12 months was 24 percent in the plac

44 Reactivation of CMV retinitis after withdrawal of anti-CMV therapy did n

45 Among persons with CMV retinitis and AIDS, if there is immune recovery, lon

46 irus (HIV)-infected subjects with or without CMV retinitis and CD4+ cell counts of <0.050 x 10(9)/L.

47 to indirect ophthalmoscopy for diagnosis of CMV retinitis and clinical features of CMV retinitis les

48 ely stopped in those patients who had stable CMV retinitis and elevated CD4+ cell counts and who were

49 significant number of HAART-responders with CMV retinitis and is unrelated to previous cidofovir the

50 Bilateral CMV retinitis and larger lesion sizes, each of which is

51 mosaic imaging may be valuable in diagnosing CMV retinitis and observing disease progression.

52 ells to >/=100 cells/muL; rates of new-onset CMV retinitis and of worsening of CMV retinitis (either

53 Sixty-four patients with CMV retinitis and retinal detachment were identified fro

54 Incidence of CMV retinitis and risk factors for incident CMV retiniti

55 Persons with cytomegalovirus (CMV) retinitis and acquired immunodeficiency syndrome (A

56 uate the rates of new-onset cytomegalovirus (CMV) retinitis and worsening existing CMV retinitis in p

57 n asymptomatic volunteers, six patients with CMV retinitis, and 46 patients with acute pulmonary symp

58 tomatic volunteers, in all six patients with CMV retinitis, and in 33 of 46 (72%) patients with pulmo

59 (AMD), glaucoma, cataract, cytomegalovirus (CMV) retinitis, and low vision.

60 als, intravitreal antivirals), resolution of CMV retinitis, any occurrence of immune recovery uveitis

61 markers to differentiate active and inactive CMV retinitis (aqueous or vitreous PCR, P<.001).

62 Most retinal detachments in CMV retinitis are rhegmatogenous in nature.

63 52 consecutive patients newly diagnosed with CMV retinitis at a tertiary university-based medical cen

64 immunodeficiency syndrome (AIDS) but without CMV retinitis at enrollment who completed at least 1 fol

65 P = 0.004), and among those with unilateral CMV retinitis at presentation, an 80% reduction in secon

66 al records of 116 HIV-infected patients with CMV retinitis attending our institution during January 2

67 In eyes with CMV retinitis, both the i2k Retina and AutoMontage softw

68 study was not highly sensitive in detecting CMV retinitis but may identify disease with an immediate

69 Three control patients with CMV retinitis but no retinal detachment were selected fo

70 o increase the number of people screened for CMV retinitis, but it is unclear whether nonophthalmolog

71 cy virus frequently results in resolution of CMV retinitis, but this may be complicated by ocular inf

72 Eligible studies assessed the occurrence of CMV retinitis by funduscopic examination within a cohort

73 ivity and specificity of remote diagnosis of CMV retinitis by nonexpert graders was variable, althoug

74 he age-adjusted prevalence of cataract among CMV retinitis cases was higher than that in a population

75 erval [CI], 1.76-4.26) and, among unilateral CMV retinitis cases, for eyes with retinitis versus with

76 By studying CMV retinitis, clinicians can investigate whether the re

77 flow cytometry (CFC) assay for patients with CMV retinitis (CMVR), stored peripheral blood mononuclea

78 Although cytomegalovirus (CMV) retinitis (CMVR) is a well-recognized complication

79 Cytomegalovirus (CMV) retinitis continues to be a leading cause of blindn

80 arinii pneumonia (PCP), and cytomegalovirus (CMV) retinitis; decreasing (P < or = .05) trends occurre

81 d subjects with progressive cytomegalovirus (CMV) retinitis despite prolonged antiviral therapy had b

82 ienced multiple relapses of cytomegalovirus (CMV) retinitis, despite suppression of human immunodefic

83 may reduce the likelihood that patients with CMV retinitis develop a retinal detachment.

84 the asymptomatic volunteers or patients with CMV retinitis developed evidence of CMV pneumonia or any

85 eport a cluster of 5 pediatric patients with CMV retinitis diagnosed in a 12-month period and compare

86 There were 5 cases of CMV retinitis diagnosed in those transplanted in 2014, a

87 e ophthalmologist, the sensitivity of remote CMV retinitis diagnosis by nonexpert graders ranged from

88 new-onset CMV retinitis and of worsening of CMV retinitis (either increasing border activity or reti

89 otherapy or adjunctive therapy, or both, for CMV retinitis, especially in eyes that are resistant, re

90 50 cells/muL at the clinical visit prior to CMV retinitis evaluation was the single most important r

91 with the consensus grade given by a panel of CMV retinitis experts.

92 ed a level of accuracy comparable to that of CMV retinitis experts.

93 eous specimens of 120 patients with AIDS and CMV retinitis from three different metropolitan centers.

94 The criteria for CMV retinitis had a low misclassification rate and appea

95 A total of 165 patients with AIDS and CMV retinitis had CMV load measurements (plasma and leuk

96 Patients with CMV retinitis had significantly lower levels of CD8+ cel

97 Management of CMV retinitis has become complex, as the life expectancy

98 Cytomegalovirus (CMV) retinitis has been extensively described in patient

99 inical trials, AIDS-related cytomegalovirus (CMV) retinitis has occurred primarily in patients with a

100 be safely discontinued in some patients with CMV retinitis if CD4+ cell counts are stable or increasi

101 e immunotherapy will reduce the frequency of CMV retinitis in a setting of retrovirus-induced immunos

102 /8 h) effective for maintenance treatment of CMV retinitis in adults.

103 les are associated with an increased risk of CMV retinitis in HIV-infected patients.

104 cells might be used to prevent or ameliorate CMV retinitis in immunocompromised patients.

105 The incidence rate of CMV retinitis in individuals with AIDS was 0.36/100 pers

106 unpublished studies reporting prevalence of CMV retinitis in low- and middle-income countries.

107 The incidence of CMV retinitis in our study of 296 patients at the Medica

108 enetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.

109 to compare the proportion of CMV viremia and CMV retinitis in patients transplanted between January 2

110 not provide sufficient protection to prevent CMV retinitis in patients who have very low CD4 counts w

111 virus (CMV) retinitis and worsening existing CMV retinitis in patients with AIDS after initiating com

112 Our recent cluster of CMV retinitis in pediatric allogeneic HSCT patients may

113 Prevalence of CMV retinitis in resource low- and middle-income countri

114 follow-up correlated with the occurrence of CMV retinitis in the contralateral eye (odds ratio = 9.0

115 nset CMV retinitis nor worsening of existing CMV retinitis in the first 6 months after initiating cAR

116 f 75 patients with immune recovery developed CMV retinitis in the first 6 months after initiating cAR

117 mmune systems, remain at risk for developing CMV retinitis in the HAART era, although the incidence r

118 iants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Co

119 en AIDS patients receiving HAART with healed CMV retinitis in whom CMV-specific maintenance therapy w

120 ols to assist in management of patients with CMV retinitis in whom the view of the retina is obscured

121 between T cell subsets and cytomegalovirus (CMV) retinitis in human immunodeficiency virus (HIV)-inf

122 Cytomegalovirus (CMV) retinitis in patients infected with human immunodef

123 presentation and course of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficienc

124 The incidence of cytomegalovirus (CMV) retinitis in the pediatric allogeneic hematopoietic

125 Key criteria for CMV retinitis included: 1) necrotizing retinitis with in

126 Characteristic appearances for CMV retinitis included: 1) wedge-shaped area of retiniti

127 Among eyes with CMV retinitis initially free of cataract, the cataract i

128 Telemedicine screening for CMV retinitis instituted at the point of care for human

129 may be one mechanism by which development of CMV retinitis is facilitated in patients with acquired i

130 y have all contributed to an assumption that CMV retinitis is no longer a concern in low- and middle-

131 Management of CMV retinitis is on the verge of major changes.

132 gB subtypes in the vitreous of patients with CMV retinitis is similar to that previously reported in

133 In the eye, however, CMV retinitis is thought to result from virus-driven nec

134 in the eyes of patients with newly diagnosed CMV retinitis is very low.

135 Cytomegalovirus (CMV) retinitis is a common opportunistic infection among

136 Cytomegalovirus (CMV) retinitis is a leading cause of blindness in many d

137 Cytomegalovirus (CMV) retinitis is a sight-threatening disease that affec

138 Cytomegalovirus (CMV) retinitis is among the most common opportunistic in

139 Cytomegalovirus (CMV) retinitis is among the most common opportunistic in

140 Cytomegalovirus (CMV) retinitis is an important ocular complication in hu

141 Cytomegalovirus (CMV) retinitis is the most common intraocular infection

142 rends occurred for 11 OIs (MAC disease, PCP, CMV retinitis, Kaposi's sarcoma, esophageal candidiasis,

143 Large CMV retinitis lesions also were associated with higher r

144 CMV retinitis lesions commonly had marked or severe bord

145 The CMV retinitis lesions missed by the remote graders (fals

146 is of CMV retinitis and clinical features of CMV retinitis lesions.

147 Earlier screening and treatment of CMV retinitis may limit progression of disease and may p

148 Clinicians should note that CMV retinitis may now occur in patients who have CD4 cou

149 e was neither an increased rate of new-onset CMV retinitis nor worsening of existing CMV retinitis in

150 variable clinical presentation than classic CMV retinitis observed in patients with HIV infection.

151 Contralateral involvement of CMV retinitis occurred in 17.6% of the patients.

152 To determine if cytomegalovirus (CMV) retinitis occurs more frequently in patients infect

153 Photographs of 99 eyes with CMV retinitis of 94 patients with HIV were taken at Maha

154 en patients (15.5%) were diagnosed as having CMV retinitis, of whom 5 (31%) had bilateral disease.

155 tively studied HIV-infected patients who had CMV retinitis on ART initiation or during the subsequent

156 tivity for the 3 remote graders in detecting CMV retinitis on fundus photography was 30.2% (95% CI, 1

157 followed clinically until the development of CMV retinitis or death.

158 No patient had reactivation of CMV retinitis or development of extraocular CMV disease

159 lates belonging to other gB groups developed CMV retinitis (P = .002).

160 rus isolates were studied from patients with CMV retinitis participating in four clinical trials of o

161 cal center in northern Thailand had advanced CMV retinitis, possibly because of delayed diagnosis.

162 Graders diagnosed each image as CMV retinitis present, CMV retinitis absent, or unknown.

163 tion of patients at the time of diagnosis of CMV retinitis prior to initiation of anti-CMV therapy (8

164 d with CMV resistance to antiviral drugs and CMV retinitis progression (from masked readings of retin

165 and leukocyte CMV loads were associated with CMV retinitis progression (odds ratios [OR], 6.3; P<.000

166 and the corresponding surface area of active CMV retinitis (r2=.69 and.44, respectively).

167 A patient with AIDS and cytomegalovirus (CMV) retinitis received ganciclovir and foscarnet for 20

168 tantially in the HAART era, cytomegalovirus (CMV) retinitis remains an important cause of ocular morb

169 MV strains is associated with higher risk of CMV retinitis than viremia due to other CMV gB groups.

170 the vitreous of some, but not all, eyes with CMV retinitis that have not responded to ganciclovir the

171 sent at the time of the initial diagnosis of CMV retinitis that predicted subsequent retinal detachme

172 CMV retinitis, the most common ophthalmic infection of A

173 overy uveitis does not occur in eyes without CMV retinitis, the ocular inflammation appears to be rel

174 Among patients with CMV retinitis, the rates of retinitis progression and in

175 During a trial of anti-CMV retinitis therapies coadministered with antiretrovir

176 rts of 115 patients (166 affected eyes) with CMV retinitis treated with ganciclovir implant in the Di

177 itional factors conferring increased risk of CMV retinitis, understanding the scope of ocular syphili

178 but where reported CD4 count at diagnosis of CMV retinitis was <50 cells/microL in 73.4% of cases.

179 The median time to progression of CMV retinitis was 22 days (95% CI, 10 to 27 days) in the

180 Resolution of CMV retinitis was achieved in 9 eyes (90%) treated with

181 Progression of CMV retinitis was assessed by bilateral, full-field reti

182 plasma CMV load at the time of diagnosis of CMV retinitis was associated with mortality (median surv

183 CMV retinitis was bilateral in 46.2% of patients.

184 d also for the initial clinic visit at which CMV retinitis was diagnosed.

185 le to receive cidofovir after progression of CMV retinitis was documented by retinal photography.

186 Before the use of HAART, CMV retinitis was the most common intraocular infection

187 Vitreous from patients with cytomegalovirus (CMV) retinitis was studied in order to identify mutation

188 o provide markers of active cytomegalovirus (CMV) retinitis, we examined the relationship between vir

189 The misclassification rates for CMV retinitis were 6.9% in the training set and 6.3% in

190 CMV retinitis and risk factors for incident CMV retinitis were assessed.

191 ical characteristics of patients with active CMV retinitis were described.

192 from 199 patient visits by 66 patients with CMV retinitis were determined.

193 nty-nine eyes of 489 patients diagnosed with CMV retinitis were evaluated.

194 No cases of CMV retinitis were identified.

195 sterior/panuveitides, including 211 cases of CMV retinitis, were evaluated by machine learning.

196 or intravitreal antiviral therapy for active CMV retinitis, whereas 5 patients (71.4%; 6 eyes [60%])

197 rvival of 13.5 months after the diagnosis of CMV retinitis, whereas those with immune recovery had a

198 r clinical practices who were diagnosed with CMV retinitis while their CD4 counts were above 195 cell

199 only other death occurred in a patient with CMV retinitis who developed staphylococcal bacteremia.

200 ctive CMV end-organ disease and survivors of CMV retinitis who had responded to highly active antiret

201 e, and disc edema may occur in patients with CMV retinitis who have experienced HAART-associated elev

202 with acquired immunodeficiency syndrome and CMV retinitis who received a ganciclovir implant, was se

203 ith AIDS and previously untreated peripheral CMV retinitis who were randomly assigned to immediate (n

204 loss in AIDS patients with cytomegalovirus (CMV) retinitis, who respond to highly active antiretrovi

205 ounts, 76 AIDS patients with newly diagnosed CMV retinitis whose CD4 lymphocyte enumerations were don

206 Treatment of CMV retinitis with standard-of-care therapy (systemic or

207 Treatment of cytomegalovirus (CMV) retinitis with oral ganciclovir results in relative

208 CMV retinitis without HIV infection was often aggressive

209 Consecutive patients with CMV retinitis without HIV infection were reviewed.