ライフサイエンスコーパス: COUP-TF

1 COUP-TF bound to an ERE half-site with high affinity, Kd

2 COUP-TF, an orphan member of the nuclear receptor superf

3 COUP-TF-interacting protein 2 (CTIP2; also known as Bcl1

4 COUP-TFs are also involved in the regulation of several

5 COUP-TFs are transcription factors which have been shown

6 COUP-TFs bind to a site between the two Smad binding ele

7 s modulators of the activity of NR2F1 and 2 (COUP-TFs), which are orphan NHRs that are critical for d

8 not remodel, the transcription factor UNC-55/COUP-TF turns off IRX-1, thus maintaining high levels of

9 DD neurons but is repressed in VDs by UNC-55/COUP-TF.

10 A COUP-TF-binding site was then identified within the B2 s

11 he promoter region of this gene identified a COUP-TF-responsive element between positions -64 and -46

12 robe were supershifted with antibody against COUP-TF, identifying COUP-TF as the candidate repressor

13 Although COUP-TFs function as potent transcription repressors, th

14 tivities and nuclear expression of Sp1/3 and COUP-TF in normal fetal mouse heart were similar to thos

15 dependent transcriptional autoactivation and COUP-TF-dependent repression.

16 functions as a corepressor for both GATA and COUP-TF proteins.

17 uilibrium between orphan receptors nur77 and COUP-TF, through their heterodimerization that regulates

18 ed COUP-TF binds to the -295/-199 region and COUP-TF represses T3-dependent activation of the PCP-2 p

19 but is through interaction between nur77 and COUP-TFs.

20 etting the balance between opposing Smad and COUP-TFs.

21 In a transient transfection assay, COUP-TF strongly induced transcriptional activity of the

22 In gel mobility shift assays, COUP-TF bound as an apparent dimer to ERE and ERE half-s

23 demonstrated a positive correlation between COUP-TF expression and the ability of trans-RA to inhibi

24 counterpart to the rodent FoxA site can bind COUP-TF factors.

25 here as RID1 and RID2) permit BCL11A to bind COUP-TFs (NR2F1;NR2F2;NR2F6) and Tailless/TLX (NR2E1), w

26 s well as potential Smad, FoxH1/FAST, T-box, COUP-TF, C/EBP, GATA, HNF3 binding sites and retinoic ac

27 stinct cell-intrinsic mechanisms mediated by COUP-TF genes to direct the specification and differenti

28 hance transcriptional repression mediated by COUP-TF II and have been implicated in hematopoietic cel

29 he transactivation of the NGFI-A promoter by COUP-TF.

30 In order to identify genes regulated by COUP-TF in this process, a rat urogenital mesenchymal ce

31 chanisms of activation of gene expression by COUP-TFs.

32 that Pax6 and Otx2 are directly regulated by COUP-TFs.

33 scription factors mediates its regulation by COUP-TFs.

34 Substitution of a consensus COUP-TF-binding site for the c-mos negative regulatory e

35 In contrast COUP-TFs are transcriptional activators of PEPCK in hepa

36 Conversely, COUP-TF transcribed and translated in vitro enhanced the

37 hly expressed in the brain, CTIP1 and CTIP2 (COUP TF-interacting proteins 1 and 2, respectively), wer

38 ein 2)-mediated repression, increased Ctip2 (COUP-TF interacting protein 2) promoter activity, and Ct

39 s that repress transcription through direct, COUP-TF-in-dependent binding to a GC-rich response eleme

40 We provide evidence that endogenous COUP-TF activity represses the COL7A1 promoter.

41 bumin upstream promoter-transcription factor COUP-TF, pregnane X receptor (PXR), and hepatocyte nucle

42 e demonstrate here that transcription factor COUP-TF-interacting protein 1 (CTIP1/BCL11A; hereafter C

43 vered that mice lacking transcription factor COUP-TF-interacting protein 2 (Ctip2) exhibit EPB defect

44 umin upstream promoter-transcription factor (COUP-TF) 2 and COUP-TF3.

45 umin upstream promoter transcription factor (COUP-TF) binds specifically to AF3 and that upstream sti

46 ding site for the COUP transcription factor (COUP-TF) is also required for Ov gene transcription.

47 umin upstream promoter-transcription factor (COUP-TF) plays a role in mediating the growth inhibitory

48 umin upstream promoter-transcription factor (COUP-TF) represses triiodothyronine (T3)-dependent trans

49 umin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which mi

50 umin upstream promoter transcription factor (COUP-TF) subfamily of orphan nuclear receptors.

51 umin upstream promoter-transcription factor (COUP-TF) was identified as a low abundance protein in bo

52 umin upstream promoter transcription factor (COUP-TF), a nuclear orphan receptor belonging to the ste

53 umin upstream promoter transcription factor (COUP-TF), repressed transcription via the gammaRXRE.

54 umin upstream promoter transcription factor (COUP-TF)-I interacts directly with 4-hydroxytamoxifen (4

55 umin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (Ctip2) knockout mice hav

56 umin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2), also known as Bc

57 umin upstream promoter transcription factor (COUP-TF)-interacting proteins 1 and 2 (CTIP1 and CTIP2)

58 umin upstream promoter transcription factor (COUP-TF)-mediated transcriptional repression.

59 umin upstream promoter transcription factor (COUP-TF).

60 umin upstream promoter transcription factor (COUP-TF)/erbA-related protein 3] families interact with

61 min upstream promoter-transcription factors (COUP-TFs), orphan members of the nuclear receptor superf

62 two functionally distinct accessory factors, COUP-TF/HNF4 and HNF3, respectively.

63 ted from -130 to -100 and designated CAR for COUP-TF adjacent repressor.

64 ssays, we show that the region necessary for COUP-TF silencing function is not sufficient for its tra

65 lts suggest that NGFI-A is a target gene for COUP-TFs and that the Sp1 family of transcription factor

66 addition to its active repression function, COUP-TF can repress several different types of activator

67 In the mouse, there are two very homologous COUP-TF genes (I and II) and their expression patterns o

68 n Strongylocentrotus purpuratus with a human COUP-TF I cDNA probe revealed the presence of a novel ge

69 Deletion of the DNA-binding domain of human COUP-TF I resulted in loss of all aspects of nuclear per

70 The pattern of human COUP-TF I subcellular localization, detected with a mono

71 subcellular localization of myc-tagged human COUP-TF I introduced into the sea urchin embryo by RNA i

72 d with antibody against COUP-TF, identifying COUP-TF as the candidate repressor previously detected i

73 In addition, stable expression of COUP-TF in COUP-TF-negative cancer cells restores induction of RARb

74 RARs), since stable expression of COUP-TF in COUP-TF-negative HT-1376 bladder cancer cells, which do

75 Stable expression of COUP-TF in COUP-TF-negative MDA-MB231 breast cancer cells restored

76 tion domain, are also required for increased COUP-TF binding to the R2 element and decreased NF-kappa

77 ation of class I transcription by increasing COUP-TF repressor binding and decreasing NF-kappaB activ

78 The nature of the ER ligand influenced COUP-TF-ERE half-site binding.

79 of reported apo A1 transcriptional inhibitor COUP-TF, which competes with HNF4 for DNA binding.

80 In human lung cancer cell lines, COUP-TF is highly expressed in RA-sensitive cell lines w

81 Moreover, COUP-TF can transrepress the ligand-dependent activation

82 Multiple COUP-TF members have been cloned and they share a high d

83 e Sp1 family of transcription factors but no COUP-TF binding site.

84 eoproteins could be the orphan nucleoprotein COUP-TF.

85 The ability of COUP-TF to bind specifically to EREs and half-sites, to

86 ther hand, relieves the repressive action of COUP-TF, resulting in the induction of the HGF promoter.

87 ls, demonstrating the functional activity of COUP-TF as a repressor of c-mos transcription.

88 ro studies demonstrated that the addition of COUP-TF inhibited c-Jun DNA binding through a direct pro

89 Mutations of AF3 that diminish binding of COUP-TF reduce the glucocorticoid response, but mutation

90 The binding of COUP-TF to the DR-8 element synergistically increases th

91 This action is mediated by the binding of COUP-TF to the glucocorticoid accessory factor 1 (gAF1)

92 hat is mediated by the DNA binding domain of COUP-TF and the leucine zipper of c-Jun.

93 The effect of COUP-TF in enhancing the trans-RA-induced antagonism of

94 rans-RA activity, we evaluated the effect of COUP-TF on antagonism of AP-1 activity by trans-RA.

95 analysis, we demonstrate that the effect of COUP-TF requires its binding to a DR-8 element present i

96 ereas inhibition of COUP-TF by expression of COUP-TF antisense RNA represses the RA effects.

97 Expression of COUP-TF correlates with RARbeta induction in a variety o

98 In addition, stable expression of COUP-TF in COUP-TF-negative cancer cells restores induct

99 receptors (RARs), since stable expression of COUP-TF in COUP-TF-negative HT-1376 bladder cancer cells

100 Stable expression of COUP-TF in COUP-TF-negative MDA-MB231 breast cancer cell

101 Stable expression of COUP-TF in nur77-positive, RA-resistant lung cancer cell

102 Conversely, expression of COUP-TF sensitizes RA responsiveness of RAREs by repress

103 transient transfection assay, expression of COUP-TF strongly inhibited tumor promoter 12-O-tetradeca

104 trategy to examine the silencing function of COUP-TF in a heterodimeric context.

105 the intrinsic active repression function of COUP-TF is not affected by heterodimerization.

106 However, this active repression function of COUP-TF may be differentially regulated by some other ac

107 , and apoptosis by RA, whereas inhibition of COUP-TF by expression of COUP-TF antisense RNA represses

108 urs in solution and results in inhibition of COUP-TF RARE binding and transcriptional activity.

109 Direct interaction of COUP-TF with ER was indicated by GST "pull-down" and co-

110 uses a rapid and profound down-regulation of COUP-TF expression in keratinocytes and fibroblasts.

111 insights into the molecular mechanism(s) of COUP-TF-mediated repression.

112 Unlike the effect of COUP-TFs, the function of nur77 does not require direct

113 2 rat brain extract indicate the presence of COUP-TFs, EAR2, and NURR1 in the DNA-protein complex.

114 the antiestrogen 4-hydroxytamoxifen (4-OHT), COUP-TF-half-site interaction decreased.

115 Complexes formed between purified COUP-TFs and the c-mos B2 probe comigrated in electropho

116 udies identified the orphan nuclear receptor COUP-TF as one of the endogenous cardiac proteins which

117 dy, we provide evidence that orphan receptor COUP-TF is required for induction of RARbeta expression,

118 The nuclear receptor, COUP-TF, binds to the C2 site.

119 ough their heterodimerization that regulates COUP-TF RARE binding, is critical for RA responsiveness

120 d through increased binding of the repressor COUP-TF to the R2 element and decreased binding of the a

121 ong binding to the transcriptional repressor COUP-TF, suggest that the class I enhancer is globally d

122 First, as we have previously shown, COUP-TF is required as an accessory factor for the compl

123 inhibit E2-induced gene expression suggests COUP-TF regulates ER action by both direct DNA binding c

124 omyocyte transfection studies confirmed that COUP-TF repressed the transcriptional activity of the MC

125 These results demonstrate that COUP-TF, by serving as an accessory protein for RARalpha

126 Finally, we demonstrated that COUP-TF can directly interact with Sp1.

127 The results of these experiments reveal that COUP-TF and Oct-1 binding does not play a functional rol

128 lly, immunohistochemical studies reveal that COUP-TF is specifically expressed in the immature fetal

129 Cotransfection experiments revealed that COUP-TF and RXRalpha compete at the gammaRXRE to modulat

130 ifferentiation of progenitor cells, and that COUP-TFs are crucial for dorsalization of the eye.

131 m their expression pattern, we proposed that COUP-TFs regulate paracrine signals important for mesenc

132 ditional knockout mouse models suggests that COUP-TFs compensate for each other to maintain morphogen

133 entral D (VD) GABAergic motor neurons by the COUP-TF (chicken ovalbumin upstream promoter transcripti

134 ted that the RA response is regulated by the COUP-TF orphan receptors.

135 Two regions of the COUP-TF molecule are shown to be important for NGFI-A ac

136 of FOG-2 and to the carboxyl terminus of the COUP-TF proteins.

137 hat has been suggested to be a member of the COUP-TF subfamily.

138 vitamin D receptor, were constituents of the COUP-TF.DNA binding complex detected in gel mobility shi

139 gen receptor gamma, which are related to the COUP-TF proteins.

140 The COUP-TFs are highly expressed in the developing nervous

141 The COUP-TFs are orphan members of the steroid/thyroid hormo

142 Thus, COUP-TF, through its physical interaction with AP-1, pro

143 port of this hypothesis, in vitro translated COUP-TF binds to the -295/-199 region and COUP-TF repres

144 erved sea urchin homologue of the vertebrate COUP-TFs and the Drosophila seven up subfamily of transc

145 nsight into the molecular mechanism by which COUP-TF regulates trans-RA activity, we evaluated the ef

146 to the promoter template by interaction with COUP-TF family members.

147 r77 is not required for its interaction with COUP-TF.