ライフサイエンスコーパス: CRRT

1 CRRT patients (n = 31) had lower plasma concentrations o

2 CRRT represents an essential dialytic modality for the p

3 CRRT was associated with a reduction in serum ammonia le

4 We aimed to design and create a CRRT machine specifically for neonates and small infants

5 nt fluid accumulation at the initiation of a CRRT course and mortality in critically ill children wit

6 In addition, CRRT has been successfully utilized for rapid clearance

7 ty whether they will survive during or after CRRT treatment.

8 ically ill adults, a drop in platelets after CRRT initiation was associated with increased hospital m

9 Among critically ill patients with AKI, CRRT was associated with increased mortality.

10 on were associated with fewer days alive and CRRT-free.

11 Although fluid overload (FO) at CRRT start has been associated with adverse outcomes, ne

12 forty-five (96%) had acute kidney injury at CRRT start, 102 (28%) patients had FO > 15%.

13 Among 1016 patients, 446 (44%) had sepsis at CRRT initiation and 650 (64%) experienced Major Adverse

14 to initiate CRRT and the interaction between CRRT initiation timing and VO to continue to improve sur

15 evidence for a survival benefit afforded by CRRT.

16 The CARPEDIEM CRRT machine can be used to provide various treatment mo

17 ctive, randomized clinical trials to compare CRRT and IHD in severe AKI are needed.

18 The delivered CRRT effluent dose (~ 30 ml/kg/h) and the delivered/pres

19 let and white blood cell (WBC) counts during CRRT could identify patients at risk for adverse outcome

20 A > 1 SD platelet count drop during CRRT was independently associated with hospital mortalit

21 alemia and alkalosis occur frequently during CRRT, but they are not associated with increased mortali

22 A > 1 SD WBC count increase during CRRT did not significantly increase mortality (aOR 1.41,

23 It was concluded that protein losses during CRRT treatments are substantially lower than previously

24 Platelet and WBC change from pre- to during CRRT were assessed as a percentage and categorized by st

25 Monitoring platelet and WBC during CRRT in reference to pre-CRRT levels could help identify

26 in platelet and WBC from pre-CRRT to during-CRRT with hospital mortality.

27 he CRRT protocol, (c) creation of electronic CRRT flowsheets, (d) selection, monitoring and reporting

28 Patients with a more positive NFB had fewer CRRT-free days.

29 dialysis, widen the range of indications for CRRT, make the use of CRRT less traumatic, and expand it

30 ngth of stay, ventilation duration, need for CRRT, or adverse events.

31 r filtration rate from baseline at 90 d from CRRT initiation).

32 c patients were less likely to liberate from CRRT by 28 days (30% vs. 38%; p < 0.001) and had higher

33 gher odds of MAKE-90 for each 1-day delay in CRRT initiation (odds ratio, 1.03 [95% CI, 1.02-1.04]).

34 r delineate the appropriate time to initiate CRRT and the interaction between CRRT initiation timing

35 other hand, for the attainment of intensive CRRT metabolic control (BUNs = 60 mg/dl), required urea

36 mined by assigned initial dialysis modality (CRRT [n = 206] versus IHD [n = 192]) using standard Kapl

37 mL/kg/hr over the study period had 5.6 more CRRT-free days and had decreased odds of major adverse k

38 kg/hr was independently associated with more CRRT-free days (beta 2.90 [0.24-5.56]) and decreased odd

39 Preservation of UOP was associated with more CRRT-free days.

40 ivalent to that readily attainable with most CRRT can only be achieved with intensive IHD regimens.

41 In >30% of CRRT and non-CRRT patients, the plasma nutrient concentrations of zin

42 ersus 98.2 mumol/L) at day 6 compared to non-CRRT patients (n = 24).

43 In >30% of CRRT and non-CRRT patients, the plasma nutrient concentr

44 In the general surgical group, each day of CRRT was associated with an increased adjusted odds rati

45 nsplant group who required 7 or more days of CRRT died (in-hospital mortality, 59.1%); among the 12 p

46 ult patients on CRRT (~ 7420 patient-days of CRRT) and tracked selected QI outcomes/metrics of CRRT d

47 surgery group who required 7 or more days of CRRT, 12 died (in-hospital mortality, 100%).

48 than 28 mmol/L, during a median of 9 days of CRRT.

49 Duration of CRRT does not correlate with survival among patients awa

50 es significantly with increasing duration of CRRT.

51 bonate and pH levels plateau after 48 hrs of CRRT.

52 or survival to discharge after initiation of CRRT among patients in a surgical intensive care unit (S

53 Whether the timing of initiation of CRRT is associated with outcomes among children and youn

54 rent data suggest that earlier initiation of CRRT to prevent excessive fluid accumulation may lead to

55 mong patients in an SICU after initiation of CRRT.

56 nitoring and reporting of quality metrics of CRRT deliverables, and (e) enhancement of education.

57 and tracked selected QI outcomes/metrics of CRRT delivery.

58 The number of CRRT access alarms per treatment day was reduced by 43%.

59 re further study to allow personalization of CRRT prescriptions to improve outcomes.

60 uality assurance system for the provision of CRRT in the ICU that enabled sustainable tracking of CRR

61 assurance system to support the provision of CRRT in the ICU.

62 the ICU that enabled sustainable tracking of CRRT deliverables and reduced filter resource utilizatio

63 clinicians in alleviating the uncertainty of CRRT patient survival outcomes, with opportunities for f

64 nge of indications for CRRT, make the use of CRRT less traumatic, and expand its use as supportive th

65 n daily fluid balance over the first week of CRRT were not associated with MAKE-90; however, increasi

66 vasoactive support during the first week of CRRT, a surrogate of potential dialytrauma, appears to b

67 term survival in patients being initiated on CRRT.

68 adverse outcomes, net fluid balance (NFB) on CRRT has not been investigated as a predictor for renal

69 month data comprising 1185 adult patients on CRRT (~ 7420 patient-days of CRRT) and tracked selected

70 lth records from patients who were placed on CRRT at multiple institutions to train a model that pred

71 Persistent acidosis and acidemia while on CRRT was a strong predictor of poor outcome.

72 Optimal CRRT delivery demands continuous communication between s

73 Two l/hr of postdilution CRRT were performed continuously.

74 RT normal platelet count that decreased, pre-CRRT elevated WBC count that remained high, and normal o

75 at remained high, and normal or elevated pre-CRRT WBC count that increased.

76 ation of change in platelet and WBC from pre-CRRT to during-CRRT with hospital mortality.

77 RT low platelet count that remained low, pre-CRRT normal platelet count that decreased, pre-CRRT elev

78 ups associated with increased mortality: pre-CRRT low platelet count that remained low, pre-CRRT norm

79 On multivariable regression, pre-CRRT vasoactive requirement, time to negative fluid bala

80 elet and WBC during CRRT in reference to pre-CRRT levels could help identify high-risk patients.

81 institutions to train a model that predicts CRRT survival outcome; on a held-out test set, the model

82 venous hemofiltration + RAD, and 18 received CRRT alone.

83 quaternary pediatric hospitals who received CRRT.

84 study of children and young adults receiving CRRT, longer time to CRRT initiation was associated with

85 ohort of children and young adults receiving CRRT.

86 rafiltration practices in children receiving CRRT are substantially different compared to adult cohor

87 ngs in filter cost per 100-patient receiving CRRT.

88 d young adults (birth to 25 years) receiving CRRT for acute kidney injury or VO at 32 centers across

89 volving 58 patients who had ARF and required CRRT was performed.

90 Regression lines of required CRRT urea K (ml/h) versus patient weight for desired BUN

91 udy included 1,413 adults with AKI requiring CRRT at two tertiary medical centers.

92 Septic children requiring CRRT have different clinical characteristics and outcome

93 nia levels, 61 (18%) were on continuous RRT (CRRT), 59 (17%) were on intermittent RRT (IRRT), and 220

94 ittent hemodialysis (IHD) or continuous RRT (CRRT), respectively.

95 rom 3.56 to 2.67 (p = 0.054) despite similar CRRT duration and mortality rates.

96 lticenter pediatric studies demonstrate that CRRT can be provided effectively to all pediatric patien

97 rate was 33% in the RAD group and 61% in the CRRT group.

98 e number of multidisciplinary experts in the CRRT team and ensured a continuum of education to health

99 as approximately 50% of that observed in the CRRT-alone group.

100 isciplinary team, (b) standardization of the CRRT protocol, (c) creation of electronic CRRT flowsheet

101 Continuous renal replacement therapies (CRRT) often are recommended and widely used, although da

102 ree of continuous renal replacement therapy (CRRT) (-7 d per ten-fold increase; 95% CI, -12 to -1).

103 Continuous renal replacement therapy (CRRT) benefits patients with renal failure who are too h

104 Continuous renal replacement therapy (CRRT) has become a popular treatment modality but may ha

105 erated continuous renal replacement therapy (CRRT) initiation strategy among adults with acute kidney

106 Continuous renal replacement therapy (CRRT) is a form of dialysis prescribed to severely ill p

107 Once continuous renal replacement therapy (CRRT) is initiated, it becomes a major determinant of ac

108 Continuous renal replacement therapy (CRRT) is the most common dialysis modality provided to c

109 egy on continuous renal replacement therapy (CRRT) is unknown for critically ill children.

110 Continuous renal replacement therapy (CRRT) machines are used off label in infants smaller tha

111 ent of continuous renal replacement therapy (CRRT) represent a growing intensive care unit (ICU) popu

112 tional continuous renal replacement therapy (CRRT), a Phase II, multicenter, randomized, controlled,

113 quires continuous renal replacement therapy (CRRT), but limited data exist regarding patient characte

114 ed for continuous renal replacement therapy (CRRT), invasive ventilation, and prevalence of acute res

115 eiving continuous renal replacement therapy (CRRT), the concentrations of the same nutrients in the e

116 d with continuous renal replacement therapy (CRRT).

117 ever, confusion still exists with respect to CRRT terminology and the optimal use of this modality ac

118 The primary exposure was time to CRRT initiation from intensive care unit admission.

119 Median (IQR) time to CRRT initiation was 2 (1-6) days.

120 Time to CRRT initiation was approximately 1 day longer among tho

121 young adults receiving CRRT, longer time to CRRT initiation was associated with greater risk of MAKE

122 ohort study included all patients undergoing CRRT from July 1, 2012, through January 31, 2016, in an

123 up of 20 patients who received uninterrupted CRRT for at least 5 days.

124 weights (50 to 100 kg) who received variable CRRT urea clearances (500 to 2000 ml/h).

125 age, etiology, and disease severity, whereas CRRT (odds ratio [OR], 0.47 [95% confidence interval {CI

126 Whether CRRT can cause dialytrauma through excessive ultrafiltra

127 With CRRT outputs of up to 50 L/day, these values would amoun

128 ammonia decreased by 38%, 23%, and 19% with CRRT, IRRT, and no RRT, respectively.

129 the relative risk for death associated with CRRT was 1.82 (95% confidence interval 1.26 to 2.62).

130 o no RRT use, whereas ammonia reduction with CRRT was significant (P = 0.007), with IRRT it was not (

131 a large percentage of patients treated with CRRT do not survive, utilizing scarce resources and rais

132 ere lower for patients who were treated with CRRT than IHD (survival at 30 d 45 versus 58%; P = 0.006

133 with severe AKI regardless of treatment with CRRT.