ライフサイエンスコーパス: CXC chemokine receptor

1 example of a CC chemokine, which binds to a CXC chemokine receptor.

2 unctioning as both a HIV-1 co-receptor and a CXC-chemokine receptor.

3 dependent on the level of the expression of CXC chemokine receptors.

4 vitro antagonistic activities against CC and CXC chemokine receptors.

5 The human CXC chemokine receptor 1 (CXCR1), a G protein-coupled re

6 Surprisingly, we found that CXC chemokine receptor 1 (CXCR1), the predominant neutro

7 "minor pocket," previously characterized in CXC chemokine receptors-1 and -2, is functionally conser

8 de neutrophils to sites of liver necrosis by CXC chemokine receptor 2 (CXCR2) and formyl peptide rece

9 flammation through activation of endothelial CXC Chemokine Receptor 2 (CXCR2) and production of endot

10 emonstrate the dependence of this process on CXC chemokine receptor 2 (CXCR2) and vascular cell adhes

11 the alpha(1A)-adrenoceptor (alpha(1A)AR) and CXC chemokine receptor 2 (CXCR2) in live cells.

12 We chose CXC chemokine receptor 2 (CXCR2) in the G-protein couple

13 Neutrophil chemokine receptor CXC chemokine receptor 2 (CXCR2) is a critical target fo

14 Our aim was to discover the role of IL-17, CXC chemokine receptor 2 (CXCR2) ligands, and cancer-ass

15 In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of p

16 We also found that neither CXC chemokine receptor 2 (CXCR2) nor interleukin-17 (IL-

17 racellular allosteric binding site (IABS) of CXC chemokine receptor 2 (CXCR2), a G protein-coupled re

18 The inhibition of CXC chemokine receptor 2 (CXCR2), a key inflammatory med

19 In contrast, the blockade of CXC chemokine receptor 2 (CXCR2), a receptor for CXC che

20 ound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B

21 Because all ELR(+) CXC chemokines bind to CXC chemokine receptor 2 (CXCR2), we hypothesized that C

22 oid cells was reduced using an antagonist of CXC chemokine receptor 2 (CXCR2).

23 l receptor is the G-coupled protein receptor CXC chemokine receptor 2 (CXCR2).

24 ivation by the C5a and C3a receptors, and by CXC chemokine receptor 2 and CCR8.

25 ssue, Belperio et al. demonstrate a role for CXC chemokine receptor 2 in the regulation of angiogenes

26 he receptor that binds these CXC chemokines, CXC chemokine receptor 2, significantly reduced the degr

27 ce markers of neutrophils (Ly6G, L-selectin, CXC chemokines receptor 2, and 7/4) and DCs (CD11c, MHC

28 ection within the liver was not dependent on CXC-chemokine receptor 2 (CXCR2) signaling as anti-CXCR2

29 CXC chemokine receptor-2 (CXCR2) has been shown to play

30 d the ligand-enhanced phosphorylation of the CXC chemokine receptor-2 (CXCR2) in a series of clonal 3

31 pulmonary nocardiosis is highly dependent on CXC chemokine receptor-2 (CXCR2) ligand-mediated neutrop

32 by activation of the murine homologue of the CXC chemokine receptor-2 (CXCR2) or IL-8R B.

33 ed the significance of signaling through the CXC chemokine receptor-2 (CXCR2) receptor in the process

34 More recently, signaling through CXC chemokine receptor-2 (CXCR2) was shown to delay live

35 CXC chemokines and their receptor, CXC chemokine receptor-2 (CXCR2), are important componen

36 sized that interaction of these ligands with CXC chemokine receptor-2 (CXCR2), their sole murine rece

37 d induced CXC chemokine ligand-1 (CXCL1) and CXC chemokine receptor-2 (CXCR2)-dependent leukocyte arr

38 or for MIP-2 and/or KC is unknown but is not CXC-chemokine receptor-2.

39 The CXC chemokine ligand 10 (CXCL10)/CXC chemokine receptor 3 (CXCR3) chemokine pathway promo

40 CXC chemokine receptor 3 (CXCR3) is the receptor for the

41 CXC chemokine receptor 3 (CXCR3) ligands CXCL9 and CXCL1

42 gamma is required for efficient induction of CXC chemokine receptor 3 (CXCR3) on T cells upon activat

43 The interaction of the CXC chemokine receptor 3 (CXCR3) receptor with its ligan

44 CXC chemokine receptor 3 (CXCR3) signaling promotes kera

45 amined the levels of chemokines that bind to CXC chemokine receptor 3 (CXCR3) to determine whether su

46 tudies suggest possible participation of the CXC chemokine receptor 3 (CXCR3)-chemokine system in med

47 CXC chemokine receptor 3 (CXCR3)-expressing B cells were

48 ited the release of chemotactic activity for CXC chemokine receptor 3 (CXCR3)-transfected lymphocytes

49 ated by three endogenous ligands of the GPCR CXC chemokine receptor 3 (CXCR3).

50 ARC and MDC, whereas Th1 lymphocytes express CXC chemokine receptor 3 and CCR5 (but not CCR4).

51 cytes coexpress the Th1-associated receptors CXC chemokine receptor 3 and CCR5, suggesting a potentia

52 tosis of hepatocytes involving TLR4, but not CXC chemokine receptor 3 signaling.

53 via IFN-gamma (interferon gamma) and CXCR3 (CXC chemokine receptor 3) signaling pathways.

54 The presence of CXC chemokine receptor 3-expressing cells, specifically

55 mulated MPhi of chemoattractant activity for CXC chemokine receptor 3-transfected (receptor for IP-10

56 ated genes, interferon-gamma (IFNgamma), and CXC chemokine receptor-3 (CXCR3).

57 ow that extracellular ubiquitin is a natural CXC chemokine receptor 4 (CXCR4 and CD184) agonist.

58 Both CXC chemokine receptor 4 (CXCR4) and atypical chemokine

59 The two CXC-type chemokine receptors, CXC chemokine receptor 4 (CXCR4) and atypical chemokine

60 demonstrates cell surface expression of both CXC chemokine receptor 4 (CXCR4) and CC chemokine recept

61 The CXC chemokine receptor 4 (CXCR4) and its ligand, stromal

62 CCR5 and CXC chemokine receptor 4 (CXCR4) are coreceptors for CD4

63 ll-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) are important regulator

64 We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by a

65 CXC chemokine receptor 4 (CXCR4) blockade promotes T cel

66 The CXC chemokine receptor 4 (CXCR4) contributes to the meta

67 romal cell-derived factor 1 and its receptor CXC chemokine receptor 4 (CXCR4) critically mediate the

68 The CXC chemokine receptor 4 (CXCR4) for the chemokine (C-X-

69 Activation of the CXC chemokine receptor 4 (CXCR4) in Cajal-Retzius cells

70 terferes with the expression and function of CXC chemokine receptor 4 (CXCR4) in CD4+ T lymphocytes.

71 have investigated the expression of surface CXC chemokine receptor 4 (CXCR4) in enriched populations

72 east cancer, GnRH in ovarian carcinomas, and CXC chemokine receptor 4 (CXCR4) in multiple malignancie

73 CXC chemokine receptor 4 (CXCR4) is a cell surface recep

74 CXC chemokine receptor 4 (CXCR4) is a co-receptor for hu

75 CXC chemokine receptor 4 (CXCR4) is a G protein-coupled

76 The human CXC chemokine receptor 4 (CXCR4) is a receptor for the c

77 38+ cells in the blood, higher leukemic cell CXC chemokine receptor 4 (CXCR4) levels, and increased r

78 al use of CC chemokine receptor 5 (CCR5) and CXC chemokine receptor 4 (CXCR4) may be intimately invol

79 Enhancement of CXC chemokine receptor 4 (CXCR4) mRNA expression was obs

80 CXC chemokine receptor 4 (CXCR4) plays a role in the dev

81 crophage-tropic coreceptor for HIV-1 whereas CXC chemokine receptor 4 (CXCR4) serves the counterpart

82 The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) signaling axis appears

83 lls expressed elevated levels of CD95, CD25, CXC chemokine receptor 4 (CXCR4), and CC chemokine recep

84 CXC chemokine receptor 4 (CXCR4), initially linked with

85 The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC c

86 NSCs express CXC chemokine receptor 4 (CXCR4), the cognate receptor f

87 The receptor for SDF-1, CXC chemokine receptor 4 (CXCR4), was found to be expres

88 gous to the V3 loop of HIV-1, which binds to CXC chemokine receptor 4 (CXCR4), we hypothesized that B

89 ations covering all 352 residues of the GPCR CXC chemokine receptor 4 (CXCR4), we identified 41 amino

90 , indicating that PTEN was not requisite for CXC chemokine receptor 4 (CXCR4)-mediated chemotaxis of

91 al derived factor-1alpha, the ligand for the CXC chemokine receptor 4 (CXCR4).

92 gp120 with CC chemokine receptor 5 (CCR5) or CXC chemokine receptor 4 (CXCR4).

93 somal dominant gain-of-function mutations in CXC chemokine receptor 4 (CXCR4).

94 erived factor-1 alpha (CXCL12/SDF-1) via the CXC chemokine receptor 4 (CXCR4).

95 cluding integrin beta1, integrin alpha4, and CXC chemokine receptor 4 (CXCR4).

96 hereas 26%-73% of cells coexpressed CCR5 and CXC chemokine receptor 4 (CXCR4).

97 or, either CC chemokine receptor 5 (CCR5) or CXC chemokine receptor 4 (CXCR4).

98 1alpha (SDF-1alpha) binding to its receptor, CXC chemokine receptor 4 (CXCR4).

99 -derived factor (SDF)-1alpha (the ligand for CXC chemokine receptor 4 [CXCR4]) did not affect T(GFP)

100 imerization among known GPCR homodimers: the CXC chemokine receptor 4 and sphingosine-1-phosphate rec

101 We observe that CXC chemokine receptor 4 and sphingosine-1-phosphate rec

102 a promising protein therapeutic and implies CXC chemokine receptor 4 as a drug target after polytrau

103 nfection, which was associated with CCR5 and CXC chemokine receptor 4 down-regulation.

104 cell-derived factor 1alpha and its receptor CXC chemokine receptor 4 in beta-selection.

105 Disrupting homing dynamics with a CXC chemokine receptor 4 inhibitor reduced the formation

106 Plasma levels of the cognate CXC chemokine receptor 4 ligand stromal cell-derived fac

107 vels and corresponding surface expression of CXC chemokine receptor 4 on clonal PCs, suggesting that

108 The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degra

109 gp120 coupled CXCR4 (CXC chemokine receptor 4) to induce NADPH oxidase-mediat

110 stem cell mobilizer or its receptor, CXCR4 (CXC chemokine receptor 4), would attenuate and reverse h

111 s, such as protease-activated receptor 1 and CXC chemokine receptor 4, RGS4 disrupted Rac1-dependent

112 We coinfected rhesus macaques with CXC chemokine receptor 4- and CC chemokine receptor 5-sp

113 upregulated in tissues infected ex vivo with CXC chemokine receptor 4-tropic but not CCR5-tropic HIV-

114 ceptor 5 (CCR5), whereas 84%-99% coexpressed CXC chemokine receptor 4.

115 growth factor receptor and G-protein-coupled CXC chemokine receptor 4.

116 bone marrow; in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis,

117 A chimeric protein consisting of CXC-chemokine receptor 4 (CXCR4) and the green fluoresce

118 CXC-chemokine receptor 4 (CXCR4) is a G protein-coupled

119 The chemokine receptor CXC-chemokine receptor 4 (CXCR4) is a transmembrane rece

120 CXC-chemokine receptor 4 (CXCR4) regulates the retention

121 The antagonism of CXC-chemokine receptor 4 (CXCR4) with AMD3100 improves c

122 iae lacking FimCDE fail to interact with the CXC-chemokine receptor 4 (CXCR4), and bacteria expressin

123 , up-regulates the surface expression of the CXC-chemokine receptor 4 (CXCR4), but not of the CC-chem

124 e the infectivity of HIV-1 isolates that use CXC-chemokine receptor 4 for entry.

125 eramide but not for CC-chemokine receptor 5, CXC-chemokine receptor 4, or CD4.

126 we reported that human RMS cells express the CXC chemokine receptor-4 (CXCR4) and postulated a role f

127 howed that inducible knockdown of endogenous CXC chemokine receptor-4 (CXCR4) gene expression in brea

128 romal cell-derived factor-1 and its receptor CXC chemokine receptor-4 (CXCR4) have received considera

129 tic parental cells (686LN-Ps), we found that CXC chemokine receptor-4 (CXCR4) mRNA levels were signif

130 the bone marrow via cross talk with the SDF-CXC chemokine receptor-4 (CXCR4) signaling axis.

131 Most importantly, BDNF reduced the levels of CXC chemokine receptor-4 (CXCR4), a receptor that mediat

132 d, these cells expressed substantial surface CXC chemokine receptor-4 (CXCR4), and CXCL12 stimulation

133 We hypothesized that the CXC chemokine receptor-4 (CXCR4)-stromal-derived factor-

134 oreceptor, whereas T cell-tropic strains use CXC chemokine receptor-4 for entry.

135 le describes the transient expression of the CXC chemokine receptor-4 in Xenopus laevis melanophores

136 These results indicate that SDF-1 and CXC chemokine receptor-4 interactions not only play a ro

137 a-mediated costimulation was blocked by anti-CXC chemokine receptor-4 mAb.

138 ral differentiation, we observed that CXCR4 (CXC chemokine receptor-4) expressing central nervous sys

139 ells with 12G5, an antibody specific for the CXC chemokine receptor-4, eliminates this response indic

140 nterleukin-10-induced apoptosis, all through CXC chemokine receptor-4.

141 Because the CXC chemokine receptor-4/stromal derived factor-1 (CXCR4

142 receptor LESTR, which we therefore designate CXC-chemokine receptor-4 (CXCR-4).

143 Deficiency in CXC chemokine receptor 5 (CXCR5), a receptor for B lymph

144 ided in the T cell areas, expressed CCR7 and CXC chemokine receptor 5 (CXCR5), and like follicular he

145 y modified unselected CD8 T cells to express CXC chemokine receptor 5 (CXCR5), the chemokine receptor

146 ssion of B-cell leukemia/lymphoma 6 (Bcl-6), CXC chemokine receptor 5, programmed death-1, and other

147 CXC chemokine receptor-5 (CXCR5) is required for B-cell

148 mokine receptor 3 (ACKR3), formerly known as CXC-chemokine receptor 7 (CXCR7), has been postulated to

149 we hypothesized that the expression of CC or CXC chemokine receptor (CCR) molecules on activated CD8(

150 Interferon-gamma-inducible protein-10/CXC chemokine receptor (CXCR) 3 interactions were specif

151 cells in tissues and reduced percentages of CXC chemokine receptor (CXCR) 3(+)/CD3(+) and CXCR3(+)/C

152 eceptors, only CC chemokine receptor (CCR5), CXC chemokine receptor (CXCR) 3, and CXCR6 correlated wi

153 ein modifier inside the cell, functions as a CXC chemokine receptor (CXCR) 4 agonist outside the cell

154 r ubiquitin has recently been described as a CXC chemokine receptor (CXCR) 4 agonist.

155 ied extracellular ubiquitin as an endogenous CXC chemokine receptor (CXCR) 4 agonist.

156 The CXC chemokine ligand (CXCL) 12/CXC chemokine receptor (CXCR) 4 axis represents a well-e

157 G(+) plasma cells accompanied by defects in CXC chemokine receptor (CXCR) 4 expression, interleukin

158 receptors CC chemokine receptor (CCR) 7 and CXC chemokine receptor (CXCR) 4 have been implicated in

159 activation and early signaling steps of the CXC chemokine receptor (CXCR) 4 in response to its natur

160 inding to this molecule, in conjunction with CXC chemokine receptor (CXCR) 4, is required for product

161 relative contribution of chemokine receptors CXC chemokine receptor (CXCR)-2 (IL-8R homologue) and CC

162 r expression and found that the frequency of CXC chemokine receptor (CXCR)4 expressing synovial tissu

163 CXC chemokine receptor (CXCR)4 is an HIV coreceptor and

164 ween stromal cell-derived factor (SDF)-1 and CXC chemokine receptor (CXCR)4.

165 chemokine 1 (BCA-1) responses correlate with CXC chemokine receptor (CXCR)5 expression, are first dis

166 CCR7 loss in activated CD4 cells accompanies CXC chemokine receptor (CXCR)5 gain, suggesting that the

167 Here we show that CXC chemokine receptor (CXCR)5, the receptor for B lymph

168 Recent crystal and NMR structures of the CXC chemokine receptors (CXCR) CXCR4 and CXCR1, combined

169 CXC-chemokine receptor (CXCR)-4/fusin, a newly discovere

170 The CXC chemokine receptor CXCR2 and its specific ligands ha

171 We have determined previously that the CXC chemokine receptor CXCR2 is involved in advanced ath

172 ine motif positive) CXC chemokines and their CXC chemokine receptor (CXCR2) in lung antibacterial hos

173 We found that mice lacking the type 2 CXC chemokine receptor (CXCR2) were relatively resistant

174 b-mediated neutralization of the common ELR+ CXC chemokine receptor, CXCR2, resulted in development o

175 CXC chemokine receptor CXCR3 and/or its main three ligan

176 Ckine is not a ligand for the human or mouse CXC chemokine receptor CXCR3.

177 nes in that it has been shown to bind to the CXC chemokine receptor CXCR4 as well as to a variety of

178 m kinase ERK also in the presence of BCR and CXC chemokine receptor CXCR4 stimulation.

179 functional role for tyrosine sulfate in the CXC-chemokine receptor family and underscore a general d

180 ines, CXCR1 functions as the single dominant CXC chemokine receptor in patients with sepsis.

181 s known about the signaling pathways used by CXC chemokine receptors in hepatocytes.

182 e simultaneous detection of mRNA for various CXC chemokine receptors in resting human umbilical vein

183 L-15 induces CC chemokine receptors, but not CXC chemokine receptors, in a dose-dependent manner.

184 broad spectrum interaction with both CC and CXC chemokine receptors including CCR5 and CXCR4, two pr

185 broad-spectrum interaction with both CC and CXC chemokine receptors including CCR5 and CXCR4, two pr

186 ively expressed mRNAs for an array of CC and CXC chemokine receptors, including CCR1-8 and CXCR4, but

187 R2, KFRHGL, which is conserved in all CC and CXC chemokine receptors, is required for the receptor bi

188 The simultaneous expression of different CXC chemokine receptors on oligodendrocytes, and their l

189 yptase-positive mast cells expressing CXCRs (CXC chemokine receptors) (P < 0.05).

190 nction of the mouse chemokine receptor fusin/CXC chemokine receptor R-4 (CXCR-4) revealed a potential

191 ion to formulate a basis for the function of CXC chemokine receptor signaling in hepatocytes.

192 derstanding of the pathways involved in both CXC chemokine receptor signaling in other cell types, mo

193 e evaluated their inhibitory activity on the CXC chemokine receptor type 4 (CXCR4), toxicity properti

194 We found that the CXC chemokine receptor type 4 accommodated the results b

195 ant proteins and with other unrelated CC and CXC chemokine receptors under transient labeling conditi