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1                                              CYP8B1 expression could contribute to the decreased toxi
2                                              CYP8B1 is a critical downstream target of VSG.
3 tochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12alpha-hydroxylated bile acids (BAs)
4  and induction of cytochrome P450 (CYP) 7A1, CYP8B1, CYP3A4, and bile acid-CoA: amino acid N-acyltran
5 rol 12alpha-hydroxylase cytochrome P450 8B1 (CYP8B1) is a validated drug target for both type 2 diabe
6                   Human cytochrome P450 8B1 (CYP8B1) is involved in conversion of cholesterol to bile
7                         Cytochrome P450 8B1 (CYP8B1), which synthesizes CA, was induced in livers of
8         This hypothesis was supported when a CYP8B1 W281F mutation did allow all three compounds to c
9 male-specific liver target genes, Cyp2d9 and CYP8B1.
10 inding to the native promoters of CYP7A1 and CYP8B1 but resulted in dissociation of PGC-1 and concomi
11 pool with cholestyramine enhanced CYP7A1 and CYP8B1 expression.
12  to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway.
13  of CYP7B1 and down-regulated the CYP7A1 and CYP8B1, shifting bile acid synthesis toward the acidic p
14 s (e.g., cytochrome P450 [CYP]7A1/Cyp7a1 and CYP8B1/Cyp8b1).
15 d MDR3 in parallel to a decrease of NTCP and CYP8B1 and an increase of MRP4.
16 sociated protein 4 (MRP4) overexpression and CYP8B1 inhibition that are involved in BA uptake, basola
17                 Activation of the G6P-ChREBP-CYP8B1 axis increases the relative abundance of cholic-a
18       Our work identifies hepatic G6P-ChREBP-CYP8B1 signaling as a regulatory axis in control of bile
19             Consistently, a polymorphic CLOF CYP8B1 mutation associated with lower fasting insulin in
20 me P450 (CYP) isoform 7A1 (CYP7A1), CYP27A1, CYP8B1, uridine 5'-diphospho-glucuronosyltransferase 1A1
21 xO1, and the key bile acid synthesis enzyme, CYP8B1.
22 indicated that the design of next-generation CYP8B1 inhibitors should be compatible with the low-ceil
23 udy reveals a connection between the hepatic CYP8B1-CA axis and colitis via regulating intestinal epi
24  4alpha (HNF4alpha) strongly activated human CYP8B1 promoter activities, whereas cholesterol 7alpha-h
25                     Bile acids repress human CYP8B1 transcription by reducing the transactivation act
26                                    The human CYP8B1 promoter activities were strongly repressed by bi
27                            Herein, the human CYP8B1 protein was generated and used to identify and ch
28 '-upstream nucleotide sequences of the human CYP8B1.
29 art by regulating the BA 12alpha-hydroxylase CYP8B1.
30                  Sterol 12alpha-hydroxylase (CYP8B1) is required for cholic acid synthesis and plays
31 is, notably cholesterol 12alpha-hydroxylase (CYP8B1), which was strongly reexpressed in the SHP null
32 lase (CYP7A1) or sterol 12alpha-hydroxylase (CYP8B1).
33 se (CYP7A1) and sterol 12-alpha hydroxylase (CYP8B1) genes.
34               The sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase) promoter is also down-regul
35  these enzymes is sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase), the specific enzyme requir
36 -hydroxylase) and sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase).
37 duction of RORalpha to mice strongly induced CYP8B1 expression, and increased liver cholesterol and 1
38  farnesoid X receptor (FXR) suppressed liver CYP8B1 expression and ameliorated colitis in mice.
39      In contrast, short hairpin RNA-mediated CYP8B1 knockdown improved metabolism similar to those ob
40 ng CYP2A6 and CYP2D6 and sterol-metabolizing CYP8B1.
41                         Deletion analysis of CYP8B1/luciferase reporter activity in HepG2 cells revea
42 eas restricted-feeding reduced expression of CYP8B1 mRNA and protein.
43                  We found that expression of CYP8B1, a key enzyme in controlling the 12alpha-hydroxyl
44 r of diurnal rhythm and fasting induction of CYP8B1, which regulates bile acid composition and serum
45                    To study the mechanism of CYP8B1 transcription by bile acids, we have cloned and d
46                Using genetic mouse models of CYP8B1 overexpression, knockdown, and knockout, we demon
47 kout, we demonstrated that overexpression of CYP8B1 dampened the metabolic improvements associated wi
48 This contrasts with the strong repression of CYP8B1 observed with short term bile acid feeding, as we
49 of fasting induction and circadian rhythm of CYP8B1 by a cholesterol-activated nuclear receptor and c
50              We aim to determine the role of CYP8B1 (cytochrome P450, family 8, subfamily B, polypept
51 romote a better understanding of the role of CYP8B1 inhibition in normal physiology and disease state
52 artner markedly inhibited transactivation of CYP8B1 by HNF4alpha.
53                             Transcription of CYP8B1 is inhibited by bile acids, cholesterol, and insu
54 alpha-OH BA ratio in the BA pool depended on CYP8B1 expression level.
55 evealed the critical roles HNF4alpha play on CYP8B1 transcription and its repression by bile acids.
56                        We found that reduced CYP8B1 activity associates with increased insulin sensit
57 at increased circulatory CDCA due to reduced CYP8B1 activity increases skeletal muscle insulin sensit
58 n humans.METHODSTo determine whether reduced CYP8B1 activity improves insulin sensitivity, we sequenc
59 y improves insulin sensitivity, we sequenced CYP8B1 in individuals without diabetes and identified ca
60 tion and gut microbiota profile by targeting CYP8B1 may provide novel insight into the development of
61                            Additionally, the CYP8B1 active site was compared with similar P450 enzyme
62 dine nitrogen was intended to coordinate the CYP8B1 active site heme iron, none of these compounds el
63  functional RORalpha response element in the CYP8B1 promoter.
64 ne of these compounds elicited shifts in the CYP8B1 Soret absorbance consistent with this type of int
65 CBP) to stimulate histone acetylation on the CYP8B1 gene promoter.
66 transcriptional activity of HNF4alpha toward CYP8B1 but not toward CYP2A2.
67                                However, when CYP8B1 was cocrystallized with the pyridine-containing c
68  functional and structural interactions with CYP8B1.