ライフサイエンスコーパス: Cal

1 Cal PA-XFS expressed significantly less PA-X than Cal wi

2 Cal WT, but not Cal PA-XFS, induced degradation of host

3 Cal- modulin was found to interact strongly with the cyt

4 the Iron/Roman period ( approximately 2,000 Cal y B.P.), with no subsequent directional change.

5 in the Neolithic ( approximately 4,000-7,000 Cal y B.P.) and continues through the Iron/Roman period

6 PA from the pH1N1 virus A/California/04/09 (Cal) strongly enhances activity of an otherwise avian po

7 ly different Ca2+ indicators, such as OGB-1, Cal-590 can be readily used for simultaneous multicolor

8 se component or NS1 of A/California/04/2009 (Cal) and found that PA has a significant impact on the e

9 ex of the pH1N1 strain A/California/04/2009 (Cal) is highly active in mammalian 293T cells, despite t

10 nd after receiving the A/California/04/2009 (Cal/09) vaccine between October 2009 and January 2010.

11 demic influenza virus, A/California/04/2009 (Cal/09).

12 t of neurons that stain for calbindin D-28K (Cal), a calcium-binding protein involved in regulating n

13 U/g KEA, and the EHGE and IDMD reached 92.29 Cal/g and 2.47%.

14 roximately 11,550 yBP ( approximately 13,390 Cal years) at "El Fin del Mundo," an archaeological site

15 5500 Cal yr BP old lake sediments.

16 U/g KEA, and the EHGE and IDMD reached 94.65 Cal/g and 2.54%.

17 DB age range for this event of 12,835-12,735 Cal B.P. at 95% probability.

18 e onset of the YD climatic episode at 12,800 Cal B.P.

19 at the Younger Dryas boundary (YDB) (12,800 Cal B.P.).

20 on dating of hydroxyproline to 34,950-33,900 Cal.

21 used by pandemic virus A/California/04/09 (A/Cal; H1N1).

22 f IAV, including A/PR/8/34(H1N1) (PR8) and A/Cal/07/2009 (H1N1) (Cal09), cause APA.

23 by DI virus, ferrets formed high levels of A/Cal-specific serum haemagglutination-inhibiting antibodi

24 d in nasal washes following infection with A/Cal, consistent with its amelioration of clinical diseas

25 nd were solidly immune to rechallenge with A/Cal.

26 lyses showed that ex vivo stimulation with A/Cal/7/2009 H1N1 influenza led to a notable increase in I

27 Oligo/Amen + Cal improved energy status [increased body mass (2.6 +/-

28 igned to an intervention group (Oligo/Amen + Cal, n = 40, mean +/- SEM age: 21.3 +/- 0.5 y; weight: 5

29 sed BSO+AUR-induced cell killing in FaDu and Cal-27 cells, while catalase and selenium supplementatio

30 er potency the viability of human HCT116 and Cal 27 cancer cells (P < 0.001).

31 The enzyme, calcium-dependent BioID (Cal-ID), biotinylates nearby proteins within minutes in

32 In both Cal and WSN viruses, PA-X showed a stronger effect than

33 ion falls within the K pathway as defined by Cal content.

34 y 13,300 to approximately 12,800 calibrated (Cal) years] made distinctive "Clovis" artifacts.

35 A recombinant WSN containing Cal PA showed enhanced host protein synthesis shutoff an

36 V683T/A684S, which are involved in enhanced Cal polymerase activity at low temperature.

37 vival compared to either drug alone in FaDu, Cal-27 and SCC-25 HNSCC cells in vitro and in vivo in Ca

38 BSO+AUR also significantly sensitized FaDu, Cal-27, SCC-25 and SQ20B cells to cell killing induced b

39 n the dLGN that were also immunoreactive for Cal varied from less than 40% to over 80%, indicating th

40 IPANTS: This survey study analyzed data from Cal-VEX 2020, a state-representative survey of Californi

41 elial cell monolayers with supernatants from Cal-stimulated mast cells resulted in upregulation of th

42 frameshift motif in the polymerase PA gene (Cal PA-XFS).

43 Sera derived from SAM(H1-Cal)-immunized animals were not cross-reactive with the

44 nstrated considerable susceptibility to H1N1 Cal/04/09 infection, whereas FluMist-vaccinated mice had

45 cificity shared with the 2009 pandemic H1N1 (Cal/04) hemagglutinin.

46 ween the pandemic A/California/04/09 (H1N1) (Cal/09) virus and another H1N1 strain, A/Puerto Rico/8/3

47 influenza A virus, A/California/04/09 (H1N1, Cal), containing mutations at the frameshift motif in th

48 PB2, is a major contributing factor to high Cal polymerase activity in 293T cells.

49 rve fitting was then performed to match (1)I(Cal) and (2)I(Cal) with (1)I(Lit) and (2)I(Lit) of these

50 second ((2)D) dimensional separations ((1)I(Cal) and (2)I(Cal), respectively) with the input data of

51 )I differences (Delta(1)I = (1)I(Lit) - (1)I(Cal) and Delta(2)I = (2)I(Lit) - (2)I(Cal), respectively

52 s then performed to match (1)I(Cal) and (2)I(Cal) with (1)I(Lit) and (2)I(Lit) of these compounds.

53 dimensional separations ((1)I(Cal) and (2)I(Cal), respectively) with the input data of compound name

54 - (1)I(Cal) and Delta(2)I = (2)I(Lit) - (2)I(Cal), respectively) within +/-60 units.

55 By comparing I(Cal) and the literature I (I(Lit)) of 495 compounds, a m

56 dinates out of the linear trendline of the I(Cal) vs I(Lit) plot) were suspected with incorrect ident

57 tis serovars D (UW-3/Cx), E (Bour), or F (IC-Cal-3) or Chlamydia muridarum strain Nigg II using CpG-1

58 -Darby canine kidney epithelial cells and in Cal-51 and BT-20 human breast cancer cells.

59 e produced using a multiphoton microscope in Cal-520-AM loaded cells.

60 and neutralizing antibodies were produced in Cal PA-XFS-infected mice than in Cal WT-infected mice, d

61 ing the presence of unidentified residues in Cal PB2 that are required for efficient growth at low te

62 produced in Cal PA-XFS-infected mice than in Cal WT-infected mice, despite the lower level of virus r

63 d SCC-25 HNSCC cells in vitro and in vivo in Cal-27 xenografts.

64 lifetime of the red-shifted Ca(2+) indicator Cal-590 is Ca(2+)-sensitive in the nanomolar range, and

65 d the red-shifted fluorescent Ca2+ indicator Cal-590 for deep tissue experiments in the mouse cortex

66 conclude that the red-shifted Ca2+ indicator Cal-590 is well suited for in vivo two-photon Ca2+ imagi

67 The p110delta-specific inhibitor, Cal-101, and small interfering RNA-mediated knockdown of

68 In this animal, large, intensely Cal-immunoreactive neurons were found scattered througho

69 troduced the ts signature from Len LAIV into Cal/09.

70 Around 10.7-10.2 ka Cal BP (early Pre-Pottery Neolithic B), the predominant

71 nd late Pre-Pottery Neolithic B (10.2-8.3 ka Cal BP).

72 have implications for future satellite lidar Cal/Val efforts, because planned satellite lidars measur

73 Meaningful Cal/Val requires intercomparison data sets with small en

74 derable along-track averaging for meaningful Cal/Val.

75 mber of days subjects were eligible for Medi-Cal).

76 ent smokers aged 18 to 64 years who had Medi-Cal insurance and consulted a health professional in the

77 [16.8] years), with 1099 (52.4%) having Medi-Cal insurance and 879 (41.9%) identifying as non-White.

78 articipation was limited to acutely ill Medi-Cal beneficiaries who were admitted November 2018 to May

79 at least 5 years old, and had Medicaid (Medi-Cal in California), Medicare, private, or no insurance w

80 sociated with white race, and Medicaid (Medi-Cal) and private insurance.

81 nostic test in the California Medicaid (Medi-Cal) program.

82 d claims data from California Medicaid (Medi-Cal).

83 resent a Medicare card amounts based on Medi-Cal rates.

84 cipating in the state Medicaid program (Medi-Cal) to charge customers who present a Medicare card amo

85 ured, and 20 (39%) had restricted-scope Medi-Cal; 25 (48%) presented initially to an emergency depart

86 Moreover, Cal WT inhibited beta interferon (IFN-beta) expression a

87 In neurons, Cal-ID labeling is triggered by neuronal activity, leadi

88 This new Cal/09 LAIV is ts in vitro, highly attenuated (att) in m

89 Cal WT, but not Cal PA-XFS, induced degradation of host beta-actin mRNA

90 that, despite the relatively low affinity of Cal-590 for Ca2+ (Kd=561 nM), single-action potential-ev

91 complexes containing various combinations of Cal and avian influenza virus A/chicken/Nanchang/3-120/0

92 also demonstrated that, while the growth of Cal PA-XFS was attenuated in the lungs of infected anima

93 An additional introduction of Cal PB2 enhanced activity at 34 degrees C, suggesting th

94 led neuron and the surrounding population of Cal-590-labeled cells were recorded simultaneously on tw

95 nea pig model to understand which segment of Cal/09 virus conferred transmissibility to the poorly tr

96 with the acetoxymethyl (AM) ester version of Cal-590, combined two-photon imaging and cell-attached r

97 In addition, when our Cal/09 LAIV with PR8 hemagglutinin and neuraminidase was

98 In particular, Cal PA significantly activates the otherwise inactive Na

99 The growth of recombinant Cal containing PB2 with Nan residues 271T/661V/683V/684A

100 fferent viruses (recombinant wild-type [rWT] Cal/09 and the 66N and 66S viruses) did not result in si

101 thermore, the generation of a conditional ST-Cal-Light knock-in mouse provides an opportunity to tag

102 e we develop the soma-targeted Cal-Light (ST-Cal-Light) which selectively converts somatic calcium ri

103 tly suppress seizure symptoms, suggesting ST-Cal-Light's applicability in controlling disease-related

104 Because of the enhanced efficacy, the ST-Cal-Light enables the tagging of functionally engaged ne

105 Thus, the versatile ST-Cal-Light system links somatic action potentials to beha

106 presynaptic Ca(2+) responses to stimulation (Cal-520 imaging) in the nTS slice.

107 a A virus A/California/7/2009 (H1N1) strain (Cal) were protected from a lethal challenge with the het

108 In summary, Cal-ID produces a biochemical record of calcium signals

109 We present a dual-protein switch system, Cal-Light, that translates neuronal-activity-mediated ca

110 Here we develop the soma-targeted Cal-Light (ST-Cal-Light) which selectively converts soma

111 expression and replicated more rapidly than Cal PA-XFS in human respiratory cells.

112 ant induced a stronger humoral response than Cal WT.

113 A-XFS expressed significantly less PA-X than Cal wild type (WT).

114 We demonstrate that Cal-590 is also suited for multicolor functional imaging

115 In a head-to-head comparison, we find that Cal/2009 has higher pandemic potential than Hong Kong/19

116 (Nan) by reporter gene assay indicates that Cal PA, but not PB2, is a major contributing factor to h

117 tured neurons and brain slices, we show that Cal-Light drives expression of the reporter EGFP with hi

118 eterogeneous in nature and also suggest that Cal content may be a critical feature of the pathway by

119 d by the empirical relationship given by the Cal Tech group, but the strength of these should be redu

120 y demonstrates that PB1-F2 expression by the Cal/09 virus modulates the immune response to infection

121 viduals (response rate, 26.2%) completed the Cal-VEX survey and were included in these analyses.

122 336M contribute to enhanced activity of the Cal polymerase.

123 Delivery of the Cal-Light components to the motor cortex of mice by vira

124 The data showed that the M segment of the Cal/09 virus promoted aerosol transmissibility to recomb

125 tant swine virus, containing segments of the Cal/09 virus.

126 who received either the NJ/76 vaccine or the Cal/09 vaccine experienced a robust boost in HA stalk-re

127 ng site-directed mutagenesis showed that the Cal PA residues 85I, 186S, and 336M contribute to enhanc

128 To see whether the Cal-immunoreactive dLGN population might potentially pla

129 Thus, Cal-Light enables dissection of neural circuits underlyi

130 ical target may be systematically related to Cal content in the geniculo-extrastriate projection.

131 ve addressed this question by generating two Cal/09 viruses with productive PB1-F2 open reading frame

132 ided enhanced protection against a wild-type Cal/09 challenge relative to a PR8 LAIV with the same at

133 nces in symptoms of infection with wild-type Cal/09 versus the 66N or 66S virus variant.

134 By using Cal-Light to drive expression of the inhibitory receptor

135 Several Calibration/Validation (Cal/Val) studies for CALIOP conducted with ground-based

136 2009 pandemic A/California/04/09 H1N1 virus (Cal/09) results in only 10-fold in vivo attenuation in m

137 ouble-labeling techniques to examine whether Cal content characterizes all or a subset of neurons mak

138 Mice infected with Cal PA-XFS had significantly lower levels of viral growt

139 mRNA in their lungs than mice infected with Cal WT.

140 s been observed in individuals infected with Cal/09.

141 A dating of 19,849 years Cal BP allows assigning this assemblage to a period of t

142 Paleolithic [11,000-33,000 calibrated years (Cal y) B.P.] through the 20th century.