ライフサイエンスコーパス: Cy5

1 colour channel opposite of their design (Cy3/Cy5).

2 idoamine) dendrimer nanoparticles (Dendrimer-Cy5).

3 t tissues using a fluorescent peptide (RK-10-Cy5).

4 BLM, and BLM disaccharide to the cyanine dye Cy5**.

5 onjugated with one of the FRET pair, Cy3 and Cy5.

6 accharide was doubly labeled with biotin and Cy5.

7 re labeled with fluorophores such as Cy3 and Cy5.

8 es commonly used in DNA microarrays, Cy3 and Cy5.

9 e quantification of cell-extracted dendrimer-Cy5.

10 deceased MM patients were stained with LLP2A-Cy5.

11 es was more than tripled compared to FAM and Cy5.

12 both nuclear and optical in vivo imaging of Cy5-(111)In -DTPA-Tyr(3)-octreotate were performed in NE

13 dies revealed similar tumor uptake values of Cy5-(111)In-DTPA-Tyr(3)-octreotate and (111)In -DTPA-Tyr

14 en apoCph1Delta and the red fluorescent dyes Cy5.18 and Atto 655 but not Alexa Fluor 660.

15 efficiencies between the juxtaposed Cy3 and Cy5 5'-end labeled viral DNA ends in the synaptic comple

16 MRI is only slightly lower than that of ZD2-Cy5.5 (0.5 micromol kg(-1)) in fluorescence imaging.

17 beacon (rMB), thus bringing Cy5 (donor) and Cy5.5 (acceptor) into close proximity to allow fluoresce

18 nt normal tissue, we developed a chlorotoxin:Cy5.5 (CTX:Cy5.5) bioconjugate that emits near-IR fluore

19 that had been site specifically labeled with Cy5.5 (scVEGF/Cy) or inactivated scVEGF/Cy (inVEGF/Cy) a

20 Epo-Cy5.5 allows the longitudinal analysis of EpoR expressio

21 optical probes based on Igs conjugated with Cy5.5 and Cy7 and demonstrate in animal models that thes

22 ologic blocker of MMP-2 and induction of CTX:Cy5.5 binding in MCF-7 cells following transfection with

23 e-2 (MMP-2) as evidenced by reduction of CTX:Cy5.5 binding in vitro and in vivo by a pharmacologic bl

24 Vessel density and Epo-Cy5.5 binding on endothelial cells were comparable.

25 of the magnetofluorescent nanoparticle CLIO-Cy5.5 by macrophages in infarcted myocardium was studied

26 The uptake of CLIO-Cy5.5 by macrophages infiltrating the infarcted myocardi

27 n vivo optical imaging using the cyanine dye Cy5.5 conjugate.

28 Tumor accumulation of Epo-Cy5.5 could be significantly reduced by adding unlabeled

29 nance energy transfer (FRET) between Cy5 and Cy5.5 double-dye terminated DNAs.

30 or magnetic resonance imaging, modified with Cy5.5 dye (for near-IR fluorescence optical imaging), an

31 e to a larger overlap between the ODN-linked Cy5.5 emission and Cy7 excitation spectra.

32 ed in p50 binding and measurable increase of Cy5.5 emission.

33 als (86Y or 111In) and the near-infrared dye Cy5.5 for dual modality PET (or SPECT) and fluorescence

34 in B domain (CTB) for RGC-targeting and with Cy5.5 for unimNP-tracing.

35 Mouse studies revealed that CTX:Cy5.5 has favorable biodistribution and toxicity profile

36 These studies show that CTX:Cy5.5 has the potential to fundamentally improve intraop

37 nging concentrations of Ac(4)ManNAz and DBCO-Cy5.5 in cultured cells.

38 of quenching and recovery of fluorescence of Cy5.5 in monomers.

39 y available NIR fluorophores IRDye800-CW and Cy5.5 in vitro for immunocytometry, histopathology and i

40 The reporter duplexes included donor NIR Cy5.5 indodicarbocyanine fluorochrome linked to the 3' e

41 When they are in dimers, fluorescence of Cy5.5 is either nearly completely quenched by the BHQ3 o

42 by trypsin, was synthesized by labeling with Cy5.5 of a pegylated poly-L-lysine copolymer.

43 ging agents, we site-specifically conjugated Cy5.5 or (64)Cu-1,4,7,10-tetra-azacyclododecane-N,N',N''

44 pancreata of mice injected with the MN-Ex10-Cy5.5 probe compared with control animals injected with

45 Epo-Cy5.5 was generated by coupling Cy5.5 to rhuEpo.

46 validation confirmed specific binding of Epo-Cy5.5 to the tumor cells, and this binding correlated wi

47 In vivo specificity of Epo-Cy5.5 was confirmed by competition analyses using micro-

48 In addition, the near-infrared (NIR) dye Cy5.5 was coupled to the polymer providing live-animal i

49 Almost constant accumulation of Epo-Cy5.5 was found in bone marrow and tumors, indicating sp

50 Epo-Cy5.5 was generated by coupling Cy5.5 to rhuEpo.

51 betic and diabetic NOD mice injected with MN-Cy5.5 was not significantly changed, reflecting the nons

52 for Survival Motor Neuron (SMN1) target, and Cy5.5 was the red channel acceptor for the glucuronidase

53 Binding of Epo-Cy5.5 was validated on tumor cryosections.

54 issue, we developed a chlorotoxin:Cy5.5 (CTX:Cy5.5) bioconjugate that emits near-IR fluorescent signa

55 lation of the targeted probe (termed MN-Ex10-Cy5.5) compared with nontargeted (termed MN-Cy5.5).

56 end-labeled with a donor (Cy5) or acceptor (Cy5.5) dye.

57 ions by the use of a mixture of Cyanine 5.5 (Cy5.5) fluorophore- and BHQ3 quencher-conjugated endogen

58 Cy5.5, conjugated dibenzylcyclooctyne (DBCO-Cy5.5) via bioorthogonal click chemistry, resulting in C

59 -Cy5.5) compared with nontargeted (termed MN-Cy5.5).

60 This 7mer is conjugated to Cy5.5, a near-infrared (NIR) cyanine dye.

61 odality nanoparticles using glycol chitosan, Cy5.5, and superparamagnetic iron oxide nanoparticles (S

62 with near infrared fluorescence (NIRF) dye, Cy5.5, conjugated dibenzylcyclooctyne (DBCO-Cy5.5) via b

63 etic NOD mice after the injection of MN-Ex10-Cy5.5, indicating the decrease of probe accumulation in

64 fer (FRET) both in the case of Cy5.5-Cy7 and Cy5.5-800CW pairs of fluorochromes, which was sensitive

65 estar (formed by descanned fluorescence from Cy5.5-conjugated dextran in brain microvessels) with ada

66 e highly correlated with the NIRF signals of Cy5.5-CTLs at targeted tumor tissues in the early stage.

67 ated with the intensity of NIRF signals from Cy5.5-CTLs at tumors after 2-3 days post-injection.

68 The labeling efficiency of Cy5.5-CTLs could be readily controlled by changing conce

69 Importantly, Cy5.5-CTLs presented the strong NIRF signals in vitro an

70 The Cy5.5-CTLs showed different therapeutic responses in E.G

71 mmune-deficient mice, intravenously injected Cy5.5-CTLs were clearly observed at targeted solid tumor

72 These different therapeutic responses of Cy5.5-CTLs were highly correlated with the NIRF signals

73 chemistry, resulting in Cy5.5-labeled CTLs (Cy5.5-CTLs).

74 e energy transfer (FRET) both in the case of Cy5.5-Cy7 and Cy5.5-800CW pairs of fluorochromes, which

75 gher FRET efficiency observed in the case of Cy5.5-Cy7 pair was due to a larger overlap between the O

76 bioorthogonal click chemistry, resulting in Cy5.5-labeled CTLs (Cy5.5-CTLs).

77 were able to visualize in vivo binding of a Cy5.5-labeled peptide specific for EGFR to the cell surf

78 n myocardial remodeling using a radiolabeled Cy5.5-RGD imaging peptide (CRIP) that targets myofibrobl

79 5-superparamagnetic iron oxide nanoparticle (Cy5.5-SPION) labeling and fluorescent microscopy, we dem

80 may/J] that had been administered AS-gfap or Cy5.5-SPION-gfap.

81 abeled with a near-infrared fluorescent dye, Cy5.5.

82 ratios of 5.1 with IRDye800-CW and 2.7 with Cy5.5.

83 s that can be labeled with near-infrared dye Cy5.5.

84 with 3 to 20 mg of iron per kilogram of CLIO-Cy5.5.

85 nched by the BHQ3 or 20% quenched by another Cy5.5.

86 nce donor, while the endo V was labeled with Cy5, a fluorescence acceptor.

87 dot (QD) streptavidin conjugate donor and a Cy5 acceptor.

88 identify the compound [(68)Ga]Ga-NODAGA-Lys(Cy5**)-AEEAc-[Me-Arg(8),Tle(12)]-NT(7-13) as the one wit

89 frequency and duration of blinking events of Cy5, an effect that scales with reducing potential.

90 wed lower maximal MEF factors of 10-fold for Cy5 and 2.5-fold for Cy3, because of the smaller amount

91 emained at a constant maximum of 28-fold for Cy5 and 4-fold for Cy3, compared to avidin-coated glass

92 tobleaching compared to organic dyes such as Cy5 and Alexa 647 in vitro, and 5-fold more photons comp

93 en the two fluorophores used in aCGH-usually Cy5 and Cy3-can be observed as a bias within the intensi

94 nce resonance energy transfer (FRET) between Cy5 and Cy5.5 double-dye terminated DNAs.

95 Utilizing single-molecule fluorescence on Cy5 and Cy5B, transient-absorption spectroscopy, and DFT

96 ition, the binding curves obtained with 8A11-Cy5 and DCP-UO22+ species changed from sigmoidal to hype

97 ingle injection of ACPPD dually labeled with Cy5 and gadolinium chelates enabled preoperative whole-b

98 nce energy transfer (FRET) between 605QD and Cy5 and Iowa Black RQ, we develop a single-QD-based apta

99 re coincubated with the optical analog LLP2A-Cy5 and mouse B220, CD4, Gr1, and Mac1 antibodies and an

100 We report that the cyanine dye Cy5 and several of its structural relatives are reversib

101 rophore (Cy5), and the FRET-coupling between Cy5 and the redox center (copper) was used to study ET t

102 conjugation with a fluorescent cyanine dye (Cy5) and biotin, resulting in binding K(i) values of 17

103 resonance energy transfer to a reporter dye (Cy5) and that can benefit from the light harvesting prop

104 In one approach, multiple organic dyes (Cy5) and Trolox molecules are randomly distributed on de

105 es were labeled with an organic fluorophore (Cy5), and the FRET-coupling between Cy5 and the redox ce

106 rescent molecular rotor dyes, including Cy3, Cy5, and Alexa Fluor 555, dissolved in micron-sized aque

107 d increased initial lifetimes of single Cy3, Cy5, and Alexa488 fluorophores.

108 r dye pairs (TMR-ATTO647N, Cy3-ATTO647N, TMR-Cy5, and Cy3-Cy5), we find that this phenomenon depends

109 rization and back-isomerization processes of Cy5, and Cy5-nucleobase interactions are shown to slow d

110 imately 540 nm), Cy3 (approximately 570 nm), Cy5 (approximately 670 nm), IRDye 680 (approximately 700

111 5(SO(3))-mas(3), EuK-(Ar)Cy5-mas(3), and EuK-Cy5(Ar)-mas(3); the Cy5 dye acts as a functional backbon

112 The indodicarbocyanine fluorophores Cy3 and Cy5 are extensively used as donor-acceptor pairs in fluo

113 The observed FBKs of Cy5 are found to predominantly originate from the isomer

114 he data show that Cy-ncAAs (based on Cy3 and Cy5) are tolerated by the eukaryotic ribosome in cell-fr

115 Using Cy5 as a model, we show that the quenching reaction occu

116 ble cell-penetrating peptides, which contain Cy5 as far red fluorescent donor and Cy7 as near-infrare

117 cceptor pairs, fluorescein/rhodamine and Cy3/Cy5, as a function of peptide concentration and donor-to

118 ent conformation, from that of either Cy3 or Cy5 attached by 3-atom tethers, with the long axes of th

119 of the indocarbocyanine fluorophores Cy3 and Cy5 attached to DNA via three-carbon atom tethers, showi

120 Cy5-avidin conjugate-bound silver nanoparticles were pre

121 by in-gel fluorescence after conjugation to Cy5-azide.

122 nzymatic oxygen-scavenging system eliminates Cy5 blinking, dramatically reduces photobleaching and im

123 or accumulation of dibenzocyclooctyne (DBCO)-Cy5 by subsequent click chemistry.

124 e fluorescent signal of the carbocyanine dye Cy5 by using an engineered virus as a scaffold to attach

125 We found that the FBKs of Cy5 can be tuned by having more or less unpaired guanine

126 d be discriminated with equal confidence for Cy5 channel and reduced levels of confidence (>68%) for

127 Here we show that these rigidly inserted Cy3/Cy5 chromophores also exhibit two additional useful prop

128 e 8A11-Cy5 conjugate; incubation of the 8A11-Cy5 conjugate with saturating concentrations of DCP-UO22

129 l of protein G bind to each mole of the 8A11-Cy5 conjugate, (ii) binding of the first equivalent of D

130 fect on the binding of protein G to the 8A11-Cy5 conjugate; incubation of the 8A11-Cy5 conjugate with

131 sured HSP90 expression within the mask using Cy5-conjugated antibodies.

132 Cy5-conjugated miR-146a and miR-181b were packaged in po

133 The synthesized Cy5-conjugated MUB(70) marker specifically stained the c

134 kness of about 9mum while it was 40ng/mL for Cy5-conjugated Rabbit Anti-Mouse IgG which is 2.5x10(5)

135 ed for d-(+)-glucose and 96cm(-1)/mug/mL for Cy5-conjungated Rabbit Anti-Mouse IgG.

136 tion of an Escherichia coli 50S subunit (50S(Cy5)) containing a Cy5-labeled L11 N-terminal domain (L1

137 40-fold and triggers tissue retention of the Cy5-containing fragment.

138 Conversely, incubation of the 8A11-Cy5 covalent conjugate with saturating concentrations of

139 ommonly used fluorophore indocarbocyanine-5 (Cy5) covalently attached to the 5'-terminus of double-he

140 Cyanines (Cy3, Cy5, Cy3B) are the most utilized dyes for single-molecul

141 Such cleavage increases the Cy5:Cy7 emission ratio 40-fold and triggers tissue reten

142 [(89)Zr]Zr-DFO- and Cy5-daratumumab demonstrated superb binding to CD38(+) h

143 Using the long-lived Cy5 dark state in conjunction with Cy3 donors, we demons

144 The method employs Cy5-dATP incorporation into a DNA primer that has been p

145 (64)Cu-LLP2A and LLP2A-Cy5 demonstrated binding specificity for VLA-4 in an imm

146 (64)Cu-LLP2A and LLP2A-Cy5 demonstrated high specificity for VLA-4-positive mou

147 Confocal microscopy with daratumumab-Cy5 demonstrated specific cell binding.

148 rease in emission lifetimes as compared with Cy5-DNA free molecules in the absence of metal.

149 the Cy5-DNA-Ag particle as compared to free Cy5-DNA resulted in an increased contribution of Cy5-DNA

150 The decrease of lifetime for the Cy5-DNA-Ag particle allowed us to resolve the correlatio

151 The increased brightness of the Cy5-DNA-Ag particle as compared to free Cy5-DNA resulted

152 The single Cy5-DNA-Ag particles showed more than 10-fold increase i

153 DNA resulted in an increased contribution of Cy5-DNA-Ag to the correlation function of the mixture.

154 ermediates of motors containing Cy3-pRNA and Cy5-DNA.

155 On this account, the adsorption behaviour of Cy5-dNTPs on a variety of surface coatings was studied b

156 mer-template DNA constructs labeled with Cy3/Cy5 donor-acceptor Forster resonance energy transfer (FR

157 everse molecular beacon (rMB), thus bringing Cy5 (donor) and Cy5.5 (acceptor) into close proximity to

158 , and 3,3'-Diethylthiadicarbocyanine iodide (CY5)-doped polymer as the reconfigurable gain media.

159 ave now applied single-molecule FRET to Cy3, Cy5 double-labeled LacI-DNA loops diffusing freely in so

160 l (NBA) or Trolox to the cyanine fluorophore Cy5 dramatically enhanced fluorophore photostability wit

161 tudy, the hybrid labeled somatostatin analog Cy5-DTPA-Tyr(3)-octreotate (DTPA is diethylene triamine

162 ing affinity and internalization capacity of Cy5-DTPA-Tyr(3)-octreotate were assessed in vitro.

163 ion constant value was 387.7 +/- 97.9 nM for Cy5-DTPA-Tyr(3)-octreotate, whereas it was 120.5 +/- 18.

164 treotate to 1.32% +/- 0.02% applied dose for Cy5-DTPA-Tyr(3)-octreotate.

165 ceptor affinity and internalization rate for Cy5-DTPA-Tyr(3)-octreotate.

166 ystals by attaching either Cy3 dye (pink) or Cy5 dye (blue-green) to the components of the crystal, y

167 -(Ar)Cy5-mas(3), and EuK-Cy5(Ar)-mas(3); the Cy5 dye acts as a functional backbone between the EuK ta

168 were explored in Caco-2 cells by fluorescent Cy5 dye as a hydrophobic drug model.

169 ng the fluorescence of a covalently attached Cy5 dye label whose fluorescence is (partly) quenched by

170 guanines (upG) and thymines (upT) around the Cy5 dye.

171 Daratumumab was conjugated to Cyanine5 (Cy5) dye for cell microscopy.

172 hiometric amounts, and in a second approach, Cy5 dyes are covalently linked to Trolox in a precise 1:

173 ling and hybridization efficiency of Cy3 and Cy5 dyes.

174 resonance energy transfer (smFRET) between (Cy5)EF-G and (Cy3)tRNALys, we studied the translational

175 nal light-sheet fluorescence microscopy with Cy5-Fab-PAS200 confirmed better tracer extravasation in

176 herefore resulting in a measurable change in Cy5 FBKs.

177 ophysical properties of dye-conjugated FDNs (Cy5-FDNs and Cy3-FDNs) were characterized using single-m

178 In addition, Cy5-FDNs were used as reporter probes in a single-molecu

179 As proof-of-principle demonstration, Cy5-FDNs were used to assay single-molecule nucleic acid

180 Fluorophore Cy3/Cy5 fluorescence intensities were analyzed both through

181 nally, we observed specific quenching of the Cy5 fluorescent dye when the FeS cluster of a bound heli

182 The RA twin cDNA was labeled with cy5 fluorescent dye, and the cDNA of the healthy co-twin

183 licase is positioned in close proximity to a Cy5 fluorophore incorporated into the DNA molecule.

184 i.e., TH peptide), and imaging probes (i.e., Cy5 fluorophore).

185 r brightness compared to the previously used Cy5 fluorophore, a 45% increase in the anisotropy range

186 ons from rat liver as a source of ASGP-R and Cy5 fluorophore-labeled triGalNAc synthetic ligand as a

187 nce of a background of hundreds of nanomolar Cy5 fluorophore.

188 Spontaneous membrane partitioning of Cy3 and Cy5 fluorophores captured in these simulations proceeds

189 measurements probe the distance between Cy3/Cy5 fluorophores that label the ends of a short (15-nt)

190 We use the normal Cy5 FRET acceptor to observe arrival of a fluorescently

191 ophilic 3'-phosphorothioate probe carrying a Cy5 FRET acceptor, and an electrophilic probe containing

192 the three stems of the DNAzyme with the Cy3/Cy5 FRET pair two stems at a time in order to gain deepe

193 The 30SIC(Cy3):50S(Cy5) FRET signal also provides a sensitive probe of the

194 l penetrating peptides (ACPPs), labeled with Cy5, gadolinium, or both.

195 in vivo and validated neuronal uptake using Cy5-goat IgPxcIgY ex vivo.

196 Photoinduced blinking of Cy5 has hampered many previous investigations using this

197 Organic fluorophores, such as Cy3 and Cy5, have been widely used as chemical labels to probe t

198 y transfer efficiency, with unlinked QDs and Cy5 hydrazide producing nearly zero background signal in

199 nd to bleach significantly less than FAM and Cy5; i.e., the final fluorescence of Atto dyes was more

200 med by measuring the ratio of bound and free Cy5-insulin and FITC-glucagon in the presence of their r

201 laser was pulsed at 73 Hz and used to excite Cy5-insulin, while a vertically polarized 488 nm laser p

202 DDS dramatically enhanced cellular uptake of Cy5 into Caco-2 cells.

203 We find that Cy5 is predominantly stacked onto the end of the duplex,

204 Cy5 is quenched in favor of Cy7 re-emission until the in

205 isible fluorophores (e.g., fluorescein, Cy3, Cy5), it should find broad applicability in FRET assays

206 Furthermore, the sulfo-Cy5 labeled (R,R)-14 retained high agonist potency as a

207 We demonstrate ITP-AC with 25 nt, Cy5 labeled DNA target and a DNA probe and study the spa

208 f concept, we demonstrate the interaction of Cy5 labeled IgG and Alexa633 labeled anti-IgG using a si

209 fluorescently stained plasmid DNA and single Cy5 labeled oligonucleotides.

210 r the dynamics of fluorescence emission from Cy5 labeled on DNA probes.

211 synuclein are then incubated with a red dye (Cy5)-labeled variant of alpha-synuclein A91C, and EtOH (

212 rescent protein show colocalization with the Cy5-labeled ACPPs.

213 the sliding via one-dimensional diffusion of Cy5-labeled adenovirus protease on DNA in the presence o

214 d TMR-labeled alpha-synuclein and aggregated Cy5-labeled alpha-synuclein from the solution are quanti

215 ing an increase in fluorescent intensity for Cy5-labeled analytes measured with a confocal microarray

216 strogen receptor, at the same time causing a Cy5-labeled coactivator to be recruited to the estrogen

217 50-nm-diameter single silver particle, and a Cy5-labeled complementary single-stranded oligonucleotid

218 Following systemic administration of the Cy5-labeled dendrimer (D-Cy5), we demonstrate dendrimer

219 Cy5-labeled DNA aptamer was embedded between the Au and

220 When Cy5-labeled Escherichia coli (Ec) SSB is bound to surfac

221 Pairs of cy3- and cy5-labeled extracts from 5-week old Alport and wild-typ

222 ocalization experiments were performed using Cy5-labeled forked DNA and Alexa 555-labeled gp59 in the

223 In the same mouse models, Cy5-labeled free ACPPs and ACPPs conjugated to dendrimer

224 luorescent quenching graphene oxide (GO) and Cy5-labeled G8 aptamer were used in this study to develo

225 Detection limits in the analysis of Cy5-labeled IgG are 0.02 ng/mL because of the high surfa

226 by electroosmotic flow and mixed online with Cy5-labeled insulin, fluorescein isothiocyanate (FITC)-l

227 erve the sequence-independent interaction of Cy5-labeled interferon-inducible protein 16 with DNA and

228 hia coli 50S subunit (50S(Cy5)) containing a Cy5-labeled L11 N-terminal domain (L11-NTD) within the G

229 l freedom, and dwell time distributions of a Cy5-labeled OTD (L1Cy5-7OTD) as it interacted with sever

230 t all the click clusters efficiently deliver Cy5-labeled pDNA into HeLa and H9c2 (2-1) cells, and com

231 e-molecule FRET (smFRET) measurements on Cy3/Cy5-labeled primer-template (p/t) DNA constructs in the

232 By loading a high density of Cy5-labeled probe DNA on microspheres (15 mum), we achie

233 abeled by pre-hybridization to complementary Cy5-labeled probes.

234 to the patterned antigens was revealed using Cy5-labeled rabbit anti-mouse IgG.

235 t whereby immobilized L7Ae protein binds Cy3-Cy5-labeled RNA from free solution.

236 dified biotin was immobilized for binding of Cy5-labeled streptavidin.

237 beled ribosomal protein L11 and A- or P-site Cy5-labeled tRNA or Cy3- and Cy5-labeled tRNAs.

238 1 stalk of the large ribosomal subunit and a Cy5-labeled tRNA(Lys) in the ribosomal peptidyl-tRNA-bin

239 nd A- or P-site Cy5-labeled tRNA or Cy3- and Cy5-labeled tRNAs.

240 Cy5-labeled, heat-killed cells were used to demonstrate

241 ed from the same source was used for Cy3 and Cy5 labeling and hybridized to the same array, signal in

242 and fluorescence imaging, (99m)Tc-EuK-(SO(3))Cy5-mas(3) had the most promising properties (e.g., half

243 e moiety adjacent to EuK ((99m)Tc-EuK-(SO(3))Cy5-mas(3)) yielded the most promising tracer candidate

244 ))Cy5-mas(3), EuK-Cy5(SO(3))-mas(3), EuK-(Ar)Cy5-mas(3), and EuK-Cy5(Ar)-mas(3); the Cy5 dye acts as

245 synthesized: glutamic acid-urea-lysine (EuK)-Cy5-mas(3), EuK-(SO(3))Cy5-mas(3), EuK-Cy5(SO(3))-mas(3)

246 cid-urea-lysine (EuK)-Cy5-mas(3), EuK-(SO(3))Cy5-mas(3), EuK-Cy5(SO(3))-mas(3), EuK-(Ar)Cy5-mas(3), a

247 FAM-labeled ATP aptamer and Cy5-modified GTP aptamer are used to construct the multi

248 ion and reduction processes of individual Az-Cy5 molecules were monitored.

249 Hence, Cy5-MUB(70) is a novel and specific fluorescent marker f

250 and back-isomerization processes of Cy5, and Cy5-nucleobase interactions are shown to slow down these

251 llography to analyze the location of Cy3 and Cy5 on dsRNA, using complexes of an RNA stem-loop bound

252 her show that the alterations of the FBKs of Cy5 on probe hybridization can be used to differentiate

253 n of 8A11 with amine-reactive derivatives of Cy5 or Alexa 488 altered the binding curves obtained wit

254 rRNA gene and were end-labeled with a donor (Cy5) or acceptor (Cy5.5) dye.

255 egion (Cy2) and 8000-fold in the red region (Cy5) over conventional state-of-the-art image acquisitio

256 nti-TRPC protein antibodies labeled with cy3-cy5 pairs.

257 RK-10-Cy5 peptide also demonstrates PD-L1 detection in NSCLC,

258 ortion of cells intensely labeled with LLP2A-Cy5 probe.

259 Taking advantage of this Cy5 quenching, we developed an equilibrium assay for ana

260 s detections of two target DNAs with FAM and Cy5 reporter conjugated probes.

261 engineered virus as a scaffold to attach >40 Cy5 reporter molecules at fixed locations on the viral c

262 trate that organized spatial distribution of Cy5 reporter molecules on the capsid obviates this commo

263 functionalized with QDs and a dye acceptor (Cy5), respectively (detection limit 12 nM).

264 Cy5-RO5323441 was injected to study the intratumor distr

265 Cy5-RO5323441 was present in the tumors mainly in the mi

266 the dye pair used, with the cyanine pair Cy3-Cy5 showing the least amount of fluctuations.

267 However, no change was observed in the Cy3/Cy5 signal intensity ratio between continuously mixed an

268 ltiplier tubes for detection of the FITC and Cy5 signal.

269 (EuK)-Cy5-mas(3), EuK-(SO(3))Cy5-mas(3), EuK-Cy5(SO(3))-mas(3), EuK-(Ar)Cy5-mas(3), and EuK-Cy5(Ar)-m

270 A total of 401 genes with Cy3 and Cy5 spot intensities of >/=500 were selected for analysi

271 een phycoerythrin-biotin (PhycoE-Biotin) and Cy5-streptavidin trapped in the two proteoliposome popul

272 Synthesis of a fluorescently (Cy5) tagged C-11 fatty acid is reported.

273 binding of recombinant HIV-1 Gag protein to Cy5-tagged 190-base RNAs.

274 ns show strong position-dependent effects of Cy5-tagging on the structure and natural dynamics of mem

275 fficiency of energy transfer between Cy3 and Cy5, that are attached to nucleic acids in this way, wil

276 e at the excitation wavelength of cyanine-5 (Cy5), thus providing an increase in fluorescent intensit

277 f the phosphine to the polymethine bridge of Cy5 to form a covalent adduct.

278 ed with the cyanine dye fluorophores Cy3 and Cy5 to quantify the melting/rebinding reaction by fluore

279 eins has been examined by covalently linking Cy5 to single- and multipass transmembrane helical prote

280 Attachment of Cy3, Cy3B and Cy5 to the 5-position of thymidine by an ethynyl linker

281 grams of the logarithms of the ratios of the Cy5 to the reference fluorophore fluorescence can be use

282 oxin B subunit-Alexa 647 and streptavidin-PE/Cy5, to membranes containing different amounts of ligand

283 chiometry followed by covalent attachment of Cy5-Trolox conjugates onto dendrimers.

284 d to single self-healing dye systems such as Cy5-Trolox, and as a proof-of-principle demonstration, w

285 uration of the three-way-junction alters the Cy5-upG or Cy5-upT interactions, therefore resulting in

286 the three-way-junction alters the Cy5-upG or Cy5-upT interactions, therefore resulting in a measurabl

287 rescence emission of the covalently attached Cy5 was largely quenched by FRET ('off'-state), whereas

288 ength and emission wavelength of Cyanines 5 (Cy5), was used to amplify the fluorescence signal intens

289 tation wavelength and emission wavelength of Cy5, was used to amplify the fluorescence signal intensi

290 ministration of the Cy5-labeled dendrimer (D-Cy5), we demonstrate dendrimer uptake in cells involved

291 TMR-ATTO647N, Cy3-ATTO647N, TMR-Cy5, and Cy3-Cy5), we find that this phenomenon depends on the nature

292 Interactions between the tagged protein and Cy5 were also observed.

293 at the model drug (Cy3) and polymer bound to Cy5 were colocalized at an early time point before the m

294 Probes labeled with Cy3 and Cy5 were individually introduced to opposite sides of a

295 mitting at the same wavelength as cyanine 5, Cy5) were found to bleach significantly less than FAM an

296 fibres labelled with different dyes (Cy3 and Cy5) were mixed, and the distribution of dyes inserting

297 ckbone was labeled with acceptor fluorophore Cy5, while donor fluorophores (Cy3 or EPI) were attached

298 r, the manner of interaction of both Cy3 and Cy5 with the terminus of the dsRNA is significantly diff

299 ially for far red emitting fluorophores like Cy5, without significantly altering current microarray p

300 ased hybrid tracer, PSMA-I&F (DOTAGA-k(Sulfo-Cy5)-y-nal-k-Sub-KuE), has been developed and evaluated.