ライフサイエンスコーパス: D1 receptor

1 be dependent on tonic stimulation of the DA D1 receptor.

2 upon the effects of activating the dopamine D1 receptor.

3 in-coupled receptors, and lacked activity at D1 receptors.

4 vation of norepinephrine alpha2 and dopamine D1 receptors.

5 cumbens pathway, via, in part, activation of D1 receptors.

6 rontal cortex influence temporal control via D1 receptors.

7 P treatment down-regulated the expression of D1 receptors.

8 tive functions, acting predominantly through D1 receptors.

9 ur, in part, via activation of dopamine (DA) D1 receptors.

10 greatly reduced cell-surface localization of D1 receptors.

11 pecific pharmacological blockade of dopamine D1-receptors.

12 its cytokine production via dopamine type 1 (D1) receptors.

13 through DA D2 and adenosine A2A, but not DA D1, receptors.

14 dopamine transporter (DAT; [(3)H]mazindol), D1 receptor ([(3)H]SCH23390), and D2 receptor ([(3)H]sul

15 NAi lead to elevated cAMP levels in dopamine D1 receptor-activated neuroblastoma cells.

16 In VTA-PFC cocultures, D1 receptor activation (10 min) increased synaptic and n

17 est a crucial and baseline-dependent role of D1 receptor activation in controlling both cue reactivit

18 sis are dependent on mating-induced dopamine D1 receptor activation in the NAc.

19 dose-dependent inverted U-shaped effects of D1 receptor activation on neuroplasticity of the motor c

20 In contrast, in older animals (P28) D1 receptor activation produces a potentiation of the NM

21 We show that dopamine D1 receptor activation promotes and D2 receptor activati

22 ockade following maintained illumination and D1 receptor activation result in minimal GABAA receptor

23 s reversed compartment-specific responses to D1 receptor activation.

24 it reduces hyperthermia produced by dopamine D1 receptor activation.

25 ncreased TrkB surface expression by dopamine D1 receptor activation.

26 Modification of D1 receptor activity prevents the aversive response to a

27 al demonstration that 5-HT1A and D2, but not D1, receptor activity influence a behavioral analog of l

28 Sustained treatment with D1 receptor agonist (SKF38393) leads to a significant de

29 slices with NR2A antagonist (NVP-AAM077) and D1 receptor agonist augmented the increase of dendritic

30 active enantiomer of the selective and full D1 receptor agonist dihydrexidine (DAR-0100A) could atte

31 ssed conditions, chronic administration of a D1 receptor agonist in conjunction with fluoxetine resto

32 conditioning rats under the partial dopamine D1 receptor agonist SKF 38393 or the opioid antagonist n

33 Direct infusion of the D1 receptor agonist SKF-38393 into the prelimbic cortex

34 tration of a low dose of either the dopamine D1 receptor agonist SKF-38393 or the D2 receptor antagon

35 s of neonatal (P7) rat striatum the dopamine D1 receptor agonist SKF-82958 significantly decreases NM

36 hibited opposite regulatory responses to the D1 receptor agonist SKF38393 (1-phenyl-2,3,4-5-tetrahydr

37 iation of synaptic plasticity induced by the D1 receptor agonist SKF38393 in spiny neurons.

38 Using the D1 receptor agonist SKF38393, we found that Trk neurotro

39 K density in rats treated with l-DOPA or the D1 receptor agonist SKF81297.

40 nuated the hyperthermia caused by a dopamine D1 receptor agonist, SKF 38393 (10 mg/kg, s.c.), indicat

41 D1 receptor agonists suppress systemic inflammation and

42 further clinical support to the potential of D1 receptor agonists to treat schizophrenia-spectrum wor

43 dyskinesia in animals treated with L-DOPA or D1 receptor agonists.

44 n males whereas females rely more heavily on D1 receptors, an effect that could be explained by sexua

45 The effect of D1 receptor and A2A receptor agonists on the phosphoryla

46 gical roles of Gs- and Golf-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and

47 d to reveal potentially therapeutic dopamine D1 receptor and adenosine A2A receptor ligands with func

48 Simultaneous activation of dopamine D1 receptors and CPARs induced additive increases in Glu

49 Binding of D1 receptors and DAT throughout the striatum correlated

50 hat activate the direct striatal pathway via D1 receptors and inhibit the indirect striato-cortical p

51 P and cGMP, whose synthesis is stimulated by D1 receptors and inhibited by D2 receptors preferentiall

52 ieved to mostly affect striatal neurons with D1 receptors, and tonic dopamine signals are believed to

53 ics we found a strong down-regulation of the D1 receptor- and DA transporter (DAT)-binding sites, but

54 d bound putative GLP-1 receptors on dopamine D1 receptor- and dopamine D2 receptor-expressing medium

55 emales were less sensitive to the effects of D1-receptor antagonism as compared with their ShA counte

56 rk tyrosine kinase inhibitor, and a dopamine D1 receptor antagonist could block the effects of SKF383

57 ven an intra-mPFC infusion of vehicle or the D1 receptor antagonist SCH 23390 (0.25 or 1.0 microg) pr

58 Pretreatment with the D1 receptor antagonist SCH-23390 before optical VTA stim

59 Pretreatment with the dopamine D1 receptor antagonist SCH23390 (0.1mg/kg, ip) 30 min pr

60 two injections: first with +/-8-OH-DPAT, the D1 receptor antagonist SCH23390 or their vehicles, and s

61 ent to induce BDNF in the mPFC, and dopamine D1 receptor antagonist treatment blocked the antidepress

62 Pre-treatment with SKF-83566, a D1 receptor antagonist, attenuated GBP-induced CPP.

63 e, attenuated the action of DBS, whereas the D1 receptor antagonist, SCH-23390, was ineffective, sugg

64 a-erythroidine (DHbetaE), and also by the DA D1 receptor antagonist, SCH-23390.

65 s paper assessed the possibility that the DA D1 receptor antagonist, SCH23390, might inhibit METH-ind

66 D2 receptor antagonist, eticlopride, and the D1 receptor antagonist, SCH23390.

67 otally abolished by pre-administration of DA-D1 receptor antagonist, SCH23390.

68 ed following saline or 0.25mg/kg SCH 23390,a D1 receptor antagonist, while awake hamsters breathed no

69 n the presence of 4 mum SCH23390, a dopamine D1 receptor antagonist.

70 he AMPA-receptor antagonist CNQX or dopamine D1-receptor antagonist SCH-23390 into the DLS before tes

71 e effects of intra-accumbens infusion of the D1-receptor antagonist, SCH-23390 (0, .3, 1.0, 3.0 micro

72 Dopamine D1 receptor antagonists (SCH23390 and SKF83566) blocked

73 ion and patch-clamp recordings, we show that D1 receptors are almost exclusively expressed in the str

74 ovide evidence that human dorsal striatal DA D1 receptors are involved in the modulation of instrumen

75 Whereas D1 receptors are known to contribute to Drosophila avers

76 In conclusion, neurokinin-1 and dopamine D1 receptors are required for the METH-induced striatal

77 striatal medium spiny neurons (MSNs) marker, D1-receptor associated signaling protein dopamine-and-cA

78 Importantly, systemic inhibition of dopamine D1 receptors attenuated the stroke-induced increase in o

79 t three anatomical sources of variance in DA D1 receptor availability separable using PET in humans,

80 he expression of this bias, we quantified DA D1 receptor availability using positron emission tomogra

81 rovide independent sources of variance in DA D1 receptor availability.

82 nd that this mechanism is associated with DA D1 receptor availability.

83 was no correlation between striatal DAT and D1 receptor binding (R(2)=0.07, p=0.33), although DAT an

84 Mean DAT, D2, and D1 receptor binding did not differ in suicide.

85 d serotonin levels in basal ganglia; reduced D1 receptor binding in nucleus accumbens; axodendritic p

86 In the rostral cortex, D1 receptor binding was 22% lower in zQ175 than WT anima

87 inding (R(2)=0.07, p=0.33), although DAT and D1 receptor binding was positively correlated in subject

88 We also show that maintained darkness and D1 receptor blockade following maintained illumination a

89 ple discrete-trial procedures employed here, D1 receptor blockade preferential reduces Pavlovian and

90 We examined here whether D1 receptor blockade within striatal or frontal cortical

91 Daun02 lesioning of vmPFC and acute dopamine D1-receptor blockade with SCH39166 in NAc core or shell)

92 Pharmacological blockade of D1 receptor, but not D2 receptor, in the NAc during sexu

93 hat the production of IP3 is mediated by the D1 receptor, but not the D2 receptor.

94 ulus depended on NAcC AMPA/NMDA and dopamine D1 receptors, but the retrieval of the response associat

95 ests; cyclic AMP responses to stimulation of D1 receptors by dopamine was selectively impaired in PrP

96 nd tonic inhibition, the acute activation of D1 receptors (by a selective agonist or indirectly by am

97 esults indicate that stimulation of dopamine D1 receptors can be coupled to the neurotrophin receptor

98 gnificantly, prior activation of presynaptic D1 receptors caused a time-dependent attenuation of mGlu

99 rly growth response 3 (EGR3) is increased in D1 receptor containing MSNs of mice susceptible to socia

100 In particular, direct pathway (dopamine D1 receptor-containing; D1R-) spiny projection neurons (

101 We observed that PFC alpha2 and D1 receptors contributed to the beneficial effects of MP

102 also demonstrate that activation of dopamine D1 receptors corrects these deficits, through a mechanis

103 ovement, whereas those that express dopamine D1 receptors (D1+) project to the substantia nigra pars

104 tudy, we show that mice lacking the dopamine D1 receptor (D1R KO mice) manifest greatly reduced FAA,

105 s working memory via high levels of dopamine D1 receptor (D1R) activation of cyclic adenosine monopho

106 e CA1 region of the hippocampus via dopamine D1 receptor (D1R) activation, a process largely facilita

107 h molecular analyses, we investigated the DA D1 receptor (D1R) and extracellular signal-regulated kin

108 is associated with an alteration in dopamine D1 receptor (D1R) and glutamate receptor interactions.

109 A dopamine D1 receptor (D1R) antagonist blocked ghrelin-induced cAM

110 B males, it had differential effects on NAcc D1 receptor (D1R) binding.

111 the process of signal bias from the dopamine D1 receptor (D1R) by exploring factors that promote the

112 tivity of agonist and antagonist of dopamine D1 receptor (D1R) by using quartz crystal microbalance (

113 The dopamine D1 receptor (D1R) facilitates reward acquisition and its

114 transgenic mice and found that the dopamine D1 receptor (D1R) is expressed in retinal bipolar cells

115 genetic regulatory elements for the dopamine D1 receptor (D1R) or dopamine D2 receptor (D2R).

116 ressing EGFP under the control of either the D1 receptor (D1R) or the D2 receptor (D2R) gene and micr

117 aptic activity and was reduced by a dopamine D1 receptor (D1R) protein kinase A pathway.

118 However, while facilitation of D1 receptor (D1R) signaling enhances the rewarding effec

119 kinase 2 (CK2) in the modulation of dopamine D1 receptor (D1R) signaling in cells.

120 g NMDARs from MSNs that express the dopamine D1 receptor (D1R) significantly attenuated AMPH sensitiz

121 ut approach to selectively delete GRK2 in DA D1 receptor (D1R)-, DA D2 receptor (D2R)-, adenosine 2A

122 Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in tri

123 conditional knock-out of Cav1.2 in dopamine D1 receptor (D1R)-expressing cells resulted in attenuati

124 y neurons triggers a multitude of changes in D1 receptor (D1R)-expressing direct-pathway neurons, whi

125 Here we isolated a population of dopamine D1 receptor (D1R)-expressing neurons within the posterov

126 from C57BL/6 male mice, that a dopamine (DA) D1 receptor (D1R)-mediated enhancement in glutamate syna

127 The role of dopamine D1 receptors (D1R) and D2 receptors (D2R) in the ERG res

128 ngiotensin AT1 receptors (AT1R) and dopamine D1 receptors (D1R) modulates renal sodium excretion and

129 s, increased activation of striatal dopamine-D1 receptors (D1R) results in desensitization of delta-o

130 ium spiny neurons (MSNs) expressing dopamine D1 receptors (D1R).

131 l dopamine, and possible changes in dopamine D1 receptors (D1R).

132 Ca(v)1.2 is a downstream target of dopamine D1-receptor (D1R) signaling, we next generated mice with

133 lation of DORs in CINs critically influences D1-receptor (D1R)-expressing projection neurons in the N

134 is modulation is mainly mediated by dopamine D1 receptors (D1Rs) and D2Rs, which are highly expressed

135 ell but not the core in mice, which required D1 receptors (D1Rs) and mechanistic target of rapamycin

136 l neurons, we demonstrate here that dopamine D1 receptors (D1Rs) and NMDARs form dynamic surface clus

137 However, while dopamine D1 receptors (D1Rs) in the prefrontal cortex (PFC) have

138 the effect of D3R overexpression on dopamine D1 receptors (D1Rs) in the striatum.

139 ipulation of FEF activity either by blocking D1 receptors (D1Rs) or by stimulating D2 receptors (D2Rs

140 m spiny neurons (MSNs) that express dopamine D1 receptors (D1Rs) or D2 receptors (D2Rs), which drive

141 The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is being con

142 triatal dopamine transporter and D2, but not D1, receptor densities.

143 n the caudate nucleus and putamen and higher D1-receptor density in the nucleus accumbens.

144 several IEGs, some of which occurred in a DA D1 receptor dependent fashion.

145 There were also delayed METH-induced DA D1 receptor-dependent effects on fosB mRNA expression.

146 sic firing, increased SC responses through a D1 receptor-dependent enhancement of excitatory transmis

147 Here we investigate the pathways involved in D1 receptor-dependent ERK1/2 activation using acute stri

148 Egr family of transcription factors in a DA D1 receptor-dependent fashion.

149 es of apical dendrites of these neurons in a D1 receptor-dependent manner.

150 nhanced cue-reward learning through dopamine D1 receptor-dependent mechanisms and suppressed task-irr

151 f the PFC, which are regulated by a dopamine D1 receptor-dependent pathway.

152 e, we describe for the first time a dopamine D1 receptor-dependent quinone reductase 2 pathway in int

153 r inhibition of engrafted neurons, revealing D1 receptor-dependent regulation of host neuronal circui

154 Indeed, we observed D1 receptor-dependent synaptic potentiation only when od

155 tamine challenge reversed CPD via a dopamine D1-receptor-dependent paradoxical presynaptic potentiati

156 -basolateral amygdala antagonism of dopamine D1-receptors did not prevent the reacquisition of fear a

157 e rat using direct infusions of the dopamine D1 receptor (DRD1) antagonist SCH 23390 or dopamine D2 r

158 ngle nucleotide polymorphism in the dopamine D1 receptor (DRD1) gene, which was associated with ADHD

159 Cells expressing the dopamine D1 receptor (DRD1) have significant functional roles in

160 tina, yet has been reported to do so by only D1 receptor-driven cyclic adenosine monophosphate (cAMP)

161 gest that activation of SN DA neurons and DS D1 receptors during fear extinction render fear extincti

162 e carriers, who are assumed to have a higher D1 receptor efficiency than carriers of the A allele.

163 In addition, D1 receptor electroporation into cells of the basal fore

164 av1.2 channels within the hippocampus and in D1 receptor-expressing cells in extinction of cocaine-as

165 at supports a role of Cav1.2 within dopamine D1 receptor-expressing cells of the hippocampus for exti

166 A and AMPA receptors and adenylyl cyclase in D1 receptor-expressing cells.

167 s accumbens, more specifically, the dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) wi

168 veal that in hemiparkinsonian mice, striatal D1 receptor-expressing medium spiny neurons (MSNs) direc

169 This mechanism is specific to D1 receptor-expressing MSNs.

170 ely vulnerable to Tat exposure compared with D1 receptor-expressing MSNs.

171 citatory synaptic transmission onto dopamine D1 receptor-expressing neurons (D1+ neurons) in the nucl

172 targeted EP1 receptors on striatal dopamine D1 receptor-expressing neurons and that this signaling s

173 CE STATEMENT ERK phosphorylation in dopamine D1 receptor-expressing neurons exerts a pivotal role in

174 hat NCS-Rapgef2 signaling to ERK in dopamine D1 receptor-expressing neurons in the NAc, but not in co

175 Stimulating D1 receptor-expressing neurons induced persistent reinfo

176 to ERK that underlies plasticity in dopamine D1 receptor-expressing neurons leading to acquired cocai

177 with a cell-specific knockdown of mGluR5 in D1 receptor-expressing neurons.

178 cerol lipase alpha (DGLalpha), from dopamine D1 receptor-expressing or adenosine A2a receptor-express

179 nd persistently elevated the excitability of D1 receptor-expressing SPNs (D1-SPNs).

180 y neurons (MSSNs) giving rise to the direct (D1 receptor-expressing) and indirect (D2 receptor-expres

181 that lack M4 mAChRs specifically in dopamine D1-receptor-expressing neurons, suggesting that postsyna

182 stores the efficacy of fluoxetine actions on D1 receptor expression and behavioral responses.

183 take inhibitor (SSRI), fluoxetine, increases D1 receptor expression in mature granule cells in the de

184 H23390 (which has been suggested to increase D1 receptor expression in the basal ganglia) did not eli

185 iabetic model, we demonstrate that the renal D1 receptor expression is down-regulated by the extracel

186 othyroidismin hamsters (HH) altered dopamine D1 receptor expression, D1 receptor-modulated ventilatio

187 2-AR), muscarinic (M1 and M2), and dopamine (D1) receptor families.

188 s, the specific contribution of the dopamine D1 receptor family to these behaviors remained elusive.

189 In this scheme, activation of dopamine D1 receptors following light exposure triggers cAMP-medi

190 to cocaine while redistributing postsynaptic D1-receptors from endosomes to plasma membrane, consiste

191 ic spines in MSN-D1 (MSN-expressing dopamine D1 receptors) from the core and shell of nucleus accumbe

192 educed oxidative stress and thereby restored D1 receptor function and normalized BP.

193 There exists a defect in renal D1 receptor function in hypertension, diabetes, and agin

194 In contrast, CIE exposure did not alter D1 receptor function or mGluR1 modulation of firing.

195 histamine H3 receptor-mediated inhibition of D1 receptor function.

196 s that down-regulate the expression of renal D1 receptor gene in diabetes are not well understood.

197 l-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multip

198 microscopy, we show that neurons expressing D1 receptors have unique morphological and physiological

199 pathway reverse the down-regulation of renal D1 receptor in diabetes.

200 We recently reported that dopamine D1 receptor in the medial prefrontal cortex (mPFC) is ac

201 mong which the IPAC is regulated by dopamine D1 receptor in the mPFC perhaps through direct projectio

202 ngs demonstrate that repeated stimulation of D1 receptors in adulthood interacts with the development

203 Our results identify a role for D1 receptors in mediating the control of visual cortical

204 orylated by PKA in response to activation of D1 receptors in striatal slices.

205 Here, we demonstrate that dopamine D1 receptors in the dentate gyrus act as a pivotal media

206 hus, our results suggest that stimulation of D1 receptors in the dentate gyrus is a potential adjunct

207 D1 receptors in the DS are a likely target mediating the

208 Pharmacological activation of D1 receptors in the DS did not impact fear extinction ac

209 ve shown that the expression and function of D1 receptors in the kidneys are decreased in animal mode

210 Local blockade of D1 receptors in the MLR decreased locomotor frequency, b

211 investigate a potential modulatory role for D1 receptors in the mPFC in amphetamine (AMPH)- and meth

212 respectively, blocked the down-regulation of D1 receptors in the primary renal cells and in the kidne

213 Dopamine D1 receptors, in contrast, stimulate GluA1 extra synapti

214 have shown that in the absence of functional D1 receptors, in null mice, the systolic, diastolic, and

215 Single-channel recordings show that direct D1 receptor inhibition of NMDA receptors cannot be obser

216 Although stimulation of D1 receptors is known to enhance motor function, the glo

217 l overactivation of ERK1/2 via dopamine (DA) D1 receptors is the hallmark of a supersensitive molecul

218 Activation of D1 receptors is thought to enable working memory by enha

219 ine in all wild-type mice but in none of the D1 receptor knock-out mice.

220 or and grooming behaviors were eliminated in D1 receptor knockout (KO) mice, verifying a key role for

221 D1-receptor knockout (D1R-KO) mice had impaired acquisit

222 D1 receptor KO mice had normal sodium appetite, indicati

223 triatal slices have shown that activation of D1 receptors leads to cAMP-dependent dephosphorylation o

224 P stimulation was unaffected in Fmr1 KO, but D1 receptor levels were reduced in these animals.

225 By a D1-receptor-linked L-VGCC-dependent mechanism, dopamine

226 bright-light-induced activation of dopamine D1 receptors located on ON-center cone bipolar cell dend

227 ing the part of visual space affected by the D1 receptor manipulation.

228 Here we show that dopamine D1 receptors mediate prefrontal control of signals in th

229 Therefore, we propose that D1 receptor-mediated dendritic growth in mPFC excitatory

230 Single social defeat stress (S-SDS) induces D1 receptor-mediated extracellular signal-regulated kina

231 Importantly, we show that although D1 receptor-mediated functions are preserved and even en

232 nd co-localized with DeltaFosB, suggesting a D1 receptor-mediated mechanism supporting the LHb involv

233 ulated striatal N/OFQ receptors opposing the D1 receptor-mediated overactivation of the striatonigral

234 We pharmacologically altered D1-receptor-mediated activity in the frontal eye field o

235 of any other NF subunit, amplifies dopamine D1-receptor-mediated motor responses to cocaine while re

236 HH) altered dopamine D1 receptor expression, D1 receptor-modulated ventilation, and ventilatory chemo

237 This finding of robust D1 receptor modulation in only a subpopulation of neuron

238 was a pronounced reduction in dopamine (DA) D1 receptor modulation of both intrinsic firing and evok

239 Here we study D1 receptor modulation of layer 5 pyramidal neurons in a

240 D1 receptor modulation of sEPSCs was absent in D1-YAC128

241 c excitability, glutamatergic signaling, and D1 receptor modulation of these cells.

242 was decreased specifically in D1 cells, and D1 receptor modulation was normal in D1-YAC128 cells.

243 Moreover, D1 receptor-modulation of breathing at rest and during g

244 g is related to changes in expression of the D1 receptor mRNA, suppression in expression of serotoner

245 Total D1 receptor number was indistinguishable in neurons from

246 vestigate the involvement of the dopamine 1 (D1) receptor on the reward and reinforcement behavior of

247 (an agonist that does not activate homomeric D1 receptors or alter cAMP levels in other systems); 2)

248 sequence of activation of either presynaptic D1 receptors or mGluR2/3 receptors may critically regula

249 recognition performance further suggest that D1 receptors place constraints on the responsiveness of

250 Dopamine D1 receptors play an important role in movement, reward,

251 What is known is that the dopamine D1 receptor plays an important role.

252 Ablation of CK2 in D1 receptor-positive striatal neurons caused enhanced lo

253 At low cortical frequencies, dopamine D1 receptors promote glutamate release to both D1 and D2

254 healing, whereas the stimulation of dopamine D1 receptors promotes angiogenesis and expedites healing

255 eptors enabling flexible decision making and D1 receptors promoting persistence in choice biases.

256 Furthermore, in HH D1 receptor protein levels are decreased in several brai

257 hyroid hamsters (EH), HH exhibited decreased D1 receptor protein levels in carotid bodies, striatum,

258 horylated in response to dopamine acting via D1 receptor/protein kinase A (PKA) signaling.

259 the striatum correlated negatively with age (D1 receptor: R(2)=0.12, p<0.05; DAT: R(2)=0.36, p<0.001)

260 E10A radioligand (18)F-MNI-659, the dopamine D1 receptor radioligand (11)C-NNC 112, and the 5-HT2A ra

261 E10A radioligand (18)F-MNI-659, the dopamine D1 receptor radioligand (11)C-NNC 112, and the 5-HT2A ra

262 nt with a specific modulatory role of NFM in D1-receptor recycling.

263 response in the subcellular distribution of D1 receptors, resulting in alterations in signaling capa

264 A decrease in the expression or function of D1 receptors results in increased sodium retention which

265 ing, whereas optimal stimulation of dopamine D1 receptors sculpts network inputs to refine mental rep

266 STDP in MSNs expressing dopamine D1 receptors shifted from spike-timing-dependent long-te

267 sm of the oxidative stress-mediated impaired D1 receptor signaling and hypertension is not known.

268 the protective H3 receptor-mediated brake on D1 receptor signaling and prevents the cell death from e

269 Both protein kinase A and dopamine D1 receptor signaling are required for the functional ex

270 sant-like effects of stress-induced dopamine D1 receptor signaling in the mPFC.

271 Although flies deficient of D1 receptor signaling present normal turning behavior de

272 ulation by postsynaptic protein kinase A and D1 receptor signaling were determined in two distinct ag

273 The increased D1 receptor signaling, in turn, contributes to the actio

274 ng and prevents the cell death from elevated D1 receptor signaling.

275 gh considerable evidence implicates dopamine D1-receptor signaling in the nucleus accumbens in motiva

276 These results suggest that the role of D1-receptor signaling, although critical in "nonaddicted

277 authors found that modulation of D2, but not D1, receptors significantly affected rats' odor discrimi

278 energic alpha1-adrenoceptor and dopaminergic D1 receptor stimulation activate feedforward calcium-pro

279 In rodents, dopamine D1 receptor stimulation causes a complex behavioral supe

280 dynorphin-B expression mediated by dopamine D1 receptor stimulation in the development of 3,4-dihydr

281 Specifically, increasing D1 receptor stimulation strengthened Pavlovian-to-instru

282 Collectively, our findings show that D1 receptor subtype and related signaling in mPFC excita

283 mice, here we identified a role of dopamine D1 receptor subtype in mPFC excitatory neurons in suppre

284 eat stress (R-SDS) reduces the expression of D1 receptor subtype in mPFC of mice susceptible to R-SDS

285 Knockdown of D1 receptor subtype in whole neuronal populations or exc

286 refractoriness was associated with decreased D1 receptor surface expression.

287 ne-mediated disruption leaves an uninhibited D1 receptor that activates Gs, freely recruits beta-arre

288 ically or genetically, reduced the amount of D1 receptor that was internalized in response to dopamin

289 /substantia nigra, preferentially expressing D1 receptors that stimulate cAMP/cGMP synthesis.

290 -methyl-D-aspartate receptor potentiation by D1 receptor to trigger ERK1/2 activation and its subsequ

291 e of ethanol inhibition may be influenced by D1 receptor tone.

292 ors, and extends this notion by showing that D1 receptor transmission within the striatum strongly su

293 d the role of dopamine signaling through the D1 receptor via a novel pathway initiated through the cA

294 Interestingly, the dopaminergic D1 receptor was overexpressed only on the lesioned side

295 formation, and a binding pose with the human D1 receptor was proposed based on this observation.

296 CPARs and dopamine D1 receptors were required in vivo for elevated locomoti

297 We also show that a mutant dopamine D1 receptor, which has likewise been described as lackin

298 Combining the previously described D1 receptor with its putative function for activating an

299 ng GABAergic input is controlled by dopamine D1 receptors, with horizontal cells serving as a plausib

300 osphorylation of a peptide from the dopamine D1 receptor without ATP preincubation.