ライフサイエンスコーパス: D2 receptor

1 ansactivated by and associated with dopamine D2 receptor.

2 -stimulated beta-arrestin recruitment to the D2 receptor.

3 o their rapid dissociation from the dopamine D2 receptor.

4 ) over beta-arrestin recruitment at dopamine D2 receptors.

5 metabolism, and signaling downstream of the D2 receptors.

6 dominant expression of either dopamine D1 or D2 receptors.

7 it the indirect striato-cortical pathway via D2 receptors.

8 s to that effected by activation of dopamine D2 receptors.

9 erived agonists on functional selectivity at D2 receptors.

10 ffinities to serotonin 5-HT(2A) and dopamine D2 receptors.

11 000-fold and 223-fold over the rat and human D2 receptors.

12 ally determined lower density of striatal DA D2 receptors.

13 ssessments and in vitro measures of dopamine D2 receptors.

14 ding and functional activities at the D3 and D2 receptors.

15 binding and unbinding of dopamine to D1 and D2 receptors.

16 midbrain afferents acting presynaptically on D2 receptors.

17 ieved to mostly affect striatal neurons with D2 receptors.

18 cognitive functions via actions on D1 and/or D2 receptors.

19 tional selectivity relationships at dopamine D2 receptors.

20 d by the frontal lobes via actions on D1 and D2 receptors.

21 se PFC that largely lack expression of D1 or D2 receptors.

22 by their enrichment of dopamine 1 (D1) or 2 (D2) receptors.

23 ant (QAW039), an antagonist of prostaglandin D2 receptor 2, might reduce eosinophilic airway inflamma

24 mazindol), D1 receptor ([(3)H]SCH23390), and D2 receptor ([(3)H]sulpiride) binding in the dorsal stri

25 Cre BAC transgenic mice rescued the dopamine D2 receptor abnormality and multiple behavioral deficits

26 suggests that dopamine D1 or combined D1 and D2 receptor activation enhances cortical SNR to boost pe

27 In contrast, prolonged D2 receptor activation modestly reduced the tonic conduc

28 we aimed to determine the specific affect of D2 receptor activation on neuroplasticity in humans, bec

29 of cocaine effects requires simultaneous DA D2 receptor activation.

30 pecifically that dopamine D1 (or combined D1/D2) receptor activation enhances the cortical signal-to-

31 ver, it is currently unknown whether and how D2-receptor activation affects prefrontal representation

32 imaging to test the hypothesis that blocking D2-receptor activation enhances prefrontal representatio

33 the integrity of such representations, with D2-receptor activation rendering them flexible but weak.

34 ppa opioid receptor agonist U69593 decreased D2-receptor activation through both pathways, whereas th

35 ng outward currents were used as a sensor of D2-receptor activation.

36 Pharmacological manipulation of dopamine D2 receptor activity using the agonist cabergoline signi

37 e mu opioid receptor agonist DAMGO decreased D2-receptor activity only as a result of cholinergic-med

38 antipsychotic medications, which demonstrate D2 receptor affinity and elicit variable, partial clinic

39 phenidate, placebo, as well as the selective D2-receptor agent sulpiride, the latter to strengthen in

40 ules, incorporating ropinirole as a dopamine D2 receptor agonist and ZM 241385 as an adenosine A2A re

41 re, we combined application of the selective D2 receptor agonist bromocriptine (2.5, 10, and 20 mg or

42 ecently as a functionally selective dopamine D2 receptor agonist contributing potentially to the rewa

43 Combining D2 receptor agonist treatment with rM3Ds-dSPN stimulatio

44 Cocaine-induced and quinpirole (D2 receptor agonist)-induced locomotion was enhanced in

45 ct different concentrations of quinpirole, a D2 receptor agonist, into a brain slice containing the d

46 e compounds such as BIM-23A760, an sst2/sst5/D2 receptors-agonist, have emerged as promising new appr

47 ylin-induced hypophagia, as combined NAcC D1/D2 receptor agonists block the intake-suppressive effect

48 stering its precursor l-DOPA and/or dopamine D2-receptor agonists.

49 observed an 80% increase in high-affinity DA D2 receptors, an increased translocation of the dopamine

50 ias of a series of agonists for the dopamine D2 receptor and can even lead to reversals in the direct

51 83959-induced motor responses were intact in D2 receptor and Galphaq KO mice, as well as in knock-in

52 zophrenia are the gene encoding the dopamine D2 receptor and those involved in the upstream regulatio

53 reased locomotor activity, expression of the D2 receptor and tyrosine hydroxylase in brain tissue, wh

54 A multistep signaling mechanism involving D2 receptors and CX3CL1 mediates nicotine-induced increa

55 duced increases in cocaine-seeking, and that D2 receptors and CX3CL1 play a mechanistic role in these

56 s of PFC neurons that are modulated by D1 or D2 receptors and in turn interface with divergent downst

57 nsiders the microenvironment of postsynaptic D2 receptors and integrates association and dissociation

58 It displayed dual blockade of 5-HT6 and D2 receptors and negligible interactions at hERG and M1

59 confirmed their antagonism of 5-HT(7/2A) and D2 receptors and weak interactions with key antitargets

60 voltage-gated calcium channels, the dopamine D2 receptor, and complement glycoproteins.

61 vity (S2 group) or with predominant dopamine D2 receptor antagonist activity (D2 group; HBBM, 40 mg,

62 ng task under the influence of either the DA D2 receptor antagonist amisulpride (400 mg), the NMDA re

63 ty, a group of rats received the dopamine D1/D2 receptor antagonist cis-flupenthixol (0.5 mg/kg) 30 m

64 acologic PRL mobilization using the dopamine D2 receptor antagonist domperidone prevented HCC in tumo

65 examined the effect of a single dose of the D2 receptor antagonist haloperidol (2 mg) on temporal di

66 examined the effects of a single dose of the D2 receptor antagonist haloperidol on temporal discounti

67 f the dopamine precursor L-dopa, 2 mg of the D2 receptor antagonist haloperidol, and placebo.

68 he reticulospinal cell responses whereas the D2 receptor antagonist raclopride increased the response

69 s methylphenidate and sulpiride, a selective D2 receptor antagonist, increased cognitive motivation m

70 effects whereas subeffective doses of the DA D2 receptor antagonist, L-741,626, rescued cocaine's abi

71 Interestingly, 1 mum sulpiride, a D2 receptor antagonist, restored tLTP.

72 n humans, we combined sulpiride, a selective D2 receptor antagonist, with the dopamine precursor l-DO

73 t of breast cancer, and (-)-IBZM, a dopamine D2 receptor antagonist.

74 and placebo controlled administration of the D2-receptor antagonist amisulpride.

75 Interestingly, dopamine D1 and D2 receptor antagonists have opposite effects on plastic

76 These included four dopamine D2 receptor antagonists, with D2 receptors having previo

77 In the striatum, where D2 receptors are abundant, antipsychotic medications may

78 e receptors, where augmenting D1 and abating D2 receptors are engaged to balance cellular cAMP levels

79 sive odor learning per se, we here show that D2 receptors are specific for support of a consolidated

80 inds with a similar affinity to the dopamine D2 receptor as hordenine (K(i) 31.3 uM) showing also sel

81 ect is primarily due to its interaction with D2 receptors, at least at low doses.

82 We show that individual differences in DA D2 receptor availability are not consistently related to

83 h baseline (placebo) measures of striatal DA D2 receptor availability did not differ between groups,

84 itron emission tomography imaging to compare D2 receptor availability in the cortex and striatal (lim

85 le from neighboring neurons expressing D1 or D2 receptors based on their dendritic morphology and sub

86 re was a positive correlation between D1 and D2 receptor binding in the dorsal striatum of control su

87 demonstrated more significant reductions in D2 receptor binding in the salience network (insular cor

88 nectivity pattern and extrastriatal baseline D2 receptor binding potential and its change after amphe

89 concentration or are associated with reduced D2 receptor binding.

90 erbation of schizophrenia, SEP-363856, a non-D2-receptor-binding antipsychotic drug, resulted in a gr

91 In humans, D2 receptor block abolishes plasticity, and the D2/D3, b

92 r activation re-establishes plasticity under D2 receptor block.

93 These results suggest that D2-receptor blockade enhances content-specific represent

94 n searchlight decoding approach we show that D2-receptor blockade enhances decoding of reward signals

95 to a computational model we show that D1 and D2 receptors both respond to phasic and tonic dopamine s

96 omer did not directly stimulate the dopamine D2 receptor but potentiated the effects of dopamine.

97 d, SEP-363856, that does not act on dopamine D2 receptors but has agonist activity at trace amine-ass

98 isconnection approach, we reveal that D1 and D2 receptors can facilitate diverse aspects of decision

99 ional low affinity and suggest that striatal D2-receptors can encode both tonic and phasic dopamine s

100 SAR) is partly mediated by the prostaglandin D2 receptor chemoattractant receptor homologous molecule

101 Here we report that atrophy of D1, but not D2 receptor containing MSNs is strongly associated with

102 Overexpression of p11 in dopamine D2 receptor-containing LHb neurons of control mice induc

103 sibly, and selectively block dopamine D1 and D2 receptors (D1R and D2R) when the PTL was conjugated t

104 er, the sex-specific role of dopamine D1 and D2 receptors (D1R, D2R) in the deleterious effect of coc

105 majority of MSNs express either the DA D1 or D2 receptors (D1R, D2R).

106 oblast growth factor (FGF2) and the dopamine D2 receptor (D2).

107 ium spiny neurons (MSNs) expressing dopamine D2 receptors (D2-MSNs), with opposite regulation occurri

108 ion, and physiological responses to dopamine D2-receptor (D2) autoinhibition.

109 usly described a phenomenon whereby dopamine D2 receptor (D2R) activation elicits afterdepolarization

110 Aberrant dopamine D2 receptor (D2R) activity is associated with neuropsych

111 heteroarylhomopiperazines with high dopamine D2 receptor (D2R) affinity.

112 cholinergic interneurons (ChIs) by dopamine D2 receptor (D2R) agonism using ex vivo slice electrophy

113 ding protein (CREB) signaling, as well as DA D2 receptor (D2R) and protein kinase B (PKB or Akt)/glyc

114 more recent studies have shown that dopamine D2 receptor (D2R) antagonism, paired with a motor task,

115 emale rats received injections of a dopamine D2 receptor (D2R) antagonist (eticlopride), D2R agonist

116 uble-blind, placebo-controlled pharmacology [D2 receptor (D2R) antagonist amisulpride] in humans with

117 ound that prochlorperazine (PCZ), a dopamine D2 receptor (D2R) antagonist approved to treat nausea, v

118 Because many APDs are dopamine (DA) D2 receptor (D2R) antagonists, such a mechanism would be

119 opioid receptor (MOR) and decreased dopamine D2 receptor (D2R) availability in addictive disorders, t

120 se in humans is associated with low dopamine D2 receptor (D2R) availability in the striatum.

121 Altered dopamine D2 receptor (D2R) binding in the striatum has been assoc

122 aberrant motor learning induced by dopamine D2 receptor (D2R) blockade in mice.

123 ss beta-arrestin-biased agonists of dopamine D2 receptor (D2R) by extensively exploring multiple regi

124 Evidence indicating an increase in dopamine D2 receptor (D2R) density and occupancy in patients with

125 69652 (1) engages one protomer of a dopamine D2 receptor (D2R) dimer in a bitopic mode to allosterica

126 a bitopic pose at one protomer of a dopamine D2 receptor (D2R) dimer to negatively modulate the bindi

127 th validation in GPCR structure and dopamine D2 receptor (D2R) function.

128 The dopamine D2 receptor (D2R) has received much attention in obesity

129 Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators of stria

130 with cell-specific ablation of the dopamine D2 receptor (D2R) in the striatal medium spiny neurons (

131 The dopamine D2 receptor (D2R) is a G protein-coupled receptor (GPCR)

132 The dopamine D2 receptor (D2R) is a G protein-coupled receptor that i

133 The dopamine D2 receptor (D2R) is a major component of the dopamine s

134 The dopamine (DA) D2 receptor (D2R) is an important target for the treatme

135 is supported by decreased available dopamine D2 receptor (D2R) levels and the failure of antipsychoti

136 The dopamine D2 receptor (D2R) mediates ligand-biased signaling with

137 Striatal dopamine D2 receptor (D2R) relies upon G protein- and beta-arrest

138 Here we report that the modulation of DA D2 receptor (D2R) signaling bidirectionally regulates th

139 s and determined if these related to central D2 receptor (D2R) specific binding independent of BMI.

140 enhance motor function, the global effect of D2 receptor (D2R) stimulation or blockade remains highly

141 ed medications target primarily the dopamine D2 receptor (D2R) to inhibit G(i/o)-mediated adenylyl cy

142 ulator dopamine signals through the dopamine D2 receptor (D2R) to modulate central nervous system fun

143 ortem studies suggest impaired dopamine (DA)-D2 receptor (D2R) trafficking in patients with schizophr

144 The dopamine D2 receptor (D2R), like many G-protein-coupled receptors

145 e G-protein-coupled receptor (GPCR) dopamine D2 receptor (D2R), regulating its internalization and su

146 eceptor family comprises three subtypes: the D2 receptor (D2R), with short and long isoform variants

147 ely delete GRK2 in DA D1 receptor (D1R)-, DA D2 receptor (D2R)-, adenosine 2A receptor (A2AR)-, or DA

148 e hypothesized that striatopallidal dopamine D2 receptor (D2R)-expressing neurons promote avoidance,

149 advantages to ligands targeting the dopamine D2 receptor (D2R).

150 ce homology between the D3R and the dopamine D2 receptor (D2R).

151 Striatal dopamine D2 receptors (D2R) are major regulators of motor activit

152 ble antipsychotic drugs (APDs) bind dopamine D2 receptors (D2R) at therapeutic concentrations, and it

153 tum, and both sweet preferences and striatal D2 receptors (D2R) decline with age and may be altered i

154 In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal striatum (DS) and the n

155 The role of dopamine D1 receptors (D1R) and D2 receptors (D2R) in the ERG responses was evaluated in

156 we found that CaMKIIalpha binds to dopamine D2 receptors (D2R) in vitro.

157 MSNs expressing dopamine D1 (D1R-MSN) vs. D2 receptors (D2R-MSN) can exert antagonistic effects in

158 Blocking dopamine D2-receptors (D2R) altered generalization behavior as re

159 Striatal DA D2 receptors (D2Rs) also regulate reinforcement learning

160 Striatal dopamine D2 receptors (D2Rs) are important for motor output.

161 Because dopamine D2 receptors (D2Rs) are involved in spatial cognition an

162 ct that in deep layers of the mPFC, dopamine D2 receptors (D2Rs) are mainly expressed by SC neurons,

163 Here we show that selective deletion of DA D2 receptors (D2Rs) from indirect-pathway medium spiny n

164 ibed to D2Rs.SIGNIFICANCE STATEMENT Dopamine D2 receptors (D2Rs) in the prefrontal cortex (PFC) are t

165 at selectively and reversibly overexpress DA D2 receptors (D2Rs) in the striatum (D2R-OE mice).

166 Low availability of dopamine (DA) D2 receptors (D2Rs) in the striatum is associated with h

167 Activation of axonal dopamine D2 receptors (D2Rs) increases action potential (AP) thre

168 Dopamine D2 receptors (D2Rs) suppress lateral inhibition from iMS

169 Although partial agonists at DA D2 receptors (D2Rs), like aripiprazole, were developed t

170 that express dopamine D1 receptors (D1Rs) or D2 receptors (D2Rs), which drive "Go" or "No-Go" behavio

171 of adult mice that is regulated by dopamine D2 receptors (D2Rs).

172 Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopa

173 rast, A1 allele carriers, who have decreased D2 receptor density, show a positive association between

174 dation homologue FXR1 and regulates dopamine D2 receptor density.

175 ontal cortex of awaken mice induces dopamine D2 receptor dependent persistent changes of CDK5 and PSD

176 However, the cocaine-induced plasticity of D2 receptor desensitization observed in wild type mice w

177 ligands also resulted in a large increase in D2 receptor dimers.

178 lso increased the expression of the dopamine D2 receptor, dopamine transporter, and adenosine A1 rece

179 (AGN 211377), that antagonizes prostaglandin D2 receptors (DPs) DP1 (49) and DP2 (558), prostaglandin

180 We have previously identified a dopamine D2 receptor (DRD2) coexpression module enriched for SCZ

181 omized clinical trials of a new class of non-D2-receptor drugs, based on opioid mechanisms, for the t

182 tent with markedly reduced signaling through D2 receptors during intoxication in active cocaine abuse

183 ors within the prefrontal cortex (PFC), with D2 receptors enabling flexible decision making and D1 re

184 ms of schizophrenia by antagonizing dopamine D2 receptors expressed by striatal spiny projection neur

185 ic spine morphology specifically in dopamine D2 receptor expressing MSNs (D2-MSNs).

186 PrL, p11 is highly concentrated in dopamine D2 receptor-expressing (D2(+)) glutamatergic neurons.

187 eptors on dopamine D1 receptor- and dopamine D2 receptor-expressing medium spiny neurons in the nucle

188 ne (cNIC) on synaptic plasticity in dopamine D2 receptor-expressing medium-spiny neurons in the indir

189 eurotransmission blocking technique in D1 or D2 receptor-expressing NAc neurons, respectively (D1-RNB

190 Here, we selectively stimulated D1 or D2 receptor-expressing neurons while visualizing whole-b

191 ns (NAc) output neuron types, dopamine D1 or D2 receptor-expressing neurons, dynamically control the

192 vidence for the opposing influence of D1 and D2 receptor-expressing striatal neurons on brain-wide ci

193 enic mice, we found that dopamine subtype 2 (D2) receptor-expressing medium spiny neurons (MSNs) are

194 amine subtype 1 (D1) and dopamine subtype 2 (D2) receptor-expressing striatal medium spiny neurons (M

195 pulation-level Ca(2+) activities of dopamine D2-receptor-expressing medium spiny neurons (D2-MSNs), o

196 paraventricular nucleus of the thalamus and D2-receptor-expressing medium spiny neurons via synaptic

197 We demonstrate that both dopamine D1- and D2-receptor-expressing MSNs (D-MSNs) additionally harbor

198 s in signaling processes in dopamine D1- and D2-receptor-expressing neurons using drd2-eGFP mice, and

199 y, and to relate its projection pattern with D2 receptor expression in particular.

200 ion is bi-directional, and that low striatal D2 receptor expression may represent a predisposing fact

201 erta, as well as the organization of D1- and D2-receptor expression in the SC.

202 ivo cocaine exposure, the desensitization of D2 receptors from neurons expressing only the D2S varian

203 ed NMDA currents in pyramidal cells, whereas D2 receptor function was unaltered.

204 pharmacological inhibition of dopamine D1 or D2 receptors, GABAA or GABAB receptors, NMDA receptors,

205 A SNP (rs17601612) in the dopamine D2 receptor gene (DRD2) was significantly associated wit

206 ms, rs2283265 and rs1076560, in the dopamine D2 receptor gene (DRD2) were found to be significantly a

207 ings imply that future studies investigating D2 receptor genes should covary for genetic ancestry or

208 y, suppression of GABAergic transmission via D2 receptor-glycogen synthase kinase-3beta signaling dra

209 In contrast, quinpirole (an agonist at D2 receptors) had no significant effect on the capsaicin

210 The dopamine D2 receptor has two splice variants, D2S (Short) and D2L

211 We show that blockade of dopamine D2 receptors has profound effects on the functional conn

212 duced FAA, whereas mice lacking the dopamine D2 receptor have normal FAA.

213 In particular, dopamine D1 and D2 receptors have been proposed to form hetero-oligomers

214 four dopamine D2 receptor antagonists, with D2 receptors having previously been suggested to regulat

215 a signaling-deficient form of human dopamine D2 receptor (hD2R).

216 preference formation: it decreased OT and DA D2 receptor immunoreactivity in the medial prefrontal co

217 st sulpiride with genetic analysis of the DA D2 receptor in a behavioral study of reinforcement learn

218 date for a causal modulatory role of the DA D2 receptor in choice performance that might be distinct

219 stimulation of JNK also inactivates dopamine D2 receptors in a PRDX6-dependent manner.

220 f D2 receptors to DANs or CINs revealed that D2 receptors in CINs mediate a fast inhibition observed

221 thways are modulated through dopamine D1 and D2 receptors in lamprey and in mammals.

222 models emphasizing a role of postsynaptic DA D2 receptors in motivational aspects of reinforcement le

223 tter results demonstrate that blockade of DA D2 receptors in mPFC or activation of 5-HT1A receptors i

224 ntify a surrogate biomarker for the Dopamine D2 receptors in the brain by comparing patients diagnose

225 ts demonstrate a role of DMS dopamine D1 and D2 receptors in the incubation of methamphetamine cravin

226 e different kinetics and abundance of D1 and D2 receptors in the striatum.

227 dendritic calcium signals in the presence of D2-receptor inhibition.

228 mulation of dopamine terminals evoked robust D2-receptor inhibitory postsynaptic currents (IPSCs) in

229 manner and a PKC inhibitor blocked dopamine D2 receptor internalization.

230 Likewise, the D2 receptor is expressed in the striatum, but little is

231 nist-induced internalization of the dopamine D2 receptor is regulated by the receptor tyrosine kinase

232 btypes, those enriched in dopamine D1 versus D2 receptors, is implicated in the behavioral responses

233 Together with the dopamine D2 receptor it is highly expressed in striatal cholinerg

234 s study we used viral receptor expression in D2 receptor knockout mice to show distinct effects of ca

235 pressing the isoforms in dopamine neurons of D2 receptor knockout mice, this study assessed the calci

236 nalysis of tyrosine hydroxylase and dopamine D2 receptor levels.

237 that of unliganded receptors, agonist-bound D2 receptor-ligand complexes resulted in an increase in

238 Addition of bivalent D2 receptor ligands also resulted in a large increase in

239 Thus, optimizing binding kinetics at the D2 receptor may result in APDs with improved therapeutic

240 ificant somatodendritic release detected via D2 receptor-mediated currents.

241 vel findings on a possible interplay between D2 receptor-mediated dopamine signaling involved in trea

242 lin-8-ol) is a highly efficacious agonist at D2 receptor-mediated G protein-linked signaling, but doe

243 e ventral tegmental area, the time course of D2-receptor-mediated IPSCs (D2-IPSCs) was consistent bet

244 ce, but they do exhibit clear alterations to D2-receptor-mediated short-term synaptic plasticity, beh

245 sk taking was associated with lower striatal D2 receptor mRNA expression, and pharmacological activat

246 ous work has shown opposing roles for D1 and D2 receptor MSN subtypes in depression-like outcomes to

247 The stimulation of dopamine D2 receptors negatively regulates the angiogenic process

248 estigations of bivalent ligands for dopamine D2 receptor/neurotensin NTS1 receptor (D2R/NTS1R) hetero

249 herapeutic functional adaptation to dopamine D2 receptor occupancy required for medication effects on

250 ine levels rather than insufficient dopamine D2 receptor occupancy.

251 d lack of agonist-induced internalization of D2 receptors on dopamine neurons indicate a purposefully

252 Together, the results indicate that D2-receptors on MSNs exhibit functional low affinity and

253 To examine how dopamine release activates D2-receptors on MSNs, G protein activated inwardly recti

254 Antagonism of GABA(B) receptors or dopamine D2 receptors partially reversed the reduction in alcohol

255 oration at baseline, whereas CK2 ablation in D2 receptor-positive neurons caused increased locomotion

256 consistent with the cortical distribution of D2 receptors, post hoc analyses showed enhanced decoding

257 stimulated by D1 receptors and inhibited by D2 receptors preferentially expressed in striatoentopedu

258 ing are tightly regulated by dopamine D1 and D2 receptors present in basal ganglia circuits.

259 Dopamine D2 receptor-promoted activation of Galpha(o) over Galpha

260 s accumbens, even in neurons in which D1 and D2 receptor promoters are both active, the receptor prot

261 BL/6J) animals were imaged with the dopamine D2 receptor radioligand (11)C-raclopride, the PDE10A rad

262 BL/6J) animals were imaged with the dopamine D2 receptor radioligand (11)C-raclopride, the PDE10A rad

263 sitron emission tomography with the dopamine D2 receptor radiotracer carbon 11-labeled FLB457 before

264 substance abuse disorders may share dopamine D2 receptor-related vulnerabilities, and opposite findin

265 ermore, these findings suggest that striatal D2 receptors represent a therapeutic target for attenuat

266 pallidal SPNs, which express dopamine D1 and D2 receptors, respectively.

267 mate and dopamine transmission, and aberrant D2-receptor responses.

268 d a more serial processing mode, whereas the D2 receptors seem to promote a shift in the opposite dir

269 ified an increase in dopamine binding at the D2 receptor selectively in the striatum.

270 for sucrose reward, blockade of either D1 or D2 receptors selectively attenuates excitation, but not

271 cal studies identified a deficit in dopamine D2 receptor signaling in the BLA of Lmo4-deficient mice.

272 Our findings suggest that both D1 and D2 receptor signaling regulate motor cortex plasticity,

273 We further discovered that dopamine D1 and D2 receptor signaling selectively and distinctly regulat

274 ity can be dynamically modulated by dopamine D2 receptor signaling.

275 to investigate cocaine-induced plasticity in D2 receptor signaling.

276 onstrated the involvement of dopamine D4 and D2 receptor subtypes in the effects of pramipexole.

277 treated with ACEA, binding of haloperidol to D2 receptors switched CB1 coupling from Galphai to Galph

278 functional consequence of dopamine release, D2-receptor synaptic activity was assessed via virally o

279 riers, who have a higher striatal density of D2 receptors than C-allele carriers, we found a less eff

280 e segment (residues 212-215) of the dopamine D2 receptor that is necessary for arrestin binding in an

281 1 is an oral antagonist of the prostaglandin D2 receptor that may inhibit recruitment and activation

282 o globus pallidus, preferentially expressing D2 receptors that inhibit cAMP/cGMP synthesis.

283 In MSNs presumably expressing dopamine D2 receptors, tLTP, the main form of plasticity in naive

284 and residue pairs that, when switched in the D2 receptor to the corresponding residues from 5-HT2A, a

285 eriments with mice with targeted deletion of D2 receptors to DANs or CINs revealed that D2 receptors

286 This study used tagged D2 receptors to identify the localization and distributi

287 results indicate that ALK regulates dopamine D2 receptor trafficking, which has implications for psyc

288 al, and anatomical consequences of selective D2 receptor upregulation in the striatum.

289 coupling to homomers or heteromers of D1 or D2 receptors using a variety of biosensors.

290 dopamine function--dopamine transporter and D2 receptors--was significantly associated with the lear

291 the highly therapeutically relevant dopamine D2 receptor, we synthesized a collection of agonists bas

292 When tagged D2 receptors were expressed in locus coeruleus neurons,

293 GFP-tagged D2 receptors were found to be unevenly clustered on the

294 nexpectedly, upon desensitization the tagged D2 receptors were not internalized.

295 f positive symptoms through antagonism of DA-D2 receptors, whereas D-Govadine improves impairments in

296 cated, the dorsal striatum, rich in dopamine D2 receptors, which are antagonized by antipsychotic med

297 cell types, those expressing dopamine D1 or D2 receptors, which exert opposing roles on motivated be

298 iny neurons (MSNs) expressing dopamine D1 or D2 receptors, which form direct and indirect pathways, r

299 correlate with drug association rates to the D2 receptor, while dissociation rates correlate with pro

300 es that potently antagonize 5-HT(6/7/2A) and D2 receptors, without interacting with M1 receptors and