ライフサイエンスコーパス: DESI

1 DESI enabled the direct, rapid, native state interrogati

2 DESI-MS enables rapid characterization of OA samples col

3 DESI-MS high throughput experimentation (HTE) reaction e

4 DESI-MS imaging allowed clear visualization of endometri

5 DESI-MS imaging and IHC experiments confirmed that the s

6 DESI-MS imaging enabled clear visualization of fine papi

7 DESI-MS imaging is therefore possible for tumors for whi

8 DESI-MS imaging revealed that FTHA uptake in tumors was

9 DESI-MS imaging was carried out on 36 human glioma sampl

10 DESI-MS offers unique advantages both for detailed chara

11 DESI-MS was employed as a high throughput experimentatio

12 DESI-MS was performed on sections of kidneys from 80 mic

13 DESI-MS was used to analyze 178 tissue samples to determ

14 DESI-MSI has the potential to be a diagnostic tool for p

15 DESI-MSI using an Orbitrap mass analyzer in full scan mo

16 in a glioblastoma xenograft tumour using 3D DESI-MS imaging.

17 To this end, a DESI interface and a custom holder accommodating SPME pr

18 ed segmentation imaging analysis of acquired DESI-IMS data reveals distinct chemical regions correspo

19 between reactions performed under analogous DESI-MS, batch, and microfluidic reaction conditions.

20 ttributed to differences between the ESI and DESI ionization processes.

21 ogeneity of this xenograft tumour model, and DESI-MS imaging can be used for lipid 3D imaging in an a

22 Dual PIRL-MS and DESI-MS imaging of consecutive sections, as suggested by

23 aine could be constructed using ToF-SIMS and DESI-MS, as the signals of methamphetamine and heroin we

24 We applied DESI-MS to identify candidate metabolic biomarkers assoc

25 , that ambient ionization techniques such as DESI-MS and LESA-MS have great potential for species-spe

26 nge of chemicals by simple switching between DESI, voltage-free EASI, or LTP ionization as well as to

27 dy shows that the metabolic data acquired by DESI-MS imaging in conjunction with statistical modeling

28 arious ovarian tissue types were analysed by DESI-MSI and co-registered with their corresponding haem

29 ts were subjected to peptidomics analysis by DESI-MS and LESA-MS.

30 ght the potential of direct swab analysis by DESI-MS for a wide range of clinical applications includ

31 good alternative for dried spot analysis by DESI-MS, improving stability of the signal and the LODs.

32 surface can then subsequently be analyzed by DESI but also by many other techniques such as gas chrom

33 mounted on a rotating device and analyzed by DESI MS using an optimized protocol considering swab-inl

34 d the crude extract was directly analyzed by DESI-MS, with a total turnaround time of less than 10 mi

35 tomy specimens were examined and analyzed by DESI-MSI.

36 hosphatidyl choline species, corroborated by DESI-MS, which again revealed heterogeneous phospholipid

37 liomas into normal tissue can be detected by DESI-MS.

38 eir derivatives are successfully detected by DESI-MSI, with a strong correlation of the spatial produ

39 tions, the sequence coverages, determined by DESI-MS, were 100% for melittin, 100% for cytochrome c,

40 n, removed, rinsed, and analyzed directly by DESI-MS (MS/MS).

41 the largest protein successfully ionized by DESI to date.

42 rat brain, 23 of which were not observed by DESI alone.

43 e that the molecular information obtained by DESI-MSI/Lasso from pancreatic tissue samples has the po

44 tients, margins were found to be positive by DESI-MSI/Lasso, but negative by frozen section analysis.

45 lipid and metabolite MS profiles recorded by DESI-MS and explored using multivariate statistics allow

46 e directly analyzed from the sample spots by DESI-MS, using a commercial rotating sample platform.

47 We accomplish this by combining DESI-MSI with immunofluorescence staining using specific

48 his unique, label-free approach of combining DESI-MSI with the ability to turn specific genes on and

49 Comparing DESI-MS imaging with biological staining allowed associa

50 a analysis pipelines already established for DESI-MS imaging, and was further validated in cancer mar

51 equentially injected as a segmented flow for DESI ionization.

52 Adjacent sections to those used for DESI-MS imaging were used for H&E staining and immunoflu

53 was unperturbed by morphologically-friendly DESI-MS analysis while allowing detection of a wide rang

54 Statistical models built from DESI-MS imaging data allowed classification of endometri

55 molecular information obtained directly from DESI-MSI.

56 gins delineated by the molecular images from DESI-MSI were consistent with those margins obtained fro

57 Quantifications from DESI-MSI revealed 0.2-1.2 ng of clozapine in individual

58 Further DESI-MS imaging of the flux of the contrast agent throug

59 Global DESI MSI models were able to distinguish adipose, stroma

60 n rate, allowing tissue polarimetry to guide DESI-MS analysis for rapid MS profiling or targeted MS i

61 sorption electrospray ionization MS imaging (DESI-MSI), specific changes in lipogenesis and specific

62 spray ionization mass spectrometric imaging (DESI-MSI), for 62 banked human cancerous and normal gast

63 ospray ionization mass spectrometry imaging (DESI MSI), both as a novel diagnostic tool and as a meth

64 ospray ionization-mass spectrometry imaging (DESI-MSI) facilitates the convergence of analytical chem

65 ospray ionization mass spectrometry imaging (DESI-MSI) for identifying and differentiating tumor from

66 tion electrospray mass spectrometry imaging (DESI-MSI) generates spatially resolved metabolic profile

67 ospray ionization-mass spectrometry imaging (DESI-MSI) gives a new perspective on the important role

68 ospray ionisation-mass spectrometry imaging (DESI-MSI) is a powerful imaging technique for the analys

69 ospray ionization mass spectrometry imaging (DESI-MSI) on 54 banked human cancerous and normal prosta

70 ospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of gen

71 ospray ionization-mass spectrometry imaging (DESI-MSI) was applied to latent fingerprints to obtain n

72 ospray ionization mass spectrometry imaging (DESI-MSI) with the least absolute shrinkage and selectio

73 ospray ionization mass spectrometry imaging (DESI-MSI), statistical analysis, and conditional transge

74 ospray ionization-mass spectrometry imaging (DESI-MSI).

75 der to verify the reliability of the imprint-DESI-MS imaging data and evaluate the capability of tape

76 Using imprint-DESI-MS imaging we annotated the secondary metabolites r

77 In DESI-MSI, microdroplets strike the tissue sample, the re

78 ts indicate that the optimized conditions in DESI are a compromise between those conditions that are

79 d the limits of detection (LODs) observed in DESI-MS.

80 spray desorption mechanism that operates in DESI can be used as a general technique to collect solub

81 Intraoperative DESI-MS analysis of tissue smears, ex vivo, can be inser

82 Intraoperative DESI-MS measurements made at surgeon-defined positions e

83 ndation for implementation of intraoperative DESI-MS evaluation of tissue smears for rapid diagnosis.

84 cules by desorption electrospray ionization (DESI) - MS of a complete swine fetus at 50 days of gesta

85 ing both desorption electrospray ionization (DESI) and easy ambient sonic-spray ionization (EASI) wit

86 ility of desorption electrospray ionization (DESI) and its various configurations for rapid and high-

87 ation of desorption electrospray ionization (DESI) and liquid-microjunction surface sampling probe (L

88 I) using desorption electrospray ionization (DESI) and matrix assisted laser desorption ionization (M

89 (MALDI), desorption electrospray ionization (DESI) and secondary ion mass spectrometry (SIMS).

90 Desorption electrospray ionization (DESI) coupled to high-resolution Orbitrap mass spectrome

91 Desorption electrospray ionization (DESI) directly analyzes soluble chemical components pres

92 such as desorption electrospray ionization (DESI) eliminate necessary sample preparation but suffer

93 Desorption electrospray ionization (DESI) has emerged as a powerful technique for mass spect

94 we apply desorption electrospray ionization (DESI) mass spectrometry (MS) imaging to chemically and s

95 we used desorption electrospray ionization (DESI) mass spectrometry (MS) to image and chemically cha

96 ion from desorption electrospray ionization (DESI) mass spectrometry, where the sampling time is on t

97 based on desorption electrospray ionization (DESI) MS for the label-free study of enzymatic reactions

98 r online desorption electrospray ionization (DESI) MS imaging of FA isomers from human tissue section

99 coupling desorption electrospray ionization (DESI) MS with a waterwheel working electrode setup to sa

100 e, using desorption electrospray ionization (DESI) MS, we rapidly detect the tumor metabolite 2-hydro

101 ility in desorption electrospray ionization (DESI) MSI, which enables cell-type-specific and in situ

102 using a desorption electrospray ionization (DESI) source coupled to a mass spectrometer.

103 Ambient desorption electrospray ionization (DESI) technique is uniquely suited for such imaging expe

104 used for desorption electrospray ionization (DESI) were optimized to achieve biocompatibility for cli

105 Desorption electrospray ionization (DESI), easy ambient sonic-spray ionization (EASI) and lo

106 ESI) and desorption electrospray ionization (DESI), hyphenated with miniaturized high-field asymmetri

107 (DART), desorption electrospray ionization (DESI), or low-temperature plasma (LTP), the desorption o

108 s study, desorption electrospray ionization (DESI)-mass spectrometry (MS) imaging was applied to stud

109 ns using desorption electrospray ionization (DESI)-MS revealed phospholipid-derived signals that diff

110 Desorption electrospray ionization (DESI)-MSI defined regions of a hypoxic core and a prolif

111 ation by desorption electrospray ionization (DESI).

112 ues like desorption electrospray ionization (DESI).

113 Desorption ES ionization (DESI) MS has however transformed the study of tissue sur

114 new in-line LS DESI MS system, in angled LS DESI MS, and in electrospray ionization (ESI) MS, which

115 sity was higher in in-line than in angled LS DESI MS.

116 S containing electrolytes was simplest by LS DESI MS.

117 In online electrochemistry (EC)/LS DESI MS, when 0 V was applied to the EC cell Tyr ion sig

118 Ion signals in a new in-line LS DESI MS system, in angled LS DESI MS, and in electrospra

119 solution flow rates was tested in in-line LS DESI MS.

120 desorption ionization mass spectrometry (LS DESI MS), supplied continuously through a LS interface s

121 ual (observation) of the operation of the LS DESI MS system showed a thick spray plume generated by t

122 All of the measured DESI mass spectra (in both positive and negative ion mod

123 y (LC-ESI-MS) via unmediated sampling by MMS DESI-IMS.

124 used desorption electrospray ionization-MSI (DESI-MSI) and bespoke chemometrics to assess the phospho

125 Nano-DESI enables rapid screening of different classes of com

126 Nano-DESI is a new ambient pressure ionization technique that

127 able performance to the capillary-based nano-DESI MSI in terms of stability and sensitivity; a spatia

128 nt of the spatial resolution offered by nano-DESI imaging combined with high detection efficiency wil

129 s and metabolites in tissue sections by nano-DESI imaging.

130 ntegrated microfluidic probe (iMFP) for nano-DESI MSI.

131 y ionization mass spectrometry imaging (nano-DESI MSI) was used to characterize the molecular speciat

132 However, lipid coverage obtained in nano-DESI mass spectrometry imaging (MSI) experiments has not

133 90% methanol/10% water mixture used in nano-DESI MSI experiments.

134 is work, the depth of lipid coverage in nano-DESI MSI of mouse lung tissues was compared to liquid ch

135 of 22 endogenous PC species observed in nano-DESI MSI.

136 ominantly observed as sodium adducts in nano-DESI spectra indicating that addition of sodium to the s

137 In nano-DESI, analyte is desorbed into a solvent bridge formed b

138 ray desorption electrospray ionization (nano-DESI) and direct infusion electrospray ionization (ESI)

139 ray desorption electrospray ionization (nano-DESI) and other ambient ionization mass spectrometry tec

140 ray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry (H

141 ray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry wa

142 ray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry wa

143 ray desorption electrospray ionization (nano-DESI) combined with tandem mass spectrometry (MS/MS), hi

144 ray desorption electrospray ionization (nano-DESI) has enabled the robust imaging of tissue sections

145 ray desorption electrospray ionization (nano-DESI) is an ambient MSI technique where a solvent is use

146 ray desorption electrospray ionization (nano-DESI) mass spectrometry, an ambient ionization technique

147 ray desorption electrospray ionization (nano-DESI) was developed by integrating a shear-force probe w

148 using nanospray desorption ionization (nano-DESI).

149 ray desorption electrospray ionization (nano-DESI).

150 ray desorption electrospray ionization, nano-DESI, is a new ambient technique that enables spatially

151 The constant-distance mode nano-DESI MSI enabled imaging of many metabolites, including

152 f positive and negative ionization mode nano-DESI MSI identified 265 unique lipids across 20 lipids s

153 Based on this effort, constant-mode nano-DESI MSI proved to be ideally suited for imaging biologi

154 e experiments indicate the potential of nano-DESI for ambient imaging with a spatial resolution of be

155 We demonstrate the utility of nano-DESI imaging for sensitive detection of the drug in tiss

156 A combination of nano-DESI MSI and LC-MS/MS lipidomics is particularly useful

157 hese results demonstrate the utility of nano-DESI MSI for comprehensive spatially resolved analysis o

158 nds in the ionization process, reactive nano-DESI analysis enables quantification of individual compo

159 ed as the working solvents for reactive nano-DESI analysis.

160 unds to examine the utility of reactive nano-DESI for the analysis of complex organic mixtures.

161 Our results indicate that reactive nano-DESI is a valuable approach for examining the presence o

162 tonitrile/toluene is used as a solvent, nano-DESI generates electrospray-like spectra.

163 cept for triacylglycerols (TG) species, nano-DESI MSI provided comparable coverage to LC-MS/MS experi

164 ctrospray ionization mass spectrometry (nano-DESI/HRMS), and ultrahigh resolution and mass accuracy 2

165 The results demonstrate that nano-DESI analysis efficiently ionizes petroleum constituents

166 o-DESI MSI platform, fabrication of the nano-DESI and shear force probes, shear force microscopy expe

167 system enables robust operation of the nano-DESI imaging source over many hours by precisely control

168 e provide a detailed description of the nano-DESI MSI platform, fabrication of the nano-DESI and shea

169 between two capillaries comprising the nano-DESI probe and the solid analyte for controlled desorpti

170 formed by scanning the sample under the nano-DESI probe at 10 mum/s, while higher-energy collision-in

171 However, the fabrication of the nano-DESI probe is challenging, which limits its disseminatio

172 the distance between the sample and the nano-DESI probe.

173 ntegrating a shear-force probe with the nano-DESI probe.

174 holine (PC) standards were added to the nano-DESI solvent for simultaneous imaging and quantification

175 ically labeled standard is added to the nano-DESI solvent to compensate for matrix effects and ion su

176 Doping the nano-DESI solvent with carefully selected standards enables o

177 The nano-DESI technique possesses distinct advantages of technica

178 plexes we report the development of a native DESI platform.

179 Overall therefore we introduce this native DESI platform with the potential for high-throughput lig

180 alysts has been well-studied, the ability of DESI to intercept intermediates formed in the first few

181 edge, this study is the first application of DESI-MSI to the study of complex and porous mineral surf

182 pes of RCC was also achieved on the basis of DESI-MS imaging data.

183 easured intact, indicating the capability of DESI for preserving weak noncovalent interactions.

184 nseen samples demonstrates the capability of DESI-MSI to characterise ovarian samples and to overcome

185 sample pretreatment, and the hyphenation of DESI with the miniaturized FAIMS enhanced the relative a

186 One hurdle to implementation of DESI-MS intraoperatively is the need for tissue freezing

187 issue smears by comparison with a library of DESI mass spectra of pathologically determined tissue ty

188 ples significantly extends the mass range of DESI-MS, allowing the analysis of high-mass proteins suc

189 mes the relatively low spatial resolution of DESI-MSI and provides a new platform for in situ metabol

190 Synchronization of DESI (sDESI) with the ion injection period (IT)of low-du

191 Generally, synchronization of DESI with IT improves performance and expands the range

192 Our results show that synchronization of DESI with the IT of an LTQ Orbitrap-XL mass spectrometer

193 ains in mass resolution and/or throughput of DESI-MSI on an FT-ICR MS by developing and implementing

194 The clinical translation of DESI-MS into a universal label-free imaging technique th

195 long-term benefits to patients of the use of DESI-MSI for surgical margin evaluation is also needed t

196 These results corroborate the utility of DESI-MS in assessing surgical margins for maximal safe t

197 , liquid sample DESI, an extended version of DESI used for analysis of liquid samples, was shown to h

198 achieved with an accuracy of 98.2% based on DESI MSI data (PPV 0.96, NVP 1, specificity 0.96, sensit

199 Reactive DESI-MS imaging in positive ion mode of rat brain and ze

200 fish tissues were investigated with reactive DESI-MS in which the dictation forms a stable bond with

201 detected in positive ion mode with reactive DESI-MS with enhanced signal intensity.

202 This type of "reactive" DESI methodology can provide rapid information on bindin

203 High-resolution DESI-MS analysis demonstrated that chemical aging result

204 Liquid sample DESI allows the direct formation of intact protein-ligan

205 Liquid sample DESI of hydrophobic peptide gramicidin D suggests that t

206 method for ligand screening by liquid sample DESI was demonstrated, in which different ligands were s

207 bin) desorbed from solution by liquid sample DESI were measured intact, indicating the capability of

208 In this study, liquid sample DESI, an extended version of DESI used for analysis of l

209 investigate the application of liquid sample DESI-MS to probe protein-ligand interactions.

210 charge can be integrated with liquid sample DESI-MS, without interfering with the formation of prote

211 Membrane scaffolded DESI-IMS has inherent advantages compared to matrix-assi

212 membrane surfaces, demonstrated by specific DESI MS signatures.

213 n electrospray ionization mass spectrometry (DESI MS) measurements has been conducted with the involv

214 n electrospray ionization mass spectrometry (DESI MS), where ion formation occurs in ambient conditio

215 n electrospray ionization mass spectrometry (DESI MS)-based molecular analysis and imprint imaging us

216 ospray ionization-imaging mass spectrometry (DESI-IMS) using microporous membrane scaffolds (MMS) ena

217 n electrospray ionization mass spectrometry (DESI-MS) analysis.

218 n electrospray ionization mass spectrometry (DESI-MS) and liquid extraction surface analysis mass spe

219 n electrospray ionization mass spectrometry (DESI-MS) and nanoDESI-MS.

220 n electrospray ionization mass spectrometry (DESI-MS) as a tool for predicting the outcome of microfl

221 n electrospray ionisation mass spectrometry (DESI-MS) can image hundreds of molecules in a 2D tissue

222 ined with high-resolution mass spectrometry (DESI-MS) for detailed chemical characterization and stud

223 n electrospray ionization mass spectrometry (DESI-MS) for unidimensional investigation of the heterog

224 n electrospray ionization-mass spectrometry (DESI-MS) has advantages for rapid sample analysis with l

225 n electrospray ionization mass spectrometry (DESI-MS) has demonstrated potential for intraoperative t

226 n electrospray ionization mass spectrometry (DESI-MS) imaging for direct analysis and diagnosis of fo

227 n Electrospray Ionization Mass Spectrometry (DESI-MS) imaging interface for dual imaging of Picosecon

228 n Electrospray Ionization Mass Spectrometry (DESI-MS) imaging validated with statistical analysis and

229 n electrospray ionization mass spectrometry (DESI-MS) imaging was applied to analyze the lipid profil

230 n electrospray ionization-mass spectrometry (DESI-MS) imaging, multivariate statistical analysis, and

231 n electrospray ionization mass spectrometry (DESI-MS) imaging.

232 n electrospray ionization mass spectrometry (DESI-MS) in combination with online reaction monitoring.

233 n electrospray ionization-mass spectrometry (DESI-MS) is able to measure large proteins and noncovale

234 n electrospray ionization mass spectrometry (DESI-MS) is an emerging analytical tool for rapid in sit

235 n electrospray ionization mass spectrometry (DESI-MS) is applied to study common lithium ion battery

236 n electrospray ionization mass spectrometry (DESI-MS) is assessed, as the sprayer is thought to be a

237 n electrospray ionization mass spectrometry (DESI-MS) is quite challenging.

238 n electrospray ionization-mass spectrometry (DESI-MS) is used to characterize tissue smears by compar

239 n electrospray ionization mass spectrometry (DESI-MS) revealed several key intermediates in the propo

240 n electrospray ionization mass spectrometry (DESI-MS) to image and chemically characterize the lipid

241 n electrospray ionization mass spectrometry (DESI-MS) was demonstrated.

242 n electrospray ionization mass spectrometry (DESI-MS) was used.

243 n electrospray ionization mass spectrometry (DESI-MS) with a stable dication on biological tissues.

244 n electrospray ionization mass spectrometry (DESI-MS), but such techniques have been almost exclusive

245 n electrospray ionization-mass spectrometry (DESI-MS), nonimaging MS, and transcriptomic analyses to

246 n electrospray ionization mass spectrometry (DESI-MS), the type of surface in addition to low gas and

247 n electrospray ionization mass spectrometry (DESI-MS).

248 n electrospray ionization mass spectrometry (DESI-MS).

249 al exposure to drugs screened using the SPME DESI-MS/MS method showed good agreement with the convent

250 The performance of the SPME DESI-MS/MS method was evaluated by preparing calibration

251 /MS also showed good agreement with the SPME DESI-MS/MS method.

252 nhanced TM-DESI-MS when compared to standard DESI-MS.

253 Under static DESI-FAIMS conditions selected for transmission of doubl

254 In this study, DESI-MS and tandem mass spectrometry experiments (MS/MS)

255 Our results suggest DESI-MS as a powerful approach for rapid serous ovarian

256 In summary, DESI-MSI identified distinct lipid composition between D

257 These results demonstrate that DESI MSI may be a valuable tool in the improved diagnosi

258 Our work demonstrates that DESI-MS technology has the potential to identify the his

259 s from 10 surgical resection cases show that DESI-MS allows detection of glioma and estimation of hig

260 These results show that DESI-MS provides intact molecular information on battery

261 s a proof-of-principle example, we show that DESI-MSI allows interrogation of the molecular products

262 This study clearly shows that DESI-based electrochemical MS is capable of capturing el

263 Our results strongly suggest that DESI-MS imaging is a valuable technology for identificat

264 The results suggest that DESI-MSI imaging of fingerprints with GDBT analysis migh

265 The results obtained suggest that DESI-MSI/Lasso may be valuable for routine intraoperativ

266 The DESI-MS approach described here provided a practical and

267 ple and the thin solvent film created by the DESI spray, resulting in more effective dissolution of t

268 Doping the DESI spray solvent with supercharging reagents resulted

269 Lasso), we analyzed all metabolites from the DESI-MS data and identified parsimonious sets of metabol

270 etyl-aspartic acid, was also observed in the DESI mass spectra, and these data further assisted in di

271 each of the explosives were observed in the DESI mass spectrum.

272 u (IV) intermediate is not observed when the DESI spray solution is sparged with Ar gas, indicating t

273 ting all of the target compounds; therefore, DESI MSI, a complementary mass spectrometry imaging tech

274 This DESI-MSI approach is generally applicable to a wide rang

275 Gadoteridol+K](+) adduct as revealed through DESI-MS complements the in vivo MRI results.

276 we explore the potential of high throughput DESI-MS experiments to identify trends in reactivity bas

277 Thus, DESI-IMS and unsupervised segmentation spatially annotat

278 Thus, DESI-MS could serve as a useful adjunct to histology in

279 Thus, DESI-MSI can objectively identify invasive esophageal ad

280 nalytical performance of surface enhanced TM-DESI-MS when compared to standard DESI-MS.

281 mode desorption electrospray ionization (TM-DESI) coupled to an ion trap mass spectrometer capable o

282 mode desorption electrospray ionization (TM-DESI).

283 These results indicate that TM-DESI/ion trap technology could be a powerful on-site too

284 ces, and experimental conditions amenable to DESI-MSI, especially for analytes that are weakly attach

285 ferred to flat hard surfaces, was coupled to DESI-MS and applied for the first time to fungal cocultu

286 dergoing surgical resections were subject to DESI MSI.

287 tic digestion and comparative analysis using DESI-MS and LESA-MS using tandem electrospray MS.

288 e prospectively collected and analyzed using DESI-MS imaging, and the performance of the statistical

289 reductive elimination was also probed using DESI-MS.

290 t analysis of adjacent tissue sections using DESI-MSI is also reported.

291 call for accelerated diagnosis studies using DESI-MSI in the upper gastrointestinal endoscopy suite,

292 y ESI and directly from steel surfaces using DESI ambient ionization at levels >/=0.0004% w/w (4 ppm)

293 information on small molecules recorded via DESI-MS imaging coupled with traditional anatomical eval

294 While DESI-MS narrowed the scope of possibilities for reaction

295 With DESI MS, we identify isocitrate dehydrogenase 1-mutant t

296 of molecular subtypes of breast cancer with DESI-MSI.

297 alysis and greater sensitivity compared with DESI-MS.

298 rared Laser Mass Spectrometry (PIRL-MS) with DESI-MS.

299 Imaging tissue sections with DESI MS shows that the 2-HG signal overlaps with areas o

300 In this work, DESI DM-MSI experiments on biological tissue samples suc