ライフサイエンスコーパス: DG

1 DG engram neurons exhibit a highly distinct pattern of g

2 DG-GluN1 KO mice show CA3 cellular hyperactivity, detect

3 2-DG inhibits proinflammatory cytokine production by MDM a

4 t combination treatment with metformin and 2-DG was efficacious in dampening mouse T cell activation-

5 itochondrial ATP synthase inhibitor), both 2-DG and glucose starvation strongly suppress tumor necros

6 g), and was exacerbated by 2-deoxyglucose (2-DG) glycolytic inhibition, despite preventing IL-1beta s

7 d the glycolytic inhibitor 2-deoxyglucose (2-DG) have been used to study the inhibition of oxidative

8 fficiently inhibited by 2-deoxy-d-glucose (2-DG) or by glucose starvation.

9 tion of glycolysis with 2-deoxy-D-glucose (2-DG) reduced osteoclast formation and activity under both

10 However, 2-DG exerts these effects by inducing unfolded protein res

11 , FCCP, and a glucose metabolic inhibitor, 2-DG, activated AMPK and inhibited Wnt signaling.

12 The effects of metformin + 2-DG on human T cells were accompanied by significant remo

13 In this study, we report that metformin + 2-DG treatment more potently suppressed IFN-gamma producti

14 cts of metabolic inhibition by metformin + 2-DG treatment on primary human T cells and provide a basi

15 Accordingly, metformin + 2-DG treatment significantly suppressed MYC-dependent meta

16 in normoxia is not obvious, and effects of 2-DG on cytokine responses should be interpreted cautiousl

17 ive to treatments with either metformin or 2-DG alone.

18 an CD4(+) T cells than either metformin or 2-DG treatment alone.

19 tion suggest that dentate gyrus and CA(2,3) (DG/CA(2,3)) are biased to differentiate highly similar m

20 3-DG concentration was between 5 and 120 umol/100 g dry we

21 n with ortho-phenylenediamine, we analyzed 3-DG with HPLC-UV.

22 MGO, GO, and 3-DG and protein-bound Nepsilon-(carboxymethyl)lysine (CML

23 The presented database of MGO, GO, and 3-DG opens the possibility to accurately estimate dietary

24 MGO, GO, and 3-DG were about equally potent in the millimolar range.

25 HPLC-MS/MS method to quantify MGO, GO, and 3-DG.

26 n that when incubated with faecal bacteria 3-DG strongly depressed this microbial community.

27 (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) are increased after an oral glucose load indicating

28 (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) in commonly-consumed products in a Western diet.

29 3-Deoxyglucosone (3-DG) is a metabolite from sugar degradation obtained by t

30 O), methylglyoxal (MGO), 3-deoxyglucosone (3-DG) were assessed against Gram-positive and Gram-negativ

31 arbonyl compounds (DCs), 3-deoxyglucosone (3-DG), glyoxal (GO) and methylglyoxal (MGO) during simulat

32 (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG).

33 estion phases (concentration loss: 11% for 3-DG, 24% for GO and MGO) and have an effect on the fermen

34 s have shown no antimicrobial activity for 3-DG, however, for the first time it has been shown that w

35 t body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar

36 To investigate the reaction pathways of 3-DG formation, we varied the composition of reactants (su

37 The abundant formation of 3-DG in the malting process is already comparable to the o

38 The formation of 3-DG increased for high malt modification levels and high

39 d to hippocampal head subfield volume (CA2-4/DG).

40 ion literature featuring 2-picolinamide as a DG.

41 Poly(A)-DG consists of a Convolution Neural Network-Multilayer P

42 e a novel deep learning method named Poly(A)-DG for cross-species PAS identification.

43 ced data issues and demonstrate that Poly(A)-DG not only outperforms state-of-the-art methods but als

44 running)-induced anxiolytic effect and adult DG neurogenesis.

45 ediated antianxiety-like behaviors and adult DG neurogenesis.

46 bated anxiety-like behaviors, impaired adult DG neurogenesis, and abolished activity (e.g., voluntary

47 d anxiety-like behaviors and increased adult DG neurogenesis, whereas ablating or chronically inhibit

48 g anxiety-like behaviors but promoting adult DG neurogenesis, and both functions are likely through a

49 omotes neuronal dendrite growth in the adult DG.

50 Although proliferation of these adult DG NSCs has been implicated in opiate dependence, whethe

51 nd post-synaptic laminin receptors and alpha-DG and pikachurin in the synaptic space to maintain prop

52 Variant 2.2 infected both alpha-DG-null or -expressing cells.

53 n alpha5 was also recognized by T cell alpha-DG and required for Th17 differentiation.

54 n (matriglycan) on alpha-dystroglycan (alpha-DG) enables diverse roles, from neuronal development to

55 the LCMV receptor alpha-dystroglycan (alpha-DG) than v2.2 and entered alpha-DG-expressing but not al

56 lycan (alpha-DG) than v2.2 and entered alpha-DG-expressing but not alpha-DG-null cells.

57 nd entered alpha-DG-expressing but not alpha-DG-null cells.

58 Hyperglycosylation of alpha-DG with LARGE overexpression is shown to inhibit cancer

59 hance the expression of matriglycan on alpha-DG in breast cancer cells.

60 nger closely associated with mGluR6 or alpha-DG in the Lamb2-null.

61 cumulation was first observed in the CA1 and DG starting at 6-8 months that progressed throughout all

62 In fact, higher activation in the CA1 and DG was associated with lower volumes in these subfields.

63 ural progenitor cells (NPCs), GNs, glia, and DG volume in whole hippocampus postmortem in four groups

64 s in whole DG, showing no effect on NPCs and DG volume in MDDSui.

65 onnections predicting hippocampus -> PFC and DG -> CA1, i.e., theta transmission is unidirectional in

66 r and mid DG GNs (p < .0001), fewer anterior DG NPCs (p < .0001), and smaller whole DG volume (p = .0

67 Anti-alpha6 integrin or anti-DG prolonged allograft survival.

68 decrease in depression scores, and baseline DG volume predicted clinical response.

69 also causes the clustering of AQP4 and beta-DG.

70 ly, agrin sliencing profoundly disrupts beta-DG clustering.

71 it co-clusters with beta-dystroglycan (beta-DG).

72 ough pikachurin remains associated with beta-DG, pikachurin is no longer closely associated with mGlu

73 tedly, cyclic amides were found to be better DGs than pyridine-containing ones or cyclic imides for t

74 vival, but not the production, of adult-born DG granule cells, possibly because of greater circuit in

75 reas it restricts the survival of adult-born DG granule cells, which compete with mature granule cell

76 To rigorously assess pattern separation by DG circuitry, we used mouse brain slices to stimulate DG

77 scardially to mice is selectively uptaken by DG NSCs within a minute, via the vessel-associated apica

78 In LFP recordings along the dorsal CA1-DG axis from sleeping male mice, we detected and classif

79 on the CA3 region and the dentate gyrus (CA3-DG) of the hippocampus, alongside associated memory impa

80 evels were specifically related to lower CA3-DG volume.

81 Our results suggest that the CA3-DG may be the hippocampal region most closely associated

82 havior indicative of pattern separation, CA3/DG neurons respond to lure images more like novel than r

83 ans while recording activity from single CA3/DG neurons.

84 Belgian Foundation Against Cancer, DG Research and Innovation of the European Commission, a

85 dorsal (dDG) and ventral (vDG) adult canine DG were comparatively examined over a period of 30 days.

86 eservoir enabling recovery from catastrophic DG damage.SIGNIFICANCE STATEMENT Adult hippocampal neuro

87 populations of dentate gyrus granule cells (DG GCs) and lateral entorhinal cortex (LEC) neurons acro

88 We assessed the contribution of circulating DG to systemic immune activation in PLWH.

89 This did not compromise DG plasticity or spatial and contextual learning and mem

90 owever, the molecular mechanisms controlling DG formation and function remain elusive.

91 re, suggesting that early life stress delays DG development.

92 ode array (MEA) was used to monitor dentate (DG), CA3, and CA1 hippocampal extracellular glutamate le

93 ycerophosphocholine (PC) and diacylglycerol (DG) lipid species from human plasma.

94 changes in triglycerides (TG), diglycerides (DG), phosphatidylcholine, phosphatidylethanolamine, cera

95 identified a group of embryonic born dorsal DG (dDG) neurons, which were activated by anxiogenic sti

96 ast, following labeling of MCs in the dorsal DG, the projections were more diffusely distributed.

97 ctional glycosylation of alpha-dystroglycan (DG), a key component in the link between the cytoskeleto

98 eactivated during overlapping pair encoding, DG/CA(2,3) and subiculum representations for indirectly

99 these observations, and find that epileptic DG networks organize into disjoint, cell-type specific p

100 erm alterations in DG structure by examining DG assembly and the generation of a stable adult stem ce

101 or class of GABAergic neurons, essential for DG function, and are involved in the pathophysiology of

102 ng in the adult human hippocampal formation (DG, CA1, CA2, CA3, subiculum, presubiculum, and parasubi

103 both cases: from hippocampus to PFC and from DG to CA1 along the tri-synaptic pathway within hippocam

104 This effect diminished when inputs from DG and CA3 into CA1 were lesioned.

105 er an explicit modal discontinuous Galerkin (DG) method utilizing Implicit Large Eddy Simulation (ILE

106 mice treated with Ghr, des-octanoyl-ghrelin (DG) or vehicle.

107 leavage of the picolinamide directing group (DG) and recycling of the byproduct generated has been de

108 tiary amide core acted as a directing group (DG) enabling formation of six-membered cycloruthenated s

109 ent, built-in bidentate N,O-directing group (DG) toward the synthesis of pyridone derivatives.

110 g citric acid (CA) and disodium 5-guanylate (DG).

111 NSCs in the dentate gyrus (DG(have enigmatic elaborated apical cellular processes t

112 expressed only in hippocampal dentate gyrus (DG) and assessed its association with hippocampal physio

113 ns for unexpected items, with dentate gyrus (DG) and CA3 being more sensitive to expectation violatio

114 tantiated upstream within the dentate gyrus (DG) and CA3 subregions.

115 ed interneurons mostly in the dentate gyrus (DG) and CA3.

116 The dentate gyrus (DG) and proximal CA3 (pCA3) regions have been implicated

117 tional circuits involving the dentate gyrus (DG) and proximal CA3.

118 range communications between dentate gyrus (DG) and the Ammon's horn (CA1) within the hippocampus.

119 Mossy cells (MCs) of the dentate gyrus (DG) are a major group of excitatory hilar neurons that a

120 STATEMENT Mossy cells in the dentate gyrus (DG) are an integral component of the DG/pCA3 circuit.

121 The dentate gyrus (DG) controls information flow into the hippocampus and i

122 the fact that the hippocampal dentate gyrus (DG) gives rise to newborn DGCs throughout the lifetime i

123 The dentate gyrus (DG) has a key role in hippocampal memory formation.

124 he mammalian hippocampus, the dentate gyrus (DG) has the unique characteristic of exhibiting neurogen

125 granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood.

126 and layers of the hippocampus dentate gyrus (DG) in an electric stimulation rodent model which displa

127 The reorganization of the dentate gyrus (DG) in TLE may create pathological conduction pathways f

128 The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cel

129 ts.SIGNIFICANCE STATEMENT The dentate gyrus (DG) is important for learning, memory, pattern separatio

130 ramammillary nucleus (SuM) to dentate gyrus (DG) is needed for contextual memory, social memory requi

131 Adult hippocampal dentate gyrus (DG) neural stem cells (NSCs) continuously undergo prolif

132 GABAergic interneurons in the dentate gyrus (DG) of AD patients and mice.

133 yperactivity was found in the dentate gyrus (DG) of leuprolide-treated females, but not males, consis

134 NCE STATEMENT The hippocampal dentate gyrus (DG) of rodents generates newborn dentate granule cells (

135 generated in the hippocampal dentate gyrus (DG) of rodents through a process called adult hippocampa

136 uronal differentiation in the dentate gyrus (DG) of the hippocampus and significantly impaired hippoc

137 populations of neurons in the dentate gyrus (DG) of the hippocampus are causally implicated in the en

138 g of ECT, neurogenesis in the dentate gyrus (DG) of the hippocampus is observed.

139 entricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus, whereas the implantation of MSCs

140 Dentate gyrus (DG) of the mammalian hippocampus gives rise to new neuro

141 risk and potentially affects dentate gyrus (DG) plasticity.

142 The dentate gyrus (DG) plays a central role in the process of memory format

143 rticular with assembly of the dentate gyrus (DG) region of the hippocampus.

144 The CA3 and dentate gyrus (DG) regions of the hippocampus are considered key for di

145 ural stem cells (NSCs) in the dentate gyrus (DG) reside in a specialized local niche that supports th

146 tion in the adult hippocampus dentate gyrus (DG) subgranular zone.

147 l synapses and perforant path-dentate gyrus (DG) synapses of the hippocampus.

148 on processes supported by the dentate gyrus (DG) to prevent interference from overlapping memory repr

149 te neuronal activation of the dentate gyrus (DG) using cFos immunohistochemistry was measured as a ne

150 to the molecular layer of the dentate gyrus (DG) where information is filtered and converted into spa

151 Dentate gyrus (DG), a "gate" that controls information flow into the hi

152 ippocampus and especially the dentate gyrus (DG), a vulnerable brain region and one of the two sites

153 GABAergic transmission in the dentate gyrus (DG), accompanied by schizophrenia-like behavior in the a

154 cell type in the hilus of the dentate gyrus (DG), are unique in providing extensive longitudinal and

155 major hippocampal subfields, dentate gyrus (DG), CA3, and CA1, has a unique function in memory forma

156 rom the entorhinal cortex and dentate gyrus (DG), the proximal CA3 region of aged rats may switch fro

157 urogenesis in the hippocampal dentate gyrus (DG), while the effects of antidepressants are mediated b

158 ether, and to what extent can dentate gyrus (DG)-resident neural stem cells drive regeneration of an

159 of neurons in the hippocampal dentate gyrus (DG).

160 mossy fiber sprouting in the dentate gyrus (DG).

161 vior and transcription in the dentate gyrus (DG).

162 the granule cell layer of the dentate gyrus (DG-GCL) in human hippocampus and contrast these data to

163 This suppression is abolished if DG expression is silenced, again demonstrating the centr

164 Odor classification accuracy in DG GCs correlated with future behavioral discrimination.

165 ife stress produces long-term alterations in DG structure by examining DG assembly and the generation

166 red with controls, implicating astrocytes in DG, immune mechanisms in CA3, and synaptic scaling in CA

167 ntributes to the sparse population coding in DG.SIGNIFICANCE STATEMENT Our study describes a long-las

168 Deficits in DG neurons contribute to the pathogenesis of not only ne

169 arity for unexpected highly similar foils in DG and CA3.

170 A large and significant increase in DG volume was observed after ECT (M = 75.44 mm(3), std e

171 Furthermore, an increase in DG volume was related to a decrease in depression scores

172 ow that conditional overexpression of MOR in DG NSCs under a doxycycline inducible system leads to fa

173 We found representations of odors in DG GCs that required synaptic input from the LEC.

174 (Arg1) ablation as well as overexpression in DG, we identified a critical role of Arg1 in microglia a

175 classifier, we classified cells recorded in DG (Neunuebel and Knierim, 2014) and pCA3 (Lee et al., 2

176 al deletion of Tiam1 in male mice results in DG granule cells with simplified dendritic arbors, reduc

177 strongly suggest that pattern separation in DG/CA3 underlies the effect that violation of expectatio

178 s: (1) pattern separation-related signals in DG/CA3 and perirhinal cortex and (2) source memory signa

179 Relative to sham, e-stim training increased DG volume by approximately 10% and astrogliogenesis by 7

180 stem cells drive regeneration of an injured DG has remained unclear.

181 thesized that use of a task requiring intact DG function would emphasize molecular signals in the DG

182 Intriguingly, DG lesions impair many, but not all, hippocampus-depende

183 Resilience to ELA involves a larger DG, perhaps related to more neurogenesis depleting NPCs,

184 ELA was associated with larger DG (p < .0001) and trending fewer NPCs (p = .0190) only

185 In associative learning, DG GCs, more so than LEC neurons, changed their response

186 Thus, with learning, DG GCs amplify the decodability of cortical representati

187 Controlling for baseline volumes, the left DG/CA3 region was significantly larger following memanti

188 how abGCs distinctively contribute to local DG information processing.

189 esonance imaging at 7 T, we found that lower DG volume and higher CA3 activation was associated with

190 provide a further rationale for maintaining DG neurogenesis in adult life.

191 Using c-Fos to mark DG neuron activation, we identified a group of embryonic

192 heria toxin-based ablation of >50% of mature DG granule cells (GCs) or by prolonged brain-specific VE

193 One limitation is the difficulty to measure DG inputs and outputs simultaneously.

194 c overexpression of human tau (hTau) in mice DG interneurons induced AHN deficits but increased neura

195 DDSui without ELA had fewer anterior and mid DG GNs (p < .0001), fewer anterior DG NPCs (p < .0001),

196 aling activities, and routes underlie mosaic DG formation.

197 Mouse DG formation shares conserved features of human neocorti

198 ns in live slices across key stages of mouse DG development, testing decades old static models of DG

199 o selectively manipulate activity of newborn DG neurons.

200 tivate the hippocampus, and in agreement, no DG activation was observed.

201 to repair a massively injured, nonfunctional DG.

202 Ghr but not DG, decreased cell proliferation via AMPK activation in

203 Notably, DG granule cell dendrites and synapses develop normally

204 hat muscle contractions alone, in absence of DG activation, are sufficient to increase adult hippocam

205 lters differentiation and dendritogenesis of DG NSCs and investigate the possibility that these alter

206 over, selective chemogenetic inactivation of DG-CA3 circuitry completely and reversibly abolishes the

207 ating in extensive, highly selective loss of DG GCs (thereby also reinforcing the notion of selective

208 exciting new insights into the mechanisms of DG computational processes, particularly for the encodin

209 opment, testing decades old static models of DG formation with molecular identification, genetic-line

210 tress exhibited a reduction in the number of DG stem cells, but unchanged neurogenesis suggesting a d

211 e Rac-GEF Tiam1 as an important regulator of DG development and associated memory processes.

212 establish Tiam1 as an essential regulator of DG granule cell development, and identify it as a possib

213 lts suggest that Tiam1 is a key regulator of DG granule cell stabilization and function within hippoc

214 results reveal a causal and specific role of DG-CA3 circuitry in the maintenance of latent informatio

215 Here we perform unbiased RNA sequencing of DG engram neurons 24 h after contextual fear conditionin

216 ate that Tiam1 promotes the stabilization of DG granule cell dendritic arbors, spines, and synapses,

217 ELA effects on DG plasticity in suicide decedents with MDD (MDDSui) and

218 the mu-opioid receptor (MOR) is expressed on DG NSCs and that MSA leads to a two-fold elevation of en

219 /survival rates, restoring a nearly original DG mass, promoting proper rewiring of regenerated neuron

220 ls of PP terminals, scaling down the overall DG activation.

221 find that Tiam1's support of perforant path-DG synapse function is dependent on its GEF domain and i

222 y confer unique properties to perforant path-DG synapses.

223 nate can be used to install the picolinamide DG in a direct or indirect manner on amines.

224 y do not change in adults, while presynaptic DG mossy fiber boutons undergo significant structural re

225 ress leads to a more immature, proliferative DG than would be expected for the animal's age immediate

226 These results indicate that Tiam1 promotes DG granule cell dendrite and synapse stabilization late

227 expressing (DCX(+)) NSC progenies in the rat DG.

228 ulate DG afferents and simultaneously record DG granule cells (GCs) and interneurons.

229 ortance, the molecular mechanisms regulating DG neural circuit assembly and function remain unclear.

230 old, we observed that greater left and right DG volume, and greater activity in the CA3 was associate

231 eby also reinforcing the notion of selective DG vulnerability).

232 ocampal activity in SzP, based on the shared DG-specific GluN1 reduction.

233 ta phase, but not vice versa; (2) similarly, DG high-gamma amplitude was significantly coupled to CA1

234 score correlated with fewer GNs and smaller DG.

235 In MDDSui without ELA, smaller DG volume, with fewer GNs and NPCs, suggests less neurog

236 try, we used mouse brain slices to stimulate DG afferents and simultaneously record DG granule cells

237 iptome changes in the hippocampal subfields, DG, CA3, and CA1 from individuals with SZ psychosis and

238 address this issue, we inflicted substantial DG-specific damage in mice of either sex either by dipht

239 Here we show that DG neurogenesis acts to replace lost neurons and restore

240 theta phase, but not vice versa, and (3) the DG high-gamma-CA1 theta PAC was significantly correlated

241 ergic input from both HRNs and LRNs, but the DG receives mainly LRN input.

242 s of, and the computations performed by, the DG.

243 e association study genetic weights from the DG-GCL, which identified many schizophrenia-associated g

244 However, the DG contains two types of excitatory cells: granule cells

245 pting us to cluster sharp waves (SWs) in the DG [dentate SWs (DSWs)] during sleep.

246 probability phase of principal cells in the DG and CA3.

247 n between newly generated neuroblasts in the DG and cognition deficits in miR-17-92 knockout (KO) mic

248 dendrites of host excitatory neurons in the DG and the CA1 subfield of the hippocampus, implying an

249 ion would emphasize molecular signals in the DG associated with a decline in performance.

250 neuropeptide Y-positive interneurons in the DG correlated with a reduced number of activated egr-1(+

251 We found that the actions of abGCs in the DG depend on the origin of incoming afferents.

252 he activity of different neuron types in the DG during memory tasks and have provided exciting new in

253 e neurons and gene expression changes in the DG following rmTBI.

254 hippocampal subregions indicated DEGs in the DG of middle-age rats, linked to synaptic function and n

255 beled cells which co-expressed Prox-1 in the DG of rmTBI-injured mice which coincided with enhanced c

256 itory synapses was markedly increased in the DG of Tau(VLW) mice and FTD patients.

257 e activity, adult-born neurons (ABNs) in the DG play critical roles in memory; however, their memory

258 pus, Tiam1 is predominantly expressed in the DG throughout life.

259 was elevated in all three age groups in the DG, but temporally delayed to 18-20 months in the CA3 of

260 is expected to be exclusively present in the DG, whereas other processes (angiogenesis, synaptogenesi

261 pe-enriched aging and genetic effects in the DG-GCL that were either absent or directionally discorda

262 on quantitative trait loci identified in the DG-GCL, 15% were not detected in bulk hippocampus, inclu

263 shape distinct neural representations in the DG.

264 ration at the level of single neurons in the DG.

265 nd classified two types of LFP events in the DG: high-amplitude dentate spikes (DSs), and a novel eve

266 cular), as well as different regions, of the DG (ventral and dorsal).

267 ntribute to changing the excitability of the DG and CA3 during memory discrimination via transient di

268 eflects the pattern separation output of the DG and instead performs a computation that reflects an a

269 ndings suggest that the volume change of the DG is related to the antidepressant properties of ECT, a

270 contributes to the mnemonic functions of the DG is uncertain.

271 tural elements and various cell types of the DG may underlie its function in cognition.

272 ng also the exceptional vulnerability of the DG to insults, these findings provide a further rational

273 rformance, suggesting that senescence of the DG underlies the impairment.

274 dentified distinct molecular profiles of the DG, CA3, and CA1 in SZ psychosis may serve to identify f

275 throughout the rostral-caudal extent of the DG, replicating the expected distribution of MC axons.

276 resent in specific layers and regions of the DG, such as PARK7, RACK1, and connexin 31/gap junction.

277 mination in the inner molecular layer of the DG, we discovered that the axonal projections of dorsal

278 n neurons in the functional circuitry of the DG.

279 gyrus (DG) are an integral component of the DG/pCA3 circuit.

280 Our results suggest that the DG is directly affected by memory consolidation processe

281 l and commissural projections throughout the DG.

282 ippocampal function, with specificity to the DG.

283 intact CREB function specifically within the DG engram during memory consolidation, and identify a no

284 xtensive longitudinal connections within the DG.

285 t all three excitatory cell types within the DG/pCA3 circuit may act as a single functional unit to s

286 Here, we review these DG-dependent mnemonic functions in light of the new find

287 and substrate has been investigated for this DG-mediated late-stage functionalization reactions along

288 Moreover, this DG has been successfully applied for ortho-selective C(s

289 s suggest that MCs in the dorsal and ventral DG differ in the distribution of their axonal projection

290 n assumed that MCs in the dorsal and ventral DG have similar patterns of termination in the inner one

291 ng unilateral labeling of MCs in the ventral DG, a dense band of fibers was present in the inner one-

292 of perforant path stimulation in the ventral DG.

293 Whereas DG's function in spatial learning and memory has been ex

294 attern separation, and spatial coding, while DG dysfunction is associated with neuropsychiatric disor

295 d a trend for more glia (p = .0160) in whole DG in MDDSui and control subjects.

296 p = .0190) only in control subjects in whole DG, showing no effect on NPCs and DG volume in MDDSui.

297 erior DG NPCs (p < .0001), and smaller whole DG volume (p = .0005) compared with control subjects wit

298 theta PAC was significantly correlated with DG -> CA1 Granger causality, a well-established analytic

299 in hippocampal function by interfering with DG assembly and ultimately diminishing the adult stem ce

300 reciated regenerative potential of the young DG and suggests hippocampal NSCs as a critical reservoir