ライフサイエンスコーパス: DMPS

1 DMPS was an effective mercury chelator in this system, s

2 DMPS with saturated acyl chains was found to be a much m

3 these vesicles was varied between 1% and 10% DMPS.

4 maximal at 4 mN m(-1) in the presence of 10% DMPS).

5 with 2,3-dimercapto-1-propanesulfonic acid (DMPS) or meso-2,3-dimercaptosuccinic acid (DMSA) caused

6 drugs 2,3-dimercapto-1-propanesulfonic acid (DMPS), marimastat, and varespladib, alone or in combinat

7 inefficient packing between cholesterol and DMPS occurs probably because of the strong interactions

8 FTIR spectroscopy, using analogs of DMPC and DMPS with perdeuterated acyl chains, showed that the mel

9 ges were detected when inorganic mercury and DMPS were added to the bath.

10 nhibited by NAC (K(i) of 2.0 +/- 0.3 mM) and DMPS (K(i) of 0.10 +/- 0.02 mM), providing further evide

11 lts indicate that the MeHg antidotes NAC and DMPS and their mercaptide complexes are transported by O

12 NAC and DMPS are themselves excreted in urine in high concentrat

13 on (P = 0.003), which was further reduced by DMPS treatment (P < 0.0001).

14 In contrast, DMPS-d54 incorporated into red cells exhibited no phase

15 In contrast, DMPS-d54 incorporated into the outer leaflet of echinocy

16 ubated with an equimolar mixture of DMPC-d54/DMPS or DMPC/DMPS-d54 remained mostly discocytic whereas

17 ncubated with equimolar mixtures of DMPC-d54/DMPS or DMPC/DMPS-d54, the deuterated species exhibited

18 Fully deuterated DMPS or DMPG is ordered in a way similar to that of DMPC

19 steine (NAC) and dimercaptopropanesulfonate (DMPS) are sulfhydryl-containing compounds that produce a

20 ithiol ligand 2,3-dimercaptopropanesulfonic (DMPS) acid has been employed to synthesize dithiol-prote

21 to penetrate dimyristoylphosphatidylcholine/DMPS monolayers, and at an initial surface pressure of 3

22 Dimyristoylphosphatidylserine (DMPS), phosphatidylserine from bovine brain (brain-PS),

23 ne (DMPC) and dimyristoylphosphatidylserine (DMPS), utilizing the nixtroxide-labeled cholesterol anal

24 DMPC-d54) and dimyristoylphosphatidylserine (DMPS-d54) were incorporated by incubation into human ery

25 atidylcholine/dimyristoylphosphatidylserine (DMPS) vesicles.

26 holine (DMPC)/dimyristoylphosphatidylserine (DMPS)/dioleoylglycerol (DO) vesicles was compared with t

27 holine (DMPC)/dimyristoylphosphatidylserine (DMPS)/dioleoylglycerol (DO), DMPC/DMPS/1-palmitoyl-2-ole

28 )O) of either dimyristoylphosphatidylserine (DMPS) or dimyristoylphosphatidylglycerol (DMPG).

29 (DMPC-d54) and dimyristoyphosphatidylserine (DMPS-d54) were incorporated into human erythrocytes.

30 , at 20 degrees C, the 14-carbon disaturated DMPS in the gel phase has an area of 40.8 A(2) vs. 48.1

31 ly 0.025 and approximately 0.5-0.6 for DMPC/ DMPS/DM.

32 /1-palmitoyl-2-oleoylglycerol (PO), and DMPC/DMPS/dimyristoylglycerol (DM) was analyzed and compared

33 DO (chi(DO)) in DMPC/DO, DMPS/DO, and [DMPC/DMPS (1:1, mol/mol)]/DO multilamellar vesicles (MLVs).

34 dylserine (DMPS)/dioleoylglycerol (DO), DMPC/DMPS/1-palmitoyl-2-oleoylglycerol (PO), and DMPC/DMPS/di

35 ximately 0.10 and approximately 0.3 for DMPC/DMPS/DO, chiPO = approximately 0.05 and approximately 0.

36 ximately 0.05 and approximately 0.4 for DMPC/DMPS/PO, and chiDM = approximately 0.025 and approximate

37 O (chiDO), PO (chiPO), or DM (chiDM) in DMPC/DMPS (1:1) multilamellar vesicles (MLVs) and of chiDO in

38 files of all three lipid components in [DMPC/DMPS (1:1, mol/mol)]/DO MLVs virtually overlay when chi(

39 n equimolar mixture of DMPC-d54/DMPS or DMPC/DMPS-d54 remained mostly discocytic whereas cells incuba

40 equimolar mixtures of DMPC-d54/DMPS or DMPC/DMPS-d54, the deuterated species exhibited no thermotrop

41 PKC activity was measured using [DMPC/DMPS (1:1, mol/mol)]/DO MLVs as the lipid activator.

42 on of mole fraction DO (chi(DO)) in DMPC/DO, DMPS/DO, and [DMPC/DMPS (1:1, mol/mol)]/DO multilamellar

43 Anionic phospholipids, especially DMPS, were located at the center of the LTRs and spanned

44 0.0001) in the renal 213Bi uptake; however, DMPS was more effective than DMSA (P < 0.001).

45 ed uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1,

46 roM for MeHg-NAC and 9 +/- 2 microM for MeHg-DMPS, indicating that these are relatively high-affinity

47 by glutarate, PAH, NAC, DMPS, MeHg-NAC, MeHg-DMPS, and a mercapturic acid, indicating that these are

48 Addition of 200 microM DMPS to the bath provided complete protection from the t

49 In the presence of 1 mg/ml DMPS in the transport milieu, the flux of FITC-Dextran-4

50 was trans-stimulated by glutarate, PAH, NAC, DMPS, MeHg-NAC, MeHg-DMPS, and a mercapturic acid, indic

51 y was further enhanced by the combination of DMPS with either chlorothiazide or furosemide (P < 0.000

52 te that the dual therapeutic combinations of DMPS or marimastat with varespladib significantly inhibi

53 port is linked to the therapeutic effects of DMPS.

54 d component grows in as the mole fraction of DMPS increases.

55 transport process involving the movement of DMPS from the bathing compartment to the luminal compart

56 reas cells incubated with either DMPC-d54 or DMPS-d54 alone became echinocytic or stomatocytic, respe

57 (14)C]MeHg when complexed with either NAC or DMPS but not when complexed with L-cysteine, glutathione

58 Saturated DMPS was also more effective in delaying resistance reco

59 ng agent 2, 3-dimercaptopropane-1-sulfonate (DMPS) significantly alters the renal tubular transport,

60 helator, 2,3-dimercaptopropane-1-sulphonate (DMPS), but was blocked by the metal chelator, calcium di

61 We also tested the hypothesis that DMPS can extract cellular mercury while being transporte

62 We also obtained data indicating that DMPS is transported by the organic anion transport syste

63 h that of the ternary mixtures suggests that DMPS/DO interactions may be more favorable than DMPC/DO

64 Additional data indicated that, when DMPS and inorganic mercury were coperfused through the l

65 Our findings showed that, when DMPS was applied to the basolateral membranes of S2 segm

66 ferentially into the outer monolayer whereas DMPS-d54 was selectively incorporated into the inner mon

67 ists in domains in the outer monolayer while DMPS-d54 is dispersed in the inner monolayer.

68 ecame echinocytic while those incubated with DMPS-d54 became stomatocytic.

69 bited became echinocytic when incubated with DMPS-d54.

70 The results with DMPS were also confirmed in a monkey model.